Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye

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Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye is …
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scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112.1565T
P356DOI10.1073/PNAS.1413347112
P932PMC publication ID4321314
P698PubMed publication ID25605911
P5875ResearchGate publication ID271223771

P50authorSarah FearnQ57972756
Marius UeffingQ28323182
Emrys A. JonesQ50618674
Antonio LanzirottiQ55427877
Imre LengyelQ57077388
P2093author name stringKarsten Boldt
Alan C Bird
Jane M Flinn
Jacob G Bundy
Richard B Thompson
Elod Kortvely
David S McPhail
Laurenz Pauleikhoff
Savanjeet Guy Singh Ratu
Valentina Reffatto
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Aging changes in Bruch's membrane. A histochemical and morphologic studyQ67656977
In vivo hydroxyapatite formation induced by lipidsQ68841598
An electron microscopic histochemical and analytical X-ray microprobe study of calcification in Bruch's membrane from human eyesQ70830933
Age-related variation in the hydraulic conductivity of Bruch's membraneQ72298033
The prevalence of age-related maculopathy in the Rotterdam StudyQ72560755
Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degenerationQ73465771
Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cellsQ74579759
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Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactionsQ84423124
Internal structure consistent with remodelling in very small drusen, revealed by filipin histochemistry for esterified cholesterolQ87329477
Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degenerationQ87698757
Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcificationQ28289334
High concentration of zinc in sub-retinal pigment epithelial depositsQ28289340
Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy.Q30540956
Abundant lipid and protein components of drusenQ33567644
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Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activationQ33652041
Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit diseaseQ33899675
The role of matrix vesicles in growth plate development and biomineralizationQ33983380
Cellular and molecular mechanisms of bone remodeling.Q34055657
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomersQ34331346
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.Q34378842
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Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteinsQ35056603
Scanning electron microscopy of human drusenQ35072222
Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophyQ35456717
Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degenerationQ35546888
Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathyQ36517811
The oil spill in ageing Bruch membraneQ36787937
Geographic atrophy: a histopathological assessmentQ36860952
Protein chromatography on hydroxyapatite columnsQ37628088
Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in miceQ39529907
Bruch's membrane in pseudoxanthoma elasticum. Histochemical, ultrastructural, and x-ray microanalytical study of the membrane and angioid streak areasQ39833397
The in vivo staining of bone with alizarin red S.Q41844827
Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroidQ42549679
Age-related macular degeneration revisited--piecing the puzzle: the LXIX Edward Jackson memorial lectureQ43560026
Xylenol orange, a fluorochrome useful in polychrome sequential labeling of calcifying tissuesQ46284549
Growth of calcium hydroxyapatite (Ca-HAp) on cholesterol and cholestanol crystals from a simulated body fluid: A possible insight into the pathological calcifications associated with atherosclerosisQ46756990
P2507corrigendum / erratumCorrection for Thompson et al., Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eyeQ61727433
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1565-1570
P577publication date2015-01-20
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIdentification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye
P478volume112

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