| review article | Q7318358 |
| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1019859884 |
| P356 | DOI | 10.1038/NRM1548 |
| P3181 | OpenCitations bibliographic resource ID | 308597 |
| P698 | PubMed publication ID | 15688065 |
| P5875 | ResearchGate publication ID | 8044603 |
| P2093 | author name string | Carl P Blobel | |
| P2860 | cites work | Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity | Q22008720 |
| Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization | Q22010229 | ||
| Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 | Q22010715 | ||
| Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases | Q24291999 | ||
| EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization | Q24296900 | ||
| Identification of SAP97 as an intracellular binding partner of TACE | Q24298989 | ||
| TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells | Q24301702 | ||
| Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1 | Q24305944 | ||
| Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE) | Q24306455 | ||
| Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha | Q24307630 | ||
| Shedding light on sheddases: role in growth and development | Q77466451 | ||
| An essential role for ectodomain shedding in mammalian development | Q77544828 | ||
| ADAMs: focus on the protease domain | Q77565735 | ||
| Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains | Q24307661 | ||
| The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts | Q24307875 | ||
| Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types | Q24310056 | ||
| MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains | Q24316013 | ||
| Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha | Q24319999 | ||
| Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28 | Q24532037 | ||
| A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. | Q24533465 | ||
| Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation | Q24558686 | ||
| Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF | Q24672346 | ||
| The cysteine-rich domain regulates ADAM protease function in vivo | Q24673136 | ||
| Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab | Q27640593 | ||
| Untangling the ErbB signalling network | Q27860884 | ||
| A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells | Q28119154 | ||
| Notch signaling: from the outside in | Q28139768 | ||
| Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease | Q28140038 | ||
| Roles of Meltrin beta /ADAM19 in the processing of neuregulin | Q28140324 | ||
| Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta | Q28143327 | ||
| Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans | Q28145545 | ||
| The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells | Q28180409 | ||
| The deaf and the dumb: the biology of ErbB-2 and ErbB-3 | Q28185247 | ||
| Catalytic properties of ADAM19 | Q28189426 | ||
| Catalytic activity of human ADAM33 | Q28191609 | ||
| gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase | Q28202328 | ||
| The TNF and TNF receptor superfamilies: integrating mammalian biology | Q28203717 | ||
| An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors | Q28207289 | ||
| Clinical proteomics: Written in blood | Q28213537 | ||
| Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness | Q28214089 | ||
| Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells | Q28215261 | ||
| Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch | Q28248448 | ||
| Therapeutic benefits from targeting of ADAM family members | Q28265352 | ||
| A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion | Q28291941 | ||
| Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion | Q40612668 | ||
| Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme | Q40774834 | ||
| A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase | Q40818059 | ||
| Membrane-anchored growth factors. | Q40856819 | ||
| Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme | Q40881816 | ||
| Male mice deficient for germ-cell cyritestin are infertile | Q40916706 | ||
| Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE). | Q40923100 | ||
| Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. | Q41199229 | ||
| Membrane protein secretases | Q41341215 | ||
| Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades | Q41708821 | ||
| Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities. | Q41784596 | ||
| Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism. | Q42016464 | ||
| TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation | Q42445689 | ||
| Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. | Q42540708 | ||
| Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation | Q42810137 | ||
| Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase | Q43559838 | ||
| Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy | Q43851616 | ||
| Fertilization defects in sperm from mice lacking fertilin beta. | Q44471252 | ||
| Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain | Q44853351 | ||
| The discovery of receptor tyrosine kinases: targets for cancer therapy | Q44879898 | ||
| Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. | Q45931354 | ||
| Defining brain wiring patterns and mechanisms through gene trapping in mice. | Q46112482 | ||
| TACE is required for fetal murine cardiac development and modeling | Q46178015 | ||
| Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta | Q46230806 | ||
| Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation. | Q46825011 | ||
| Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis | Q46965935 | ||
| Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17). | Q51824970 | ||
| Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). | Q51831758 | ||
| Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. | Q54806502 | ||
| Regulation of Human ADAM 12 Protease by the Prodomain | Q58460385 | ||
| The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction | Q69052663 | ||
| Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme | Q73204078 | ||
| Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells | Q73694697 | ||
| Catalytic activity of ADAM28 | Q73965342 | ||
| Neuregulins: functions, forms, and signaling strategies | Q35089314 | ||
| Nuclear localization and possible functions of receptor tyrosine kinases | Q35089368 | ||
| Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs) | Q35107604 | ||
| Intramembrane proteolysis by presenilin and presenilin-like proteases | Q35154986 | ||
| Potential role for ADAM15 in pathological neovascularization in mice | Q35169697 | ||
| Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer | Q35177848 | ||
