p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis is …
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scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/20.23.6672
P3181OpenCitations bibliographic resource ID1005290
P932PMC publication ID125773
P698PubMed publication ID11726503
P5875ResearchGate publication ID11628383

P50authorMichele PaganoQ28357961
P2093author name stringL Di Marcotullio
G F Draetta
G Rodier
P Coulombe
S Meloche
A Montagnoli
P2860cites workNew functional activities for the p21 family of CDK inhibitorsQ24313427
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signalsQ24314293
Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathwayQ24532945
Role of the F-box protein Skp2 in lymphomagenesisQ24603883
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progressionQ24685645
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27Q28137813
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27Q28137860
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1Q28139243
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27Q28202908
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expressionQ28250231
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2Q28304169
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplicationQ28507216
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formationQ28609667
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27Q29617346
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cellsQ32084034
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2Q33604295
Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.Q33825158
Regulation of the cdk inhibitor p27 and its deregulation in cancerQ33853211
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Q33887383
Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycleQ34076834
Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1.Q35168200
Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanismsQ36327496
Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cellsQ36561469
Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translationQ39460424
Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60.Q40749133
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stabilityQ40876935
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cellsQ40918524
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblastsQ40967344
Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cellsQ41033252
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.Q41120998
Translational control of p27Kip1 accumulation during the cell cycleQ41213467
Inhibitors of the Cip/Kip family.Q41710956
Intracellular distribution of proteasomesQ41729840
Cyclin E-CDK2 is a regulator of p27Kip1.Q42800258
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.Q46229708
Regulation of nuclear transport and degradation of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1.Q50722198
Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexesQ63407040
Formation of p27-CDK complexes during the human mitotic cell cycleQ71569498
Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of p44mapk and p42mapk isoforms in the G1 phase and their inactivation at the G1/S transitionQ72299070
Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanismQ73039012
p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytesQ73505007
Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitorQ74027724
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migrationQ77658726
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
phosphorylationQ242736
P304page(s)6672-6682
P577publication date2001-12-01
P1433published inThe EMBO JournalQ1278554
P1476titlep27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
P478volume20

