| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/0014-5793(94)80235-1 |
| P8608 | Fatcat ID | release_ef4xu2y4tjginngt77zd725kbe |
| P3181 | OpenCitations bibliographic resource ID | 4980330 |
| P698 | PubMed publication ID | 8137918 |
| P5875 | ResearchGate publication ID | 15061173 |
| P50 | author | Marc Parmentier | Q1444262 |
| Catherine Mollereau | Q59784775 | ||
| P2093 | author name string | C Moisand | |
| D Caput | |||
| G Vassart | |||
| J C Meunier | |||
| J L Butour | |||
| P Chalon | |||
| P Mailleux | |||
| P2860 | cites work | Molecular cloning of a human cannabinoid receptor which is also expressed in testis | Q24337626 |
| Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy | Q27684426 | ||
| Cloning of a delta opioid receptor by functional expression | Q28213132 | ||
| Selective amplification and cloning of four new members of the G protein-coupled receptor family | Q28251917 | ||
| CLUSTAL: a package for performing multiple sequence alignment on a microcomputer | Q28293854 | ||
| Cloning and pharmacological characterization of a rat kappa opioid receptor | Q28378330 | ||
| Cloning and functional comparison of kappa and delta opioid receptors from mouse brain | Q28378630 | ||
| The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization | Q30800519 | ||
| Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin | Q33669928 | ||
| The use of thin acrylamide gels for DNA sequencing | Q34055309 | ||
| Mu and delta receptors belong to a family of receptors that are coupled to potassium channels | Q34336041 | ||
| Morphine receptors as regulators of adenylate cyclase activity | Q35069916 | ||
| Model systems for the study of seven-transmembrane-segment receptors | Q36417986 | ||
| mu opiate receptor: cDNA cloning and expression | Q36641338 | ||
| Cloning and expression of a cDNA for the rat kappa-opioid receptor | Q36741807 | ||
| Opioid receptor-coupled second messenger systems | Q37179761 | ||
| Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphine | Q37555862 | ||
| Muscarinic receptor subtypes | Q37925400 | ||
| Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry | Q38331458 | ||
| The molecular basis of opioid receptor function | Q39243644 | ||
| High efficiency polyoma DNA transfection of chloroquine treated cells | Q40490478 | ||
| A separation method for the assay of adenylylcyclase, intracellular cyclic AMP, and cyclic-AMP phosphodiesterase using tritium-labeled substrates | Q41624421 | ||
| Retroviruses expressing different levels of the normal epidermal growth factor receptor: biological properties and new bioassay | Q43785921 | ||
| Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated | Q44241904 | ||
| The delta-opioid receptor in neuroblastoma x glioma NG 108-15 hybrid cells is strongly precoupled to a G-protein | Q44331327 | ||
| Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. | Q44340286 | ||
| cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands. | Q44340426 | ||
| Evidence for a new type of opioid binding site in the brain of the frog Rana ridibunda | Q44343198 | ||
| The GTP-binding protein, Go, regulates neuronal calcium channels | Q44508440 | ||
| Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo | Q59061346 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | opioid | Q427523 |
| opioid related nociceptin receptor 1 | Q12746346 | ||
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | Q14864081 | ||
| P304 | page(s) | 33-8 | |
| P577 | publication date | 1994-03-14 | |
| P1433 | published in | FEBS Letters | Q1388051 |
| P1476 | title | ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization | |
| P478 | volume | 341 |
| Q28372299 | 8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists |
| Q41739476 | A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin |
| Q30357121 | A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist. |
| Q34708540 | A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay |
| Q33953034 | A new synthetic approach to 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one(J-113397), the first non-peptide ORL-1 receptor antagonist.. |
| Q37367805 | A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor |
| Q33887997 | A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397. |
| Q24649537 | A role for brain stress systems in addiction |
| Q28344114 | A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat. |
| Q47549684 | A systematic review of the role of the nociceptin receptor system in stress, cognition, and reward: relevance to schizophrenia. |
| Q48222357 | Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats |
| Q28345171 | Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro |
| Q41885468 | Actions of orphanin FQ/nociceptin on rat ventral tegmental area neurons in vitro |
| Q51549972 | Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro. |
| Q92989018 | Activation of Membrane Estrogen Receptors Attenuates NOP-Mediated Tactile Antihypersensitivity in a Rodent Model of Neuropathic Pain |
| Q37511488 | Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism |
| Q51538753 | Activation of mitogen-activated protein kinase by the nociceptin receptor expressed in Chinese hamster ovary cells. |
| Q28576218 | Activation of opioid receptor like-1 receptor in the spinal cord produces sex-specific antinociception in the rat: estrogen attenuates antinociception in the female, whereas testosterone is required for the expression of antinociception in the male |
| Q59135168 | Activation of spinal nociceptin receptors induces cardiovascular depression and antinociception in an independent manner in mice |
| Q36456876 | Activities of mixed NOP and mu-opioid receptor ligands. |
| Q51433695 | Acute desensitization of nociceptin/orphanin FQ inhibition of voltage-gated calcium channels in freshly dissociated hippocampal neurons. |
| Q92635639 | Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists |
| Q22010428 | Agonistic effect of buprenorphine in a nociceptin/OFQ receptor-triggered reporter gene assay |
| Q43507347 | Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor |
| Q43213776 | Alterations in the level of OFQ/N-IR in rat brain regions by cocaine |
| Q51411434 | Altered release of prostaglandins contributes to hypoxic/ischemic impairment of NOC/oFQ cerebrovasodilation. |
