Molecular identification of a malaria merozoite surface sheddase

scientific article

Molecular identification of a malaria merozoite surface sheddase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PPAT.0010029
P3181OpenCitations bibliographic resource ID583716
P932PMC publication ID1291349
P698PubMed publication ID16322767
P5875ResearchGate publication ID7445862

P50authorMichael J BlackmanQ56786712
Chrislaine Withers-MartinezQ87837775
Fiona HackettQ107404870
P2093author name stringSharon Yeoh
Anton R Dluzewski
Graham H Mitchell
Lawrence H Bannister
Rebecca A O'Donnell
Philippa K Harris
P2860cites workEffects of cytochalasin, phalloidin, and pH on the elongation of actin filaments.Q52455490
Cytochalasin D does not produce net depolymerization of actin filaments in HEp-2 cells.Q52503934
Functional analysis of the propeptide of subtilisin E as an intramolecular chaperone for protein folding. Refolding and inhibitory abilities of propeptide mutants.Q54601480
Expression of the 19-kilodalton carboxy-terminal fragment of the Plasmodium falciparum merozoite surface protein-1 in Escherichia coli as a correctly folded protein.Q54638975
Actin Microfilaments Facilitate the Retrograde Transport from the Golgi Complex to the Endoplasmic Reticulum in Mammalian CellsQ58493556
Processing of thePlasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasionQ59394239
Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondiiQ63409196
The synthesis and analytical use of a highly sensitive and convenient substrate of elastaseQ68827466
Secretion of micronemal proteins is associated with toxoplasma invasion of host cellsQ73510453
Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite developmentQ73764830
A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.Q36352078
Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modelingQ38288459
Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasiteQ39600996
Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondiiQ39647004
Purification of Plasmodium falciparum merozoites for analysis of the processing of merozoite surface protein-1.Q40501263
Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cellsQ40582637
Induction of secretion and surface capping of microneme proteins in Eimeria tenellaQ40843439
Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and HfurinQ42059728
Inhibition of actin polymerization by latrunculin A.Q42217562
Vectors for the expression of tagged proteins in Schizosaccharomyces pombe.Q42543117
Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparumQ42727356
1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilaseQ43016000
A sensitive new substrate for chymotrypsinQ44163410
A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavageQ44397889
Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparumQ44588579
Active intranuclear movement of herpesvirus capsidsQ46415497
Malaria parasite actin filaments are very shortQ46474283
PfSUB-2: a second subtilisin-like protein in Plasmodium falciparum merozoitesQ47855436
PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.Q47857173
Functional conservation of the malaria vaccine antigen MSP-119across distantly related Plasmodium speciesQ47857319
Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium speciesQ47874885
Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.Q47884690
Gene targeting demonstrates that the Plasmodium berghei subtilisin PbSUB2 is essential for red cell invasion and reveals spontaneous genetic recombination events.Q47971767
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.Q48004368
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogensQ48013866
A conserved parasite serine protease processes the Plasmodium falciparum merozoite surface protein-1.Q48014494
Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarrayQ24804829
Latrunculin alters the actin-monomer subunit interface to prevent polymerizationQ27624918
Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculusQ27639322
Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisinQ27642831
The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolutionQ27766005
How to measure and predict the molar absorption coefficient of a proteinQ27860551
Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoitesQ27973516
Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturaseQ27973702
A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycleQ27974188
Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegmentQ28640526
Discovery of gene function by expression profiling of the malaria parasite life cycleQ29547840
Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference setQ29616463
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanilQ29619882
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1Q30043446
Actin filament polymerization regulates gliding motility by apicomplexan parasitesQ30477554
Characterisation of the rhoph2 gene of Plasmodium falciparum and Plasmodium yoeliiQ30765884
Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomainsQ30769503
Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complexQ31050217
Structure and invasive behaviour ofPlasmodium knowlesimerozoitesin vitroQ31060680
A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3.Q33195225
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by ToxoplasmaQ33932480
Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasionQ33938442
Antibodies against thrombospondin-related anonymous protein do not inhibit Plasmodium sporozoite infectivity in vivoQ34004839
Mix and match modules: structure and function of microneme proteins in apicomplexan parasites.Q34167780
Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targetsQ34320843
The global distribution and population at risk of malaria: past, present, and futureQ34548302
Band 3 is a host receptor binding merozoite surface protein 1 during thePlasmodium falciparuminvasion of erythrocytesQ34982236
Proteolysis within the membrane: rhomboids revealedQ35678316
Role of proteases in host cell invasion by Toxoplasma gondii and other ApicomplexaQ35781639
Subtilisin-like proteases of the malaria parasite.Q35822049
Molecular and functional aspects of parasite invasionQ35937482
A new release on life: emerging concepts in proteolysis and parasite invasionQ36063959
Dense granules: are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?Q36174886
Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formationQ36341089
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
merozoiteQ2296434
subtilisin-like protease 2Q56576371
subtilisin-like protease 2, putativeQ56734511
subtilisin-like protease 2, putativeQ59744999
subtilisin-like protease 2, putativeQ59879520
subtilisin-like protease 2Q59913444
subtilisin-like protease 2, putativeQ59959982
subtilisin-like protease 2, putativeQ59972382
subtilisin-like protease 2, putativeQ59985821
subtilisin-like protease 2, putativeQ59992683
subtilisin-like protease 2, putativeQ59999538
subtilisin-like protease 2, putativeQ61614328
P304page(s)241-51
P577publication date2005-11-01
P1433published inPLOS PathogensQ283209
P1476titleMolecular identification of a malaria merozoite surface sheddase
P478volume1

