Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways

scientific article

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.041483
P3181OpenCitations bibliographic resource ID4353401
P932PMC publication ID2788863
P698PubMed publication ID19666465

P50authorMark J. CrabtreeQ42533046
Keith ChannonQ56420294
P2093author name stringAshley B Hale
Nicholas J Alp
Amy L Tatham
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Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cellsQ37176379
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.Q37294875
Superoxide and peroxynitrite in atherosclerosisQ37558573
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expressionQ39916287
Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissueQ40285898
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Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involvedQ42225151
Tetrahydropterin therapy for hyperphenylalaninemia caused by defective synthesis of tetrahydrobiopterinQ42242064
Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy.Q43568582
Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidantsQ44177935
Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout miceQ44714954
Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assayQ45015147
Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive processQ45092363
Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cellsQ45193952
IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunctionQ46805078
Neurochemical effects following peripheral administration of tetrahydropterin derivatives to the hph-1 mouse.Q49087031
Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†Q57837809
Determination of quinonoid dihydrobiopterin by high-performance liquid chromatography and electrochemical detectionQ69385952
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
endotheliumQ111140
Nitric oxide synthase 3Q408853
sapropterinQ419808
GTP cyclohydrolase 1Q1487359
Dihydrofolate reductaseQ14819390
regulation of removal of superoxide radicalsQ14864571
P304page(s)28128-36
P577publication date2009-10-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleCritical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
P478volume284

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