Reverse relations

cites work (P2860)
Q2432293514-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)
Q582710686‐Aminonicotinamide induces G1arrest by elevating p27kip1as well as inhibiting cdk2, cyclin E and p‐Rb in IMR32 neuroblastoma cell line
Q358908729-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema
Q36205587A crosstalk imbalance between p27(Kip1) and its interacting molecules enhances breast carcinogenesis
Q24300746A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression
Q34324068A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression
Q37675816AKT1 induces caspase-mediated cleavage of the CDK inhibitor p27Kip1 during cell cycle progression in leukemia cells transformed by FLT3-ITD.
Q35094511Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis
Q24319434Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway
Q30437070Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation
Q39068932Adhesion to fibronectin induces p27(Kip1) nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance (CAM-DR) in RPMI 8,226 cells
Q35445077Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer
Q34880437Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region
Q34223641Akt: a double-edged sword in cell proliferation and genome stability
Q65000122An Insight into the Difficulties in the Discovery of Specific Biomarkers of Limbal Stem Cells.
Q39929205Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480.
Q35615629Are SOCS suppressors, regulators, and degraders?
Q46630801Attenuation of cell cycle regulator p27(Kip1) expression in vertebrate epithelial cells mediated by extracellular signals in vivo and in vitro
Q36808366Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1.
Q24307810C-terminal phosphorylation controls the stability and function of p27kip1
Q39742035C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells.
Q100162564CDKN1B is phosphorylated in response to estrogen
Q34981345CDKs and CKIs: molecular targets for tissue remodelling
Q37071718CRM-1 knockdown inhibits extrahepatic cholangiocarcinoma tumor growth by blocking the nuclear export of p27Kip1.
Q24540387CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis
Q47662413CacyBP/SIP inhibits the migration and invasion behaviors of glioblastoma cells through activating Siah1 mediated ubiquitination and degradation of cytoplasmic p27.
Q36473356Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation
Q42566933Casein kinase iγ2 impairs fibroblasts actin stress fibers formation and delays cell cycle progression in g1.
Q37323185Cdk5 and the non-catalytic arrest of the neuronal cell cycle
Q81601109Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
Q35808893Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs
Q33898315Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.
Q39330291Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1.
Q35083763Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization
Q40142298Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition
Q48287164Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro
Q34365993Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase
Q37629048DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage
Q34167777Deregulated degradation of the cdk inhibitor p27 and malignant transformation.
Q24803723Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
Q38717609Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity
Q24299753Drf1, a novel regulatory subunit for human Cdc7 kinase
Q41206555Dual effects of Ral-activated pathways on p27 localization and TGF-β signaling
Q100162393ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
Q24675583Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5
Q44510040Erk 1,2 phosphorylates p27(Kip1): Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells
Q44540468Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway
Q42832588Evidence for cytosolic p27(Kip1) ubiquitylation and degradation during adipocyte hyperplasia
Q39896000Expression of Jun activation domain-binding protein 1 and Ser10 phosphorylated p27 protein in human epithelial ovarian carcinoma
Q37675716Expression of p27Kip1, a cell cycle repressor protein, is inversely associated with potential carcinogenic risk in the genetic rodent models of obesity and long-lived Ames dwarf mice
Q40079763FOXO transcription factor-dependent p15(INK4b) and p19(INK4d) expression.
Q40013439Formation of E-cadherin/beta-catenin-based adherens junctions in hepatocytes requires serine-10 in p27(Kip1).
Q54321696Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells.
Q38310248HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.
Q40681056Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.
Q42224639Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland
Q35009496Increased cytoplasmic localization of p27(kip1) and its modulation of RhoA activity during progression of chronic myeloid leukemia
Q34350229Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.
Q35841989Interwoven ubiquitination oscillators and control of cell cycle transitions
Q87525921JAB1 and phospho-Ser10 p27 expression profile determine human hepatocellular carcinoma prognosis
Q37396923Lapatinib induces p27(Kip1)-dependent G₁ arrest through both transcriptional and post-translational mechanisms
Q39967050Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity
Q53531908Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK.
Q52869749Modification of p27 with O-linked N-acetylglucosamine regulates cell proliferation in hepatocellular carcinoma.
Q39664689Molecular architecture of the DNA replication origin activation checkpoint
Q34399893Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase
Q37966332Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors
Q24563960N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome
Q39758775Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways
Q41848575Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors
Q24540538Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
Q36476441Overview of calpain-mediated regulation of bone and fat mass in osteoblasts
Q37184060P21 and p27: roles in carcinogenesis and drug resistance
Q43207235P27Kip1 serine 10 phosphorylation determines its metabolism and interaction with cyclin-dependent kinases
Q30593254PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells
Q45098656PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression
Q100162348PRKCZ recruits RAS in response to estrogen stimulation
Q42196968Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling
Q34412491Phosphorylation and subcellular localization of p27Kip1 regulated by hydrogen peroxide modulation in cancer cells
Q40484925Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry
Q34194645Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation
Q44592831Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization
Q43099184Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication
Q39949579Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4
Q40492430Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells
Q37433244Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process
Q48951875Potential role of Jun activation domain-binding protein 1 and phosphorylated p27 expression in prognosis of glioma
Q56973092Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart
Q34202288Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human
Q24683060Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation
Q47669969Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies
Q28246814Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"
Q35147982Regulation of CDK4
Q41632273Regulation of p27Kip1 phosphorylation and G1 cell cycle progression by protein phosphatase PPM1G.
Q37678214Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1).
Q39756674Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells
Q36291960Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells
Q45140457Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation
Q24534914Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle
Q36953811S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines
Q37015793Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity
Q24297942Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
Q35232589Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.
Q34711378Silencing kinase-interacting stathmin gene enhances erlotinib sensitivity by inhibiting Ser¹⁰ p27 phosphorylation in epidermal growth factor receptor-expressing breast cancer
Q47640200Skp2-mediated degradation of p27 regulates progression into mitosis
Q34758456Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas
Q24669675Spy1 interacts with p27Kip1 to allow G1/S progression
Q24337721Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
Q90245099Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma
Q28565092Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2
Q37298372TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation
Q33876950Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation
Q90391047Targeting PML in triple negative breast cancer elicits growth suppression and senescence
Q37847584Targeting p27Kip1 protein: its relevance in the therapy of human cancer.
Q30443359Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma
Q36782507The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1.
Q41860863The CRM1 nuclear export protein in normal development and disease.
Q34763495The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Q40691690The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism
Q50335521The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis
Q37459379The function of p27 KIP1 during tumor development.
Q34195072The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules
Q41848509The non-classical MAP kinase ERK3 controls T cell activation
Q47423700The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27.
Q36294480The priming/completion paradigm to explain growth factor-dependent cell cycle progression
Q24794459Transforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor protein
Q42558518Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization
Q46412617Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation
Q28583199USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1
Q29617992Ubiquitin ligases: cell-cycle control and cancer
Q35871417Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors
Q45856686Upregulation of CRM1 relates to neuronal apoptosis after traumatic brain injury in adult rats
Q38563401Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine
Q33737205Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids
Q34580835Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism
Q55460780Wnt signalling in mammary carcinogenesis.
Q31060526Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication
Q100162575p-S10 CDKN1B translocates to the cytosol
Q36321251p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2.
Q37420848p27 Is a critical prognostic biomarker in non-alcoholic steatohepatitis-related hepatocellular carcinoma
Q38247694p27 and leukemia: cell cycle and beyond
Q35745141p27 deregulation in breast cancer: prognostic significance and implications for therapy
Q39016914p27 modulates tropism of mesenchymal stem cells toward brain tumors
Q24294568p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
Q36368949p27(KIP1) regulates neurogenesis in the rostral migratory stream and olfactory bulb of the postnatal mouse
Q35907198p27(Kip1) and Ser10-phosphorylated p27(Kip1) in breast cancer: clinical significance and expression
Q34659823p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor
Q35002490p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation
Q33292354p27Kip1 localization depends on the tumor suppressor protein tuberin
Q40795456p27Kip1 modulates cell migration through the regulation of RhoA activation.
Q33554593p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway
Q38828016δ-Tocopherol inhibits receptor tyrosine kinase-induced AKT activation in prostate cancer cells

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