scholarly article | Q13442814 |
P356 | DOI | 10.1016/S0092-8674(01)00526-8 |
P953 | full work available at URL | http://www.cell.com/article/S0092867401005268/pdf |
https://api.elsevier.com/content/article/PII:S0092867401005268?httpAccept=text/plain | ||
https://api.elsevier.com/content/article/PII:S0092867401005268?httpAccept=text/xml | ||
P698 | PubMed publication ID | 11672524 |
P5875 | ResearchGate publication ID | 11679192 |
P50 | author | Matthew Freeman | Q84560953 |
P2093 | author name string | J. R. Lee | |
S. Urban | |||
C. F. Garvey | |||
P2860 | cites work | A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface | Q22009486 |
Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55 | Q24595955 | ||
Untangling the ErbB signalling network | Q27860884 | ||
Macrogolgin--a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections | Q28118740 | ||
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans | Q28145545 | ||
A thousand and one roles for the Drosophila EGF receptor | Q30054101 | ||
Control of EGF receptor signalling: lessons from fruitflies. | Q33870383 | ||
The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. | Q33909902 | ||
EGF receptor signalling: the importance of presentation | Q33932869 | ||
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases | Q34098885 | ||
The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor | Q39757659 | ||
Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE) | Q40892360 | ||
Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. | Q41199229 | ||
The Drosophila rhomboid protein is concentrated in patches at the apical cell surface | Q42517686 | ||
Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development | Q43489656 | ||
Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic | Q46105720 | ||
The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway | Q46172909 | ||
rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster | Q46216729 | ||
Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis | Q46392129 | ||
Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1. | Q46650620 | ||
The role of star in the production of an activated ligand for the EGF receptor signaling pathway | Q46780819 | ||
The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis | Q48162492 | ||
An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. | Q50741937 | ||
In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development | Q52192958 | ||
Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters | Q52195782 | ||
Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. | Q52207720 | ||
Multiple functions of the EGF receptor in Drosophila eye development. | Q52566171 | ||
Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway | Q52567522 | ||
An essential role for ectodomain shedding in mammalian development | Q77544828 | ||
Control of EGF receptor activation in Drosophila | Q80818417 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | proteolysis | Q33123 |
ligand | Q193161 | ||
Drosophila | Q312154 | ||
epidermal growth factor receptor ligand maturation | Q22284314 | ||
Star Dmel_CG4385 | Q29815113 | ||
Spitz Dmel_CG10334 | Q29816356 | ||
Rhomboid Dmel_CG1004 | Q29819552 | ||
Drosophila proteins | Q76518326 | ||
P304 | page(s) | 161-171 | |
P577 | publication date | 2001-10-01 | |
2001-10-19 | |||
P1433 | published in | Cell | Q655814 |
P1476 | title | Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila | |
Regulated Intracellular Ligand Transport and Proteolysis Control EGF Signal Activation in Drosophila | |||
P478 | volume | 107 |
Q34589821 | A Drosophila model of multiple endocrine neoplasia type 2. |
Q47670617 | A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion |
Q33658165 | A combinatorial code for pattern formation in Drosophila oogenesis |
Q34155681 | A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes. |
Q35133575 | A discrete model of Drosophila eggshell patterning reveals cell-autonomous and juxtacrine effects |
Q34079257 | A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands |
Q34165208 | A fly's eye view of EGF receptor signalling |
Q47070152 | A function for Egf receptor signaling in expanding the developing brain in Drosophila |
Q34586856 | A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye. |
Q52592847 | A guiding star |
Q47071472 | A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye. |
Q41952077 | A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses |
Q34408339 | A rhomboid protease gene deletion affects a novel oligosaccharide N-linked to the S-layer glycoprotein of Haloferax volcanii |
Q34020108 | A screen for dominant mutations applied to components in the Drosophila EGF-R pathway |
Q33932480 | A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma |
Q36674481 | A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? |
Q28305519 | ADAMs: key components in EGFR signalling and development |
Q28484985 | Allosteric regulation of rhomboid intramembrane proteolysis |
Q39732913 | An Arabidopsis Rhomboid homolog is an intramembrane protease in plants. |
Q42008705 | An Arabidopsis rhomboid protease has roles in the chloroplast and in flower development |
Q34786925 | An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion |
Q33650430 | Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs |
Q34016597 | Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1 |
Q47071965 | Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila |
Q47071808 | Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. |
