p27 deregulation in breast cancer: prognostic significance and implications for therapy

scientific article published on January 2004

p27 deregulation in breast cancer: prognostic significance and implications for therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1048757661
P356DOI10.1023/B:JOMG.0000023589.00994.5E
P698PubMed publication ID15082919

P2093author name stringJordan R
Slingerland J
Alkarain A
P2860cites workROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activityQ22009487
A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progressionQ24300746
New functional activities for the p21 family of CDK inhibitorsQ24313427
E-cadherin gene mutations provide clues to diffuse type gastric carcinomasQ24314169
Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrestQ24537257
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysisQ24540387
Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functionsQ24540538
Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein exportQ24552769
Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinomaQ77221208
p27/kip1 expression in normal epithelium, benign and neoplastic breast lesionsQ77364820
Prognostic impact of cyclin-dependent kinase inhibitor p27kip1 in node-positive breast cancerQ77371084
Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylationQ77827563
Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinomaQ77869089
Breast cancer banishes p27 from nucleusQ78306567
Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cellsQ95793363
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.Q41120998
Translational control of p27Kip1 accumulation during the cell cycleQ41213467
Dependence of cyclin E-CDK2 kinase activity on cell anchorage.Q41237386
Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation.Q41380571
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycinQ41412030
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.Q41559119
Role of the F-box protein Skp2 in lymphomagenesisQ24603883
Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cellsQ24672087
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27Q28137813
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27Q28137860
Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORFQ28184117
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27Q28202908
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancerQ28203143
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrestQ28258615
Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 StudyQ28283241
Functional interaction of beta-catenin with the transcription factor LEF-1Q28286884
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysisQ28365491
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formationQ28609667
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryosQ28619032
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
Nuclear localization of beta-catenin by interaction with transcription factor LEF-1Q29614379
G1 phase progression: cycling on cueQ29615162
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumorsQ29616203
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27Q29617346
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*Q33188817
Prognostic implications of expression of the cell cycle inhibitor protein p27Kip1.Q33538422
HER-2/neu as a predictive marker of response to breast cancer therapyQ33538428
The murine gene p27Kip1 is haplo-insufficient for tumour suppressionQ33574523
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2Q33604295
Regulation of the cdk inhibitor p27 and its deregulation in cancerQ33853211
Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiationQ33885995
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Q33887383
Increased expression levels of cyclin-dependent kinase inhibitor p27 correlate with good responses to platinum-based chemotherapy in non-small cell lung cancerQ33898348
Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.Q33928300
Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalizationQ33929011
Tamoxifen in cancer therapy: minireviewQ33952349
ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependencyQ33963261
Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytesQ41975129
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor actionQ42523855
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.Q42527819
Cyclin E-CDK2 is a regulator of p27Kip1.Q42800258
Regulation of the cell cycle machinery by oncogenic ras.Q42817741
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cellsQ43723448
Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinomaQ43725713
A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phaseQ43743452
Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathwayQ43781438
Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer.Q44049183
Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysisQ44049906
Role of cell shape in growth controlQ44152787
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.Q46229708
Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas.Q46806113
Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathwayQ48046157
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.Q50335523
Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation.Q53419140
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.Q54031538
p27kip1 expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-upQ56779871
TSC1–TSC2: a complex tale of PKB-mediated S6K regulationQ58438038
ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathwaysQ64379568
Up-regulation of p27Kip1, p21WAF1/Cip1 and p16Ink4a is associated with, but not sufficient for, induction of squamous differentiationQ64382063
Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cellsQ70840022
Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agentsQ71739769
Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitorsQ71934600
Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignanciesQ72255920
Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemiasQ72610925
p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumorsQ72610929
c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancerQ72673347
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patientsQ73034313
Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)Q73076685
The role of p27kip1 in the in vitro differentiation of murine keratinocytesQ73090470
Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: resultsQ73169036
The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomasQ73221172
Prognostic value of the type I growth factor receptors in a large series of human primary breast cancers quantified with a real-time reverse transcription-polymerase chain reaction assayQ73269384
Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinoma patientsQ73275607
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphomaQ73337946
Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 casesQ73409852
Cell cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breastQ73554842
Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosisQ73555066
PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)Q73617626
Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomasQ73833543
Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone: radiotherapeutic effect and prognosisQ73931437
Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27Q73959940
Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitorQ74027724
p27 expression correlates with short-term, but not with long-term prognosis in breast cancerQ74414840
High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomasQ74590945
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localizationQ34150579
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).Q34381917
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient miceQ34381923
E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.Q34408492
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancerQ34415244
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.Q34415250
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancerQ34436736
Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinomaQ34455472
Prognostic factors in breast cancer: current and new predictors of metastasisQ34639820
p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras ActivationQ35002490
Growth signaling: TSC takes its place.Q35006055
Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancerQ35049854
Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalizationQ35053647
The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblastsQ35116922
Clinical trial design and end points for epidermal growth factor receptor-targeted therapies: implications for drug development and practiceQ35124313
Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.Q35190958
A cell cycle-regulated inhibitor of cyclin-dependent kinasesQ35428836
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.Q35747423
Skp2 is oncogenic and overexpressed in human cancersQ35862209
p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survivalQ36135459
High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancersQ36184676
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma proteinQ36236717
Anchorage-dependent cell cycle progressionQ36254508
Prognostic role of p27Kip1 and apoptosis in human breast cancerQ36619089
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cellsQ36654228
A comparison of cell cycle markers in well-differentiated lobular and ductal carcinomasQ38464166
Low p27 expression predicts poor disease-free survival in patients with prostate cancerQ38472792
ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.Q39864466
Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.Q40022664
Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblastsQ40023331
G1 control in mammalian cells.Q40608634
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrestQ40702262
Correlation of p27 protein expression with HER-2/neu expression in breast cancer.Q40713599
ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation.Q40714786
Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60.Q40749133
Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory stateQ40773957
Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cellsQ40851784
BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathwayQ40852113
Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.Q40872982
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stabilityQ40876935
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cellsQ40918524
Prediction of recurrence for advanced breast cancer. Traditional and contemporary pathologic and molecular markers.Q40931725
Third annual William L. McGuire Memorial Lecture. "Studies on the estrogen receptor in breast cancer"--20 years as a target for the treatment and prevention of cancerQ40952791
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblastsQ40967344
RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activityQ40977598
Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cellsQ41006497
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progressionQ41109515
P433issue1
P921main subjectbreast cancerQ128581
P304page(s)67-80
P577publication date2004-01-01
P1433published inJournal of Mammary Gland Biology and NeoplasiaQ15724460
P1476titlep27 deregulation in breast cancer: prognostic significance and implications for therapy
P478volume9