| Q41736471 | An alternatively spliced transcript of the rat nociceptin receptor ORL1 gene encodes a truncated receptor |
| Q43656881 | Analgesia elicited by OFQ/nociceptin and its fragments from the amygdala in rats |
| Q44346809 | Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test |
| Q44347382 | Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain |
| Q77332078 | Antinociceptive analogs of orphanin FQ/nociceptin(1-11) |
| Q48730514 | Antisense mapping DOR-1 in mice: further support for delta receptor subtypes |
| Q44334055 | Antisense mapping the MOR‐1 opioid receptor: evidence for alternative splicing and a novel morphine‐6β‐glucuronide receptor |
| Q46970878 | Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence |
| Q44406474 | Autoradiographic localization of (125)i[Tyr(14)] nociceptin/orphanin FQ binding sites in macaque primate CNS. |
| Q48658925 | Autoradiographic localization of [3H]nociceptin binding sites from telencephalic to mesencephalic regions of the mouse brain |
| Q73081319 | Autoradiographic localization of [3H]nociceptin binding sites in the rat brain |
| Q38347903 | Behavioral and endocrine changes following antisense oligonucleotide-induced reduction in the rat NOP receptor |
| Q24647780 | Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys |
| Q43574489 | Bi-directional modulation of 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint by nociceptin |
| Q42561263 | Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. |
| Q36849604 | Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain |
| Q42167607 | Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors |
| Q48259953 | Biotransformation of nociceptin/orphanin FQ by enzyme activity from morphine-naive and morphine-treated cell cultures |
| Q74338139 | Blockade effects of (Nphe1)Nociceptin(1-13)-NH(2) on anti-nociception induced by intrathecal administration of nociceptin in rats |
| Q35043035 | Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test |
| Q41953872 | Bradycardia elicited by microinjections of nociceptin/orphanin FQ into the intermediolateral cell column at T1-T2 in the rat. |
| Q35551256 | Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors |
| Q37329257 | Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A. |
| Q36232833 | Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. |
| Q44343463 | Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. |
| Q24642980 | Buprenorphine: a unique drug with complex pharmacology |
| Q44275456 | CJ-15,208, a novel kappa opioid receptor antagonist from a fungus, Ctenomyces serratus ATCC15502. |
| Q38175134 | Calcium-permeable ion channels in pain signaling |
| Q48142276 | Caloric restriction increases the sensitivity to the hyperphagic effect of nociceptin/orphanin FQ limiting its ability to reduce binge eating in female rats. |
| Q58542262 | Cancer-related chronic pain: investigation of the novel analgesic drug candidate cebranopadol in a randomized, double-blind, non-inferiority trial |
| Q48094185 | Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves |
| Q48220227 | Cardiovascular responses to microinjections of nociceptin into a midline area in the commissural subnucleus of the nucleus tractus solitarius of the rat. |
| Q41028896 | Catecholaminergic CATH.a cells express predominantly delta-opioid receptors |
| Q38990121 | Cebranopadol: novel dual opioid/NOP receptor agonist analgesic |
| Q36776707 | Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. |
| Q37094760 | Central N/OFQ-NOP Receptor System in Pain Modulation |
| Q73505763 | Central changes in nociceptin dynorphin B and Met-enkephalin-Arg-Phe in different models of nociception |
| Q41858244 | Characterization of nociceptin hyperalgesia and allodynia in conscious mice |
| Q44347811 | Characterization of nociceptin-stimulated in situ [35S]GTPgammaS binding in comparison with opioid agonist-stimulated ones in brain regions of the mice |
| Q36733530 | Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys |
| Q24319950 | ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains |
| Q41965545 | Cloning and expression of a cDNA encoding a mouse brain orphanin FQ/nociceptin precursor |
| Q42692118 | Cloning, expression and functional role of a nociceptin/orphanin FQ receptor in the porcine gastrointestinal tract |
| Q22253202 | Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans |
| Q42615216 | Cloning, sequencing, expression and function of a cDNA encoding a receptor for the opioid growth factor, [Met(5)]enkephalin |
| Q48338587 | Colocalization of estrogen β-receptor messenger RNA with orphanin FQ, vasopressin and oxytocin in the rat hypothalamic paraventricular and supraoptic nuclei |
| Q44031623 | CompB (J-113397), selectively and competitively antagonizes nociceptin activation of inwardly rectifying K(+) channels in rat periaqueductal gray slices |
| Q73327064 | Comparison of behavioural effects of NocII or NocIII, two related pronociceptin-derived peptides |
| Q35044107 | Comparison of the ORL1 receptor-mediated inhibition of noradrenaline release in human and rat neocortical slices |
| Q73966943 | Comparison of the structure-activity relationships of nociceptin and dynorphin A using chimeric peptides |
| Q40444494 | Correlating the pharmacology and molecular biology of opioid receptors. Cloning and antisense mapping a kappa 3-related opiate receptor |
| Q27693220 | Current research on opioid receptor function |
| Q44138153 | Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study |
| Q34431119 | Denatured G-protein coupled receptors as immunogens to generate highly specific antibodies |
| Q41825204 | Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro |
| Q31155686 | Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor |
| Q43165858 | Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I. |
| Q73189038 | Determination of nociceptin-like immunoreactivity in the rat dorsal spinal cord |
| Q96768816 | Development and Biological Applications of Fluorescent Opioid Ligands |
| Q37680813 | Development of nociceptin receptor (NOP) agonists and antagonists |
| Q44348858 | Different domains of the ORL1 and kappa-opioid receptors are involved in recognition of nociceptin and dynorphin A. |
