| scholarly article | Q13442814 |
| P2093 | author name string | Alan C. Bird | |
| P2860 | cites work | Correlation between lipids extracted from Bruch's membrane and age | Q70562346 |
| The fate of the phagosome: conversion to 'age pigment' and impact in human retinal pigment epithelium | Q70950495 | ||
| Photoreceptor loss in age-related macular degeneration | Q71104955 | ||
| Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor | Q71402232 | ||
| Indocyanine green videoangiography of choroidal neovascular membrane in age-related macular degeneration | Q71607346 | ||
| Analysis of lipid deposits extracted from human macular and peripheral Bruch's membrane | Q72296425 | ||
| Age-related variation in the hydraulic conductivity of Bruch's membrane | Q72298033 | ||
| The prevalence of age-related maculopathy in the Rotterdam Study | Q72560755 | ||
| In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics | Q72631037 | ||
| The prevalence of age-related maculopathy in iceland: Reykjavik eye study | Q73080416 | ||
| The role of the atherosclerotic process in the pathogenesis of age-related macular degeneration | Q73191249 | ||
| Ultrastructural changes associated with accumulation of inclusion bodies in rat retinal pigment epithelium | Q73234863 | ||
| Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells | Q74579759 | ||
| Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin | Q74586647 | ||
| CHOROIDAL VASCULAR PATTERNS IN HYPERTENSION | Q76776716 | ||
| MACULAR DISEASES: PATHOGENESIS. ELECTRON MICROSCOPY OF BRUCH'S MEMBRANE | Q78555332 | ||
| Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA | Q24317658 | ||
| A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration | Q24523983 | ||
| The potential role of amyloid beta in the pathogenesis of age-related macular degeneration | Q24532130 | ||
| Complement factor H polymorphism in age-related macular degeneration | Q24553334 | ||
| Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications | Q24681724 | ||
| An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration | Q28190470 | ||
| Complement factor H variant increases the risk of age-related macular degeneration | Q28239239 | ||
| High concentration of zinc in sub-retinal pigment epithelial deposits | Q28289340 | ||
| Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations | Q28754379 | ||
| Complement factor H polymorphism and age-related macular degeneration | Q29614931 | ||
| Expression of vascular endothelial growth factor and its receptor (KDR/flk-1) mRNA in experimental choroidal neovascularization | Q30702404 | ||
| Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. | Q30984629 | ||
| Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration | Q31036499 | ||
| Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss | Q31039696 | ||
| Expression of pigment epithelium-derived factor in experimental choroidal neovascularization. | Q31050171 | ||
| Age-related macular degeneration: what's new. | Q31076837 | ||
| Pathogenesis of laser-induced choroidal subretinal neovascularization | Q33254687 | ||
| Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction | Q33301870 | ||
| Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination | Q33326383 | ||
| High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration | Q33335646 | ||
| Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma. | Q33440977 | ||
| Complement 5b-9 complex-induced alterations in human RPE cell physiology | Q33520910 | ||
| Bilaterality of tears of the retinal pigment epithelium | Q33646821 | ||
| Ageing and degeneration in the macular region: a clinico-pathological study | Q33649685 | ||
| Senile macular changes in the black African | Q33650851 | ||
| Soluble and mature amyloid fibrils in drusen deposits | Q33735695 | ||
| A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease | Q33897528 | ||
| Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration | Q33905581 | ||
| The role of oxidative stress in the pathogenesis of age-related macular degeneration. | Q34060719 | ||
| The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration | Q34154466 | ||
| Senile macular degeneration: a histopathologic study | Q34209340 | ||
| Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. | Q34292373 | ||
| Retinal angiomatous proliferation in age-related macular degeneration | Q34408086 | ||
| Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk | Q34452441 | ||
| Complement C3 variant and the risk of age-related macular degeneration | Q34651682 | ||
| Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization | Q34749337 | ||
| Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration | Q34960196 | ||
| Vascular endothelial growth factors and angiogenesis in eye disease | Q35070749 | ||
| The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells | Q35865044 | ||
| Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue. | Q35865480 | ||
| Distribution of fundus autofluorescence with a scanning laser ophthalmoscope | Q36687458 | ||
| Relationship between RPE and choriocapillaris in age-related macular degeneration | Q36791715 | ||
| Digital indocyanine green angiography in chorioretinal diseases. | Q36824962 | ||
| Localization of the site of major resistance to fluid transport in Bruch's membrane. | Q36850491 | ||
| Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration | Q37064822 | ||
| Complement activation by bisretinoid constituents of RPE lipofuscin | Q37158928 | ||
| Multilocus analysis of age-related macular degeneration | Q37312888 | ||
| Is the incidence of registrable age-related macular degeneration increasing? | Q37317621 | ||
| Regulated secretion of complement factor H by RPE and its role in RPE migration | Q37373220 | ||
| An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris | Q37413610 | ||
| Symptomatic abnormalities of dark adaptation in patients with age-related Bruch's membrane change | Q37477052 | ||
| The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited | Q37644606 | ||
| Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study | Q39442873 | ||
| Retinal pigment epithelial detachments in the elderly. | Q39671758 | ||
| Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement | Q39699065 | ||
| The prevalence of age-related maculopathy (ARM) in an urban Norwegian population: the Oslo Macular study. | Q39768286 | ||
| Cigarette smoking and age-related macular degeneration in the EUREYE Study | Q39788735 | ||
| Increased vitronectin production by complement-stimulated human retinal pigment epithelial cells | Q39858250 | ||
| VEGF modulation of retinal pigment epithelium resistance | Q40072183 | ||
| Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. | Q40187815 | ||
| Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation | Q40937602 | ||
| Correlation between biochemical composition and fluorescein binding of deposits in Bruch's membrane | Q41102797 | ||
| RPE destruction causes choriocapillary atrophy. | Q42458037 | ||
| Age-related macular degeneration: the molecular link between oxidative damage, tissue-specific inflammation and outer retinal disease: the Proctor lecture | Q43149005 | ||
| Prevalence and causes of blindness in Greenland | Q43910466 | ||
| Photoreactivity of aged human RPE melanosomes: a comparison with lipofuscin. | Q44045967 | ||
| Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranes | Q44250118 | ||
| Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy | Q44743301 | ||
| Functional loss in age-related Bruch's membrane change with choroidal perfusion defect | Q44779797 | ||
| Features of age-related macular degeneration in a black population. The Barbados Eye Study Group | Q46246780 | ||
| ??? | Q94716345 | ||
| Uncontrolled zinc- and copper-induced oligomerisation of the human complement regulator factor H and its possible implications for function and disease. | Q46270582 | ||
| Macular lesions predisposing to senile disciform macular degeneration | Q46284148 | ||
| Enhanced depth imaging spectral-domain optical coherence tomography | Q46474979 | ||
| Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization | Q46568410 | ||
| Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results | Q46940817 | ||
| Subgroup analysis of the MARINA study of ranibizumab in neovascular age-related macular degeneration | Q46956320 | ||
| Introducing Joe G. Hollyfield, the 2009 Recipient of the Proctor Medal | Q48309511 | ||
| [Implication of retinal pigment epithelium on experimental subretinal neovascularization in the developmental stage]. | Q52250210 | ||
| Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging. | Q52883818 | ||
| Age-Related Macular Degeneration | Q54263427 | ||
| The relationships of age changes in retinal pigment epithelium and Bruch's membrane | Q59305717 | ||
| Aging changes in Bruch's membrane. A histochemical and morphologic study | Q67656977 | ||
| Changes in causes of visual handicaps in Tokyo | Q67822968 | ||
| Conservation of Docosahexaenoic Acid in Rod Outer Segments of Rat Retina During n-3 and n-6 Fatty Acid Deficiency | Q67903311 | ||
| Recycling of docosahexaenoic acid in rat retinas during n-3 fatty acid deficiency | Q67907726 | ||
| Histopathology of Incipient Fundus Flavimaculatus | Q67935526 | ||
| Fundus changes in membranoproliferative glomerulonephritis type II. A fluorescein angiographic study of 23 patients | Q68038284 | ||
| Influence of dietary vitamin A on autofluorescence of leupeptin-induced inclusions in the retinal pigment epithelium | Q68090876 | ||
| Prevalence of age-related maculopathy. The Beaver Dam Eye Study | Q68207448 | ||
| Prevalence of blindness caused by senile macular degeneration in Greenland | Q68531629 | ||
| Choroidal perfusion abnormality with age-related Bruch's membrane change | Q68705001 | ||
| Pathogenetic factors of aging macular degeneration | Q68935504 | ||
| The pathogenesis of tears of the retinal pigment epithelium | Q69019548 | ||
| Sorsby's fundus dystrophy. A light and electron microscopic study | Q69130080 | ||
| Sorsby's fundus dystrophy. A clinical study | Q69443860 | ||
| Orbital and ocular micro-vascular corrosion casting in man | Q69456313 | ||
| Role of the retinal pigment epithelium in macular disease | Q70369590 | ||
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | human ageing | Q332154 |
| P304 | page(s) | 3033-41 | |
| P577 | publication date | 2010-09-01 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | Therapeutic targets in age-related macular disease | |
| P478 | volume | 120 |
| Q34684652 | A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina |
| Q34937219 | AMD-associated genes encoding stress-activated MAPK pathway constituents are identified by interval-based enrichment analysis |
| Q34991275 | Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization |
| Q39423391 | Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration |
| Q36826856 | Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. |
| Q41962534 | An elderly lady with blurring of vision |
| Q42456498 | An eye for discovery |
| Q36752978 | Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity |
| Q38974093 | Biological and pathophysiological roles of end-products of DHA oxidation. |
| Q24311571 | Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin |
| Q28512223 | Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration |
| Q99412056 | Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration |
| Q38767261 | Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases |
| Q89509850 | Circadian Rhythms in Exudative Age-Related Macular Degeneration: The Key Role of the Canonical WNT/β-Catenin Pathway |
| Q34355357 | Clinical applications of age-related macular degeneration genetics |
| Q35917824 | Cyclic intensive light exposure induces retinal lesions similar to age-related macular degeneration in APPswe/PS1 bigenic mice |
| Q34555655 | DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways |
| Q36266703 | Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction |
| Q33567989 | Detection of early age-related macular degeneration using novel functional parameters of the focal cone electroretinogram |
| Q35192906 | Development of gene therapy for treatment of age-related macular degeneration |
| Q89763365 | Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration |
| Q37395303 | Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging |
| Q38958610 | Effects of p75 neurotrophin receptor on regulating hypoxia-induced angiogenic factors in retinal pigment epithelial cells |
| Q35459066 | Efficient derivation of retinal pigment epithelium cells from stem cells |
| Q39300304 | Electroretinogram measures in a septuagenarian population. |
| Q37623450 | Endothelial NADPH oxidase 4 mediates vascular endothelial growth factor receptor 2-induced intravitreal neovascularization in a rat model of retinopathy of prematurity |
| Q42261791 | Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue: Imaging Zinc as a Biomarker for Age-Related Macular Degeneration (An American Ophthalmological Society Thesis). |
| Q61799608 | Establishing Liposome-Immobilized Dexamethasone-Releasing PDMS Membrane for the Cultivation of Retinal Pigment Epithelial Cells and Suppression of Neovascularization |
| Q35188790 | Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy |
| Q36033617 | Hedgehog Signaling Components Are Expressed in Choroidal Neovascularization in Laser-induced Retinal Lesion |
| Q90342753 | High-yield, automated intracellular electrophysiology in retinal pigment epithelia |
| Q34025192 | Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration |
| Q37148310 | Hyperactivation of retina by light in mice leads to photoreceptor cell death mediated by VEGF and retinal pigment epithelium permeability |
| Q36844624 | Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration |
| Q35062847 | Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye |
| Q37614752 | Immunology of age-related macular degeneration |
| Q33960351 | Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization |
| Q36314850 | Inflammatory Cytokines Induce Expression of Chemokines by Human Retinal Cells: Role in Chemokine Receptor Mediated Age-related Macular Degeneration |
| Q36129163 | Inflammatory priming predisposes mice to age-related retinal degeneration |
| Q88737557 | Intra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration |
| Q42011687 | Let's play a game of chutes and ladders: Lysosome fusion with the epithelial plasma membrane |
| Q27000182 | Mechanisms of age-related macular degeneration |
| Q38205436 | Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands. |
| Q39426754 | Molecular responses of choroidal endothelial cells to elastin derived peptides through the elastin-binding protein (GLB1). |
| Q35663757 | Morphological and functional evaluation of an animal model for the retinal degeneration induced by N-methyl-N-nitrosourea |
| Q47098865 | Nicotinamide: a novel treatment for age-related macular degeneration? |
| Q41961558 | Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration. |
| Q90456952 | Partial thickness sclerectomy and intravitreal anti-VEGF therapy for intractable uveal effusion syndrome |
| Q54868115 | Perceiving polarization with the naked eye: characterization of human polarization sensitivity. |
| Q35161969 | Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension |
| Q35540652 | Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration |
| Q27329045 | Protection of retina by αB crystallin in sodium iodate induced retinal degeneration |
| Q97883064 | Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice |
| Q38819731 | Quantitative metabolomics of photoreceptor degeneration and the effects of stem cell-derived retinal pigment epithelium transplantation |
| Q34109426 | ROCK Inhibition Extends Passage of Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium |
| Q42360527 | ROCK Inhibition Promotes Attachment, Proliferation, and Wound Closure in Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium |
| Q39126432 | Rap1 in endothelial biology |
| Q26751293 | Regulation of signaling events involved in the pathophysiology of neovascular AMD |
| Q42481764 | Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9. |
| Q49632281 | Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism |
| Q36126070 | Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization |
| Q36781055 | Silibinin inhibits VEGF secretion and age-related macular degeneration in a hypoxia-dependent manner through the PI-3 kinase/Akt/mTOR pathway |
| Q35577903 | Suppression of Laser-Induced Choroidal Neovascularization by the Oral Medicine Targeting Histamine Receptor H4 in Mice. |
| Q87883903 | Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor |
| Q37547846 | Sustained inhibition of neovascularization in vldlr-/- mice following intravitreal injection of cerium oxide nanoparticles and the role of the ASK1-P38/JNK-NF-κB pathway |
| Q35106035 | T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration |
| Q28590969 | TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy |
| Q35930190 | TNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activation |
| Q28513588 | Targeted deletion of Vegfa in adult mice induces vision loss |
| Q37577214 | Targeting Müller cell-derived VEGF164 to reduce intravitreal neovascularization in the rat model of retinopathy of prematurity |
| Q36317120 | The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field. |
| Q36954609 | The retinal pigment epithelium as a gateway for monocyte trafficking into the eye. |
| Q58738012 | Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces |
| Q97867234 | VEGF is an autocrine/paracrine neuroprotective factor for injured retinal ganglion neurons |
| Q37545004 | VEGF regulates local inhibitory complement proteins in the eye and kidney. |
| Q35473907 | Vascular endothelial growth factor antagonist therapy for retinopathy of prematurity |
| Q27012671 | βA3/A1-crystallin: more than a lens protein |
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