| Structure, function and evolutionary relationship of proteins containing a disintegrin domain | Q35455332 | ||
| Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail | Q35572214 | ||
| EGFR signal transactivation in cancer cells | Q35594162 | ||
| Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10. | Q35897595 | ||
| Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence | Q36223191 | ||
| The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor | Q36235363 | ||
| Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization | Q36256364 | ||
| Back signaling by the Nrg-1 intracellular domain | Q36323571 | ||
| The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors | Q36323845 | ||
| The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation | Q36327499 | ||
| The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications | Q36673157 | ||
| Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor | Q37202595 | ||
| Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process | Q37414612 | ||
| Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin | Q38355318 | ||
| Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila | Q39583868 | ||
| Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. | Q40484501 | ||
| ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain | Q28301451 | ||
| Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function | Q28505013 | ||
| The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion | Q28511911 | ||
| Essential roles of Meltrin beta (ADAM19) in heart development | Q28512451 | ||
| Essential role for ADAM19 in cardiovascular morphogenesis | Q28594617 | ||
| Ligand-induced, receptor-mediated dimerization and activation of EGF receptor | Q28646134 | ||
| Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis | Q28646378 | ||
| Evidence for an interaction of the metalloprotease‒disintegrin tumour necrosis factor α convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease‒disintegrin MDC9 with a novel MAD2-related protein, MAD2β | Q29012034 | ||
| EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF | Q29619098 | ||
| PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13. | Q30168633 | ||
| Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence | Q30177037 | ||
| ADAMs: modulators of cell–cell and cell–matrix interactions | Q30311872 | ||
| Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands | Q30443463 | ||
| Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability | Q30805022 | ||
| ADAM family protein Mde10 is essential for development of spore envelopes in the fission yeast Schizosaccharomyces pombe. | Q31044218 | ||
| Proteomic analysis at the bedside: early detection of cancer | Q31130063 | ||
| Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates | Q33202468 | ||
| Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion | Q33904129 | ||
| A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands | Q34079257 | ||
| Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases | Q34098885 | ||
| EGF receptor ligands | Q34185050 | ||
| Epidermal growth factor receptor: mechanisms of activation and signalling. | Q34185055 | ||
| Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. | Q34194714 | ||
| PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor | Q34227481 | ||
| Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life. | Q34302573 | ||
| Expression of a disintegrin-like protein in cultured human vascular cells and in vivo. | Q34417047 | ||
| Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis | Q34462638 | ||
| Human ADAM 12 (meltrin alpha) is an active metalloprotease. | Q34473479 | ||
| Implication of APP secretases in notch signaling | Q34509767 | ||
| TACE is required for the activation of the EGFR by TGF-alpha in tumors | Q34775269 | ||
| kuzbanian-mediated cleavage of Drosophila Notch | Q35005131 | ||
| Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling | Q35032897 | ||
| The ADAMs family of metalloproteases: multidomain proteins with multiple functions | Q35039313 | ||
| Metalloproteases: carving out a role in axon guidance | Q35070714 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 32-43 | |
| P577 | publication date | 2005-01-01 | |
| P1433 | published in | Nature Reviews Molecular Cell Biology | Q1573120 |
| P1476 | title | ADAMs: key components in EGFR signalling and development | |
| P478 | volume | 6 |
| Q26749364 | A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions |
| Q28072451 | A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems |
| Q63246504 | A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection |
| Q37234144 | A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor |
| Q40267315 | A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration |
| Q28831250 | A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation |
| Q30440543 | A co-culture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells |
| Q34193829 | A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells |
| Q35055620 | A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells |
| Q35848839 | A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature |
| Q39132527 | A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture |
| Q38917646 | A metal-based tumour necrosis factor-alpha converting enzyme inhibitor. |
| Q93163061 | A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries |
| Q24602445 | A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis |
| Q90705460 | A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo |
| Q40361195 | A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44 |
| Q35616136 | A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation |
| Q36332111 | A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation. |
| Q39651468 | A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17 |
| Q34505020 | A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. |
| Q34434205 | ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells |
| Q37303309 | ADAM function in embryogenesis |
| Q37730662 | ADAM metallopeptidase domain 33 (ADAM33): a promising target for asthma |
| Q36187030 | ADAM proteases, ErbB pathways and cancer |
| Q90591189 | ADAM proteases: Emerging role and targeting of the non-catalytic domains |
| Q37111322 | ADAM proteases: ligand processing and modulation of the Notch pathway |
| Q36895696 | ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling |
| Q55028663 | ADAM-17 is a poor prognostic indicator for patients with hilar cholangiocarcinoma and is regulated by FoxM1. |
| Q48951792 | ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells. |
| Q39281011 | ADAM-17: a novel therapeutic target for triple negative breast cancer |
| Q33737421 | ADAM-17: the enzyme that does it all. |