| Q41027630 | Differential neurotoxicity of etorphine-like opiates: lack of correlation with their ability to activate opiate receptors. |
| Q35243402 | Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors. |
| Q43594272 | Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor |
| Q44148511 | Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype |
| Q35044530 | Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro |
| Q44332139 | Direct identification of a peptide binding region in the opioid receptor-like 1 receptor by photoaffinity labeling with [Bpa(10),Tyr(14)]nociceptin |
| Q28256196 | Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors |
| Q42874981 | Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pa |
| Q38352142 | Dissociation of affinity and efficacy in KOR-3 chimeras |
| Q43514515 | Distribution and chemical coding of orphanin FQ/nociceptin-immunoreactive neurons in the myenteric plexus of guinea pig intestines and sphincter of Oddi |
| Q42167045 | Distribution of ORL-1 receptor binding and receptor-activated G-proteins in rat forebrain and their experimental localization in anterior cingulate cortex |
| Q42513327 | Distribution of an orphan G-protein coupled receptor (JP05) mRNA in the human brain |
| Q41055751 | Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells. |
| Q48401695 | Distribution of prepro-nociceptin/orphanin FQ mRNA and its receptor mRNA in developing and adult mouse central nervous systems |
| Q48172353 | Distribution of the nociceptin and nocistatin precursor transcript in the mouse central nervous system |
| Q40916015 | Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ). |
| Q28221363 | Does nociceptin play a role in pain disorders in man? |
| Q38276410 | Does the kappa opioid receptor system contribute to pain aversion? |
| Q89956203 | Dynorphin and its role in alcohol use disorder |
| Q57010023 | Effects of an antisense oligonucleotide to pronociceptin and long-term prevention of morphine actions by nociceptin |
| Q35045885 | Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices |
| Q44345625 | Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection into the rat paw. |
| Q48572752 | Effects of maternal separation on brain nociceptin/orphanin FQ peptide levels in male Wistar rats |
| Q79150023 | Effects of nociceptin and analogues of nociceptin upon spontaneous dorsal root activity recorded from an in vitro preparation of rat spinal cord |
| Q31920176 | Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion |
| Q74014783 | Effects of pre-emptively administered nociceptin on the development of thermal hyperalgesia induced by two models of experimental mononeuropathy in the rat |
| Q42182035 | Effects of sigma ligands on the nociceptin/orphanin FQ receptor co-expressed with the G-protein-activated K+ channel in Xenopus oocytes |
| Q93003837 | Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys |
| Q44006667 | Endocrine effects of centrally injected nociceptin in the rat. |
| Q89935533 | Endogenous Opioids at the Intersection of Opioid Addiction, Pain, and Depression: The Search for a Precision Medicine Approach |
| Q42175918 | Endogenous nociceptin / orphanin FQ system involvement in hypothalamic-pituitary-adrenal axis responses: relevance to models of inflammation. |
| Q43070748 | Endogenous opioids: overview and current issues |
| Q44333220 | Endomorphin-1 and -2, endogenous ligands for the mu-opioid receptor, inhibit striated and smooth muscle contraction in the rat oesophagus |
| Q38302664 | Enhanced mu-opioid responses in the spinal cord of mice lacking protein kinase Cgamma isoform |
| Q48489490 | Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice. |
| Q43262399 | Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity |
| Q40521405 | Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. |
| Q36753837 | Estradiol: a key biological substrate mediating the response to cocaine in female rats |
| Q37217560 | Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat |
| Q78051822 | Evidence for a localization of [(3)H]nociceptin binding sites on medullar primary afferent fibers |
| Q37320271 | Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians |
| Q36926870 | Evolution of vertebrate opioid receptors |
| Q28551105 | Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis |
| Q44352567 | Expression of ZFOR1, a delta-opioid receptor, in the central nervous system of the zebrafish (Danio rerio). |
| Q49096929 | Expression of nociceptin/OFQ receptor and prepro-nociceptin/OFQ in lymphoid tissues |
| Q44337044 | Expression of orphanin FQ and the opioid receptor-like (ORL1) receptor in the developing human and rat brain |
| Q88649842 | Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity |
| Q73390724 | Fos expression in feeding-related brain areas following intracerebroventricular administration of orphanin FQ in rats |
| Q50882470 | Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis. |
| Q44351502 | Functional blockade of opioid analgesia by orphanin FQ/nociceptin |
| Q33892751 | Functional characterization of corticotropin-releasing factor type 1 receptor endogenously expressed in human embryonic kidney 293 cells |
| Q48747818 | Functional coupling of the nociceptin/orphanin FQ receptor with the G-protein-activated K+ (GIRK) channel |
| Q44347745 | Functional expression of opioid receptor-like receptor and its endogenous specific agonist nociceptin/orphanin FQ during mouse embryogenesis. |
| Q36617402 | Functional genomics of sex hormone-dependent neuroendocrine systems: specific and generalized actions in the CNS. |
| Q48974965 | Functional heterogeneity of nociceptin/orphanin FQ receptors revealed by (+)-5a Compound and Ro 64-6198 in rat periaqueductal grey slices |
| Q26852027 | Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists |
| Q77738391 | Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility |
| Q35028805 | Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro |
| Q42857325 | Further evidence for an involvement of nociceptin/orphanin FQ in the pathophysiology of Parkinson’s disease: a behavioral and neurochemical study in reserpinized mice |
| Q93551696 | G Protein-Coupled Receptors |
| Q28608943 | G Proteins and Opioid Receptor-Mediated Signalling |
| Q38047341 | G protein-coupled receptor deorphanizations |
