Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells

scientific article published on 12 March 2009

Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M809295200
P932PMC publication ID2675998
P698PubMed publication ID19286667
P5875ResearchGate publication ID24201253

P2093author name stringBruce D Levy
Thomas Michel
Toru Sugiyama
P2860cites workRegulation of endothelium-derived nitric oxide production by the protein kinase AktQ22010149
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The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping studyQ28609860
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertensionQ30080036
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Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimerQ33722120
Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-SrcQ33871655
Oxygen reduction by nitric-oxide synthasesQ34201782
Nitric oxide insufficiency, platelet activation, and arterial thrombosisQ34234301
Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?Q34341995
Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular diseaseQ34375943
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Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthaseQ35026148
Endothelial nitric oxide synthase, caveolae and the development of atherosclerosisQ35058386
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactorsQ36253833
Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4.Q36300275
Phosphorylation and subcellular translocation of endothelial nitric oxide synthaseQ36402798
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Diminished lipoxin biosynthesis in severe asthmaQ37282577
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.Q37294875
Nitric oxide synthases: which, where, how, and why?Q37374087
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expressionQ39916287
Nitric oxide and its role in the cardiovascular systemQ40418256
Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA.Q40609122
Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthaseQ41093585
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiencyQ42090666
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulationQ43599368
Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A.Q44018080
Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthaseQ44110016
Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesisQ46874738
Evaluation of assays for the measurement of bovine neutrophil reactive oxygen species.Q50716938
Epinephrine regulation of the endothelial nitric-oxide synthase: roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling.Q53527970
Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase.Q54039650
Low-Temperature Optical Absorption Spectra Suggest a Redox Role for Tetrahydrobiopterin in Both Steps of Nitric Oxide Synthase Catalysis†Q61906284
Analysis of reduced forms of biopterin in biological tissues and fluidsQ71136634
2,4-Diamino-6-hydroxypyrimidine, an inhibitor of tetrahydrobiopterin synthesis, downregulates the expression of iNOS protein and mRNA in primary murine macrophagesQ71690294
Tetrahydrobiopterin and endothelial nitric oxide synthase activityQ73119905
Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin contentQ73575143
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
sapropterinQ419808
P304page(s)12691-12700
P577publication date2009-03-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleTetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells
P478volume284

Reverse relations

cites work (P2860)
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