Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation

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Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.564674
P932PMC publication ID4031511
P698PubMed publication ID24711457

P2093author name stringBärbel Rohrer
Kannan Kunchithapautham
Carl Atkinson
P2860cites workA common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degenerationQ24523983
Complement factor H polymorphism in age-related macular degenerationQ24553334
Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injuryQ27311630
An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degenerationQ28190470
Complement factor H variant increases the risk of age-related macular degenerationQ28239239
ERAD: the long road to destructionQ28264823
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptorsQ28284980
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The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Complement factor H polymorphism and age-related macular degenerationQ29614931
Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus facesQ30039723
The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing light microscopyQ30990840
Accumulation of cholesterol with age in human Bruch's membrane.Q31776587
Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell deathQ33240491
Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunctionQ33301870
The role of complement in AMD.Q33391415
Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degenerationQ33434526
Complement factor h is critical in the maintenance of retinal perfusionQ33471110
Abundant lipid and protein components of drusenQ33567644
Methods for monitoring endoplasmic reticulum stress and the unfolded protein response.Q33652280
The endocrine effects of nicotine and cigarette smokeQ34272966
Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion.Q34315819
Biological effects of cigarette smoke in cultured human retinal pigment epithelial cellsQ34479008
Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complementQ34537546
Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent mannerQ34620560
Free-radical chemistry of cigarette smoke and its toxicological implicationsQ35035584
Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroidQ35068037
Lipids, lipoproteins, and age-related macular degenerationQ35138088
Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophyQ35456717
Acute effects of cigarette smoke on inflammation and oxidative stress: a reviewQ35536904
Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degenerationQ35546888
Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisationQ35761464
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targetingQ35964550
Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal DegenerationQ36052285
Age-related macular degeneration: economic burden and value-based medicine analysis.Q36157996
A novel role of complement in retinal degenerationQ36164495
Detection of complement activation using monoclonal antibodies against C3d.Q36793448
The role of the immune response in age-related macular degenerationQ36914129
Regulated complement deposition on the surface of human endothelial cells: effect of tobacco smoke and shear stressQ37077715
Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protectionQ37207734
Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profileQ37218150
Environmental tobacco smoke exposure and eye diseaseQ37227960
Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury.Q37285079
Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degenerationQ37331431
Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degenerationQ37421027
A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injuryQ37434667
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visitedQ37644606
Misfolded proteins and retinal dystrophiesQ37711179
Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complementQ37716557
Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularizationQ37777653
Pathway-based therapies for age-related macular degeneration: an integrated survey of emerging treatment alternativesQ37798126
Endoplasmic reticulum stress and lipid dysregulationQ37834712
Respiratory epithelial cell responses to cigarette smoke: the unfolded protein responseQ38030759
Clinical classification of age-related macular degenerationQ38075266
Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site.Q38343651
Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damageQ39681985
Cigarette smoking and age-related macular degeneration in the EUREYE StudyQ39788735
Cigarette smoke extract stimulates interleukin-8 production in human airway epithelium and is attenuated by superoxide dismutase in vitro.Q39796909
Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approachQ39956415
VEGF modulation of retinal pigment epithelium resistanceQ40072183
Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.Q40595070
Human interleukin-6 acts as a co-factor for the up-regulation of C3 production by rat liver epithelial cells.Q41459390
Modified low density lipoprotein stimulates complement C3 expression and secretion via liver X receptor and Toll-like receptor 4 activation in human macrophages.Q41482082
Regulated expression of apolipoprotein E by human retinal pigment epithelial cellsQ42452134
Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD.Q42489825
Immunohistochemical localization of complement regulatory proteins in the human retinaQ42500395
Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroidQ42549679
Smoking and the 5-year incidence of age-related maculopathy: the Blue Mountains Eye StudyQ44169196
Expression and modulation of RPE cell membrane complement regulatory proteins.Q46147680
Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species.Q50759187
Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells.Q53197854
Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation.Q54399040
Antioxidant enzymes in the aging human retinal pigment epitheliumQ68027792
Age-dependent change in the hyaluronic acid content of the human chorioretinal complexQ72825576
Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient miceQ73990815
Do we need a new classification for choroidal neovascularization in age-related macular degeneration?Q85160758
P4510describes a project that usesImageJQ1659584
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)14534-14546
P577publication date2014-04-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleSmoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation
P478volume289

Reverse relations

cites work (P2860)
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