| Q51763940 | G-protein-coupled receptor-mediated MAPK and PI3-kinase signaling is maintained in Chinese hamster ovary cells after γ-irradiation. |
| Q28200904 | Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19 |
| Q44449856 | Glycinergic inputs to cardiac vagal neurons in the nucleus ambiguus are inhibited by nociceptin and mu-selective opioids |
| Q34206778 | Gonadal steroids differentially modulate the actions of orphanin FQ/nociceptin at a physiologically relevant circuit controlling female sexual receptivity |
| Q38057852 | Grand opening of structure-guided design for novel opioids. |
| Q39779553 | Heterodimerization of ORL1 and opioid receptors and its consequences for N-type calcium channel regulation. |
| Q59038199 | Home for an orphan endorphin |
| Q90061794 | IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism |
| Q44345014 | Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus. |
| Q48019302 | Identification and differential regional expression of KOR-3/ORL-1 gene splice variants in mouse brain |
| Q40627534 | Identification of a hexapeptide binding region in the nociceptin (ORL1) receptor by photo-affinity labelling with Ac-Arg-Bpa-Tyr-Arg-Trp-Arg-NH2 |
| Q41293219 | Identification of dynorphins as endogenous ligands for an opioid receptor-like orphan receptor |
| Q89948288 | Identification of significant gene biomarkers of low back pain caused by changes in the osmotic pressure of nucleus pulposus cells |
| Q43111874 | Identification of the G-protein-coupled ORL1 receptor in the mouse spinal cord by [35S]-GTPgammaS binding and immunohistochemistry |
| Q44331522 | Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity |
| Q36633126 | Imaging of opioid receptors in the central nervous system |
| Q51426449 | In vitro agonist effects of nociceptin and [Phe(1)psi(CH(2)-NH)Gly(2)]nociceptin(1-13)NH(2) in the mouse and rat colon and the mouse vas deferens. |
| Q41990054 | In vitro and ex vivo effects of a selective nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist, CompB, on specific binding of [3H]N/OFQ and [35S]GTPgammaS in rat brain and spinal cord |
| Q33913544 | In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist |
| Q35873638 | Increase by the ORL1 receptor (opioid receptor-like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones. |
| Q48497100 | Inflammatory mediators increase the expression of nociceptin/orphanin FQ in rat astrocytes in culture |
| Q44164119 | Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla |
| Q43668141 | Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function. |
| Q44352119 | Inhibition of cardiovascular activity following microinjection of novel opioid-like neuropeptide nociceptin (orphanin FQ) into the rat rostral ventrolateral medulla |
| Q48473857 | Inhibition of rat oxytocin and vasopressin supraoptic nucleus neurons by nociceptin in vitro |
| Q42118698 | Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide |
| Q48534735 | Inhibitory effect of nociceptin on somatostatin secretion of the isolated perfused rat stomach |
| Q46474494 | Injection of orphanin FQ/nociceptin into the periaqueductal gray suppresses the forebrain-elicited vocalization in the guinea pig. |
| Q82083544 | Internalizing channels: a mechanism to control pain? |
| Q37355278 | Intersection of chronic pain treatment and opioid analgesic misuse: causes, treatments, and policy strategies |
| Q73163391 | Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells |
| Q44061583 | Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats |
| Q44340949 | Involvement of kappa-opioid receptors in peripheral response to nerve stimulation in kappa-opioid receptor knockout mice |
| Q54647401 | Involvement of nociceptin/orphanin FQ in release of hypothalamic GnRH mediated by ORL1 receptor in ovariectomized rats. |
| Q43610828 | Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin. |
| Q44306594 | Involvement of sympathetic efferents but not capsaicin-sensitive afferents in nociceptin-mediated dual control of rat synovial blood flow |
| Q73145899 | Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice |
| Q44213529 | Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures. |
| Q44066373 | Involvement of the neuropeptide orphanin FQ/nociceptin in kainate and kindling seizures and epileptogenesis |
| Q24311708 | Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor |
| Q45067530 | Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study. |
| Q40011278 | Kainic acid down-regulates NOP receptor density and gene expression in human neuroblastoma SH-SY5Y cells. |
| Q44240042 | Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin. |
| Q48377398 | Location, location, location-gene expression studies of brainstem ganglioglioma: a rare tumor in a very rare location |
| Q34714823 | MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats |
| Q43502834 | Mercaptoacetate induces feeding through central opioid-mediated mechanisms in rats |
| Q78048882 | Metabolic fate of nociceptin/orphanin FQ in the rat spinal cord and biological activity of its released fragment |
| Q41525016 | Milk protein-derived opioid receptor ligands |
| Q28181106 | Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) |
| Q73118858 | Modification of acetylcholine release by nociceptin in conscious rat striatum |
| Q48466757 | Modification of dopamine release by nociceptin in conscious rat striatum |
| Q90396507 | Modified synthesis of NOP receptor antagonist SB612111 |
| Q43264475 | Modulation of 5-hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin |
| Q46498696 | Modulation of enkephalin release by nociceptin (orphanin FQ). |
| Q42080877 | Modulation of excitatory synaptic transmission by nociceptin in superficial dorsal horn neurones of the neonatal rat spinal cord |
| Q34247711 | Modulation of pain transmission by G-protein-coupled receptors |
| Q42461397 | Modulation of the induction of ornithine decarboxylase by some opioid receptor agonists in immune cells and cardiomyocytes. |
| Q48215378 | Modulation of vestibular function by nociceptin/orphanin FQ: an in vivo and in vitro study |
| Q48884442 | Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons. |
| Q36520628 | Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis |
| Q29302543 | Molecular Cloning and Characterization of a Novel Form of Neuropeptide Gene as a Developmentally Regulated Molecule |
| Q42638809 | Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse |
| Q41106175 | Molecular characterization and functional expression of opioid receptor-like1 receptor. |
| Q28300160 | Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor |
| Q41460325 | Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type |
| Q42646868 | Molecular cloning of the orphanin FQ receptor gene and differential tissue expression of splice variants in rat. |
| Q41460331 | Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family |
| Q34922365 | Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys? |
| Q47796479 | Molecular modelling studies on the ORL1-receptor and ORL1-agonists |
| Q44342017 | Mu opioid receptor-like sequences are present throughout vertebrate evolution |
| Q33581970 | Mu opioid receptors in pain management |
| Q37236111 | Mu opioids and their receptors: evolution of a concept |
| Q44344301 | Multiple opioid receptor-like genes are identified in diverse vertebrate phyla |
| Q33910436 | Mutational analysis of the structure and function of opioid receptors |
| Q51372430 | NOC/oFQ PKC-dependent superoxide generation contributes to hypoxic-ischemic impairment of NMDA cerebrovasodilation. |
| Q51374765 | NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury. |
| Q51397815 | NOC/oFQ contributes to hypoxic-ischemic impairment of N-methyl-D-aspartate-induced cerebral vasodilation. |
| Q35025851 | Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin |
| Q77332082 | Naltrexone, but not atropine or yohimbine, antagonizes suppression of formalin-induced spinal sensitization by intrathecal nociceptin |
| Q34012381 | Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system |
| Q33937785 | Neuroendocrine regulation of gonadotropins in the male and the female |
| Q34040227 | Neurohumoral effects of orphanin FQ/nociceptin: relevance to cardiovascular and renal function |
| Q38217456 | Neuropeptides: metabolism to bioactive fragments and the pharmacology of their receptors |
| Q38718788 | New Technologies for Elucidating Opioid Receptor Function |
| Q36159969 | Next-generation sequencing of human opioid receptor genes based on a custom AmpliSeq™ library and ion torrent personal genome machine |
| Q53940398 | Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat. |
| Q41979277 | Nociceptin (1 - 7) antagonizes nociceptin-induced hyperalgesia in mice |
| Q48767093 | Nociceptin (Orphanin FQ) abolishes gestational and ovarian sex steroid-induced antinociception and induces hyperalgesia |
| Q54062023 | Nociceptin Has Vasodilator Activity in the Pulmonary Vascular Bed of the Rat. |
| Q37211503 | Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility |
| Q41070461 | Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells: functional homology with opioid receptors |
| Q46661650 | Nociceptin and its receptor in guinea-pig sympathetic ganglia |
| Q34040165 | Nociceptin and neurotransmitter release in the periphery |
| Q28257948 | Nociceptin and the nociceptin receptor in learning and memory |
| Q44333166 | Nociceptin attenuates opioid and gamma-aminobutyric acid(B) receptor-mediated analgesia in the mouse tail-flick assay |
| Q35922020 | Nociceptin effect on intestinal motility depends on opioid-receptor like-1 receptors and nitric oxide synthase co-localization |
| Q34040179 | Nociceptin effects in the airways |
| Q44308138 | Nociceptin immunoreactivity and receptor mRNA in the human trigeminal ganglion. |
| Q45223516 | Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats |
| Q35884736 | Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices |
| Q44551688 | Nociceptin inhibits acquisition of amphetamine-induced place preference and sensitization to stereotypy in rats. |
| Q41863746 | Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation. |
| Q28360573 | Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse |
| Q74162664 | Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung |
| Q28360135 | Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors |
| Q43860485 | Nociceptin inhibits excitatory but not inhibitory transmission to substantia gelatinosa neurones of adult rat spinal cord |
| Q43185908 | Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway |
| Q51419462 | Nociceptin inhibits tonic nitric oxide release in the mouse isolated proximal colon. |
| Q48094166 | Nociceptin modulates renal sympathetic nerve activity through a central action in conscious rats |
| Q28754925 | Nociceptin produces antinociception after spinal administration in amphibians |
| Q28378225 | Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension |
| Q35884565 | Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro |
| Q41020355 | Nociceptin receptor-mediated Ca2+ channel inhibition and its desensitization in NG108-15 cells |
| Q48137453 | Nociceptin receptors in the rat spinal cord during morphine tolerance |
| Q48774528 | Nociceptin stimulates locomotion and exploratory behaviour in mice |
| Q35041807 | Nociceptin, Phe(1)psi-nociceptin(1 - 13), nocistatin and prepronociceptin(154 - 181) effects on calcium channel currents and a potassium current in rat locus coeruleus in vitro. |
| Q54109739 | Nociceptin, a novel endogenous ligand for the ORL1 receptor, dilates isolated resistance arteries from the rat. |
| Q73489047 | Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat |
| Q73208327 | Nociceptin, an endogenous ligand for the ORL1 receptor, has novel hypotensive activity in the rat |
| Q73670981 | Nociceptin, an endogenous ligand for the ORL1 receptor, has vasodilator activity in the hindquarters vascular bed of the rat |
| Q43816328 | Nociceptin-induced outward current in substantia gelatinosa neurones of the adult rat spinal cord |
| Q42108142 | Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors |
| Q73865304 | Nociceptin-like immunoreactivity in autonomic nuclei of the rat spinal cord |
| Q73788091 | Nociceptin-like immunoreactivity in the rat dorsal horn and inhibition of substantia gelatinosa neurons |
| Q36744366 | Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems |
| Q35112207 | Nociceptin/Orphanin FQ: Actions within the Brain |