Q27313376 | Bridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells. |
Q37209170 | Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types |
Q52598713 | Bristles induce bracts via the EGFR pathway on Drosophila legs |
Q35728121 | Catalytic Mechanism of Rhomboid Protease GlpG Probed by 3,4-Dichloroisocoumarin and Diisopropyl Fluorophosphonate |
Q44361635 | Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. |
Q34427646 | Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands |
Q46570020 | Computational analysis of EGFR inhibition by Argos |
Q27678610 | Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites |
Q24305015 | Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins |
Q39615340 | Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids |
Q27346248 | Cytoplasmic capes are nuclear envelope intrusions that are enriched in endosomal proteins and depend upon βH-spectrin and Annexin B9 |
Q52666789 | DE-cadherin, a core component of the adherens junction complex modifies subcellular localization of the Drosophila gap junction protein innexin2. |
Q24306785 | Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 |
Q34016110 | Distinct functional units of the Golgi complex in Drosophila cells |
Q30443463 | Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands |
Q36632611 | Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases |
Q35355864 | Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation. |
Q37956222 | Drosophila as a model for epithelial tube formation |
Q33589834 | Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development |
Q34098885 | Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases |
Q34573337 | Drosophila signal peptide peptidase is an essential protease for larval development |
Q24314670 | Dynamics of the Rhomboid-like Protein RHBDD2 Expression in Mouse Retina and Involvement of Its Human Ortholog in Retinitis Pigmentosa |
Q37079731 | Dynein and Star interact in EGFR signaling and ligand trafficking |
Q43854000 | EGF Receptor Signalling: Roles of Star and Rhomboid Revealed |
Q24794899 | EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid |
Q28646129 | ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals |
Q36932347 | ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling |
Q42005192 | Ectopic expression of the male BmDSX affects formation of the chitin plate in female Bombyx mori. |
Q30480821 | Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing |
Q40080379 | Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses |
Q38193041 | Endocytosis and signaling during development |
Q41100689 | Entamoeba histolytica rhomboid protease 1 has a role in migration and motility as validated by two independent genetic approaches |
Q37676070 | Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer. |
Q24336330 | Exosome-Related Multi-Pass Transmembrane Protein TSAP6 Is a Target of Rhomboid Protease RHBDD1-Induced Proteolysis |
Q40740543 | Expression in mammalian cell cultures reveals interdependent, but distinct, functions for Star and Rhomboid proteins in the processing of the Drosophila transforming-growth-factor-alpha homologue Spitz |
Q41816395 | Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling |
Q37295257 | Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis |
Q36568772 | From fate to function: the Drosophila trachea and salivary gland as models for tubulogenesis |
Q24672054 | Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases |
Q34207332 | Functions of Rhomboid Family Protease RHBDL2 and Thrombomodulin in Wound Healing |
Q28510255 | GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic capacity in mouse seminiferous tubules |
Q34810184 | Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling |
Q24555733 | Gene regulatory networks for development |
Q24522635 | Generating patterns from fields of cells. Examples from Drosophila segmentation |
Q39100331 | Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonic Drosophila brain. |
Q52655213 | Genome wide analysis of transcript levels after perturbation of the EGFR pathway in the Drosophila ovary |
Q39655656 | Genome-wide genetic screen identified the link between dG9a and epidermal growth factor receptor signaling pathway in vivo |
Q35234613 | Golgi during Development |
Q36328467 | Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation |
Q47835945 | How does the exosite of rhomboid protease affect substrate processing and inhibition? |
Q34982248 | How intramembrane proteases bury hydrolytic reactions in the membrane. |
Q24318727 | Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells |
Q28475644 | Identification of an archaeal presenilin-like intramembrane protease |
Q34088111 | Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila |
Q52058054 | Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development |
Q39753706 | Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz |
Q37876486 | Intramembrane Proteolysis in Regulated Protein Trafficking |
Q36111814 | Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy |
Q37155734 | Intramembrane proteolysis |
Q30043432 | Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite |
Q37384495 | Intramembrane-cleaving proteases |
Q35057311 | Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides |
Q39658967 | Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1 |
Q39647920 | Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage |
Q39120825 | Lentiviral Vector Mediated Delivery of RHBDD1 shRNA down Regulated the Proliferation of Human Glioblastoma Cells |
Q33589807 | Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans |
Q47071235 | Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. |
Q34180352 | Long-range signal transmission in autocrine relays |
Q34178493 | Mammalian EGF receptor activation by the rhomboid protease RHBDL2 |
Q34379351 | Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. |
Q27935531 | Mitochondrial membrane remodelling regulated by a conserved rhomboid protease |
Q37688019 | Mitogenic effects of phosphatidylcholine nanoparticles on MCF-7 breast cancer cells. |
Q34784720 | Modeling pattern formation: counting to two in the Drosophila egg. |
Q44612451 | Modifiers of muscle and heart cell fate specification identified by gain-of-function screen in Drosophila |
Q33777125 | Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases |
Q37602752 | Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration |
Q47070996 | Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. |
Q37783446 | New insights into the types and function of proteases in plastids. |
Q35757335 | On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane |
Q46595840 | Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states |
Q47072882 | Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development |
Q28475685 | Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery |
Q34588474 | Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers |
Q33267197 | Protease gene families in Populus and Arabidopsis |
Q35678316 | Proteolysis within the membrane: rhomboids revealed |
Q89433901 | Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments |
Q35457014 | RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye |
Q45015381 | RHBDD2: a 5-fluorouracil responsive gene overexpressed in the advanced stages of colorectal cancer |
Q54341350 | RHBDL2 is a critical membrane protease for anoikis resistance in human malignant epithelial cells |
Q37315655 | Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila |
Q33836549 | Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity |
Q51814356 | Recycling of cell surface pro-transforming growth factor-{alpha} regulates epidermal growth factor receptor activation. |
Q37847814 | Regulated Intramembrane Proteolysis: Signaling Pathways and Biological Functions |
Q24298773 | Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b |
Q38193549 | Regulated intramembrane proteolysis of the TGFβ type I receptor conveys oncogenic signals |
Q43799853 | Regulated intramembrane proteolysis takes another twist |
Q52594202 | Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling |
Q37924096 | Regulation of developmental intercellular signalling by intracellular trafficking |
Q41994915 | Regulation of receptor tyrosine kinase ligand processing |
Q34644858 | Regulation of the Drosophila epidermal growth factor-ligand vein is mediated by multiple domains |
Q38758386 | Regulatory mechanisms of EGFR signalling during Drosophila eye development |
Q33274072 | Rhomboid cleaves Star to regulate the levels of secreted Spitz |
Q44441240 | Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP‐1 activity and its downstream target Bcl‐3 |
Q24298141 | Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling |
Q36970233 | Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα |
Q42051309 | Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5 |
Q27014686 | Rhomboid proteases in mitochondria and plastids: Keeping organelles in shape |
Q37946954 | Rhomboid proteases in plants – still in square one? |
Q28070034 | Rhomboids, signalling and cell biology |
Q27004729 | Role of rhomboid proteases in bacteria |
Q38078127 | Sampling the membrane: function of rhomboid-family proteins |
Q33410396 | Sec61beta, a subunit of the Sec61 protein translocation channel at the endoplasmic reticulum, is involved in the transport of Gurken to the plasma membrane |
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Q36245015 | Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases |
Q85185815 | Sequence analysis and verification of Eimeria tenella rhomboid bait plasmid suitability for CytoTrap yeast two-hybrid system |
Q34092101 | Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates |
Q43200075 | Serine proteases from two cell types target different components of a complex that governs regulated intramembrane proteolysis of pro-sigmaK during Bacillus subtilis development |
Q47070691 | Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation. |
Q39953010 | Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells |
Q30531514 | Shooting from the hip: spatial control of signal release by intracellular waves |
Q36648414 | Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk |
Q38031468 | Signaling mechanisms controlling cell fate and embryonic patterning |
Q38960315 | Site-2 protease responds to oxidative stress and regulates oxidative injury in mammalian cells |
Q37098030 | Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents |
Q48229303 | Species-specific activation of EGF receptor signaling underlies evolutionary diversity in the dorsal appendage number of the genus Drosophila eggshells |
Q36440700 | Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development |
Q36813846 | Steric trapping reveals a cooperativity network in the intramembrane protease GlpG |
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Q38083850 | Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids |
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Q47071208 | The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye. |
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