| Q51791386 | ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study. |
| Q38283936 | ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets |
| Q35197805 | ADAM-mediated amphiregulin shedding and EGFR transactivation |
| Q35077020 | ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1). |
| Q93185172 | ADAM10 controls the differentiation of the coronary arterial endothelium |
| Q79314167 | ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23 |
| Q33730084 | ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo |
| Q33676656 | ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A. |
| Q40596798 | ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing |
| Q44963738 | ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of Notch |
| Q53572097 | ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. |
| Q34374623 | ADAM10 regulates transcription factor expression required for plasma cell function |
| Q42059040 | ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase |
| Q36081396 | ADAM10: a new player in breast cancer progression? |
| Q58460359 | ADAM12 Is a Four-leafed Clover |
| Q33794994 | ADAM12 and ADAM17 gene expression in laser-capture microdissected and non-microdissected breast tumors |
| Q53628066 | ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression. |
| Q35560725 | ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression |
| Q39149986 | ADAM12-cleaved ephrin-A1 contributes to lung metastasis |
| Q36751530 | ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion. |
| Q37173718 | ADAM12: a potential target for the treatment of chronic wounds |
| Q35941467 | ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer |
| Q33302700 | ADAM15 gene structure and differential alternative exon use in human tissues. |
| Q92995593 | ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells |
| Q38287715 | ADAM15 modulates outside-in signalling in chondrocyte-matrix interactions |
| Q39356608 | ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions |
| Q33954946 | ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling |
| Q24318285 | ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin |
| Q35691781 | ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells. |
| Q37122908 | ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes |
| Q33728091 | ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression |
| Q52584359 | ADAM17 inhibition enhances platinum efficiency in ovarian cancer. |
| Q49307913 | ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer |
| Q53831425 | ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin. |
| Q42382724 | ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site |
| Q52689175 | ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. |
| Q37093660 | ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice. |
| Q41963486 | ADAM17 mediates OSCC development in an orthotopic murine model. |
| Q37398747 | ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation |
| Q39561009 | ADAM17 promotes glioma cell malignant phenotype |
| Q84752497 | ADAM17 regulates prostate cancer cell proliferation through mediating cell cycle progression by EGFR/PI3K/AKT pathway |
| Q37076062 | ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells |
| Q34515863 | ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis |
| Q89721924 | ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1) |
| Q36530577 | ADAM17 transactivates EGFR signaling during embryonic eyelid closure |
| Q39836663 | ADAM17 upregulation in human renal disease: a role in modulating TGF-alpha availability? |
| Q39683133 | ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C γ1 and protein kinase C pathways |
| Q92783310 | ADAM17: An Emerging Therapeutic Target for Lung Cancer |
| Q57892013 | ADAM19 expression in human nephrogenesis and renal disease: Associations with clinical and structural deterioration |
| Q43595578 | ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death |
| Q27324447 | ADAM8 as a drug target in pancreatic cancer. |
| Q39745622 | ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice |
| Q28509307 | ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice |
| Q61799832 | ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma |
| Q34053644 | ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury. |
| Q28591506 | ADAM9 is involved in pathological retinal neovascularization |
| Q28084468 | ADAMTS proteins as modulators of microfibril formation and function |
| Q37127274 | ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha |
| Q38621957 | ADAMs family and relatives in cardiovascular physiology and pathology. |
| Q36840033 | APP Receptor? To Be or Not To Be. |
| Q37285322 | ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli |
| Q34563028 | ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. |
| Q36840255 | Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer |
| Q35235319 | Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis |
| Q36103879 | Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer |
| Q38752773 | Activation of Epidermal Growth Factor Receptor in Macrophages Mediates Feedback Inhibition of M2 Polarization and Gastrointestinal Tumor Cell Growth |
| Q33891230 | Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy. |
| Q37312014 | Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates |
| Q33304677 | Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease. |
| Q36186814 | Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 2: role of growth factors in normal and pathological wound healing: therapeutic potential and methods of delivery |
| Q42145206 | Adenoviral delivery of recombinant soluble human tumor necrosis factor receptor 1 partially normalized mouse model of asthma |
| Q33610265 | Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure. |
| Q30829734 | Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development. |
| Q40074672 | An arginine stretch limits ADAM10 exit from the endoplasmic reticulum |
| Q36493654 | An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family |
| Q60910659 | Analysis of mutations in primary and metastatic synovial sarcoma |
| Q35012297 | Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma |
| Q34501400 | Anchoring junctions as drug targets: role in contraceptive development |
| Q39367074 | Angiogenesis and Proteinases: Influence on Vascular Morphogenesis, Stabilization and Regression |
| Q40130425 | Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor. |
| Q39617483 | Anti-angiogenic effects of two cystine-knot miniproteins from tomato fruit |
| Q54222811 | Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression. |
