Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells

scientific article

Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2008.07.013
P698PubMed publication ID18687326

P2093author name stringNita J Maihle
Blanca L Valle
Elsa M Cora
Lisandra Negron-Vega
Marianela Perez-Torres
Rene Nieves-Alicea
P2860cites workA metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.Q24533465
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Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane siteQ28646381
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsQ29616544
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Identification of a novel AU-Rich element in the 3' untranslated region of epidermal growth factor receptor mRNA that is the target for regulated RNA-binding proteinsQ33967590
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Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.Q34379351
A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptorQ34614751
Metalloproteinase inhibitors: biological actions and therapeutic opportunities.Q34863959
CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodelingQ35005223
Protein ectodomain sheddingQ35021911
The ADAMs family of metalloproteases: multidomain proteins with multiple functionsQ35039313
Proteolysis within the membrane: rhomboids revealedQ35678316
Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies.Q35878888
The prognostic value of epidermal growth factor receptor mRNA expression in primary ovarian cancerQ36135007
Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.Q36556065
A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cellsQ36678230
Characterization of Glycosylation Sites of the Epidermal Growth Factor ReceptorQ37396323
Cleavage of the membrane precursor for transforming growth factor alpha is a regulated processQ37414612
Identification of serum factor inducing ectodomain shedding of proHB-EGF and sStudies of noncleavable mutants of proHB-EGF.Q38300911
The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreadingQ38320220
Regulated intracellular ligand transport and proteolysis control EGF signal activation in DrosophilaQ39583868
Soluble receptors for cytokines and growth factors: generation and biological functionQ40656511
EGF receptor expression, regulation, and function in breast cancerQ40665432
Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzymeQ40774834
Membrane-anchored growth factors.Q40856819
EGFR family-mediated signal transduction in the human keratinocyte cell line HaCaT.Q40922182
EGF-induced programmed cell death of human mammary carcinoma MDA-MB-468 cells is preceded by activation AP-1.Q41051794
Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.Q41199229
Progressive abrogation of TGF-beta 1 and EGF growth control is associated with tumour progression in ras-transfected human keratinocytesQ41602632
Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells.Q41701569
Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascadesQ41708821
Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin.Q42540708
Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activationQ42810137
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapyQ43851616
Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepinesQ44033487
Generation and characterization of polyclonal antibodies specific for human p110 sEGFR.Q44091925
Production of an Epidermal Growth Factor Receptor-Related ProteinQ44454765
Endocytosis-independent mechanisms of Delta ligand proteolysisQ46951847
Properties of pervanadate and permolybdate. Connexin43, phosphatase inhibition, and thiol reactivity as model systems.Q52243093
Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion.Q52829599
Monoclonal Antibodies Specific for Peptide Epitopes of the Epidermal Growth Factor Receptor's Extracellular DomainQ53442709
MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF.Q54451512
The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factorQ67975102
Cell surface localization of proteolysis of human endothelial angiotensin I-converting enzyme. Effect of the amino-terminal domain in the solubilization processQ71585920
Conformation of the transmembrane domain of the epidermal growth factor receptorQ72688309
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3Q77357145
An essential role for ectodomain shedding in mammalian developmentQ77544828
A sandwich type acridinium-linked immunosorbent assay (ALISA) detects soluble ErbB1 (sErbB1) in normal human seraQ77609274
Epidermal growth factor receptor transmembrane domain: 2H NMR implications for orientation and motion in a bilayer environmentQ77648611
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)2907-2918
P577publication date2008-07-25
P1433published inExperimental Cell ResearchQ1524289
P1476titleShedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells
P478volume314

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