Reverse relations

described by source (P1343)
Q59985821subtilisin-like protease 2, putative
Q59992683subtilisin-like protease 2, putative
Q59999538subtilisin-like protease 2, putative
Q56734511subtilisin-like protease 2, putative
Q59744999subtilisin-like protease 2, putative
Q59879520subtilisin-like protease 2, putative
Q59972382subtilisin-like protease 2, putative

cites work (P2860)
Q28474023A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates
Q87837788A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.
Q30043444A multifunctional serine protease primes the malaria parasite for red blood cell invasion
Q47597994A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress
Q27695596A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase
Q38729151A polyvalent hybrid protein elicits antibodies against the diverse allelic types of block 2 in Plasmodium falciparum merozoite surface protein 1.
Q34504148A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes
Q38556666A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum
Q36550447Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria
Q33402457An inhibitory antibody blocks interactions between components of the malarial invasion machinery
Q33761687Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion
Q28481599Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41
Q36309063Changes in surface glycosylation and glycocalyx shedding in Trichobilharzia regenti (Schistosomatidae) during the transformation of cercaria to schistosomulum
Q41870504Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion.
Q27973701Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodium falciparum Osmiophilic Bodies in Malaria Parasite Transmission
Q92697532Comparative and functional genomics of the protozoan parasite Babesia divergens highlighting the invasion and egress processes
Q35668397Conditional U1 Gene Silencing in Toxoplasma gondii
Q42571297Cryptosporidium parvum glycoprotein gp40 localizes to the sporozoite surface by association with gp15.
Q37973123Crystalloid body, refractile body and virus-like particles in Apicomplexa: what is in there?
Q41703382Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.
Q36058850Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum
Q37315245Development of protease inhibitors for protozoan infections
Q91973616Differential IL-18 Dependence of Canonical and Adaptive NK Cells for Antibody Dependent Responses to P. falciparum
Q33905364Epitope mapping of PfCP-2.9, an asexual blood-stage vaccine candidate of Plasmodium falciparum
Q60046643Essentiality of Plasmodium falciparum plasmepsin V
Q36155945Evaluation of the immunogenicity and vaccine potential of recombinant Plasmodium falciparum merozoite surface protein 8.
Q41994264Exploitation of a newly-identified entry pathway into the malaria parasite-infected erythrocyte to inhibit parasite egress
Q30043915Expression and characterization of catalytic domain of Plasmodium falciparum subtilisin-like protease 3
Q39392376Expression of exogenous human hepatic nuclear factor-1α by a lentiviral vector and its interactions with Plasmodium falciparum subtilisin-like protease 2
Q35980267Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.
Q37887281Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.
Q33366572Formation of the food vacuole in Plasmodium falciparum: a potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP1(19))
Q40068658Gliding motility powers invasion and egress in Apicomplexa.
Q34739743Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease
Q33625538Identification and characterization of a surface-associated, subtilisin-like serine protease in Trichomonas vaginalis
Q33317962Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum
Q34591062Immunization against a merozoite sheddase promotes multiple invasion of red blood cells and attenuates Plasmodium infection in mice.
Q33381611In silico identification of specialized secretory-organelle proteins in apicomplexan parasites and in vivo validation in Toxoplasma gondii
Q37643881Inside scoop on outside proteins
Q33825130Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites
Q34157453Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.
Q30043432Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite
Q33880777Isolation and characterization of the MSP1 genes from Plasmodium malariae and Plasmodium ovale
Q34069682Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development
Q34109788Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies
Q47862670MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking
Q27490898Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms
Q27334909Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress
Q27010243Mechanisms of cellular invasion by intracellular parasites
Q27230075Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells
Q26772878Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
Q21147068Merozoite surface proteins of the malaria parasite: The MSP1 complex and the MSP7 family
Q27974553Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs
Q47828966Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2.
Q38065630New approaches to studying Plasmodium falciparum merozoite invasion and insights into invasion biology
Q34602992New insights for native production of MSP1(19), the disulfide-rich C-terminal fragment from Plasmodium falciparum merozoite surface protein 1.
Q27972792Novel putative glycosylphosphatidylinositol-anchored micronemal antigen of Plasmodium falciparum that binds to erythrocytes
Q30844001Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress
Q61995217Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion
Q38755598Plasmodium berghei PIMMS2 promotes ookinete invasion of the Anopheles gambiae mosquito midgut
Q35805390Plasmodium falciparum 19-kilodalton merozoite surface protein 1 (MSP1)-specific antibodies that interfere with parasite growth in vitro can inhibit MSP1 processing, merozoite invasion, and intracellular parasite development
Q55236860Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.
Q30046956Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle
Q37188081Plasmodium in the postgenomic era: new insights into the molecular cell biology of malaria parasites.
Q34016204Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole
Q37301136Plasmodium sporozoite-host interactions from the dermis to the hepatocyte
Q36045121Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.
Q27972787Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs
Q28540732Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound
Q39362514Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation
Q37891227Proteases as regulators of pathogenesis: examples from the Apicomplexa.
Q35228790Proteases in malaria parasites - a phylogenomic perspective
Q27314651Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite
Q36368252Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte
Q39637179Proteomic Analysis of the Plasmodium berghei Gametocyte Egressome and Vesicular bioID of Osmiophilic Body Proteins Identifies Merozoite TRAP-like Protein (MTRAP) as an Essential Factor for Parasite Transmission
Q34369560Regulated maturation of malaria merozoite surface protein‐1 is essential for parasite growth
Q37001788Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle
Q34929677Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro
Q37643916Sequential processing of merozoite surface proteins during and after erythrocyte invasion by Plasmodium falciparum
Q37706424Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets.
Q27345395Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity
Q43293256Shelph2, a bacterial-like phosphatase of the malaria parasite Plasmodium falciparum, is dispensable during asexual blood stage
Q27682474Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum
Q30041188Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase
Q64062417Structural Insights Into Key Proteases as Therapeutic Drug Targets
Q27648686Structure of the Malaria Antigen AMA1 in Complex with a Growth-Inhibitory Antibody
Q91959043Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors
Q64264199Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
Q37608790The Plasmodium TRAP/MIC2 family member, TRAP-Like Protein (TLP), is involved in tissue traversal by sporozoites.
Q33880801The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes
Q70202802The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion.
Q37559892The carboxy-terminus of merozoite surface protein 1: structure, specific antibodies and immunity to malaria.
Q37568142The malaria merozoite, forty years on.
Q27974532The merozoite surface protein 1 complex is a platform for binding to human erythrocytes by Plasmodium falciparum
Q36070086The moving junction, a key portal to host cell invasion by apicomplexan parasites
Q34698064The role of serine-type serine repeat antigen in Plasmodium yoelii blood stage development
Q39608060Transcriptional activity of Plasmodium subtilisin-like protease 2 (Pf-Sub2) 5'untranslated regions and its interaction with hepatocyte growth factor
Q27972762Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria
Q49927350Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.