Hyperthermia-induced Hsp90·eNOS Preserves Mitochondrial Respiration in Hyperglycemic Endothelial Cells by Down-regulating Glut-1 and Up-regulating G6PD Activity

scientific article published on September 22, 2010

Hyperthermia-induced Hsp90·eNOS Preserves Mitochondrial Respiration in Hyperglycemic Endothelial Cells by Down-regulating Glut-1 and Up-regulating G6PD Activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.147728
P953full work available at URLhttp://www.jbc.org/article/S0021925820606846/pdf
http://intl.jbc.org/cgi/content/abstract/285/49/38194
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20861020/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20861020/?tool=EBI
https://europepmc.org/articles/PMC2992253
https://europepmc.org/articles/PMC2992253?pdf=render
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https://api.elsevier.com/content/article/PII:S0021925820606846?httpAccept=text/xml
https://doi.org/10.1074/jbc.m110.147728
https://syndication.highwire.org/content/doi/10.1074/jbc.M110.147728
P932PMC publication ID2992253
P698PubMed publication ID20861020

P2093author name stringGovindasamy Ilangovan
Kaushik Vedam
Tennille Presley
Lawrence J. Druhan
P2860cites workHeat shock factor 1 is a powerful multifaceted modifier of carcinogenesisQ24655006
Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetesQ28281744
Delayed autoregulation of glucose transport in vascular endothelial cellsQ42474939
Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cellsQ43653363
Influence of type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteriesQ43820393
High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells.Q44367158
Heat-induced increases in endothelial NO synthase expression and activity and endothelial NO releaseQ44381093
Microximetry: simultaneous determination of oxygen consumption and free radical production using electron paramagnetic resonance spectroscopyQ44829463
4-Hydroxy tempol-induced impairment of mitochondrial function and augmentation of glucose transport in vascular endothelial and smooth muscle cells.Q44886376
Up-regulation of the association between heat shock protein 90 and endothelial nitric oxide synthase prevents high glucose-induced apoptosis in human endothelial cellsQ45139105
Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions.Q46740157
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseQ46917092
Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitriteQ46974160
Heat shock treatment suppresses angiotensin II-induced activation of NF-kappaB pathway and heart inflammation: a role for IKK depletion by heat shock?Q47755897
The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxideQ71703916
Mitochondrial NAD(P)H, ADP, oxidative phosphorylation, and contraction in isolated heart cellsQ73015241
High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cellsQ73542912
Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthaseQ28565622
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO releaseQ28609861
Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signalingQ28609890
NAD(P)H oxidase: role in cardiovascular biology and diseaseQ29616102
The pathobiology of diabetic complications: a unifying mechanismQ29617766
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertensionQ30080036
The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide productionQ30434679
Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cellsQ30434846
Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxideQ30890753
Mechanisms underlying endothelial dysfunction in diabetes mellitusQ31829307
The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor deltaQ33750688
Activation of Hsp90/NOS and increased NO generation does not impair mitochondrial respiratory chain by competitive binding at cytochrome c oxidase in low oxygen concentrationsQ33838793
High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosisQ33890987
Endothelial dysfunction in diabetes.Q33959485
Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damageQ34149797
Mechanisms of the antioxidant effects of nitric oxide.Q34276243
Heat shock proteins and cardiovascular pathophysiology.Q34388079
Electron paramagnetic resonance oximetry as a quantitative method to measure cellular respiration: a consideration of oxygen diffusion interferenceQ35606656
Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.Q36002621
Vascular complications in diabetes mellitus: the role of endothelial dysfunctionQ36201628
Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversalQ36666934
Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitriteQ36805343
Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stressQ36977302
Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cellsQ36977767
The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetesQ37044976
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunctionQ37086442
Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH.Q37264479
Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respirationQ37340468
Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signallingQ37380419
Reactive oxygen species and endothelial function in diabetes.Q37725305
Inhibition of lactate transport and glycolysis in Ehrlich ascites tumor cells by bioflavonoidsQ39268014
Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells.Q39953661
Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cellsQ40001271
Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulationQ40709879
Dynamic activation of endothelial nitric oxide synthase by Hsp90.Q41044129
Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertensionQ42438968
P433issue49
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
hyperglycemiaQ271993
P304page(s)38194-38203
P577publication date2010-09-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleHyperthermia-induced Hsp90·eNOS preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD activity
Hyperthermia-induced Hsp90·eNOS Preserves Mitochondrial Respiration in Hyperglycemic Endothelial Cells by Down-regulating Glut-1 and Up-regulating G6PD Activity
P478volume285

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cites work (P2860)
Q3941712325-Hydroxycholesterol impairs endothelial function and vasodilation by uncoupling and inhibiting endothelial nitric oxide synthase
Q40564967Changes in glucose transporter expression and nitric oxide production are associated with liver injury in diabetes
Q47294278Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective
Q36735715Role of genetic changes in the progression of cardiovascular diseases
Q41870434Signaling of reactive oxygen and nitrogen species in Diabetes mellitus

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