Posttranslational regulation of Fas ligand function.

scientific article published on 29 December 2008

Posttranslational regulation of Fas ligand function. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1048329674
P356DOI10.1186/1478-811X-6-11
P932PMC publication ID2647539
P698PubMed publication ID19114018

P50authorOttmar JanssenQ51115166
P2093author name stringMatthias Voss
Marcus Lettau
Maren Paulsen
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SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 productionQ24296666
Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasLQ24297477
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cellsQ24308074
Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosisQ24319106
A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cellsQ24338698
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Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factorQ28210406
Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)Q28218575
Characterization of Fas (Apo-1, CD95)-Fas ligand interactionQ28244083
A new class of reverse signaling costimulators belongs to the TNF familyQ28249377
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor familyQ28285445
Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domainQ28291501
The ADAM metalloproteinasesQ28292696
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapyQ28303181
ADAMs: key components in EGFR signalling and developmentQ28305519
Notch signalling: a simple pathway becomes complexQ29555851
The Fas death factorQ29620461
Signal-dependent membrane protein trafficking in the endocytic pathwayQ29622948
Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transductionQ30014849
Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytesQ30157452
The adaptor protein Grb2 regulates cell surface Fas ligand in Schwann cells.Q30157514
The cytoplasmic domain of Fas ligand costimulates TCR signalsQ30159720
Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activityQ30160067
The Nck family of adapter proteins: regulators of actin cytoskeletonQ30165392
Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail.Q30167917
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.Q30336360
Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.Q33289418
The Fas counterattack: cancer as a site of immune privilegeQ33542332
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.Q33752819
Fas ligand-induced apoptosisQ33847658
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.Q33878896
A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'Q33890754
The molecular architecture of the TNF superfamilyQ34109796
PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factorQ34227481
Tumor counterattack: fact or fiction?Q34418305
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complexQ34472898
Secretory lysosomesQ34522863
The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapseQ34596132
Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreasQ34792019
Non-apoptotic Fas signaling.Q35027104
The ADAMs family of metalloproteases: multidomain proteins with multiple functionsQ35039313
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptidesQ35057311
The CD95(APO-1/Fas) DISC and beyondQ35091401
Signaling and transcriptional control of Fas ligand gene expression.Q35091405
Delivering the kiss of deathQ35116674
Activation-induced cell death in T cellsQ35129715
CD95 ligand--death factor and costimulatory molecule?Q35190128
Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune systemQ35902539
Induction of tolerance using Fas ligand: a double-edged immunomodulatorQ35918998
Considering Fas ligand as a target for therapyQ36066300
Shedding light on ADAM metalloproteinasesQ36159565
Metalloproteinase-mediated release of human Fas ligandQ36365559
Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.Q36370300
Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligandQ36381058
Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicityQ36400613
Emerging roles for ectodomain shedding in the regulation of inflammatory responsesQ36432148
Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion.Q36454471
How T lymphocytes switch between life and deathQ36515075
Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeletonQ36639196
Secretory lysosomes and their cargo in T and NK cellsQ36650422
Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactionsQ36734210
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?Q36879036
CD8 T cells utilize TRAIL to control influenza virus infectionQ37029404
Clipping, shedding and RIPping keep immunity on cue.Q37053286
Storage, expression and function of Fas ligand, the key death factor of immune cells.Q37232916
Death receptor Fas (CD95) signaling in the central nervous system: tuning neuroplasticity?Q37233845
2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cellsQ39957412
Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid raftsQ40342735
Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand-mediated cytotoxicityQ40437985
Asparagine-linked oligosaccharides protect Lamp-1 and Lamp-2 from intracellular proteolysisQ40923003
Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cellsQ40981770
Separate domains of the human fas ligand dictate self-association and receptor bindingQ41070378
Downregulation of Fas ligand by sheddingQ41071790
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signallingQ41107179
Regulation of cell surface APO-1/Fas (CD95) ligand expression by metalloproteasesQ41321495
The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stabilityQ41839673
CTLs contain and use intracellular stores of FasL distinct from cytolytic granulesQ42825924
Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligandQ44237377
Receptor-like properties of the 26 kDa transmembrane form of TNF.Q52544124
Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells.Q53431419
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.Q53572097
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.Q53582778
Comparative molecular modelling of the Fas-ligand and other members of the TNF familyQ57075447
The CD95 Receptor: Apoptosis RevisitedQ62734296
Fas Ligand-Induced Apoptosis as a Mechanism of Immune PrivilegeQ63408406
Fas ligand costimulates the in vivo proliferation of CD8+ T cellsQ73163098
Newly discovered role for Fas ligand in the cell-cycle arrest of CD4+ T cellsQ77658689
Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesiclesQ78025377
Analysis of Fas-ligand interactions using a molecular model of the receptor-ligand interfaceQ78057597
Cutting edge: two distinct motifs within the Fas ligand tail regulate Fas ligand-mediated costimulationQ81464205
P304page(s)11
P577publication date2008-12-29
P1433published inCell Communication and SignalingQ1254390
P1476titlePosttranslational regulation of Fas ligand function
P478volume6

Reverse relations

cites work (P2860)
Q50252931Apoptosis of rat ovarian granulosa cells by 2,5-hexanedione in vitro and its relevant gene expression
Q52655011Association analysis of FAS-670A/G and FASL-844C/T polymorphisms with risk of generalized aggressive periodontitis disease.
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Q39791226Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells
Q33488348Enrichment and analysis of secretory lysosomes from lymphocyte populations
Q39236160Fas ligand plays an important role for the production of pro-inflammatory cytokines in intervertebral disc nucleus pulposus cells
Q35051748Herpes simplex virus type 1-induced FasL expression in human monocytic cells and its implications for cell death, viral replication, and immune evasion
Q24322679Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening
Q48191024Impairment of Fas-ligand-caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death.
Q47171898Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective.
Q41894662Pro- and anti-apoptotic CD95 signaling in T cells
Q92643838miR-21 induces endothelial progenitor cells proliferation and angiogenesis via targeting FASLG and is a potential prognostic marker in deep venous thrombosis

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