c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

scientific article

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/18.1.188
P3181OpenCitations bibliographic resource ID1656158
P932PMC publication ID1171114
P698PubMed publication ID9878062
P5875ResearchGate publication ID13410558

P50authorRandall S. JohnsonQ40744820
P2093author name stringC Moore
R Wisdom
P2860cites workFADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosisQ24307362
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Activation of cAMP and mitogen responsive genes relies on a common nuclear factorQ24313652
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathwaysQ24317441
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activationQ24318742
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
Convergence of MAP kinase pathways on the ternary complex factor Sap-1aQ24532138
Avian sarcoma virus 17 carries the jun oncogeneQ24611660
A Restriction Point for Control of Normal Animal Cell ProliferationQ24620882
Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2Q24642851
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4Q28266936
Activation of ternary complex factor Elk-1 by stress-activated protein kinasesQ28272395
Ras signalling linked to the cell-cycle machinery by the retinoblastoma proteinQ28305440
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBQ29614706
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
D-type cyclin-dependent kinase activity in mammalian cellsQ29614966
G1 events and regulation of cell proliferationQ29618317
Regulation of transcription by MAP kinase cascadesQ29618477
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient miceQ29618716
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell deathQ29620021
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domainQ29620169
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domainQ29620270
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene productQ29620421
Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factorsQ30452676
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycleQ33319961
Fos family members induce cell cycle entry by activating cyclin D1.Q33779543
Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.Q34061286
Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation.Q35196825
Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cellsQ36552538
Cellular transformation and malignancy induced by ras require c-junQ36561672
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.Q36572588
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB controlQ36580820
Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growthQ36640038
Rapid and preferential activation of the c-jun gene during the mammalian UV responseQ36693305
Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activityQ36783092
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking regionQ36842600
Growth-regulated expression of D-type cyclin genes in human diploid fibroblastsQ37257805
High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.Q40023426
The jun and fos protein families are both required for cell cycle progression in fibroblastsQ40640263
CBP-induced stimulation of c-Fos activity is abrogated by E1A.Q40789535
Fos is an essential component of the mammalian UV responseQ40789823
The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.Q41078766
Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activityQ41190286
Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicityQ41593458
Transformation by FosB requires a trans-activation domain missing in FosB2 that can be substituted by heterologous activation domainsQ41632670
Inducible regulatory elements in the human cyclin D1 promoterQ42498965
Induction of apoptosis by the transcription factor c-JunQ42614297
Functional analysis of a growth factor-responsive transcription factor complexQ42810320
Continuous protein synthesis is required to maintain the probability of entry into S phaseQ42831274
Prolonged activation of jun and collagenase genes by tumour necrosis factor-alphaQ43819767
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1.Q46795550
c-Jun is essential for normal mouse development and hepatogenesisQ57083732
Integration of MAP kinase signal transduction pathways at the serum response elementQ58415341
A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in cultureQ62555340
Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer elementQ69845699
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)188-197
P577publication date1999-01-01
P1433published inThe EMBO JournalQ1278554
P1476titlec-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
P478volume18

