| scholarly article | Q13442814 |
| P50 | author | Houda Alachkar | Q60976735 |
| Wolfgang Hiddemann | Q23062357 | ||
| Klaus H Metzeler | Q40607412 | ||
| Tobias Herold | Q43994247 | ||
| P2093 | author name string | Yusuke Nakamura | |
| Yo Matsuo | |||
| Wendy Stock | |||
| Stefan K Bohlander | |||
| Karsten Spiekermann | |||
| Gregory Malnassy | |||
| Noreen Fulton | |||
| Martin B G Mutonga | |||
| P2860 | cites work | MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells. | Q50994627 |
| The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia. | Q53295548 | ||
| Migratory behavior of leukemic cells from acute myeloid leukemia patients | Q77962236 | ||
| Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family | Q21195232 | ||
| Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation | Q24313276 | ||
| Substrate specificity and activity regulation of protein kinase MELK | Q24338012 | ||
| New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo | Q28506665 | ||
| Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells | Q28585777 | ||
| Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression | Q29615223 | ||
| Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma | Q29615607 | ||
| IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study | Q33897586 | ||
| Melk-like kinase plays a role in hematopoiesis in the zebra fish | Q33925180 | ||
| Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer | Q34530885 | ||
| Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia | Q36206410 | ||
| The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia | Q36498517 | ||
| Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study | Q36678141 | ||
| Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia | Q36758390 | ||
| MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. | Q37098261 | ||
| Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells | Q37099799 | ||
| Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer | Q37360234 | ||
| SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome | Q37679943 | ||
| Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo | Q37708563 | ||
| Over-expression of FoxM1 is associated with adverse prognosis and FLT3-ITD in acute myeloid leukemia | Q39019814 | ||
| The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer | Q39286062 | ||
| Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations | Q42614586 | ||
| Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers | Q42808469 | ||
| Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit | Q43085095 | ||
| Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells | Q46137091 | ||
| Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. | Q46931943 | ||
| Transcription factors as master regulator for cancer stemness: remove milk from fox? | Q48663024 | ||
| P433 | issue | 23 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | maternal health | Q6786626 |
| leukemia | Q29496 | ||
| P304 | page(s) | 12371-12382 | |
| P577 | publication date | 2014-12-01 | |
| P1433 | published in | Oncotarget | Q1573155 |
| P1476 | title | Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia | |
| P478 | volume | 5 |
| Q36627944 | A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells |
| Q42108657 | CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials |
| Q50123858 | Challenges in validating candidate therapeutic targets in cancer. |
| Q98505940 | Differentiation of cancer stem cells using synthetic small molecules: toward new therapeutic strategies against therapy resistance |
| Q41900139 | Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer |
| Q54107598 | Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase (MELK) in Adrenocortical Carcinoma. |
| Q50043890 | Identification of potential therapeutic targets in prostate cancer through a cross-species approach. |
| Q91846035 | Inhibition of MELK produces potential anti-tumour effects in bladder cancer by inducing G1/S cell cycle arrest via the ATM/CHK2/p53 pathway |
| Q89082194 | Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia |
| Q36213492 | Integrated methylome and transcriptome analysis reveals novel regulatory elements in pediatric acute lymphoblastic leukemia |
| Q49187608 | MELK is a novel therapeutic target in high-risk neuroblastoma |
| Q36275700 | MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells |
| Q38648606 | MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies. |
| Q89668182 | Maternal Embryonic Leucine Zipper Kinase Promotes Tumor Growth and Metastasis via Stimulating FOXM1 Signaling in Esophageal Squamous Cell Carcinoma |
| Q38701009 | Maternal embryonic leucine zipper kinase inhibits epithelial-mesenchymal transition by regulating transforming growth factor-β signaling |
| Q91329661 | Maternal embryonic leucine zipper kinase is a novel target for diffuse large B cell lymphoma and mantle cell lymphoma |
| Q49869942 | Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma |
| Q36905898 | Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer |
| Q58593899 | Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target of cervical cancer |
| Q92465189 | Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1 |
| Q35942699 | Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells |
| Q92060222 | Phillygenin, a MELK Inhibitor, Inhibits Cell Survival and Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells |
| Q38790859 | Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor |
| Q38261327 | T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia. |
| Q42292977 | TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer |
| Q26801412 | Targeting LKB1 in cancer - exposing and exploiting vulnerabilities |
| Q38881119 | Targeting Programmed Cell Death Using Small-Molecule Compounds to Improve Potential Cancer Therapy |
| Q41709133 | p53-independent p21 induction by MELK inhibition |
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