Reverse relations

cites work (P2860)
Q363933161,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice
Q50026357A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.
Q24672490A comprehensive pathway map of epidermal growth factor receptor signaling
Q30574210A pathway-based data integration framework for prediction of disease progression
Q58376144Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation
Q44688054Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions
Q36312422An essential role of p27 downregulation in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells
Q46349486Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor-positive and triple-negative breast cancer cells.
Q26851594Arginine methyltransferases as novel therapeutic targets for breast cancer
Q35737592Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27
Q35050546Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms
Q34940834Biological Markers in DCIS and Risk of Breast Recurrence: A Systematic Review
Q34940620Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.
Q44786986CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27(Kip1) via Skp2 and FOXO3a regulation
Q36786766Challenges to defining a role for progesterone in breast cancer
Q28240913Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1
Q46216419Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells.
Q34769657Cooperative interactions of HER-2 and HPV-16 oncoproteins in the malignant transformation of human mammary epithelial cells
Q36101771Cyclins and cdks in development and cancer: a perspective
Q36421097Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity
Q39987931Direct interactions with both p27 and Cdk2 regulate Spy1-mediated proliferation in vivo and in vitro
Q39705410Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide
Q41849048K(+) channels and cell cycle progression in tumor cells
Q55347484Nucleocytoplasmic p27Kip1 Export Is Required for ERK1/2-Mediated Reactive Astroglial Proliferation Following Status Epilepticus.
Q37184060P21 and p27: roles in carcinogenesis and drug resistance
Q40486142Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.
Q35846896Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma
Q33687459Progesterone and breast cancer.
Q36175746Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?
Q38630291Protein expression patterns of cell cycle regulators in operable breast cancer
Q33641523Retracted: Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27Kip1 Upregulation
Q34029956Role of phosphorylation in progesterone receptor signaling and specificity
Q35745139Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice
Q36956900Skp2 is over-expressed in breast cancer and promotes breast cancer cell proliferation
Q30823432Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data
Q35605773Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating
Q34387697Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer
Q54687051The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients.
Q21195244The expression of the ubiquitin ligase subunit Cks1 in human breast cancer
Q98164823The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: a rising star
Q36794538Therapeutic targets in chronic myeloid leukaemia
Q33221792VSGP/F-spondin: a new ovarian cancer marker
Q35161430cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma
Q24294568p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
Q37295292p27(Kip1) as a prognostic factor in breast cancer: a systematic review and meta-analysis

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