Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

scientific article (publication date: 25 September 2006)

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.200604136
P8608Fatcat IDrelease_edrmmqd7anbfhishxvyztslrui
P3181OpenCitations bibliographic resource ID4294368
P932PMC publication ID2064393
P698PubMed publication ID17000879
P5875ResearchGate publication ID6793574

P50authorMoritz TreeckQ55175676
Michael J BlackmanQ56786712
Chrislaine Withers-MartinezQ87837775
Fiona HackettQ107404870
P2093author name stringTim W Gilberger
Steven A Howell
Rebecca A O'Donnell
Zita Krnajski
Nicole Struck
P2860cites workThe rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfersQ24791324
Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarrayQ24804829
Molecular identification of a malaria merozoite surface sheddaseQ24811597
A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytesQ27230006
Glycophorin B as an EBA-175 independent Plasmodium falciparum receptor of human erythrocytesQ28247650
Discovery of gene function by expression profiling of the malaria parasite life cycleQ29547840
Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparumQ48013061
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogensQ48013866
C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cellsQ78625792
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanilQ29619882
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparumQ30038991
A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytesQ30042539
A Plasmodium falciparum homologue of Plasmodium vivax reticulocyte binding protein (PvRBP1) defines a trypsin-resistant erythrocyte invasion pathwayQ30043024
Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complexQ31050217
A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3.Q33195225
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by ToxoplasmaQ33932480
Plasmodium falciparum field isolates commonly use erythrocyte invasion pathways that are independent of sialic acid residues of glycophorin AQ34002398
Characterization of the 175-kilodalton erythrocyte binding antigen of Plasmodium falciparumQ34028376
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteasesQ34098885
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populationsQ34163026
Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domainQ34207965
Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparumQ34259232
An expanding ebl family of Plasmodium falciparumQ34264741
Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2.Q34309079
Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathwaysQ34960640
Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasionQ35162176
Proteolysis within the membrane: rhomboids revealedQ35678316
A new release on life: emerging concepts in proteolysis and parasite invasionQ36063959
Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature.Q36142573
The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein traffickingQ36323222
A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.Q36352078
Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificityQ36602637
The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteasesQ38312554
Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytesQ38321747
Regulated intracellular ligand transport and proteolysis control EGF signal activation in DrosophilaQ39583868
Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondiiQ39647004
Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboidsQ39675497
Purification of Plasmodium falciparum merozoites for analysis of the processing of merozoite surface protein-1.Q40501263
Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cellsQ40582637
Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum.Q41460430
Vectors for the expression of tagged proteins in Schizosaccharomyces pombe.Q42543117
A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavageQ44397889
Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparumQ45197048
Apicomplexan rhomboids have a potential role in microneme protein cleavage during host cell invasionQ46507314
Disruption of the C-terminal region of EBA-175 in the Dd2/Nm clone of Plasmodium falciparum does not affect erythrocyte invasionQ47871290
Plasmodium knowlesi: studies on invasion of rhesus erythrocytes by merozoites in the presence of protease inhibitorsQ47988661
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.Q48004368
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
cell biologyQ7141
proteolysisQ33123
rhomboid protease ROM1Q18971065
rhomboid protease ROM4Q56560672
rhomboid protease ROM4, putativeQ56711660
rhomboid protease ROM1, putativeQ56732716
rhomboid protease ROM1Q61717018
rhomboid protease ROM1, putativeQ61927853
erythrocyte invasionQ122665572
P1104number of pages11
P304page(s)1023-1033
P577publication date2006-09-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleIntramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite
P478volume174

Reverse relations

described by source (P1343)
Q61717018rhomboid protease ROM1
Q56732716rhomboid protease ROM1, putative
Q61927853rhomboid protease ROM1, putative