| Q36648232 | Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function |
| Q38193464 | Architecture and function of metallopeptidase catalytic domains |
| Q60916114 | Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers |
| Q35631417 | Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation. |
| Q21195230 | Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation |
| Q41907490 | Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage |
| Q35591371 | Baculovirus-mediated miRNA regulation to suppress hepatocellular carcinoma tumorigenicity and metastasis |
| Q33728352 | Betacellulin Induces Increased Retinal Vascular Permeability in Mice |
| Q38993903 | Bile acid accelerates erbB2-induced pro-tumorigenic activities in biliary tract cancer |
| Q28307734 | Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells |
| Q38541387 | Bone metastases in lung cancer. Potential novel approaches to therapy |
| Q37211796 | Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics |
| Q58692091 | CD200:CD200R-Mediated Regulation of Immunity |
| Q34333685 | CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes |
| Q34662928 | CD23: an overlooked regulator of allergic disease. |
| Q47547369 | Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19-positive hepatocellular carcinoma |
| Q37257244 | Catalytic domain architecture of metzincin metalloproteases. |
| Q59126592 | Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation |
| Q53196124 | Changes in expressions of ADAM9, 10, and 17 as well as α-secretase activity in renal cell carcinoma. |
| Q33296116 | Characterisation of endothelin converting enzyme-1 shedding from endothelial cells |
| Q34406075 | Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15. |
| Q33407630 | Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays |
| Q33959517 | Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer |
| Q37278959 | Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. |
| Q54237266 | Cilostazol inhibits interleukin-1-induced ADAM17 expression through cAMP independent signaling in vascular smooth muscle cells. |
| Q64071566 | CircHIPK3 overexpression accelerates the proliferation and invasion of prostate cancer cells through regulating miRNA-338-3p |
| Q46066628 | Clarification of the C-terminal proteolytic processing site of human Amphiregulin. |
| Q37176101 | Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies. |
| Q34009507 | Cloning and expression of ADAM-related metalloproteases in equine laminitis |
| Q41371069 | Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase. |
| Q37772147 | Comprehensive gene expression profiling and functional analysis of matrix metalloproteinases and TIMPs, and identification of ADAM-10 gene expression, in a corneal model of epithelial resurfacing |
| Q34076325 | Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF. |
| Q30432953 | Conservation and divergence of ADAM family proteins in the Xenopus genome |
| Q46674120 | Continuous real-time measurement of tumor necrosis factor-alpha converting enzyme activity on live cells |
| Q57808143 | Contribution of the plasma and lymph Degradome and Peptidome to the MHC Ligandome |
| Q35634038 | Corin in clinical laboratory diagnostics |
| Q34676632 | Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold |
| Q36459524 | Crystallization and preliminary X-ray crystallographic analysis of two vascular apoptosis-inducing proteins (VAPs) from Crotalus atrox venom |
| Q27326381 | Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10 |
| Q34568946 | Deciphering the human platelet sheddome. |
| Q37325289 | Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice |
| Q35140965 | Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures |
| Q37265001 | Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis |
| Q38822173 | Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. |
| Q33911904 | Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation |
| Q51864177 | Differential expression of the ADAMs in developing chicken retina. |
| Q51860129 | Differential regional expression of multiple ADAMs during feather bud formation. |
| Q36129113 | Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. |
| Q34555877 | Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation |
| Q34450973 | Distinct roles of N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding. |
| Q39804174 | Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells |
| Q35532126 | Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis. |
| Q28572999 | EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF |
| Q39453489 | EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells. |
| Q26771265 | EGFR Signaling in Liver Diseases |
| Q34282375 | EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation |
| Q37350200 | EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis |
| Q36850617 | ERK1/2 mediate wounding- and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding |
| Q34695497 | Ectodomain shedding and autocleavage of the cardiac membrane protease corin |
| Q30495814 | Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice |
| Q42137709 | Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme. |
| Q35070932 | Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation |
| Q36626435 | Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers |
| Q38715123 | Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. |
| Q40275569 | Elevated urinary ADAM12 protein levels in lithium-treated bipolar patients |
| Q29048183 | Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease |
| Q30488978 | Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices |
| Q57808758 | Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1 |
| Q37862381 | Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis |
| Q37971902 | Eph-dependent cell-cell adhesion and segregation in development and cancer. |
| Q30539320 | EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion |
| Q49738799 | EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling |
| Q42064860 | Epidermal ADAM17 is dispensable for notch activation |
| Q30515730 | Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation |
| Q33814199 | Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System |
| Q34978954 | Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus |
| Q46770898 | Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via an Src-dependent p38 mitogen-activated protein kinase signaling pathway |
| Q38207484 | Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors |
| Q39626743 | Epidermal growth factor receptor transactivation is implicated in IL-6-induced proliferation and ERK1/2 activation in non-transformed prostate epithelial cells |
