PML colocalizes with and stabilizes the DNA damage response protein TopBP1

scientific article

PML colocalizes with and stabilizes the DNA damage response protein TopBP1 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.23.12.4247-4256.2003
P3181OpenCitations bibliographic resource ID4256975
P932PMC publication ID156140
P698PubMed publication ID12773567

P2093author name stringZhi-Xiang Xu
Rui-Xun Zhao
Kun-Sang Chang
Anna Timanova-Atanasova
P2860cites workSequestration and inhibition of Daxx-mediated transcriptional repression by PMLQ22253162
Role of SUMO-1-modified PML in nuclear body formationQ22253970
PML regulates p53 acetylation and premature senescence induced by oncogenic RasQ22254666
Regulation of p53 activity in nuclear bodies by a specific PML isoformQ24290520
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylasesQ24290948
Regulation and localization of the Bloom syndrome protein in response to DNA damageQ24291133
Role of PML and PML-RARalpha in Mad-mediated transcriptional repressionQ24291380
Stable overexpression of PML alters regulation of cell cycle progression in HeLa cellsQ24312086
Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosisQ24315554
PML, a growth suppressor disrupted in acute promyelocytic leukemiaQ24324168
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma proteinQ24324766
The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoterQ24522845
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survivalQ24540067
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1Q24670576
Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signalingQ24674185
The function of PML in p53-dependent apoptosisQ28140732
Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemiaQ28143297
The transcriptional role of PML and the nuclear bodyQ28144176
Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNAQ28145077
BRCT domain-containing protein TopBP1 functions in DNA replication and damage responseQ28200771
Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactionsQ28200940
DNA double-strand breaks: signaling, repair and the cancer connectionQ28204231
Regulation of Pax3 transcriptional activity by SUMO-1-modified PMLQ28204429
PML interaction with p53 and its role in apoptosis and replicative senescenceQ28204830
Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage responseQ28206127
The promyelocytic leukemia protein represses A20-mediated transcriptionQ28206387
Cancer susceptibility and the functions of BRCA1 and BRCA2Q28217784
Identification of three major sentrinization sites in PMLQ28284098
PML is essential for multiple apoptotic pathwaysQ28508348
Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damageQ28610023
Homologous recombinational repair of DNA ensures mammalian chromosome stabilityQ28646561
Brca1 controls homology-directed DNA repairQ29614844
DNA damage-dependent nuclear dynamics of the Mre11 complexQ33975168
DNA repair: spot(light)s on chromatin.Q34218073
The molecular control of DNA damage-induced cell deathQ34220065
Transcriptional regulation in acute promyelocytic leukemia.Q34435531
SUMO: of branched proteins and nuclear bodiesQ34435551
PML induces a novel caspase-independent death processQ34478914
ATM function and telomere stabilityQ34535665
Interfaces between the detection, signaling, and repair of DNA damageQ34762844
PML is induced by oncogenic ras and promotes premature senescenceQ35201220
Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.Q36062156
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.Q40444140
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.Q40717542
Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleusQ40761429
Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.Q40793814
ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle.Q40841848
A role for PML and the nuclear body in genomic stabilityQ40905918
Transcriptional repression by the promyelocytic leukemia protein, PML.Q41071228
Failure to unwind causes cancer. Genome stabilityQ41110581
Molecular genetics of Bloom's syndromeQ41170320
NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3).Q41692539
The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear bodyQ42951383
Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cellsQ45881890
Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia proteinQ47814142
Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.Q48068389
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damageQ64387887
The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangementsQ64387924
Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) bodyQ78257210
P4510describes a project that usesImageQuantQ112270642
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectDNA topoisomerase II binding protein 1Q21116531
DNA damageQ5205747
cell biologyQ7141
P304page(s)4247-56
P577publication date2003-06-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlePML colocalizes with and stabilizes the DNA damage response protein TopBP1
P478volume23

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cites work (P2860)
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Q28261299TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis
Q40116480Tyrosine kinase inhibitor, methyl 2,5-dihydromethylcinnimate, induces PML nuclear body formation and apoptosis in tumor cells
Q36399088Ubiquitin-dependent degradation of p73 is inhibited by PML.

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