scholarly article | Q13442814 |
P50 | author | Michele Pagano | Q28357961 |
P2093 | author name string | L Di Marcotullio | |
G F Draetta | |||
G Rodier | |||
P Coulombe | |||
S Meloche | |||
A Montagnoli | |||
P2860 | cites work | New functional activities for the p21 family of CDK inhibitors | Q24313427 |
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals | Q24314293 | ||
Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway | Q24532945 | ||
Role of the F-box protein Skp2 in lymphomagenesis | Q24603883 | ||
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression | Q24685645 | ||
CRM1 is an export receptor for leucine-rich nuclear export signals | Q27860453 | ||
CDK inhibitors: positive and negative regulators of G1-phase progression | Q27860983 | ||
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 | Q28137813 | ||
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 | Q28137860 | ||
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 | Q28139243 | ||
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 | Q28202908 | ||
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression | Q28250231 | ||
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2 | Q28304169 | ||
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication | Q28507216 | ||
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation | Q28609667 | ||
Inhibitors of mammalian G1 cyclin-dependent kinases | Q29547907 | ||
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 | Q29617346 | ||
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells | Q32084034 | ||
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2 | Q33604295 | ||
Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1. | Q33825158 | ||
Regulation of the cdk inhibitor p27 and its deregulation in cancer | Q33853211 | ||
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27 | Q33887383 | ||
Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle | Q34076834 | ||
Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1. | Q35168200 | ||
Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms | Q36327496 | ||
Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells | Q36561469 | ||
Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation | Q39460424 | ||
Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60. | Q40749133 | ||
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability | Q40876935 | ||
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells | Q40918524 | ||
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts | Q40967344 | ||
Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells | Q41033252 | ||
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. | Q41120998 | ||
Translational control of p27Kip1 accumulation during the cell cycle | Q41213467 | ||
Inhibitors of the Cip/Kip family. | Q41710956 | ||
Intracellular distribution of proteasomes | Q41729840 | ||
Cyclin E-CDK2 is a regulator of p27Kip1. | Q42800258 | ||
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. | Q46229708 | ||
Regulation of nuclear transport and degradation of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1. | Q50722198 | ||
Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes | Q63407040 | ||
Formation of p27-CDK complexes during the human mitotic cell cycle | Q71569498 | ||
Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of p44mapk and p42mapk isoforms in the G1 phase and their inactivation at the G1/S transition | Q72299070 | ||
Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanism | Q73039012 | ||
p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes | Q73505007 | ||
Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor | Q74027724 | ||
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration | Q77658726 | ||
P433 | issue | 23 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | proteolysis | Q33123 |
phosphorylation | Q242736 | ||
P304 | page(s) | 6672-6682 | |
P577 | publication date | 2001-12-01 | |
P1433 | published in | The EMBO Journal | Q1278554 |
P1476 | title | p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis | |
P478 | volume | 20 |
Q24322935 | 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1) |
Q58271068 | 6‐Aminonicotinamide induces G1arrest by elevating p27kip1as well as inhibiting cdk2, cyclin E and p‐Rb in IMR32 neuroblastoma cell line |
Q35890872 | 9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema |
Q36205587 | A crosstalk imbalance between p27(Kip1) and its interacting molecules enhances breast carcinogenesis |
Q24300746 | A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression |
Q34324068 | A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression |
Q37675816 | AKT1 induces caspase-mediated cleavage of the CDK inhibitor p27Kip1 during cell cycle progression in leukemia cells transformed by FLT3-ITD. |
Q35094511 | Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis |
Q24319434 | Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway |
Q30437070 | Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation |
Q39068932 | Adhesion to fibronectin induces p27(Kip1) nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance (CAM-DR) in RPMI 8,226 cells |
Q35445077 | Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer |
Q34880437 | Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region |
Q34223641 | Akt: a double-edged sword in cell proliferation and genome stability |
