Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling

scientific article published on 8 November 2012

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.415992
P932PMC publication ID3537053
P698PubMed publication ID23139420

P50authorKeith ChannonQ56420294
Mark J. CrabtreeQ42533046
P2093author name stringAshley B Hale
Rachel Brixey
Helen Batchelor
P2860cites workRedox signaling and the emerging therapeutic potential of thiol antioxidantsQ46556962
Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†Q57837809
Determination of quinonoid dihydrobiopterin by high-performance liquid chromatography and electrochemical detectionQ69385952
Impaired endothelium-dependent vasodilation in patients with essential hypertension. Evidence that nitric oxide abnormality is not localized to a single signal transduction pathwayQ72611416
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathwaysQ24322688
The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping studyQ28609860
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineQ29547539
Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathwaysQ33589215
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimerQ33722120
Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescenceQ33937018
Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery diseaseQ34252918
Protein S-glutathionylation: a regulatory device from bacteria to humans.Q34918945
Nitric oxide as a unique signaling molecule in the vascular system: a historical overviewQ35038901
Hypercholesterolemia increases endothelial superoxide anion productionQ35610616
Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.Q36002621
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function.Q36017535
S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response.Q37058729
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.Q37294875
Superoxide and peroxynitrite in atherosclerosisQ37558573
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expressionQ39916287
Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissueQ40285898
Origin of superoxide production by endothelial nitric oxide synthaseQ40992852
Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assayQ45015147
Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cellsQ45193952
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)561-569
P577publication date2012-11-08
P1433published inJournal of Biological ChemistryQ867727
P1476titleIntegrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling
P478volume288

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cites work (P2860)
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