Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation

scientific article

Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.17.1.519
P932PMC publication ID231776
P698PubMed publication ID8972232

P50authorCharles David AllisQ1064064
P2093author name stringL Wang
S L Berger
C Ying
N Barlev
R Candau
J Brownell
C Mizzen
P2860cites workCdk-activating kinase complex is a component of human transcription factor TFIIHQ24306759
TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74Q24309172
OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteinsQ24313516
Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5Q24315711
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcriptionQ24319163
Nuclear protein CBP is a coactivator for the transcription factor CREBQ24319801
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1AQ24336667
The bromodomain: a conserved sequence found in human, Drosophila and yeast proteinsQ24604489
Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-BQ24651545
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
Mammalian Ras interacts directly with the serine/threonine kinase RafQ27860833
ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complexQ27930121
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.Q27930548
SPT10 and SPT21 are required for transcription of particular histone genes in Saccharomyces cerevisiaeQ27930578
The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activationQ27932341
ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcriptionQ27932447
Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription.Q27935228
Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complexQ27935940
A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID.Q27936818
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activationQ27937778
Identification of a gene encoding a yeast histone H4 acetyltransferaseQ27939819
Association of Cdk-activating kinase subunits with transcription factor TFIIHQ28236002
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIKQ28243206
Phosphorylated CREB binds specifically to the nuclear protein CBPQ28265019
Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of JunQ28283776
Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activationQ28303864
The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18Q28509358
Transcriptional activation: a complex puzzle with few easy piecesQ29616518
Transcriptional silencing in yeast is associated with reduced nucleosome acetylationQ29618497
An RNA polymerase II holoenzyme responsive to activatorsQ29620210
Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domainsQ29620928
Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo.Q33938368
An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronucleiQ34120369
Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.Q35850301
A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream siteQ36324085
ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2.Q36822602
Chloramphenicol acetyltransferaseQ37234378
Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.Q37631005
Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcriptionQ38324867
Structural and functional analysis of yeast putative adaptors. Evidence for an adaptor complex in vivoQ38361167
Transcription: in tune with the histonesQ38483205
SPT20/ADA5 encodes a novel protein functionally related to the TATA-binding protein and important for transcription in Saccharomyces cerevisiaeQ40019111
The SWI-SNF complex: a chromatin remodeling machine?Q40539112
The SNF/SWI family of global transcriptional activatorsQ40626454
Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.Q40793485
Transcriptional coactivators in yeast and beyondQ40951549
Targeting chromatin disruption: Transcription regulators that acetylate histonesQ40970395
Contacts in context: promoter specificity and macromolecular interactions in transcriptionQ40970406
Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activationQ41044061
Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activatorsQ42491732
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factorQ42494377
Yeast histone H4 N-terminal sequence is required for promoter activation in vivoQ45268200
Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding ProteinQ58130306
Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysinesQ59051030
Negative effect of the transcriptional activator GAL4Q59072863
SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiaeQ68203604
A positive role for histone acetylation in transcription factor access to nucleosomal DNAQ70535287
The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expressionQ72863039
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)519-27
P577publication date1997-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleHistone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation
P478volume17

