| scholarly article | Q13442814 |
| P50 | author | C N Johnson | Q73049523 |
| P2093 | author name string | Aleyde Van Eynde | |
| Souichi Ogata | |||
| Tarig Bashir | |||
| An De Bondt | |||
| Mathieu Bollen | |||
| Lijs Beke | |||
| Monique Beullens | |||
| Dirk Brehmer | |||
| Joannes T M Linders | |||
| Lieven Meerpoel | |||
| Ilse Van den Wyngaert | |||
| An Boeckx | |||
| Marc Parade | |||
| Shannah Boens | |||
| Cenk Kig | |||
| Erika van Heerde | |||
| P2860 | cites work | Bioconductor: open software development for computational biology and bioinformatics | Q21194861 |
| Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family | Q21195232 | ||
| A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability | Q24298271 | ||
| On methods for gene function scoring as a means of facilitating the interpretation of microarray results | Q83363273 | ||
| LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 | Q24310603 | ||
| Substrate specificity and activity regulation of protein kinase MELK | Q24338012 | ||
| Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data | Q24537656 | ||
| Significance analysis of microarrays applied to the ionizing radiation response | Q24606608 | ||
| Structural Basis for the Regulation of Maternal Embryonic Leucine Zipper Kinase | Q27679427 | ||
| Exploration, normalization, and summaries of high density oligonucleotide array probe level data | Q27861098 | ||
| Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1 | Q28236635 | ||
| Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation | Q28590590 | ||
| Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation | Q28591125 | ||
| Patterns of somatic mutation in human cancer genomes | Q29547841 | ||
| DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis | Q29614217 | ||
| Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression | Q33289965 | ||
| Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancers | Q33723151 | ||
| MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. | Q33762222 | ||
| Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics | Q34140962 | ||
| ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system | Q34333456 | ||
| Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer | Q34530885 | ||
| Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia. | Q35068076 | ||
| Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation | Q36033101 | ||
| DNA damage checkpoints: from initiation to recovery or adaptation | Q36736655 | ||
| The DNA damage response during an unperturbed S-phase | Q36765196 | ||
| MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. | Q37098261 | ||
| Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells | Q37099799 | ||
| DNA damage tolerance: a double-edged sword guarding the genome | Q37187991 | ||
| Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer | Q37360234 | ||
| Beyond ATM: the protein kinase landscape of the DNA damage response | Q37875377 | ||
| Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3. | Q38321368 | ||
| Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression | Q39497051 | ||
| M-phase MELK activity is regulated by MPF and MAPK. | Q40289655 | ||
| Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase | Q42130307 | ||
| Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers | Q42808469 | ||
| Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit | Q43085095 | ||
| The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions. | Q44846511 | ||
| Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells | Q46137091 | ||
| Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas. | Q46931943 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 6 | |
| P921 | main subject | DNA damage | Q5205747 |
| P577 | publication date | 2015-10-02 | |
| P1433 | published in | Bioscience Reports | Q2790714 |
| P1476 | title | MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells | |
| P478 | volume | 35 |
| Q47761894 | An ensemble predictive modeling framework for breast cancer classification |
| Q42108657 | CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials |
| Q50123858 | Challenges in validating candidate therapeutic targets in cancer. |
| Q54107598 | Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase (MELK) in Adrenocortical Carcinoma. |
| Q89983194 | Enhanced DNA-repair capacity and resistance to chemically induced carcinogenesis upon deletion of the phosphatase regulator NIPP1 |
| Q92713810 | FOXM1 functions collaboratively with PLAU to promote gastric cancer progression |
| Q36289944 | Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant |
| Q45943794 | Identifying and analyzing different cancer subtypes using RNA-seq data of blood platelets. |
| Q59799523 | In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors |
| Q92153843 | Inhibition of MELK Protooncogene as an Innovative Treatment for Intrahepatic Cholangiocarcinoma |
| Q91846035 | Inhibition of MELK produces potential anti-tumour effects in bladder cancer by inducing G1/S cell cycle arrest via the ATM/CHK2/p53 pathway |
| Q89082194 | Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia |
| Q52653219 | Kinase inhibitors: the road ahead. |
| Q91753666 | Kinome expression profiling to target new therapeutic avenues in multiple myeloma |
| Q49701324 | MELK expression correlates with tumor mitotic activity but is not required for cancer growth. |
| Q38715935 | MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells |
| Q41705554 | MELK is not necessary for the proliferation of basal-like breast cancer cells |
| Q91329661 | Maternal embryonic leucine zipper kinase is a novel target for diffuse large B cell lymphoma and mantle cell lymphoma |
| Q58593899 | Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target of cervical cancer |
| Q92465189 | Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1 |
| Q27313731 | OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases |
| Q38790859 | Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor |
| Q41709133 | p53-independent p21 induction by MELK inhibition |
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