| scholarly article | Q13442814 |
| P2093 | author name string | Jiandong Chen | |
| Lihong Chen | |||
| Daniele M Gilkes | |||
| Cynthia LeBron | |||
| P2860 | cites work | Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein | Q22010970 |
| Identification of a cryptic nucleolar-localization signal in MDM2 | Q22253304 | ||
| Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development | Q24300985 | ||
| Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 | Q24303581 | ||
| DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation | Q24338364 | ||
| DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms | Q24540261 | ||
| MDMX: a novel p53-binding protein with some functional properties of MDM2 | Q24561971 | ||
| Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53 | Q24610106 | ||
| MDM2 interacts with MDMX through their RING finger domains | Q28142437 | ||
| 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax | Q28214507 | ||
| Mutual dependence of MDM2 and MDMX in their functional inactivation of p53 | Q28214705 | ||
| Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 | Q28214793 | ||
| STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. | Q28253106 | ||
| ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins | Q28273233 | ||
| 14-3-3sigma is a p53-regulated inhibitor of G2/M progression | Q28276061 | ||
| Cell cycle roles for two 14-3-3 proteins during Drosophila development | Q28362778 | ||
| Mapping of the p53 and mdm-2 Interaction Domains | Q28609886 | ||
| A genetic approach to mapping the p53 binding site in the MDM2 protein | Q28758655 | ||
| The structural basis for 14-3-3:phosphopeptide binding specificity | Q29547190 | ||
| The p53 pathway: positive and negative feedback loops | Q29617535 | ||
| Chk1 and Chk2 kinases in checkpoint control and cancer | Q29617706 | ||
| Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 | Q29617850 | ||
| 14-3-3 proteins: structure, function, and regulation | Q29619100 | ||
| Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle | Q29619289 | ||
| Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. | Q30804251 | ||
| The p53 pathway | Q33643359 | ||
| Regulation of p53-MDMX interaction by casein kinase 1 alpha | Q33925248 | ||
| Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage | Q33935906 | ||
| ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage | Q34116228 | ||
| Control of p53 ubiquitination and nuclear export by MDM2 and ARF. | Q34237563 | ||
| 14-3-3 proteins; bringing new definitions to scaffolding | Q34405540 | ||
| MDM2 promotes ubiquitination and degradation of MDMX | Q35161842 | ||
| The 14-3-3 cancer connection | Q35635340 | ||
| 14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth | Q36549508 | ||
| DNA damage-induced MDMX degradation is mediated by MDM2. | Q40636352 | ||
| Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation | Q40763347 | ||
| Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms | Q40773986 | ||
| Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53. | Q40816015 | ||
| Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest. | Q43755867 | ||
| The Chk2 tumor suppressor is not required for p53 responses in human cancer cells | Q44374511 | ||
| Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2. | Q44521310 | ||
| mdmx is a negative regulator of p53 activity in vivo | Q74198977 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1196-1206 | |
| P577 | publication date | 2006-03-02 | |
| P1433 | published in | The EMBO Journal | Q1278554 |
| P1476 | title | Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. | |
| P478 | volume | 25 |
| Q34568342 | 14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53. |
| Q24313042 | 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition |
| Q39472408 | A critical role for noncoding 5S rRNA in regulating Mdmx stability |
| Q37494380 | A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer |
| Q37546075 | AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity |
| Q24328822 | An essential function of the extreme C-terminus of MDM2 can be provided by MDMX |
| Q36298331 | Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein |
| Q35485193 | Autoinhibition of MDMX by intramolecular p53 mimicry |
| Q35082715 | Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc |
| Q34977480 | CHK2 kinase in the DNA damage response and beyond |
| Q37001375 | CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? |
| Q36397318 | Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding |
| Q28114807 | Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity |
| Q91657624 | Competitive ubiquitination activates the tumor suppressor p53 |
| Q34011009 | Controlling the Mdm2-Mdmx-p53 Circuit |
| Q39125363 | DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. |
| Q27003153 | Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1 |
| Q46692713 | Dichlorvos-induced cell cycle arrest and DNA damage repair activation in primary rat microglial cells. |
| Q35071233 | Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. |
| Q34618435 | Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis |
| Q39141247 | Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells. |
| Q33970628 | EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma |
| Q90229840 | Estrogens Counteract Platinum-Chemosensitivity by Modifying the Subcellular Localization of MDM4 |
| Q37871861 | Functions of MDMX in the modulation of the p53-response |
| Q42232791 | Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo |
| Q39675744 | HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity. |
| Q28257444 | Hdmx modulates the outcome of p53 activation in human tumor cells |
| Q36033129 | Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein |
| Q33662376 | Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3. |
| Q36801098 | Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents |
| Q37379017 | Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases |
| Q91846035 | Inhibition of MELK produces potential anti-tumour effects in bladder cancer by inducing G1/S cell cycle arrest via the ATM/CHK2/p53 pathway |
| Q28611422 | MDM2 and MDMX: Alone and together in regulation of p53 |
| Q30380283 | MDM4 (MDMX) and its Transcript Variants. |
| Q24337839 | MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway |
| Q38884006 | MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond |
| Q40244145 | MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. |
| Q40034309 | MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. |
| Q24316958 | MDMX regulation of p53 response to ribosomal stress |
| Q57498791 | MDMX under stress: the MDMX-MDM2 complex as stress signals hub |
| Q37099799 | Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells |
| Q38016717 | Mdm2 and MdmX partner to regulate p53. |
| Q34296531 | Mechanism of p53 stabilization by ATM after DNA damage |
| Q38769323 | Mouse modelling of the MDM2/MDMX-p53 signalling axis |
| Q34198570 | Phosphatases in the cellular response to DNA damage. |
| Q36619894 | Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress |
| Q24313228 | Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding |
| Q35748395 | Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity |
| Q41287206 | Protecting the genome from mdm2 and mdmx |
| Q35927931 | Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation |
| Q24294849 | Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity |
| Q36498007 | Regulation of MDMX expression by mitogenic signaling |
| Q37992789 | Regulation of p53: a collaboration between Mdm2 and Mdmx |
| Q39424924 | Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis |
| Q39812243 | Ribosomal protein S7 is both a regulator and a substrate of MDM2 |
| Q39555703 | SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. |
| Q39492626 | Stochastic and Deterministic Models of Cellular p53 Regulation. |
| Q27649717 | Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans |
| Q37497709 | Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response |
| Q39434457 | The DNA damage response pathway in normal hematopoiesis and malignancies |
| Q36387600 | The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53. |
| Q89144664 | The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions |
| Q47116674 | The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2). |
| Q64107802 | The long and the short of it: the MDM4 tail so far |
| Q51281633 | The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. |
| Q34020353 | The p53 orchestra: Mdm2 and Mdmx set the tone |
| Q24310255 | The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis |
| Q98771728 | USP7 Is a Master Regulator of Genome Stability |
| Q54309795 | [EEF1A2 inhibits the p53 function in hepatocellular carcinoma via PI3K/AKT/mTOR-dependent stabilization of MDM4]. |
| Q39310656 | c-Abl phosphorylates Hdmx and regulates its interaction with p53. |
| Q34452497 | c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation |
| Q38946989 | hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. |
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