Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation

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Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1046314509
P356DOI10.1038/SJ.ONC.1205870
P3181OpenCitations bibliographic resource ID2295741
P698PubMed publication ID12400006
P5875ResearchGate publication ID11063683

P2093author name stringBernard Ducommun
Véronique Baldin
Noélie Davezac
Jean-Pierre Tassan
Joëlle Blot
P2860cites workStudy of the cytolethal distending toxin-induced cell cycle arrest in HeLa cells: involvement of the CDC25 phosphataseQ73896708
Cell cycle dependent subcellular distribution of Cdc25B subtypesQ77811811
Specific interaction between 14-3-3 isoforms and the human CDC25B phosphataseQ22253333
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruptionQ24313701
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complexQ24314687
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclinsQ24314904
14-3-3 proteins associate with cdc25 phosphatasesQ24324041
Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2Q24338853
Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15Q24564843
Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosisQ24685826
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25Q28247761
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216Q28247771
Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1Q28285538
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributedQ28301842
Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding siteQ28610026
Cyclin-dependent kinases: engines, clocks, and microprocessorsQ29614786
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosisQ29618506
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homologQ29618844
A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variationQ32179961
Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosisQ33756990
A putative protein kinase gene (kin1+) is important for growth polarity in Schizosaccharomyces pombe.Q33861197
Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear importQ33890764
Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradationQ34450218
Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.Q35203445
p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.Q37629320
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transitionQ40793182
Cdc25B activity is regulated by 14-3-3.Q43683797
Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.Q46903641
Cell cycle regulation of pEg3, a new Xenopus protein kinase of the KIN1/PAR-1/MARK familyQ48871311
Regulation of CDC25B phosphatases subcellular localizationQ63681677
Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2Q73836216
P433issue50
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
protein serine/threonine kinase activityQ14326094
Cell division cycle 25BQ21109234
Maternal embryonic leucine zipper kinaseQ21173216
P304page(s)7630-41
P577publication date2002-10-31
P1433published inOncogeneQ1568657
P1476titleHuman pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation
P478volume21

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cites work (P2860)
Q28509021Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction
Q36643905Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions
Q37233429Cell-cycle dependent localization of MELK and its new partner RACK1 in epithelial versus mesenchyme-like cells in Xenopus embryo
Q24323019Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells
Q92068313Cloning, tissue distribution, expression pattern, and function of porcine maternal embryonic leucine zipper kinase
Q38703734Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.
Q38577467Cortical localization of maternal embryonic leucine zipper kinase (MELK) implicated in cytokinesis in early xenopus embryos
Q53387038Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers.
Q21284186Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries
Q50043890Identification of potential therapeutic targets in prostate cancer through a cross-species approach.
Q92153843Inhibition of MELK Protooncogene as an Innovative Treatment for Intrahepatic Cholangiocarcinoma
Q89082194Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia
Q28236635Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1
Q47113243KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Q57188204Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus
Q47105077MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway
Q54977971MELK as a potential target to control cell proliferation in triple-negative breast cancer MDA-MB-231 cells.
Q38715935MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells
Q50994627MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells.
Q33762222MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.
Q41705554MELK is not necessary for the proliferation of basal-like breast cancer cells
Q92501934MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway
Q38648606MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.
Q37099799Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells
Q28591125Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation
Q27022633Maternal embryonic leucine zipper kinase (MELK): a novel regulator in cell cycle control, embryonic development, and cancer
Q33960305Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway
Q91329661Maternal embryonic leucine zipper kinase is a novel target for diffuse large B cell lymphoma and mantle cell lymphoma
Q43085095Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit
Q30609345Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β-cell, regeneration
Q36905898Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer
Q26738538Molecular mechanisms of peritoneal dissemination in gastric cancer
Q28537936Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition
Q36033101Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation
Q27313731OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases
Q35068076Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia.
Q46227422Protein kinase A modulates Cdc25B activity during meiotic resumption of mouse oocytes
Q48664813Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells
Q39242272Size Matters: How C. elegans Asymmetric Divisions Regulate Apoptosis
Q41884226Small interfering RNA targeting CDC25B inhibits liver tumor growth in vitro and in vivo
Q38706288Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth.
Q53597964Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast.
Q36679284Stathmin involvement in the maternal embryonic leucine zipper kinase pathway in glioblastoma.
Q27679427Structural Basis for the Regulation of Maternal Embryonic Leucine Zipper Kinase
Q24338012Substrate specificity and activity regulation of protein kinase MELK
Q26739923Targeting DNA Replication Stress for Cancer Therapy
Q34097169The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration.
Q27681770The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity
Q64053382Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice
Q30818142pEg6, a spire family member, is a maternal gene encoding a vegetally localized mRNA in Xenopus embryos

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