Q65000122 | An Insight into the Difficulties in the Discovery of Specific Biomarkers of Limbal Stem Cells. |
Q39929205 | Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480. |
Q35615629 | Are SOCS suppressors, regulators, and degraders? |
Q46630801 | Attenuation of cell cycle regulator p27(Kip1) expression in vertebrate epithelial cells mediated by extracellular signals in vivo and in vitro |
Q36808366 | Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. |
Q24307810 | C-terminal phosphorylation controls the stability and function of p27kip1 |
Q39742035 | C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells. |
Q100162564 | CDKN1B is phosphorylated in response to estrogen |
Q34981345 | CDKs and CKIs: molecular targets for tissue remodelling |
Q37071718 | CRM-1 knockdown inhibits extrahepatic cholangiocarcinoma tumor growth by blocking the nuclear export of p27Kip1. |
Q24540387 | CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis |
Q47662413 | CacyBP/SIP inhibits the migration and invasion behaviors of glioblastoma cells through activating Siah1 mediated ubiquitination and degradation of cytoplasmic p27. |
Q36473356 | Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation |
Q42566933 | Casein kinase iγ2 impairs fibroblasts actin stress fibers formation and delays cell cycle progression in g1. |
Q37323185 | Cdk5 and the non-catalytic arrest of the neuronal cell cycle |
Q81601109 | Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration |
Q35808893 | Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs |
Q33898315 | Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors. |
Q39330291 | Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1. |
Q35083763 | Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization |
Q40142298 | Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition |
Q48287164 | Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro |
Q34365993 | Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase |
Q37629048 | DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage |
Q34167777 | Deregulated degradation of the cdk inhibitor p27 and malignant transformation. |
Q24803723 | Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer |
Q38717609 | Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity |
Q24299753 | Drf1, a novel regulatory subunit for human Cdc7 kinase |
Q41206555 | Dual effects of Ral-activated pathways on p27 localization and TGF-β signaling |
Q100162393 | ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus |
Q24675583 | Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5 |
Q44510040 | Erk 1,2 phosphorylates p27(Kip1): Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells |
Q44540468 | Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway |
Q42832588 | Evidence for cytosolic p27(Kip1) ubiquitylation and degradation during adipocyte hyperplasia |
Q39896000 | Expression of Jun activation domain-binding protein 1 and Ser10 phosphorylated p27 protein in human epithelial ovarian carcinoma |
Q37675716 | Expression of p27Kip1, a cell cycle repressor protein, is inversely associated with potential carcinogenic risk in the genetic rodent models of obesity and long-lived Ames dwarf mice |
Q40079763 | FOXO transcription factor-dependent p15(INK4b) and p19(INK4d) expression. |
Q40013439 | Formation of E-cadherin/beta-catenin-based adherens junctions in hepatocytes requires serine-10 in p27(Kip1). |
Q54321696 | Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells. |
Q38310248 | HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1. |
Q40681056 | Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. |
Q42224639 | Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland |
Q35009496 | Increased cytoplasmic localization of p27(kip1) and its modulation of RhoA activity during progression of chronic myeloid leukemia |
Q34350229 | Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells. |
Q35841989 | Interwoven ubiquitination oscillators and control of cell cycle transitions |
Q87525921 | JAB1 and phospho-Ser10 p27 expression profile determine human hepatocellular carcinoma prognosis |
Q37396923 | Lapatinib induces p27(Kip1)-dependent G₁ arrest through both transcriptional and post-translational mechanisms |
Q39967050 | Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity |
Q53531908 | Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK. |
Q52869749 | Modification of p27 with O-linked N-acetylglucosamine regulates cell proliferation in hepatocellular carcinoma. |
Q39664689 | Molecular architecture of the DNA replication origin activation checkpoint |
Q34399893 | Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase |
Q37966332 | Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors |
Q24563960 | N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome |
Q39758775 | Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways |
Q41848575 | Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors |
Q24540538 | Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions |
Q36476441 | Overview of calpain-mediated regulation of bone and fat mass in osteoblasts |
Q37184060 | P21 and p27: roles in carcinogenesis and drug resistance |
Q43207235 | P27Kip1 serine 10 phosphorylation determines its metabolism and interaction with cyclin-dependent kinases |
Q30593254 | PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells |
Q45098656 | PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression |
Q100162348 | PRKCZ recruits RAS in response to estrogen stimulation |
Q42196968 | Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling |
Q34412491 | Phosphorylation and subcellular localization of p27Kip1 regulated by hydrogen peroxide modulation in cancer cells |
Q40484925 | Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry |
Q34194645 | Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation |
Q44592831 | Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization |
Q43099184 | Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication |
Q39949579 | Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4 |
Q40492430 | Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells |
Q37433244 | Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process |
Q48951875 | Potential role of Jun activation domain-binding protein 1 and phosphorylated p27 expression in prognosis of glioma |
Q56973092 | Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart |
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Q47669969 | Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies |
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Q35147982 | Regulation of CDK4 |
Q41632273 | Regulation of p27Kip1 phosphorylation and G1 cell cycle progression by protein phosphatase PPM1G. |
Q37678214 | Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1). |
Q39756674 | Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells |
Q36291960 | Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells |
Q45140457 | Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation |
Q24534914 | Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle |
Q36953811 | S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines |
Q37015793 | Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity |
Q24297942 | Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells |
Q35232589 | Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress. |
Q34711378 | Silencing kinase-interacting stathmin gene enhances erlotinib sensitivity by inhibiting Ser¹⁰ p27 phosphorylation in epidermal growth factor receptor-expressing breast cancer |
Q47640200 | Skp2-mediated degradation of p27 regulates progression into mitosis |
Q34758456 | Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas |
Q24669675 | Spy1 interacts with p27Kip1 to allow G1/S progression |
Q24337721 | Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase |
Q90245099 | Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma |
Q28565092 | Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2 |
Q37298372 | TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation |
Q33876950 | Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation |
Q90391047 | Targeting PML in triple negative breast cancer elicits growth suppression and senescence |
Q37847584 | Targeting p27Kip1 protein: its relevance in the therapy of human cancer. |
Q30443359 | Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma |
Q36782507 | The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1. |
Q41860863 | The CRM1 nuclear export protein in normal development and disease. |
Q34763495 | The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy |
Q40691690 | The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism |
Q50335521 | The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis |
Q37459379 | The function of p27 KIP1 during tumor development. |
Q34195072 | The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules |
Q41848509 | The non-classical MAP kinase ERK3 controls T cell activation |
Q47423700 | The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27. |
Q36294480 | The priming/completion paradigm to explain growth factor-dependent cell cycle progression |
Q24794459 | Transforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor protein |
Q42558518 | Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization |
Q46412617 | Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation |
Q28583199 | USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1 |
Q29617992 | Ubiquitin ligases: cell-cycle control and cancer |
Q35871417 | Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors |
Q45856686 | Upregulation of CRM1 relates to neuronal apoptosis after traumatic brain injury in adult rats |
Q38563401 | Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine |
Q33737205 | Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids |
Q34580835 | Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism |
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Q31060526 | Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication |
Q100162575 | p-S10 CDKN1B translocates to the cytosol |
Q36321251 | p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. |
Q37420848 | p27 Is a critical prognostic biomarker in non-alcoholic steatohepatitis-related hepatocellular carcinoma |
Q38247694 | p27 and leukemia: cell cycle and beyond |
Q35745141 | p27 deregulation in breast cancer: prognostic significance and implications for therapy |
Q39016914 | p27 modulates tropism of mesenchymal stem cells toward brain tumors |
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Q33292354 | p27Kip1 localization depends on the tumor suppressor protein tuberin |
Q40795456 | p27Kip1 modulates cell migration through the regulation of RhoA activation. |
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