| Q43916448 | Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems |
| Q44205443 | Nociceptin/orphanin FQ and related peptides reduce the increase in plasma corticosterone elicited in mice by an intracerebroventricular injection |
| Q40864660 | Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor |
| Q51348275 | Nociceptin/orphanin FQ contributes to hypoxic/ischemic impairment of hypercapnic cerebrovasodilation. |
| Q48156464 | Nociceptin/orphanin FQ dilates pial arteries by K(ATP) and K(ca) channel activation |
| Q44610338 | Nociceptin/orphanin FQ increases anxiety-related behavior and circulating levels of corticosterone during neophobic tests of anxiety. |
| Q78161826 | Nociceptin/orphanin FQ increases blood pressure and heart rate via sympathetic activation in sheep |
| Q44328327 | Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain |
| Q48806858 | Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats. |
| Q64239371 | Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner |
| Q34687187 | Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala |
| Q30656675 | Nociceptin/orphanin FQ receptor ligands. |
| Q32065672 | Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis |
| Q41098806 | Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response involves protein kinase C. |
| Q33554431 | Nociceptin/orphanin FQ suppresses adaptive immune responses in vivo and at picomolar levels in vitro |
| Q83896331 | Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus |
| Q43870652 | Nociceptin/orphanin FQ tissue concentration in the rat brain. Effects of repeated ethanol administration at various post-treatment intervals |
| Q33601153 | Nociceptin/orphanin FQ: role in nociceptive information processing |
| Q44345060 | Nociceptin: an endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties |
| Q44583614 | Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice |
| Q24319975 | Nocistatin, a peptide that blocks nociceptin action in pain transmission |
| Q34040233 | Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor |
| Q40404477 | Nonphotic entrainment of the circadian body temperature rhythm by the selective ORL1 receptor agonist W-212393 in rats |
| Q73546734 | Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor |
| Q41525142 | Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198) |
| Q74775350 | Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells |
| Q44349876 | ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing |
| Q40883724 | ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones |
| Q46823356 | ORL1 receptor-mediated internalization of N-type calcium channels |
| Q37061890 | On the g-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation |
| Q33855336 | Opiate modulating properties of nociceptin/orphanin FQ. |
| Q43070545 | Opiate tolerance and dependence: receptors, G-proteins, and antiopiates |
| Q44349475 | Opioid activity of alkaloids extracted from Picralima nitida (fam. Apocynaceae). |
| Q33891278 | Opioid activity profiles indicate similarities between the nociceptin/orphanin FQ and opioid receptors. |
| Q36882493 | Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression |
| Q93498454 | Opioid and opioid-like |
| Q33859854 | Opioid modulation of magnocellular neurosecretory cell activity. |
| Q34729984 | Opioid receptor desensitization: mechanisms and its link to tolerance |
| Q36304802 | Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution. |
| Q38004941 | Opioid system and Alzheimer's disease |
| Q27006830 | Opioid-induced cardioprotection |
| Q52165012 | Opioids affect acquisition of LiCl-induced conditioned taste aversion: involvement of OT and VP systems. |
| Q34437456 | Opioids and their receptors: Are we there yet? |
| Q34179298 | Opioids, opioid receptors, and the immune response |
| Q36046359 | Orphan anxiety |
| Q44349373 | Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia |
| Q48125368 | Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-D-aspartate-evoked responses |
| Q28257200 | Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress |
| Q48185038 | Orphanin FQ and behavioral sensitization to cocaine |
| Q44348469 | Orphanin FQ antagonizes the inhibition of Ca(2+) currents induced by mu-opioid receptors |
| Q35044127 | Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors |
| Q43774332 | Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations |
| Q48443010 | Orphanin FQ/nociceptin analgesia in the rat. |
| Q43264621 | Orphanin FQ/nociceptin and [Phe(1)Psi(CH(2)-NH)Gly(2)] nociceptin(1-13)-NH(2) stimulate gastric motor function in anaesthetized rats |
| Q28362126 | Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats |
| Q28361042 | Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats |
| Q40798965 | Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation. |
| Q28370690 | Orphanin FQ/nociceptin inhibits morphine withdrawal |
| Q46512982 | Orphanin FQ/nociceptin inhibits synaptic transmission and long-term potentiation in rat dentate gyrus through postsynaptic mechanisms |
| Q48298849 | Orphanin FQ/nociceptin modulates glutamate- and kainic acid-induced currents in acutely isolated rat spinal dorsal horn neurons |
| Q34040147 | Orphanin FQ/nociceptin receptor binding studies |
| Q37323636 | Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats |
| Q40857019 | Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more |
| Q48270359 | Orphanin-FQ/nociceptin (OFQ/N) modulates the activity of suprachiasmatic nucleus neurons |
| Q35753144 | Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats |
| Q34040031 | Overview of chemical diversity |
| Q44251624 | PTK, MAPK, and NOC/oFQ impair hypercapnic cerebrovasodilation after hypoxia/ischemia |
| Q93090641 | Pain And Opioid Systems, Implications In The Opioid Epidemic |
| Q47300004 | Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus |
| Q74132199 | Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene |
| Q28178485 | Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agents |
| Q73943309 | Peripheral modulation of rat knee joint afferent mechanosensitivity by nociceptin/orphanin FQ |
| Q34081709 | Pharmacogenetics of alcohol and alcohol dependence treatment |
| Q37679197 | Pharmacological Profiles of Oligomerized μ-Opioid Receptors |