cites work (P2860)
Q27976477A Presenilin-like protease associated with Plasmodium falciparum micronemes is involved in erythrocyte invasion
Q28551592A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells
Q37300389A complex of three related membrane proteins is conserved on malarial merozoites
Q34977077A new class of rhomboid protease inhibitors discovered by activity-based fluorescence polarization
Q64843247A pan-apicomplexan phosphoinositide-binding protein acts in malarial microneme exocytosis.
Q37220749Acquisition of Functional Antibodies That Block the Binding of Erythrocyte-Binding Antigen 175 and Protection Against Plasmodium falciparum Malaria in Children
Q27676041Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay
Q33290851Adhesion molecules and other secreted host-interaction determinants in Apicomplexa: insights from comparative genomics
Q34786925An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion
Q35569042Antibodies to Plasmodium falciparum erythrocyte-binding antigen-175 are associated with protection from clinical malaria
Q27230046Antibodies to reticulocyte binding protein-like homologue 4 inhibit invasion of Plasmodium falciparum into human erythrocytes
Q27671783Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
Q27973510Biochemical analysis of the Plasmodium falciparum erythrocyte-binding antigen-175 (EBA175)-glycophorin-A interaction: implications for vaccine design
Q52371964Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum.
Q37283662Calcium-dependent signaling and kinases in apicomplexan parasites
Q35728121Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate
Q37351351Comparative Genomics and Systems Biology of Malaria Parasites Plasmodium
Q27678610Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites
Q37149083Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases
Q37160400Cryptosporidium parvum rhomboid1 has an activity in microneme protein CpGP900 cleavage
Q91917073Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery
Q41703382Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.
Q28741027Delineation of stage specific expression of Plasmodium falciparum EBA-175 by biologically functional region II monoclonal antibodies
Q33400318Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis
Q89936440Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle
Q84774063Efficacy of Eimeria tenella rhomboid-like protein as a subunit vaccine in protective immunity against homologous challenge
Q53066383Eimeria tenella rhomboid 3 has a potential role in microneme protein cleavage.
Q41100689Entamoeba histolytica rhomboid protease 1 has a role in migration and motility as validated by two independent genetic approaches
Q36640728Evolution of apicomplexan secretory organelles
Q48037113Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.
Q37887281Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.
Q33366572Formation of the food vacuole in Plasmodium falciparum: a potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP1(19))
Q35850068From rhomboid function to structure and back again
Q34420141Functional analysis of rhomboid proteases during Toxoplasma invasion
Q24672054Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases
Q85415617Functional annotation of serine hydrolases in the asexual erythrocytic stage of Plasmodium falciparum.
Q39870390Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain
Q47171557General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases
Q40068658Gliding motility powers invasion and egress in Apicomplexa.
Q34122826How apicomplexan parasites move in and out of cells
Q44175631Identification of trafficking determinants for polytopic rhomboid proteases in Toxoplasma gondii
Q37290269Improved prediction of malaria degradomes by supervised learning with SVM and profile kernel
Q33381611In silico identification of specialized secretory-organelle proteins in apicomplexan parasites and in vivo validation in Toxoplasma gondii
Q37643881Inside scoop on outside proteins
Q34157453Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.
Q38790377Intramembrane proteases as drug targets
Q37876486Intramembrane proteolysis in regulated protein trafficking
Q37319948Intriguing parasites and intramembrane proteases
Q37845443Invasion factors are coupled to key signalling events leading to the establishment of infection in apicomplexan parasites
Q34109788Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies
Q27677496Large Lateral Movement of Transmembrane Helix S5 Is Not Required for Substrate Access to the Active Site of Rhomboid Intramembrane Protease
Q36518609Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion
Q34332951Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.
Q27490898Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms
Q27010243Mechanisms of cellular invasion by intracellular parasites
Q26772878Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
Q36538947Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii
Q47828966Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2.
Q33777125Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases
Q36289035Mononeme: a new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 protease
Q27972792Novel putative glycosylphosphatidylinositol-anchored micronemal antigen of Plasmodium falciparum that binds to erythrocytes
Q27643738Open-cap conformation of intramembrane protease GlpG
Q27010002Parasites, proteomes and systems: has Descartes' clock run out of time?
Q61995217Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion
Q30043551Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion
Q27230103Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains
Q37649200Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria
Q37188081Plasmodium in the postgenomic era: new insights into the molecular cell biology of malaria parasites.
Q34016204Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole
Q34173524Protease-associated cellular networks in malaria parasite Plasmodium falciparum
Q39362514Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation
Q37891227Proteases as regulators of pathogenesis: examples from the Apicomplexa.
Q35228790Proteases in malaria parasites - a phylogenomic perspective
Q87423156Protective immunity induced by a DNA vaccine encoding Eimeria tenella rhomboid against homologous challenge
Q40163833Protein-protein interactions indicate composition of a 480 kDa SELMA complex in the second outermost membrane of diatom complex plastids
Q57251411Proteomics
Q42707456PvRON2, a new Plasmodium vivax rhoptry neck antigen
Q37105948Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites
Q90065038Reduced expression of a rhomboid protease, EhROM1, correlates with changes in the submembrane distribution and size of the Gal/GalNAc lectin subunits in the human protozoan parasite, Entamoeba histolytica
Q37414548Reticulocyte binding protein homologues are key adhesins during erythrocyte invasion by Plasmodium falciparum
Q44441240Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3.
Q36245015Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases
Q34092101Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates
Q37706424Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets.
Q60301624Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion
Q27345395Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity
Q27659886Structural Determination of Functional Units of the Nucleotide Binding Domain (NBD94) of the Reticulocyte Binding Protein Py235 of Plasmodium yoelii
Q34581109Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
Q38083850Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids
Q37342295Structure and mechanism of intramembrane protease
Q30429374Structure and mechanism of rhomboid protease
Q30391943Structures of membrane proteins
Q35090253Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis
Q36255544Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host
Q90391215Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release
Q30039603The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake
Q44318900The glideosome, a unique machinery that assists the Apicomplexa in gliding into host cells
Q37950553The rhomboid protease family: a decade of progress on function and mechanism
Q26829687The roles of intramembrane proteases in protozoan parasites
Q27664874The structural basis for catalysis and substrate specificity of a rhomboid protease
Q39608060Transcriptional activity of Plasmodium subtilisin-like protease 2 (Pf-Sub2) 5'untranslated regions and its interaction with hepatocyte growth factor

Search more.