Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export

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Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.20.15.5619-5630.2000
P932PMC publication ID86026
P698PubMed publication ID10891499

P50authorEric C SchirmerQ61204793
P2093author name stringL Gerace
N Arnheim
T Guan
F Fan
E C Schirmer
R H Kehlenbach
A Kehlenbach
B E Clurman
P2860cites workA conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96Q22009078
Transport between the cell nucleus and the cytoplasmQ22065411
Identification of a tRNA-specific nuclear export receptorQ24314506
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complexQ24316128
Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filamentsQ24318735
Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complexQ24320085
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88Q24322912
Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domainQ24534076
Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complexQ24552683
The nucleoporin nup153 plays a critical role in multiple types of nuclear exportQ24641817
RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complexQ24649249
Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteinsQ24671748
A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear exportQ24682010
Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein TprQ24683280
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
Mapping and complex expression pattern of the human NPAP60L nucleoporin geneQ28115089
Nucleocytoplasmic transport: the soluble phaseQ28131723
The nuclear pore complex: from molecular architecture to functional dynamicsQ28138909
From nucleoporins to nuclear pore complexesQ28238651
Identification of a nuclear export receptor for tRNAQ28265348
Identification of a signal for rapid export of proteins from the nucleusQ29547742
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factorsQ29620194
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
Architecture and design of the nuclear pore complexQ29622853
Transport pathways of macromolecules between the nucleus and the cytoplasm.Q33680772
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicaseQ33959492
Matrix-assisted laser desorption/ionization mass spectrometry of biopolymersQ34692948
Inhibition of in vitro nuclear transport by a lectin that binds to nuclear poresQ36215912
Monoclonal antibodies identify a group of nuclear pore complex glycoproteinsQ36216116
Nuclear pore complex glycoproteins contain cytoplasmically disposed O-linked N-acetylglucosamineQ36216148
Interactions and three-dimensional localization of a group of nuclear pore complex proteinsQ36234494
A chromatin binding site in the tail domain of nuclear lamins that interacts with core histonesQ36236111
Targeting and function in mRNA export of nuclear pore complex protein Nup153.Q36237348
The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathwaysQ36259385
cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiationQ36850730
Toward a more complete 3-D structure of the nuclear pore complexQ39244460
Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitorsQ44792760
Karyopherins and kissing cousinsQ47721363
Two-way trafficking with Ran.Q47721385
Transport routes through the nuclear pore complexQ47926615
Time-of-flight mass spectrometry for the structural analysis of biological moleculesQ67586920
Organization and modulation of nuclear lamina structureQ70974307
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)5619-30
P577publication date2000-08-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleNup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export
P478volume20

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cites work (P2860)
Q34248662A change in nuclear pore complex composition regulates cell differentiation
Q34260840A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells
Q24314249An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1
Q41883265Analysis of the Lotus japonicus nuclear pore NUP107-160 subcomplex reveals pronounced structural plasticity and functional redundancy.
Q24294968Autoantigens of the nuclear pore complex
Q24540387CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis
Q34467322Caspases target only two architectural components within the core structure of the nuclear pore complex
Q24552683Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex
Q33728281Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe
Q58425617Cleave to Leave
Q24653594Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin
Q31029703Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex
Q26779126Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint
Q34368610Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint
Q24803723Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
Q24304534Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex
Q48841715Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex
Q24314464ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division
Q93386730Evolutionary divergence of the nuclear pore complex from fungi to metazoans
Q42770841Identification and characterization of nuclear pore complex components in Arabidopsis thaliana.
Q36666347Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry
Q28215961In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap
Q33290560Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus.
Q33695055Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo
Q42801001Mapping the dynamic organization of the nuclear pore complex inside single living cells.
Q48024359Mitotic nuclear pore complex segregation involves Nup2 in Aspergillus nidulans.
Q92861913Modulation of Cell Identity by Modification of Nuclear Pore Complexes
Q24291848Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export
Q28217732Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import
Q35057301Npap60: a new player in nuclear protein import
Q42792243Nuclear envelope irregularity is induced by RET/PTC during interphase
Q42060064Nuclear export of the transcription factor NirA is a regulatory checkpoint for nitrate induction in Aspergillus nidulans
Q35909029Nuclear membrane diversity: underlying tissue-specific pathologies in disease?
Q39728994Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells
Q38054510Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions
Q28508056Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo
Q34245411Nuclear pores and nuclear assembly
Q34152863Nucleocytoplasmic transport: more than the usual suspects
Q27675889Nucleoporin Nup50 Stabilizes Closed Conformation of Armadillo repeat 10 in Importin  5
Q24298298Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket
Q57793293Nup2 performs diverse interphase functions in Aspergillus nidulans
Q34455685Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region
Q38411212Nup214 is required for CRM1-dependent nuclear protein export in vivo
Q27933375Nup2p dynamically associates with the distal regions of the yeast nuclear pore complex
Q34081450Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics
Q30445728Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling
Q30475776Nup98 is a mobile nucleoporin with transcription-dependent dynamics
Q24550796Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes
Q91891549POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation
Q40484925Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry
Q27309089Posttranslational marks control architectural and functional plasticity of the nuclear pore complex basket
Q34384095Protein export from the nucleus
Q40788028Qualitative highly divergent nuclear export signals can regulate export by the competition for transport cofactors in vivo
Q34092094RNA association defines a functionally conserved domain in the nuclear pore protein Nup153.
Q37152866Regulation of nuclear import and export of negative cofactor 2
Q47138357Release of condensin from mitotic chromosomes requires the Ran-GTP gradient in the reorganized nucleus
Q92062161Role of Nucleoporins and Transport Receptors in Cell Differentiation
Q64080646SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses
Q46458319Sequence-dependent structural dynamics of primate adenosine-to-inosine editing substrates
Q42129111Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1.
Q43559962Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.
Q36385778The Nup153-Nup50 protein interface and its role in nuclear import.
Q42725755The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export.
Q35612295The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex.
Q34024480The importin β binding domain as a master regulator of nucleocytoplasmic transport
Q55005482The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype.
Q39308124The roles of the nuclear pore complex in cellular dysfunction, aging and disease.
Q24292285Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export
Q29615611Transport into and out of the nucleus
Q39762380Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import
Q42848617VRK2A is an A-type lamin-dependent nuclear envelope kinase that phosphorylates BAF.
Q51062331Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites.
Q35745141p27 deregulation in breast cancer: prognostic significance and implications for therapy

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