| Q73178994 | Pharmacological activation of nociceptin receptors in the nucleus tractus solitarius inhibits baroreceptor reflex in pentobarbital-anesthetized rats |
| Q34070380 | Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models |
| Q44352558 | Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor. |
| Q44349414 | Pharmacological studies on the "orphan" opioid receptor in central and peripheral sites |
| Q24675084 | Pharmacology of nociceptin and its receptor: a novel therapeutic target |
| Q27027736 | Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications |
| Q48380247 | Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to nociceptin/orphanin FQ. |
| Q44352045 | Pre- and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro |
| Q43641570 | Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro |
| Q46520263 | Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea-pig left atrium |
| Q48658537 | Presence and characterization of nociceptin (orphanin FQ) receptor binding in adult rat and human fetal hypothalamus |
| Q48545936 | Presence of nociceptin (orphanin FQ) receptors in rat retina: comparison with receptors in striatum |
| Q41673628 | Presence of opioid receptor-like (ORL1) receptor mRNA splice variants in peripheral sensory and sympathetic neuronal ganglia |
| Q37414913 | Primary structure and tissue distribution of the orphanin FQ precursor |
| Q42378885 | Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships |
| Q44000391 | Pseudo-akuammigine, an alkaloid from Picralima nitida seeds, has anti-inflammatory and analgesic actions in rats |
| Q35999761 | Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor. |
| Q43656813 | Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene |
| Q42456478 | Rat central ORL-1 receptor uncouples from adenylyl cyclase during membrane preparation. |
| Q48873794 | Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ. |
| Q43781731 | Real day in neonatology: JALON 2001, Nancy, October 6 2001. Fentanyl-ORL 1 receptor interactions in the perinatal period: should the "principle of precaution" be applied to premature newborns? |
| Q41041826 | Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides |
| Q36181190 | Recent advances in the understanding of the effects of opioid agents on feeding and appetite |
| Q37697788 | Recently patented and promising ORL-1 ligands: where have we been and where are we going? |
| Q24795856 | Receptorphin: a conserved peptide derived from the sequence of the opioid receptor, with opioid displacement activity and potent antiproliferative actions in tumor cells |
| Q44514449 | Reciprocal interactions between the amygdala and ventrolateral periaqueductal gray in mediating of Q/N(1-17)-induced analgesia in the rat. |
| Q28306785 | Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids |
| Q44343476 | Region selective up-regulation of μ-, δ- and κ-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice |
| Q40659357 | Regulation of STAT3 activity by G16-coupled receptors |
| Q35136683 | Regulation of male fertility by the opioid system. |
| Q42545875 | Relationship between binding affinity and functional activity of nociceptin/orphanin FQ. |
| Q51419498 | Relationship between nociceptin/orphanin FQ and cerebral hemodynamics after hypoxia-ischemia in piglets. |
| Q74566897 | Release of nociceptin-like substances from the rat spinal cord dorsal horn |
| Q35783163 | Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosis |
| Q51559839 | Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids. |
| Q44332033 | Role of NOC/oFQ in impaired opioid-induced pial artery dilation following brain injury |
| Q49026029 | Role of altered cyclooxygenase metabolism in impaired cerebrovasodilation to nociceptin/orphanin FQ following brain injury |
| Q33625290 | Role of opioid receptor like-1 receptor in modulation of endocrine, immunological, and behavioral responses to the T-cell superantigen staphylococcal enterotoxin A |
| Q37551339 | Role of the mu-opioid receptor in opioid modulation of immune function |
| Q73276461 | Scanning of five chromosomes for alcohol consumption loci |
| Q73919665 | Selective suppression of inhibitory synaptic transmission by nocistatin in the rat spinal cord dorsal horn |
| Q44342839 | Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide |
| Q36451963 | Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling |
| Q60916740 | Sex Differences in Nociceptin/Orphanin FQ Peptide Receptor-Mediated Pain and Anxiety Symptoms in a Preclinical Model of Post-traumatic Stress Disorder |
| Q37228616 | Sex differences in the Nociceptin/Orphanin FQ system in rat spinal cord following chronic morphine treatment |
| Q28575631 | Sex-related differences in the distribution of opioid receptor-like 1 receptor mRNA and colocalization with estrogen receptor mRNA in neurons of the spinal trigeminal nucleus caudalis in the rat |
| Q44329816 | Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system. |
| Q40620939 | Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice |
| Q30580552 | Solution structure of dynorphin A (1-17): a NMR study in a cryoprotective solvent mixture at 278 K. |
| Q74348544 | Species differences in the efficacy of compounds at the nociceptin receptor (ORL1) |
| Q51715971 | Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand. |
| Q73195158 | Spinal analgesic activity of orphanin FQ/nociceptin and its fragments |
| Q33247174 | Stimulation of sensory neuropeptide release by nociceptin/orphanin FQ leads to hyperaemia in acutely inflamed rat knees |
| Q35747694 | Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor |
| Q35669512 | Structural requirements of N-substituted spiropiperidine analogues as agonists of nociceptin/orphanin FQ receptor |
| Q27679151 | Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic |
| Q27679153 | Structure of the δ-opioid receptor bound to naltrindole |
| Q24626729 | Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene |
| Q37739812 | Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands |
| Q57159474 | Structure-Activity Relationship Studies of 6α- and 6β-Indolylacetamidonaltrexamine Derivatives as Bitopic Mu Opioid Receptor Modulators and Elaboration of the "Message-Address Concept" To Comprehend Their Functional Conversion |
