review article | Q7318358 |
scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1048757661 |
P356 | DOI | 10.1023/B:JOMG.0000023589.00994.5E |
P698 | PubMed publication ID | 15082919 |
P2093 | author name string | Jordan R | |
Slingerland J | |||
Alkarain A | |||
P2860 | cites work | ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | Q22009487 |
A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression | Q24300746 | ||
New functional activities for the p21 family of CDK inhibitors | Q24313427 | ||
E-cadherin gene mutations provide clues to diffuse type gastric carcinomas | Q24314169 | ||
Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest | Q24537257 | ||
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis | Q24540387 | ||
Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions | Q24540538 | ||
Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export | Q24552769 | ||
Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma | Q77221208 | ||
p27/kip1 expression in normal epithelium, benign and neoplastic breast lesions | Q77364820 | ||
Prognostic impact of cyclin-dependent kinase inhibitor p27kip1 in node-positive breast cancer | Q77371084 | ||
Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation | Q77827563 | ||
Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma | Q77869089 | ||
Breast cancer banishes p27 from nucleus | Q78306567 | ||
Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells | Q95793363 | ||
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. | Q41120998 | ||
Translational control of p27Kip1 accumulation during the cell cycle | Q41213467 | ||
Dependence of cyclin E-CDK2 kinase activity on cell anchorage. | Q41237386 | ||
Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. | Q41380571 | ||
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin | Q41412030 | ||
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. | Q41559119 | ||
Role of the F-box protein Skp2 in lymphomagenesis | Q24603883 | ||
Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells | Q24672087 | ||
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene | Q27860693 | ||
CDK inhibitors: positive and negative regulators of G1-phase progression | Q27860983 | ||
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 | Q28137813 | ||
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 | Q28137860 | ||
Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF | Q28184117 | ||
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 | Q28202908 | ||
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer | Q28203143 | ||
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest | Q28258615 | ||
Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study | Q28283241 | ||
Functional interaction of beta-catenin with the transcription factor LEF-1 | Q28286884 | ||
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis | Q28365491 | ||
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation | Q28609667 | ||
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos | Q28619032 | ||
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer | Q29547699 | ||
Inhibitors of mammalian G1 cyclin-dependent kinases | Q29547907 | ||
Nuclear localization of beta-catenin by interaction with transcription factor LEF-1 | Q29614379 | ||
G1 phase progression: cycling on cue | Q29615162 | ||
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors | Q29616203 | ||
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 | Q29617346 | ||
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model | Q32069431 | ||
The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients* | Q33188817 | ||
Prognostic implications of expression of the cell cycle inhibitor protein p27Kip1. | Q33538422 | ||
HER-2/neu as a predictive marker of response to breast cancer therapy | Q33538428 | ||
The murine gene p27Kip1 is haplo-insufficient for tumour suppression | Q33574523 | ||
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2 | Q33604295 | ||
Regulation of the cdk inhibitor p27 and its deregulation in cancer | Q33853211 | ||
Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation | Q33885995 | ||
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27 | Q33887383 | ||
Increased expression levels of cyclin-dependent kinase inhibitor p27 correlate with good responses to platinum-based chemotherapy in non-small cell lung cancer | Q33898348 | ||
Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer. | Q33928300 | ||
Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization | Q33929011 | ||
Tamoxifen in cancer therapy: minireview | Q33952349 | ||
ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency | Q33963261 | ||
Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes | Q41975129 | ||
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action | Q42523855 | ||
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. | Q42527819 | ||
Cyclin E-CDK2 is a regulator of p27Kip1. | Q42800258 | ||
Regulation of the cell cycle machinery by oncogenic ras. | Q42817741 | ||
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells | Q43723448 | ||
Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma | Q43725713 | ||
A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase | Q43743452 | ||
Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway | Q43781438 | ||
Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer. | Q44049183 | ||
Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis | Q44049906 | ||
Role of cell shape in growth control | Q44152787 | ||
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. | Q46229708 | ||
Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. | Q46806113 | ||
Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway | Q48046157 | ||
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. | Q50335523 | ||
Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation. | Q53419140 | ||
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. | Q54031538 | ||
p27kip1 expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up | Q56779871 | ||
TSC1–TSC2: a complex tale of PKB-mediated S6K regulation | Q58438038 | ||
ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways | Q64379568 | ||
Up-regulation of p27Kip1, p21WAF1/Cip1 and p16Ink4a is associated with, but not sufficient for, induction of squamous differentiation | Q64382063 | ||
Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells | Q70840022 | ||
Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents | Q71739769 | ||
Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors | Q71934600 | ||
Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies | Q72255920 | ||
Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias | Q72610925 | ||
p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors | Q72610929 | ||
c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer | Q72673347 | ||
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients | Q73034313 | ||
Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1) | Q73076685 | ||
The role of p27kip1 in the in vitro differentiation of murine keratinocytes | Q73090470 | ||
Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results | Q73169036 | ||
The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas | Q73221172 | ||
Prognostic value of the type I growth factor receptors in a large series of human primary breast cancers quantified with a real-time reverse transcription-polymerase chain reaction assay | Q73269384 | ||
Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinoma patients | Q73275607 | ||
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma | Q73337946 | ||
Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases | Q73409852 | ||
Cell cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breast | Q73554842 | ||
Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis | Q73555066 | ||
PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2) | Q73617626 | ||
Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas | Q73833543 | ||
Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone: radiotherapeutic effect and prognosis | Q73931437 | ||
Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27 | Q73959940 | ||
Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor | Q74027724 | ||
p27 expression correlates with short-term, but not with long-term prognosis in breast cancer | Q74414840 | ||
High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas | Q74590945 | ||
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization | Q34150579 | ||
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). | Q34381917 | ||
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice | Q34381923 | ||
E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. | Q34408492 | ||
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer | Q34415244 | ||
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. | Q34415250 | ||
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer | Q34436736 | ||
Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma | Q34455472 | ||
Prognostic factors in breast cancer: current and new predictors of metastasis | Q34639820 | ||
p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation | Q35002490 | ||
Growth signaling: TSC takes its place. | Q35006055 | ||
Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer | Q35049854 | ||
Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization | Q35053647 | ||
The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts | Q35116922 | ||
Clinical trial design and end points for epidermal growth factor receptor-targeted therapies: implications for drug development and practice | Q35124313 | ||
Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. | Q35190958 | ||
A cell cycle-regulated inhibitor of cyclin-dependent kinases | Q35428836 | ||
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. | Q35747423 | ||
Skp2 is oncogenic and overexpressed in human cancers | Q35862209 | ||
p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival | Q36135459 | ||
High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers | Q36184676 | ||
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein | Q36236717 | ||
Anchorage-dependent cell cycle progression | Q36254508 | ||
Prognostic role of p27Kip1 and apoptosis in human breast cancer | Q36619089 | ||
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells | Q36654228 | ||
A comparison of cell cycle markers in well-differentiated lobular and ductal carcinomas | Q38464166 | ||
Low p27 expression predicts poor disease-free survival in patients with prostate cancer | Q38472792 | ||
ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. | Q39864466 | ||
Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. | Q40022664 | ||
Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts | Q40023331 | ||
G1 control in mammalian cells. | Q40608634 | ||
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest | Q40702262 | ||
Correlation of p27 protein expression with HER-2/neu expression in breast cancer. | Q40713599 | ||
ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation. | Q40714786 | ||
Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60. | Q40749133 | ||
Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state | Q40773957 | ||
Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells | Q40851784 | ||
BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway | Q40852113 | ||
Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. | Q40872982 | ||
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability | Q40876935 | ||
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells | Q40918524 | ||
Prediction of recurrence for advanced breast cancer. Traditional and contemporary pathologic and molecular markers. | Q40931725 | ||
Third annual William L. McGuire Memorial Lecture. "Studies on the estrogen receptor in breast cancer"--20 years as a target for the treatment and prevention of cancer | Q40952791 | ||
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts | Q40967344 | ||
RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity | Q40977598 | ||
Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells | Q41006497 | ||
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression | Q41109515 | ||
P433 | issue | 1 | |
P921 | main subject | breast cancer | Q128581 |
P304 | page(s) | 67-80 | |
P577 | publication date | 2004-01-01 | |
P1433 | published in | Journal of Mammary Gland Biology and Neoplasia | Q15724460 |
P1476 | title | p27 deregulation in breast cancer: prognostic significance and implications for therapy | |
P478 | volume | 9 |
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