| Q40371888 | A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains |
| Q36793166 | A cell-biological model of p75NTR signaling |
| Q39132527 | A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture |
| Q34999166 | A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-like 1 |
| Q39363398 | A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells |
| Q87687015 | A parent-of-origin analysis of paternal genetic variants and increased risk of conotruncal heart defects |
| Q40361195 | A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44 |
| Q37303309 | ADAM function in embryogenesis |
| Q38283936 | ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets |
| Q33676656 | ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A. |
| Q35010009 | ADAM10 is upregulated in melanoma metastasis compared with primary melanoma. |
| Q34362287 | ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx |
| Q34374623 | ADAM10 regulates transcription factor expression required for plasma cell function |
| Q59945070 | ADAM17 activity during human neutrophil activation and apoptosis |
| Q40912652 | ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses |
| Q28305519 | ADAMs: key components in EGFR signalling and development |
| Q30427703 | ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation |
| Q64057471 | Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling |
| Q64998957 | Activation of the CXCL16/CXCR6 pathway promotes lipid deposition in fatty livers of apolipoprotein E knockout mice and HepG2 cells. |
| Q36241112 | Adipokines, diabetes and atherosclerosis: an inflammatory association. |
| Q37347126 | Adrenergic regulation of IgE involves modulation of CD23 and ADAM10 expression on exosomes |
| Q39250622 | An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions |
| Q42733342 | Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses |
| Q34218604 | Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis |
| Q59795879 | Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy |
| Q34180389 | Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function. |
| Q36573667 | Cellular Cholesterol Distribution Influences Proteolytic Release of the LRP-1 Ectodomain |
| Q40555100 | Cellular cholesterol regulates MT1 MMP dependent activation of MMP 2 via MEK-1 in HT1080 fibrosarcoma cells |
| Q37492314 | Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). |
| Q40282211 | Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged mice |
| Q39783884 | Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments |
| Q39326946 | Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation |
| Q41090382 | Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17. |
| Q64096767 | Current Knowledge of IL-6 Cytokine Family Members in Acute and Chronic Kidney Disease |
| Q37217455 | Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells |
| Q41335207 | Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy |
| Q30601949 | Cytoskeletal confinement of CX3CL1 limits its susceptibility to proteolytic cleavage by ADAM10 |
| Q46021567 | Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event. |
| Q30864727 | Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells. |
| Q34712473 | Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells |
| Q41751738 | Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression |
| Q35651962 | Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE |
| Q40276991 | Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling |
| Q26738992 | Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation |
| Q43159909 | Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells |
| Q26774879 | IL-6 Plays a Crucial Role in HBV Infection |
| Q41893572 | IL-6 and type 1 diabetes mellitus: T cell responses and increase in IL-6 receptor surface expression |
| Q38241232 | IL-6 biology: implications for clinical targeting in rheumatic disease |
| Q92686848 | IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis |
| Q52366207 | IL-6 signalling pathways and the development of type 2 diabetes. |
| Q38058509 | IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. |
| Q40097383 | IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels |
| Q57021960 | Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble IL-6 receptor |
| Q36217826 | Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion |
| Q24309589 | Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells |
| Q33586501 | Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update |
| Q48540777 | Interleukin-6 Trans-Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells via Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer |
| Q36495258 | Interleukin-6 and its receptor: from bench to bedside |
| Q36518670 | Interleukin-6 in aging and chronic disease: a magnificent pathway |
| Q40468389 | Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. |
| Q90282089 | Interleukin-6 secretion is limited by self-signaling in endosomes |
| Q43965056 | Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease |
| Q36460931 | Interleukin-6 trans-signalling in chronic inflammation and cancer |
| Q38288110 | Interleukin-6: a new therapeutic target in systemic sclerosis? |
| Q35150394 | Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling |
| Q45656671 | Ionising radiation increases permeability of endothelium through ADAM10-mediated cleavage of VE-cadherin |
| Q79323637 | Is inflammation the missing link between low fat mass and low survival in hemodialysis patients? |
| Q34097273 | L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth |
| Q33908463 | Leukocyte ADAM17 regulates acute pulmonary inflammation. |
| Q35340703 | Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3 |
| Q24294850 | Long-range nonanomalous diffusion of quantum dot-labeled aquaporin-1 water channels in the cell plasma membrane |
| Q34503158 | Low cholesterol triggers membrane microdomain-dependent CD44 shedding and suppresses tumor cell migration. |
| Q40160293 | Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells |
| Q38825625 | Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells |
| Q37690147 | Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling |
| Q35083542 | Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation |
| Q41017172 | Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling |
| Q89965577 | Modulation of Immune Responses by Platelet-Derived ADAM10 |
| Q40236626 | Modulation of the cellular cholesterol level affects shedding of the type XIII collagen ectodomain |
| Q36210626 | Molecular and cellular mechanisms of ectodomain shedding |
| Q36662741 | Molecular mechanisms of soluble cytokine receptor generation |
| Q44950435 | Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17). |
| Q37344621 | Neutrophil apoptosis and the resolution of infection |
| Q38498202 | Omega-3 fatty acids, lipid rafts, and T cell signaling |
| Q37322198 | On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells. |
| Q33625452 | Oncostatin M receptor β and cysteine/histidine-rich 1 are biomarkers of the response to erythropoietin in hemodialysis patients |
| Q35456998 | Plasma membrane microdomains regulate TACE-dependent TNFR1 shedding in human endothelial cells |
| Q27022976 | Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor |
| Q28468416 | Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation |
| Q28727037 | Proteomic identification of ADAM12 as a regulator for TGF-β1-induced differentiation of human mesenchymal stem cells to smooth muscle cells |
| Q39580605 | RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding |
| Q35888942 | Radiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells |
| Q39214249 | Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms |
| Q36954878 | Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance |
| Q39847460 | Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways |
| Q37942089 | Regulation of α-secretase ADAM10 expression and activity |
| Q46674037 | Release of interleukin-6 and its soluble receptors by activated peripheral blood monocytes is elevated in hypocholesterolemic hemodialysis patients |
| Q35939308 | Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence. |
| Q39376860 | Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins. |
| Q24633569 | Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth |
| Q38836137 | Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles |
| Q28261785 | Shedding of collagen XVII ectodomain depends on plasma membrane microenvironment |
| Q34649929 | Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment |
| Q35631767 | Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance |
| Q28577816 | Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts |
| Q40621223 | Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway |
| Q36085075 | Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst |
| Q37252579 | Soluble interleukin-6 receptor-mediated innate immune response to DNA and RNA viruses |
| Q42722712 | Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding |
| Q39106836 | Statins stimulate the production of a soluble form of the receptor for advanced glycation end products |
| Q34559443 | Systemic overexpression of TNFα-converting enzyme does not lead to enhanced shedding activity in vivo |
| Q45799693 | T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding |
| Q55261441 | Taking the Occam's Razor Approach to Hedgehog Lipidation and Its Role in Development. |
| Q37730861 | Targeting Notch signaling in pancreatic cancer |
| Q38134113 | Targeting gp130 to prevent inflammation and promote insulin action. |
| Q42283918 | Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance |
| Q37324256 | The ADAMs: signalling scissors in the tumour microenvironment |
| Q36131162 | The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma |
| Q52938750 | The Protective Roles of IL-6 Trans-Signaling Regulated by ADAM9 on the Liver in Carbon Tetrachloride-Induced Liver Injury in Mice. |
| Q40147932 | The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation |
| Q50827435 | The balance of Interleukin (IL)-6, IL-6:soluble IL-6 receptor (IL-6R) and IL-6:sIL-6R:sgp130 complexes allows simultaneous classic and trans-signaling |
| Q99346270 | The genetics of asthma and the promise of genomics-guided drug target discovery |
| Q36447798 | The involvement of lipid rafts in Alzheimer's disease |
| Q50082084 | The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Aβ metabolism |
| Q39215645 | The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis. |
| Q40292409 | The role of lipid rafts in cancer cell adhesion and migration |
| Q37326973 | The role of protease activity in ErbB biology |
| Q24305222 | The shedding activity of ADAM17 is sequestered in lipid rafts |
| Q36368339 | The varying faces of IL-6: From cardiac protection to cardiac failure. |
| Q61807469 | Therapeutic Targeting of the Proinflammatory IL-6-JAK/STAT Signalling Pathways Responsible for Vascular Restenosis in Type 2 Diabetes Mellitus |
| Q39704977 | Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha |
| Q28265871 | Trafficking and proteolytic processing of APP |
| Q28477321 | Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli |
| Q45158969 | Treatment with fluvastatin rapidly modulates, via different pathways, and in dependence on the baseline level, inflammation in hemodialysis patients |
| Q42450605 | Trk receptors need neutral sphingomyelinase activity to promote cell viability |
| Q51568269 | Tumor necrosis factor-α driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment. |
| Q39839864 | Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17. |
| Q42841077 | Unsaturated fatty acids drive disintegrin and metalloproteinase (ADAM)-dependent cell adhesion, proliferation, and migration by modulating membrane fluidity |
| Q35940287 | Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies |
| Q33888245 | n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4⁺ T cells |
| Q36921227 | sIL-6R: more than an agonist? |