Reverse relations

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Q34284148Neuronal differentiation and protection from nitric oxide-induced apoptosis require c-Jun-dependent expression of NCAM140.
Q40560449Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs.
Q28138110Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation
Q36962403Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11).
Q35943342Oxidant-induced cell death and Nrf2-dependent antioxidative response are controlled by Fra-1/AP-1
Q33850204Pain and the pathogenesis of biceps tendinopathy
Q28546967Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences
Q35620896Photochemical genotoxicity: principles and test methods. Report of a GUM task force.
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Q44188955Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation
Q40090069Prognostic value from integrative analysis of transcription factors c-Jun and Fra-1 in oral squamous cell carcinoma: a multicenter cohort study
Q34282536Promoter specificity and biological activity of tethered AP-1 dimers
Q43607743Protective role for c-Jun in the cellular response to DNA damage
Q36952392Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury
Q42812579RAS and TGF-beta exert antagonistic effects on extracellular matrix gene expression and fibroblast transformation
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Q44324572Reactive nitrogen species block cell cycle re-entry through sustained production of hydrogen peroxide
Q38293794Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling.
Q34164622Regulation of MyoD function in the dividing myoblast
Q28146223Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase
Q40386886Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.
Q33944881Regulation of gene expression in ovarian cancer cells by luteinizing hormone receptor expression and activation
Q39080578Repeated H2 O2 exposure drives cell cycle progression in an in vitro model of ulcerative colitis
Q42705907Resveratrol stimulates AP-1-regulated gene transcription
Q43919066Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats
Q24556611Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis
Q40691142Role of c-Jun concentration in neuronal cell death
Q36059868Role of oxidative stress in peroxisome proliferator-mediated carcinogenesis
Q40870782Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium
Q33624528SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal Carcinoma
Q28364720SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Q40832473Scavenging of extracellular H2O2 by catalase inhibits the proliferation of HER-2/Neu-transformed rat-1 fibroblasts through the induction of a stress response
Q41471015Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth.
Q42476940Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites.
Q51800786Sepsis reveals compartment-specific responses in intestinal proliferation and apoptosis in transgenic mice whose enterocytes re-enter the cell cycle.
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Q36231607Stat1-independent regulation of gene expression in response to IFN-gamma
Q40205386Stress-induced c-Jun-dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity
Q24336620Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer
Q40171928Suppression of keratinocyte stratification by a dominant negative JunB mutant without blocking cell proliferation
Q33848045Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo
Q38894416Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis
Q24514481TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage
Q36771972TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway
Q39610319TRADD domain of Epstein-Barr virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblasts
Q38916414TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor.
Q35951960Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation
Q38357290The -148 to -124 region of c-jun interacts with a positive regulatory factor in rat liver and enhances transcription
Q31138518The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart
Q61947599The AP-1 transcription factor regulates postnatal mammary gland development
Q36089334The EGF receptor is required for efficient liver regeneration
Q34664167The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun
Q47570670The Interplay between Natural Killer Cells and Human Herpesvirus-6.
Q36111490The MAPK signalling pathways and colorectal cancer
Q41438489The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk
Q35754457The UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFκB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFκBp65 Ser276 Axis
Q54355360The anti-angiogenic activity of rPAI-1(23) inhibits fibroblast growth factor-2 functions.
Q33825170The cancer/testis antigen CAGE with oncogenic potential stimulates cell proliferation by up-regulating cyclins D1 and E in an AP-1- and E2F-dependent manner
Q58554048The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma
Q34503476The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells
Q77368785The expression of genes induced in melanocytes by exposure to 365-nm UVA: study by cDNA arrays and real-time quantitative RT-PCR
Q38981224The interruption of PKC-ι signaling and TRAIL combination therapy against glioblastoma cells
Q34279339The mammalian Jun proteins: redundancy and specificity.
Q43976249The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition
Q47784628The prognostic significance of Jun transcription factors in ovarian cancer
Q24337110The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage
Q39672712The role of signal transducer and activator of transcription 3 in Rift Valley fever virus infection
Q38069898Therapeutic targeting of cancer cell cycle using proteasome inhibitors
Q90633242Transcriptional Regulation of Energy Metabolism in Cancer Cells
Q42116808Transcriptional tools: Small molecules for modulating CBP KIX‐dependent transcriptional activators
Q38901206Transcriptome analysis reveals that Müllerian inhibiting substance regulates signaling pathways that contribute to endometrial carcinogenesis.
Q52128471Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation.
Q40817283Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol
Q40750843Transient activation of the c-Jun N-terminal kinase (JNK) activity by ligation of the tetraspan CD53 antigen in different cell types
Q35981303Trim69 regulates zebrafish brain development by ap-1 pathway
Q36561559Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway
Q40127489UV Radiation Activates Toll-Like Receptor 9 Expression in Primary Human Keratinocytes, an Event Inhibited by Human Papillomavirus 38 E6 and E7 Oncoproteins
Q40511411UV-induced apoptosis in SH-SY5Y cells: contribution to apoptosis by JNK signaling and cytochrome c.
Q52348274Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration.
Q51752901Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition.
Q24672626Understanding tendinopathies
Q33611802Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells.
Q24297063Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling
Q58796905Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics
Q36160009Vitamin A depletion induced by cigarette smoke is associated with an increase in lung cancer-related markers in rats
Q36286873WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice
Q43644891Widespread transcriptional changes pre-empt the critical pelagic-benthic transition in the vetigastropod Haliotis asinina.
Q28301962Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases
Q24617313c-JUN prevents methylation of p16(INK4a) (and Cdk6): the villain turned bodyguard
Q37684175c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis
Q94601787c-Jun Overexpression Accelerates Wound Healing in Diabetic Rats by Human Umbilical Cord-Derived Mesenchymal Stem Cells
Q54960299c-Jun Proto-Oncoprotein Plays a Protective Role in Lung Epithelial Cells Exposed to Staphylococcal α-Toxin.
Q73291709c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin
Q39676079c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription.
Q46540555c-Jun controls the efficiency of MAP kinase signaling by transcriptional repression of MAP kinase phosphatases
Q35691254c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis
Q40274276c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation
Q40283457c-Jun promotes cellular survival by suppression of PTEN.
Q73173837c-Jun promotes neurite outgrowth and survival in PC12 cells
Q40527005c-Jun regulates the stability and activity of the p53 homologue, p73.
Q40027627c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21.
Q40025608c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.
Q39450413c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents
Q41621199c-Jun-mediated β-1,3-N-acetylglucosaminyltransferase 8 expression: A novel mechanism regulating the invasion and metastasis of colorectal carcinoma cells
Q36041982c-Jun/AP-1 is required for CCK-induced pancreatic acinar cell dedifferentiation and DNA synthesis in vitro.
Q36325145c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation
Q64104308c‑Jun/Ap‑1 is upregulated in an Ang II‑induced abdominal aortic aneurysm formation model and mediates Chop expression in mouse aortic smooth muscle cells
Q28115960eIF3 targets cell-proliferation messenger RNAs for translational activation or repression
Q28118876eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
Q38924845miR-1470 mediates lapatinib induced p27 upregulation by targeting c-jun
Q36906971miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis
Q42807486p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity
Q33971766p75 neurotrophin receptor signaling: mechanisms for neurotrophic modulation of cell stress?
Q39451919v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.
Q73322475v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release

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