| Q90886378 | Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics |
| Q39761331 | Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation. |
| Q30415389 | Epithelial inflammation resulting from an inherited loss-of-function mutation in EGFR |
| Q34596026 | Epithelial innate immune response to Acinetobacter baumannii challenge |
| Q37668848 | ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases |
| Q47974787 | ErbB Receptors and Cancer |
| Q38998305 | Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression |
| Q47407256 | Essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells (hDPMCs). |
| Q54385982 | Estrogen signalling through amphiregulin may be implicated in human hepatocellular carcinoma. |
| Q81815182 | Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2 |
| Q42450275 | Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung |
| Q51912760 | Expression of seven members of the ADAM family in developing chicken spinal cord. |
| Q51825434 | Expression patterns of ADAMs in the developing chicken lens. |
| Q50753870 | Expression patterns of the ADAMs in early developing chicken cochlea. |
| Q35250443 | Extracellular ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptor |
| Q39643536 | Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity |
| Q39236160 | Fas ligand plays an important role for the production of pro-inflammatory cytokines in intervertebral disc nucleus pulposus cells |
| Q91523126 | Feedback activation of EGFR is the main cause for STAT3 inhibition-irresponsiveness in pancreatic cancer cells |
| Q48543248 | Fell‐Muir Lecture: Metalloproteinases: from demolition squad to master regulators |
| Q39162354 | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases. |
| Q33535845 | Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kappaB-independent and EGFR-dependent pathway |
| Q91795790 | Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation |
| Q37891849 | Functional interplay between tetraspanins and proteases |
| Q37824814 | G protein-coupled receptors: novel targets for drug discovery in cancer |
| Q40373265 | GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways. |
| Q39959829 | GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature |
| Q38107250 | Generation of soluble NKG2D ligands: proteolytic cleavage, exosome secretion and functional implications |
| Q97530811 | Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation |
| Q92539053 | Genetic Modification of CD8+ T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies |
| Q58199697 | Grb2 signaling in cell motility and cancer |
| Q38928508 | Growth Factors in the Pathogenesis of Retinal Neurodegeneration in Diabetes Mellitus |
| Q37592665 | Growth factors and corneal epithelial wound healing |
| Q28476604 | HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer |
| Q54310179 | High percentage of ADAM-10 positive melanoma cells correlates with paucity of tumor-infiltrating lymphocytes but does not predict prognosis in cutaneous melanoma patients. |
| Q37352425 | High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy |
| Q35598075 | High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation. |
| Q40437113 | Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling |
| Q92406780 | Host-microbial dialogues in atopic dermatitis |
| Q42740131 | How to exploit stress-related immunity against Hodgkin's lymphoma: Targeting ERp5 and ADAM sheddases. |
| Q34121376 | Human beta1-adrenergic receptor is subject to constitutive and regulated N-terminal cleavage |
| Q27002075 | Human epidermal growth factor receptor signaling in acute lung injury |
| Q36837862 | Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice |
| Q36189855 | IGFBP2 potentiates nuclear EGFR-STAT3 signaling. |
| Q37961730 | Identification and biology of α-secretase. |
| Q30418617 | Identification and characterization of ADAM41, a novel ADAM metalloproteinase in Xenopus |
| Q31808704 | Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea. |
| Q64251109 | Identification of ADAM12 as a Novel Basigin Sheddase |
| Q47844206 | Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8. |
| Q38937127 | Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF. |
| Q92601601 | Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus |
| Q36863620 | Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases |
| Q36678647 | Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer |
| Q95832172 | Inflammatory Cytokines During Cardiac Rehabilitation After Heart Surgery and Their Association to Postoperative Atrial Fibrillation |
| Q30438011 | Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils. |
| Q37438518 | Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors |
| Q39307072 | Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells. |
| Q35575197 | Inhibitory role of TACE/ADAM17 cytotail in protein ectodomain shedding |
| Q26741112 | Insights into Soluble Toll-Like Receptor 2 as a Downregulator of Virally Induced Inflammation |
| Q26999922 | Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease |
| Q26853412 | Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics |
| Q39919544 | Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis. |
| Q34181792 | Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735 |
| Q36241932 | International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected]. |
| Q28066445 | Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis |
| Q39012270 | Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals |
| Q36581303 | Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice. |
| Q28580958 | Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis |
| Q24170383 | Irritant activation of epithelial cells is mediated via protease-dependent EGFR activation |
| Q35691003 | Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core |
| Q34097273 | L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth |
| Q64059752 | L1cam-mediated developmental processes of the nervous system are differentially regulated by proteolytic processing |
| Q26998200 | LGI proteins in the nervous system |
| Q28587107 | LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11 |
| Q34979935 | Lateral organization of membrane proteins: tetraspanins spin their web. |
| Q43777578 | Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury |
| Q47220619 | Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer |
| Q39196199 | Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay |
| Q34619329 | Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC. |
| Q51250457 | Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage. |
| Q46225399 | Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema |
| Q37150910 | Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor |
| Q50113156 | Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α converting enzyme |
| Q34178493 | Mammalian EGF receptor activation by the rhomboid protease RHBDL2 |
| Q41936018 | Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. |
| Q34706838 | Mammary Gland Reprogramming: Metalloproteinases Couple Form with Function |
| Q24646364 | Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin |
| Q37412311 | Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer |
| Q37743354 | Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation. |
| Q39345036 | Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation |
| Q40160293 | Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells |
| Q33373332 | Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction |
| Q37856396 | Membrane proteases and tetraspanins. |
| Q36940312 | Membrane-anchored proteases in endothelial cell biology |
| Q34526248 | Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10. |
| Q28073613 | Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment |
| Q42513445 | Metalloprotease-dependent activation of EGFR modulates CD44+/CD24- populations in triple negative breast cancer cells through the MEK/ERK pathway. |
| Q37620891 | Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer |
| Q36994561 | Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling? |
| Q35612460 | Metalloproteases regulate T-cell proliferation and effector function via LAG-3 |
| Q37142719 | Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z |
| Q34756662 | Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production |
| Q58211711 | Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia |
| Q36313201 | Metalloproteinases: mediators of pathology and regeneration in the CNS. |
| Q38237985 | Metastasis review: from bench to bedside |
| Q27656261 | Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site |
| Q38787480 | MiR-181b modulates chemosensitivity of glioblastoma multiforme cells to temozolomide by targeting the epidermal growth factor receptor |
| Q39335270 | MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17. |
| Q38995494 | MicroRNA-126 inhibits invasion in bladder cancer via regulation of ADAM9. |
| Q47143534 | MicroRNA-154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells |
| Q36617808 | MicroRNAs and the hallmarks of cancer |
| Q30537792 | Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D |
| Q36095677 | Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1 |
| Q34781580 | Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. |
| Q99550893 | Mitochondrial Targeting of the Enteropathogenic Escherichia coli Map Triggers Calcium Mobilization, ADAM10-MAP Kinase Signaling, and Host Cell Apoptosis |
| Q37475351 | Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding |
| Q35856833 | Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite |
| Q89965577 | Modulation of Immune Responses by Platelet-Derived ADAM10 |
| Q33240511 | Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases |
| Q37863911 | Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting |
| Q36662741 | Molecular mechanisms of soluble cytokine receptor generation |
| Q43650121 | Molecular profiling of ADAM12 and ADAM17 genes in human malignant melanoma |
| Q92912576 | Mutagenesis of the ADAM17-phosphatidylserine-binding motif leads to embryonic lethality in mice |
| Q36529001 | Mutations of the lutropin/choriogonadotropin receptor that do not activate the phosphoinositide cascade allow hCG to induce aromatase expression in immature rat granulosa cells |
| Q36111349 | Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α. |
| Q38946653 | Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach |
| Q28294422 | Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation |
| Q34695953 | Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. |
| Q38676029 | Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. |
| Q89068457 | Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation |
| Q38706629 | New insights into the tetraspanin Tspan5 using novel monoclonal antibodies |
| Q38025278 | New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. |
| Q36740642 | New molecular targets for hepatocellular carcinoma: the ErbB1 signaling system |
| Q36519041 | New therapies for hepatocellular carcinoma. |
| Q26771258 | Notch Signaling in Pancreatic Development |
| Q64059020 | Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder |
| Q39706014 | Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer. |
| Q38615458 | Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. |
| Q37787450 | Nrg1/ErbB signaling networks in Schwann cell development and myelination |
| Q36017260 | Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17 |
| Q90642521 | Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer |
| Q47157413 | Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma |
| Q41425790 | Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer |
| Q31001916 | PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways. |
| Q40845859 | Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells. |
| Q39717818 | Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. |
| Q54273943 | Periodontal disease and gene-expression levels of metalloendopeptidases in human buccal mucosal epithelium. |
| Q47437633 | Phagocyte-extracellular matrix crosstalk empowers tumor development and dissemination |
| Q38953008 | Pharmacophore modeling for the identification of small-molecule inhibitors of TACE. |
| Q40066641 | Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. |
| Q27317119 | Phosphatidylserine exposure is required for ADAM17 sheddase function |
| Q57257089 | Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells |
| Q41903115 | Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding |
| Q30159638 | Pore-forming Staphylococcus aureus alpha-toxin triggers epidermal growth factor receptor-dependent proliferation |
| Q48364154 | Post-resistance exercise ingestion of milk protein attenuates plasma TNFα and TNFr1 expression on monocyte subpopulations |
| Q40182579 | Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors. |
| Q40015586 | Posttranslational regulation of Fas ligand function. |
| Q50419857 | Potential lymphangiogenesis therapies: Learning from current antiangiogenesis therapies-A review. |
| Q48344924 | Potential roles of metalloproteinases of endometrium-derived exosomes in embryo-maternal crosstalk during implantation. |
| Q36291677 | Preeclampsia, Eve, and Adam join forces |
| Q46343091 | Preeclampsia: increased expression of soluble ADAM 12. |
| Q34803510 | Presenilin-dependent intramembrane cleavage of ephrin-B1. |
| Q58044786 | Profiling of the Tetraspanin Web of Human Colon Cancer Cells |
