| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2007PNAS..10415081D |
| P356 | DOI | 10.1073/PNAS.0702986104 |
| P932 | PMC publication ID | 1986616 |
| P698 | PubMed publication ID | 17848522 |
| P5875 | ResearchGate publication ID | 5991066 |
| P2093 | author name string | Yong Xia | |
| Giuseppe Ambrosio | |||
| Jay L Zweier | |||
| Lawrence J Druhan | |||
| Arturo J Cardounel | |||
| Cristian Dumitrescu | |||
| Roberto Biondi | |||
| P2860 | cites work | Cell transformation by the superoxide-generating oxidase Mox1 | Q22010372 |
| Caveolae and caveolins in the cardiovascular system | Q28266609 | ||
| Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor | Q28299224 | ||
| Substrate Control of Free Radical Generation from Xanthine Oxidase in the Postischemic Heart | Q71977246 | ||
| Regulation of nitric oxide production by tetrahydrobiopterin | Q72369046 | ||
| Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy | Q72391858 | ||
| Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart | Q73596256 | ||
| Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process | Q77332973 | ||
| Altered structural and mechanistic properties of mutant dihydropteridine reductases | Q28578013 | ||
| Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction | Q28585710 | ||
| Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization | Q28609898 | ||
| Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis | Q28609904 | ||
| Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress | Q29615436 | ||
| Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide | Q29619956 | ||
| Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension | Q30080036 | ||
| Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin | Q32129593 | ||
| Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues | Q33579059 | ||
| Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog. | Q33863946 | ||
| Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. | Q34190234 | ||
| Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum | Q34320881 | ||
| Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro | Q34556297 | ||
| Direct measurement of free radical generation following reperfusion of ischemic myocardium | Q34602572 | ||
| Tetrahydrobiopterin radical enzymology | Q35150179 | ||
| The discovery of nitric oxide and its role in vascular biology | Q35566587 | ||
| Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages | Q36244224 | ||
| Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors | Q36253833 | ||
| The role of oxidants and free radicals in reperfusion injury | Q36437576 | ||
| Peroxidase catalysed aerobic degradation of 5,6,7,8-tetrahydrobiopterin at physiological pH. | Q36617151 | ||
| Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. | Q37362273 | ||
| Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats | Q37380401 | ||
| Generation of superoxide by purified brain nitric oxide synthase | Q41590269 | ||
| Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation | Q42282009 | ||
| Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia | Q43610521 | ||
| Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction | Q43746731 | ||
| Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical | Q43762641 | ||
| Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform. | Q44640441 | ||
| Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process | Q45092363 | ||
| The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain | Q48123444 | ||
| The auto-oxidation of tetrahydrobiopterin | Q52070518 | ||
| Tetrahydropterin oxidation without hydroxylation catalyzed by rat liver phenylalanine hydroxylase. | Q53761723 | ||
| Impaired canine coronary vasodilator response to acetylcholine and bradykinin after occlusion-reperfusion. | Q54117934 | ||
| Inducible nitric-oxide synthase generates superoxide from the reductase domain | Q57220882 | ||
| Evaluation of the role of xanthine oxidase in myocardial reperfusion injury | Q68455267 | ||
| Measurement and characterization of postischemic free radical generation in the isolated perfused heart | Q69358707 | ||
| Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow | Q69405249 | ||
| Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury | Q69814424 | ||
| Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury | Q71763431 | ||
| Enzyme-independent formation of nitric oxide in biological tissues | Q71803601 | ||
| P433 | issue | 38 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | endothelium | Q111140 |
| sapropterin | Q419808 | ||
| myocardial ischemia | Q6947906 | ||
| P1104 | number of pages | 6 | |
| P304 | page(s) | 15081-15086 | |
| P577 | publication date | 2007-09-11 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4. | |
| P478 | volume | 104 |
| Q36701748 | Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling |
| Q37095264 | Ambient ultrafine particles reduce endothelial nitric oxide production via S-glutathionylation of eNOS. |
| Q43170086 | An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning |
| Q29346995 | Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN. |
| Q40374460 | Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure |
| Q35073570 | Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia |
| Q42599755 | Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: a case study with folic acid |
| Q47350829 | Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion |
| Q47654308 | Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice. |
| Q41859845 | Coronary artery spasm related to thiol oxidation and senescence marker protein-30 in aging |
| Q27329406 | Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation |
| Q27001628 | Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise |
| Q36962909 | Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes |
| Q41597227 | DOCA-salt hypertension impairs artery function in rat middle cerebral artery and parenchymal arterioles |
| Q35543543 | Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning |
| Q36079082 | Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart |
| Q41884706 | Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction |
| Q43267895 | Dihydrofolate reductase and biopterin recycling in cardiovascular disease |
| Q36481332 | Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation |
| Q40217656 | Effect of an Ilex paraguariensis (yerba mate) extract on infarct size in isolated rat hearts: the mechanisms involved |
| Q48191312 | Effects of tetrahydrobiopterin on cerebral infarction after transient focal ischemia in rats |
| Q39879102 | Effects of tirofiban on the reperfusion-related no-reflow in rats with acute myocardial infarction |
| Q33788999 | Endothelial NOS activity and myocardial oxygen metabolism define the salvageable ischemic time window for ischemic postconditioning |
| Q34491640 | Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke |
| Q34980336 | Endothelial nitric oxide synthase uncoupling: a novel pathway in OSA induced vascular endothelial dysfunction |
| Q45941940 | Exercise-induced cardioprotection: a role for eNOS uncoupling and NO metabolites. |
| Q51440774 | Exposure to cigarette smoke abrogates the beneficial effect of ischemic postconditioning. |
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| Q51226497 | Fenofibrate Therapy Restores Antioxidant Protection and Improves Myocardial Insulin Resistance in a Rat Model of Metabolic Syndrome and Myocardial Ischemia: The Role of Angiotensin II. |
| Q36742028 | Fenofibrate plus Metformin Produces Cardioprotection in a Type 2 Diabetes and Acute Myocardial Infarction Model. |
| Q35986974 | Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress |
| Q51767539 | Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides. |
| Q88540298 | Gestational Hypoxia and Developmental Plasticity |
| Q42576287 | HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation |
| Q41176327 | Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms |
| Q35830289 | Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes. |
| Q34352151 | Hyperthermia-induced Hsp90·eNOS preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD activity |
| Q33739113 | Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation |
| Q37089253 | Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications |
| Q42532978 | Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling |
| Q35977477 | Isoflurane favorably modulates guanosine triphosphate cyclohydrolase-1 and endothelial nitric oxide synthase during myocardial ischemia and reperfusion injury in rats |
| Q36021710 | Liposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection |
| Q51176986 | Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H). |
| Q49188523 | Mechanisms of I/R-Induced Endothelium-Dependent Vasodilator Dysfunction. |
| Q38752188 | Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis |
| Q40225096 | Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species |
| Q34024200 | Moderate exercise prevents impaired Ca2+ handling in heart of CO-exposed rat: implication for sensitivity to ischemia-reperfusion |
| Q37881801 | Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy |
| Q37265507 | NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology |
| Q38364230 | NO Better Way to Protect the Heart during Ischemia-Reperfusion: To be in the Right Place at the Right Time |
| Q49501122 | Nitric oxide signalling in cardiovascular health and disease. |
| Q27334444 | Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria |
| Q38196172 | Nitric oxide synthase regulation of cardiac excitation-contraction coupling in health and disease |
| Q37987724 | Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases |
| Q26830146 | Nitric oxide synthases in heart failure |
| Q35803799 | Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine monophosphate-dependent protein kinase |
| Q37887771 | Nitric oxide: a guardian for vascular grafts? |
| Q35848552 | Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin |
| Q41957529 | Oral tetrahydrobiopterin improves the beneficial effect of adenoviral-mediated eNOS gene transfer after induction of hindlimb ischemia |
| Q35556516 | Overexpression of mitochondrial antioxidant manganese superoxide dismutase (MnSOD) provides protection against AZT- or 3TC-induced endothelial dysfunction. |
| Q36185112 | PGC-1α overexpression suppresses blood pressure elevation in DOCA-salt hypertensive mice |
| Q42119587 | Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme |
| Q30583630 | Pulmonary arterial hypertension: the clinical syndrome |
| Q33815525 | Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production |
| Q26822833 | Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling |
| Q38611682 | Redox regulation of vascular remodeling |
| Q36481833 | Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms |
| Q34544549 | Relationship between post-cardiac arrest myocardial oxidative stress and myocardial dysfunction in the rat. |
| Q37648491 | Reoxygenation-derived toxic reactive oxygen/nitrogen species modulate the contribution of bone marrow progenitor cells to remodeling after myocardial infarction |
| Q36221276 | Reperfusion injury and reactive oxygen species: The evolution of a concept |
| Q37719406 | Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation |
| Q60735126 | Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart |
| Q29346977 | Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats |
| Q42718346 | S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling |
| Q36017535 | S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. |
| Q35693498 | S-nitrosylation: a radical way to protect the heart |
| Q35839144 | Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation |
| Q38179749 | Signaling by S-nitrosylation in the heart |
| Q34021554 | Simulated urban carbon monoxide air pollution exacerbates rat heart ischemia-reperfusion injury |
| Q58075704 | Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation |
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| Q35309938 | Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling |
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| Q37968218 | Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities |
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