| Q41191876 | Structure-activity relationship studies on the novel neuropeptide orphanin FQ. |
| Q34040140 | Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. |
| Q34408300 | Structure-based virtual screening of the nociceptin receptor: hybrid docking and shape-based approaches for improved hit identification |
| Q57951324 | Structure–activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist |
| Q39750953 | Study of the cytotoxicity and antioxidant capacity of N/OFQ(1-13)NH2 and its structural analogues |
| Q80625346 | Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes |
| Q57011333 | Supraspinal and spinal effects of [Phe1psi(CH2-NH)Gly2]-nociceptin(1-13)-NH2 on nociception in the rat |
| Q48422238 | Synthesis and evaluation of 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-[11C]ethyl-1,3-dihydro-2H-benzimidazol-2-one as a brain ORL1 receptor imaging agent for positron emission tomography |
| Q43801210 | Synthesis and in vivo evaluation of [11C]methyl-Ro 64-6198 as an ORL1 receptor imaging agent |
| Q44173901 | Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands |
| Q57073139 | Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile |
| Q35623039 | Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice |
| Q91796599 | The Cholinergic System as a Treatment Target for Opioid Use Disorder |
| Q30486707 | The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors |
| Q40374577 | The G protein-coupled receptor family and one of its members, the TSH receptor |
| Q34500216 | The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor |
| Q42446522 | The NMDA receptor antagonist, NPC 12626, reduces the pronociceptive effects of orphanin FQ and kappa opiate antinociception in the land snail, Cepaea nemoralis. |
| Q34510753 | The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction |
| Q28297686 | The Nociceptin/Orphanin FQ Receptor (NOP) as a Target for Drug Abuse Medications |
| Q41201289 | The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line |
| Q35026981 | The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys |
| Q43236063 | The efficacy of a NOP1 agonist (SCH486757) in subacute cough. |
| Q27011915 | The endogenous nociceptin/orphanin FQ-NOP receptor system as a potential therapeutic target for intestinal disorders |
| Q42325921 | The endogenous opioid system and drug addiction |
| Q38479752 | The epigenetic regulation of the opioid system: new individualized prompt prevention and treatment strategies. |
| Q24627645 | The evolution of vertebrate opioid receptors |
| Q74348505 | The hyperphagic effect of nociceptin/orphanin FQ in rats |
| Q42647932 | The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ. |
| Q34040119 | The nociceptin (ORL1) receptor: molecular cloning and functional architecture |
| Q42467056 | The nociceptin receptor-mediated inhibition of the rat rostral ventrolateral medulla neurons in vitro. |
| Q22254078 | The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors |
| Q33180249 | The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics |
| Q56591848 | The orphan opioid receptor and its endogenous ligand — nociceptin/orphanin FQ |
| Q34040126 | The orphanin FQ/nociceptin gene: structure, tissue distribution of expression and functional implications obtained from knockout mice |
| Q34333349 | The pharmacology of mu analgesics: from patients to genes |
| Q43651472 | The putative OP(4) antagonist, [Nphe(1)]nociceptin(1-13)NH(2), prevents the effects of nociceptin in neuropathic rats |
| Q30448074 | The role of orphanin FQ/nociceptin in neuroplasticity: relationship to stress, anxiety and neuroinflammation |
| Q34160423 | The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons. |
| Q31885962 | The role of the ORL1 receptor in the modulation of spinal neurotransmission by nociceptin/orphanin FQ and nocistatin |
| Q38139197 | The role of the opioid system in alcohol dependence |
| Q36638633 | The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability |
| Q28139226 | Tissue distribution of the opioid receptor-like (ORL1) receptor |
| Q37760247 | UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor |
| Q30499644 | Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor |
| Q35141408 | Visualizing activation of opioid circuits by internalization of G protein-coupled receptors |
| Q37901296 | Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757. |
| Q44346542 | [125I][Tyr14]Orphanin binding to rat brain: evidence for labelling the opioid-receptor-like 1 (ORL1). |
| Q44343154 | [3H]-nociceptin ligand-binding and nociceptin opioid receptor mrna expression in the human brain. |
| Q54594685 | [Expression und function of the ORL-1 receptor on human leukocytes]. |
| Q43264416 | [Nphe(1)]-Nociceptin (1-13)-NH(2), a nociceptin receptor antagonist, reverses nociceptin-induced spatial memory impairments in the Morris water maze task in rats |
| Q43862505 | [Nphe(1)]N/OFQ-(1-13)-NH(2) is a competitive and selective antagonist at nociceptin/orphanin FQ receptors mediating K(+) channel activation in rat periaqueductal gray slices |
| Q46173698 | [Nphe(1)]nociceptin-(1-13)NH(2) selectively antagonizes nociceptin effects in the rabbit isolated ileum |
| Q43929869 | [Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat. |
| Q48642533 | [Phe(1)Psi(CH(2)-NH)Gly(2)]NC(1-13)NH(2) does not antagonize orphaninFQ/nociceptin-induced prolactin release |
| Q35041403 | [Phe1psi(CH2-NH)Gly2]nociceptin-(1 - 13)-NH2 activation of an inward rectifier as a partial agonist of ORL1 receptors in rat periaqueductal gray. |
| Q41024284 | [Phe1psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 is an agonist of the nociceptin (ORL1) receptor. |
| Q80051357 | [Regulation of spinal nociceptin expression by neuropathic pain] |
| Q73994236 | [Tyr1]-nociceptin has naloxone-insensitive vasodilator activity in the hindquarters vascular bed of the rat |
| Q37455456 | kappa-Opioid receptor signaling and brain reward function |
| Q44341575 | μ-Opioid-Induced Desensitization of Opioid Receptor-Like 1 and μ-Opioid Receptors: Differential Intracellular Signaling Determines Receptor Sensitivity |
| Q39538303 | ∆(9)-Tetrahydrocannabinol decreases NOP receptor density and mRNA levels in human SH-SY5Y cells. |
Search more.