| Q53573656 | Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy. |
| Q40272193 | Proteases at work: cues for understanding neural development and degeneration. |
| Q64069807 | Protein Kinase C: Targets to Regenerate Brain Injuries? |
| Q38431347 | Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities |
| Q37472880 | Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity. |
| Q38092801 | Proteolytic factors in exosomes |
| Q41922643 | Proteolytic processing causes extensive heterogeneity of tissue matrilin forms |
| Q37218310 | Proteolytic processing of delta-like 1 by ADAM proteases |
| Q59281355 | Proteolytic processing of platelet receptors |
| Q28069428 | Proteomic Substrate Identification for Membrane Proteases in the Brain |
| Q34718289 | Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis |
| Q33237686 | Proteomic profiling of metalloprotease activities with cocktails of active-site probes |
| Q33809899 | Pyk2 activation triggers epidermal growth factor receptor signaling and cell motility after wounding sheets of epithelial cells |
| Q40177482 | Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody |
| Q44045406 | Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development. |
| Q33351256 | RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis |
| Q48142240 | RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity |
| Q34097404 | RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum |
| Q90328866 | RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models? |
| Q51380060 | Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme. |
| Q38899428 | Recent progress in protein-protein interaction study for EGFR-targeted therapeutics |
| Q36124854 | Recombinant disintegrin domain of human ADAM9 inhibits migration and invasion of DU145 prostate tumor cells |
| Q45338276 | Redox Regulation of Inflammatory Processes Is Enzymatically Controlled. |
| Q37713541 | Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice. |
| Q35190609 | Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL. |
| Q44396192 | Regional expression of ADAM19 during chicken embryonic development |
| Q51903468 | Regional expression of the ADAMs in developing chicken cochlea. |
| Q48082064 | Regionalized expression of ADAM13 during chicken embryonic development |
| Q48269632 | Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase |
| Q82719031 | Regulating inflammation: ADAM8--a new player in the game |
| Q39847460 | Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways |
| Q41994915 | Regulation of receptor tyrosine kinase ligand processing |
| Q37287092 | Requirement for metalloproteinase-dependent ERK and AKT activation in UVB-induced G1-S cell cycle progression of human keratinocytes |
| Q38069466 | Rhomboid proteins: a role in keratinocyte proliferation and cancer. |
| Q34943914 | Role of A disintegrin and metalloprotease-12 in neutrophil recruitment induced by airway epithelium |
| Q38031233 | Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma |
| Q47740308 | Role of EGF receptor signaling on morphogenesis of eyelid and meibomian glands. |
| Q33888529 | Roles for trafficking and O-linked glycosylation in the turnover of model cell surface proteins |
| Q30422114 | Roles of ADAM13-regulated Wnt activity in early Xenopus eye development |
| Q87124373 | SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation |
| Q37152342 | SRC-family tyrosine kinases in wound- and ligand-induced epidermal growth factor receptor activation in human corneal epithelial cells |
| Q40601530 | Saliva induces expression of antimicrobial peptides and promotes intracellular killing of bacteria in keratinocytes by epidermal growth factor receptor transactivation. |
| Q50096790 | Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair |
| Q52003749 | Sea urchin metalloproteases: a genomic survey of the BMP-1/tolloid-like, MMP and ADAM families. |
| Q30437660 | Selective modulation of integrin-mediated cell migration by distinct ADAM family members |
| Q24633569 | Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth |
| Q38067641 | Shaping of NK cell responses by the tumor microenvironment |
| Q43263728 | Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibalpha shedding |
| Q37358108 | Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9. |
| Q39176227 | Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17. |
| Q39953010 | Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells |
| Q35312825 | Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK). |
| Q36891815 | Signaling axis in osteoclast biology and therapeutic targeting in the RANKL/RANK/OPG system |
| Q36895457 | Smoking and lung cancer: future research directions |
| Q37432727 | Smoking and microRNA dysregulation: a cancerous combination |
| Q26750970 | Soluble Epidermal Growth Factor Receptors (sEGFRs) in Cancer: Biological Aspects and Clinical Relevance |
| Q36977717 | Soluble cadherins as cancer biomarkers |
| Q42722712 | Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding |
| Q52714326 | Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells. |
| Q37000191 | Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL |
| Q34042804 | Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways |
| Q37132196 | Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin α6β1-ADAM17/tumor necrosis factor-α-converting enzyme (TACE) signaling pathway |
| Q36002952 | Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions |
| Q33254880 | Stroke-induced subventricular zone proliferation is promoted by tumor necrosis factor-alpha-converting enzyme protease activity |
| Q27673367 | Structural basis for the sheddase function of human meprin metalloproteinase at the plasma membrane |
| Q24315151 | Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex |
| Q48332917 | Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis |
| Q35545249 | Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx |
| Q89578231 | Substrate-Specific Activation of α-Secretase by 7-Deoxy-Trans-Dihydronarciclasine Increases Non-Amyloidogenic Processing of β-Amyloid Protein Precursor |
| Q89903812 | Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains |
| Q37976074 | Synergistic Regulation of Angiogenic Sprouting by Biochemical Factors and Wall Shear Stress |
| Q57293856 | Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes |
| Q34559443 | Systemic overexpression of TNFα-converting enzyme does not lead to enhanced shedding activity in vivo |
| Q33930447 | TACE (ADAM17) inhibits Schwann cell myelination |
| Q34626693 | TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. |
| Q37440520 | TACE in perinatal mouse lung epithelial cells promotes lung saccular formation |
