Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms

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Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1004029827
P356DOI10.1038/NRMICRO2130
P932PMC publication ID2818034
P698PubMed publication ID19421188
P5875ResearchGate publication ID24407230

P2093author name stringSinisa Urban
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Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malariaQ27972762
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A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysisQ28303405
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Identification and characterization of a determinant (eep) on the Enterococcus faecalis chromosome that is involved in production of the peptide sex pheromone cAD1.Q33635750
Providencia stuartii genes activated by cell-to-cell signaling and identification of a gene required for production or activity of an extracellular factorQ33636480
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolutionQ33694348
Aggregation and binding substances enhance pathogenicity in rabbit models of Enterococcus faecalis endocarditisQ33748332
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificityQ33836549
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by ToxoplasmaQ33932480
Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a disciplineQ33937086
A paracrine peptide sex pheromone also acts as an autocrine signal to induce plasmid transfer and virulence factor expression in vivoQ34098454
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteasesQ34098885
Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malariaQ37649200
Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformansQ38302324
The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteasesQ38312554
Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytesQ38321747
Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboidsQ39615340
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In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cellsQ39861099
Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus productionQ39990457
Fine-tuning of the Escherichia coli sigmaE envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA.Q40294668
Hepatitis C virus core protein: carboxy-terminal boundaries of two processed species suggest cleavage by a signal peptide peptidaseQ41163457
Site-2 protease regulated intramembrane proteolysis: sequence homologs suggest an ancient signaling cascadeQ41846950
Signal peptide peptidase-catalyzed cleavage of hepatitis C virus core protein is dispensable for virus budding but destabilizes the viral capsidQ42036653
Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivoQ43001715
Degradation of the membrane-localized virulence activator TcpP by the YaeL protease in Vibrio choleraeQ34132245
Intramembrane proteolysis controls diverse signalling pathways throughout evolutionQ34146440
A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes.Q34155681
Membrane-bound transcription factors: regulated release by RIP or RUP.Q34245396
Identification of the cAD1 sex pheromone precursor in Enterococcus faecalisQ34308128
Intramembrane proteolysis: theme and variations.Q34342964
Functional characterization of Escherichia coli GlpG and additional rhomboid proteins using an aarA mutant of Providencia stuartiiQ34564965
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entryQ34581109
Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocaseQ34600228
Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gateQ34623352
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Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysisQ34770334
An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasionQ34786925
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptidesQ35057311
An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartiiQ35137673
The Tat protein translocation pathway and its role in microbial physiologyQ35560170
Intracellular parasite invasion strategiesQ35741714
Regulated proteolysis controls mucoid conversion in Pseudomonas aeruginosaQ35808927
Enterococcal peptide sex pheromones: synthesis and control of biological activity.Q35890665
Expression of hurP, a gene encoding a prospective site 2 protease, is essential for heme-dependent induction of bhuR in Bordetella bronchisepticaQ35949568
Characterization of aarA, a pleiotrophic negative regulator of the 2'-N-acetyltransferase in Providencia stuartiiQ35968625
The Aggregation Domain of Aggregation Substance, Not the RGD Motifs, Is Critical for Efficient Internalization by HT-29 EnterocytesQ36045393
Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosisQ36090700
Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature.Q36142573
Mononeme: a new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 proteaseQ36289035
Regulatory networks controlling Vibrio cholerae virulence gene expressionQ36313974
Pulling together: an integrated model of Toxoplasma cell invasionQ36534509
Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondiiQ36538947
Rhomboid proteins: conserved membrane proteases with divergent biological functionsQ36657554
Signal peptide peptidases and gamma-secretase: cousins of the same protease family?Q36863031
Cutting proteins within lipid bilayers: rhomboid structure and mechanism.Q37045042
Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteasesQ37149083
RseP (YaeL), an Escherichia coli RIP protease, cleaves transmembrane sequencesQ37605202
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
P304page(s)411-23
P577publication date2009-06-01
P1433published inNature Reviews MicrobiologyQ1071797
P1476titleMaking the cut: central roles of intramembrane proteolysis in pathogenic microorganisms
P478volume7