| Q34123782 | TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination |
| Q38785433 | TIMPs: versatile extracellular regulators in cancer |
| Q35159634 | TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells |
| Q35219817 | TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells |
| Q38785881 | Taking the stock of granule cargo: Platelet releasate proteomics |
| Q35671213 | Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer |
| Q91712029 | Targeting ADAM10 in Cancer and Autoimmunity |
| Q34563752 | Targeting proteases: successes, failures and future prospects |
| Q34296287 | Testicular and epididymal ADAMs: expression and function during fertilization |
| Q28292696 | The ADAM metalloproteinases |
| Q34777834 | The ADAM17-amphiregulin-EGFR axis in mammary development and cancer |
| Q35206311 | The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer? |
| Q37324256 | The ADAMs: signalling scissors in the tumour microenvironment |
| Q64069844 | The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1 |
| Q38539526 | The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease |
| Q49375848 | The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression |
| Q99571028 | The Role of Extracellular Proteases in Tumor Progression and the Development of Innovative Metal Ion Chelators that Inhibit their Activity |
| Q33593917 | The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration |
| Q44605770 | The cleavage of thyroid-stimulating hormone receptor is dependent on cell-cell contacts and regulates the hormonal stimulation of phospholipase c. |
| Q41130845 | The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage |
| Q38291507 | The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation |
| Q35627300 | The effect of lysophosphatidic acid during in vitro maturation of bovine cumulus-oocyte complexes: cumulus expansion, glucose metabolism and expression of genes involved in the ovulatory cascade, oocyte and blastocyst competence |
| Q37828761 | The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity |
| Q37982722 | The emerging role of matrix metalloproteases of the ADAM family in male germ cell apoptosis |
| Q52645849 | The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis. |
| Q39960326 | The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. |
| Q33282314 | The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio |
| Q42131728 | The extracellular linker of pro-neuregulin-alpha2c is required for efficient sorting and juxtacrine function. |
| Q34979150 | The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation |
| Q38365416 | The human β-amyloid precursor protein: biomolecular and epigenetic aspects |
| Q34810293 | The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity |
| Q33728467 | The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation |
| Q39415242 | The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins. |
| Q36288254 | The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. |
| Q54365136 | The metalloproteinase ADAM17 and the epidermal growth factor receptor (EGFR) signaling drive the inflammatory epithelial response in Sjögren's syndrome. |
| Q36013553 | The pancreatic beta cell surface proteome |
| Q53701281 | The pleiotropic roles of ADAM9 in the biology of solid tumors. |
| Q47842101 | The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization |
| Q98897004 | The quest for substrates and binding partners: A critical barrier for understanding the role of ADAMTS proteases in musculoskeletal development and disease |
| Q46881400 | The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates |
| Q37714303 | The regulatory crosstalk between kinases and proteases in cancer |
| Q34470363 | The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate |
| Q38961857 | The role of ADAM17 in tumorigenesis and progression of breast cancer |
| Q37991568 | The role of Adams in Notch signaling |
| Q37326973 | The role of protease activity in ErbB biology |
| Q36125009 | The role of proteases in regulating Eph/ephrin signaling. |
| Q38860417 | The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. |
| Q36503385 | The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. |
| Q33535689 | The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17. |
| Q46457656 | The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands |
| Q38729407 | Therapeutic potential of ADAM17 modulation in gastric cancer through regulation of the EGFR and TNF-α signalling pathways |
| Q28477321 | Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli |
| Q42579310 | Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia |
| Q39593323 | Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration |
| Q38259322 | Triple-negative breast cancer: investigating potential molecular therapeutic target |
| Q37457827 | Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer |
| Q91617744 | TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life |
| Q36762907 | TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization. |
| Q24301578 | TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals |
| Q24314291 | Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation |
| Q41890825 | Tumor necrosis factor-α-induced a disintegrin and metalloprotease 10 increases apoptosis resistance in prostate cancer cells |
| Q39839864 | Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17. |
| Q40333980 | Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members |
| Q24313064 | UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes |
| Q46259318 | Upregulation of tumor necrosis factor receptor 1 and TNF-alpha converting enzyme during corneal wound healing |
| Q36953025 | VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. |
| Q24294196 | VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells |
| Q59351210 | Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility |
| Q39536410 | Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. |
| Q27334354 | Visualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo. |
| Q40173877 | Wound-induced ATP release and EGF receptor activation in epithelial cells |
| Q33610372 | Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFR |
| Q42023686 | Xenopus ADAM19 is involved in neural, neural crest and muscle development |
| Q42056708 | iRHOM2 is a critical pathogenic mediator of inflammatory arthritis |
| Q34272237 | iRhom2 is required for the secretion of mouse TNFα |
| Q51530886 | iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice. |
| Q35616369 | iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling |
| Q36640392 | iRhoms; Its Functions and Essential Roles |
Search more.