Reverse relations

cites work (P2860)
Q48906137A copper-responsive promoter replacement system to investigate gene functions in Trichoderma reesei: a case study in characterizing SAGA genes
Q24682174A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription
Q28571312A role for Gcn5 in cardiomyocyte differentiation of rat mesenchymal stem cells
Q28363091A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300
Q37994551ATAC-king the complexity of SAGA during evolution
Q47858497Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast
Q24548503Acetylation of histones and transcription-related factors
Q44747129Acetylation of histones associated with the p21WAF1/CIP1 gene by butyrate is not sufficient for p21WAF1/CIP1 gene transcription in human colorectal adenocarcinoma cells
Q43691949Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5.
Q33964757Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF.
Q24530608An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor
Q38320487AnCF, the CCAAT binding complex of Aspergillus nidulans, is essential for the formation of a DNase I-hypersensitive site in the 5' region of the amdS gene
Q77892623Analysis of activity and regulation of hGcn5, a human histone acetyltransferase
Q24310576And-1 is required for the stability of histone acetyltransferase Gcn5
Q22254743Androgen receptor interacts with a novel MYST protein, HBO1
Q73445322Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity
Q34064159Chromatin-remodeling complexes involved in gene activation by the glucocorticoid receptor
Q39729515Cloning and analysis of a Toxoplasma gondii histone acetyltransferase: a novel chromatin remodelling factor in Apicomplexan parasites
Q46623959Co-activators and co-repressors in the integration of transcriptional responses
Q27932566Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes
Q35193069Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo
Q38331920Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4.
Q27619265Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator
Q27644364Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A
Q48294220Deletion of ADA2 increases antifungal drug susceptibility and virulence in Candida glabrata
Q34478777Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID
Q34831586Distinct roles of the Gcn5 histone acetyltransferase revealed during transient stress-induced reprogramming of the genome
Q24319748E1A directly binds and regulates the P/CAF acetyltransferase
Q90470355Epigenetic Regulation of MDR1 and BCRP Transporters by HDAC Inhibition
Q41913369Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase
Q28140995Estrogen receptor interaction with co-activators and co-repressors
Q28203389Full Activation of Estrogen Receptor α Activation Function-1 Induces Proliferation of Breast Cancer Cells
Q58514612Gcn5p, a Transcription-related Histone Acetyltransferase, Acetylates Nucleosomes and Folded Nucleosomal Arrays in the Absence of Other Protein Subunits
Q33546141Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles
Q35192911Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
Q33959141Histone acetyltransferase complexes can mediate transcriptional activation by the major glucocorticoid receptor activation domain
Q35199451Histone acetyltransferases regulate HIV-1 enhancer activity in vitro
Q35253477Histone chaperones, histone acetylation, and the fluidity of the chromogenome
Q77109285How do histone acetyltransferases select lysine residues in core histones?
Q22010568Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein
Q30437262Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification
Q34338533Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo
Q58692929Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3
Q38976614KATapulting toward Pluripotency and Cancer
Q47926688Life with nucleosomes: chromatin remodelling in gene regulation
Q28593423Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos
Q24522706Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates
Q36319684Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat.
Q30443104Multi-tasking on chromatin with the SAGA coactivator complexes
Q34608754Mutational analysis of a histone deacetylase in Drosophila melanogaster: missense mutations suppress gene silencing associated with position effect variegation
Q35486433Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming
Q34374051N-terminal domain of nuclear IL-1α shows structural similarity to the C-terminal domain of Snf1 and binds to the HAT/core module of the SAGA complex.
Q34452475NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF.
Q28574433Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases
Q42071678Nucleosome positioning and histone H3 acetylation are independent processes in the Aspergillus nidulans prnD-prnB bidirectional promoter
Q36222404On the epigenetics of vascular regulation and disease
Q43569963Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA.
Q27934501Plasmodium falciparum histone acetyltransferase, a yeast GCN5 homologue involved in chromatin remodeling
Q55920649RETRACTED: Nuclear Receptor Function Requires a TFTC-Type Histone Acetyl Transferase Complex
Q38177727Regulation of ISWI chromatin remodelling activity
Q40580833Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.
Q33336341Regulators of cellular levels of histone acetylation in Saccharomyces cerevisiae
Q24522344Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex
Q36164767Role of histone acetylation in the control of gene expression
Q39858162Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells
Q27930044Sgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo
Q30833764Site-specific acetylation of ISWI by GCN5.
Q27618997Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A
Q28742062Stemming epigenetics in marine stramenopiles
Q34197768TFIIB and subunits of the SAGA complex are involved in transcriptional activation of phospholipid biosynthetic genes by the regulatory protein Ino2 in the yeast Saccharomyces cerevisiae
Q27931014The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae
Q24601182The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis
Q91529794The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways
Q33772811The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex
Q33667278The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation
Q27935220The N-terminus and Tudor domains of Sgf29 are important for its heterochromatin boundary formation function
Q28513184The PCAF acetylase complex as a potential tumor suppressor
Q51492828The SAGA complex in the rice pathogen Fusarium fujikuroi: structure and functional characterization.
Q42459431The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes.
Q24310327The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
Q22010950The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene
Q35666251The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
Q24310357The double-histone-acetyltransferase complex ATAC is essential for mammalian development
Q24554343The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
Q38411598The essential gene wda encodes a WD40 repeat subunit of Drosophila SAGA required for histone H3 acetylation
Q37405061The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.
Q37571931The role of the double bromodomain-containing BET genes during mammalian spermatogenesis
Q36569298Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene
Q33775085Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.
Q42490012Transforming growth factor-beta and bone morphogenetic proteins: cooperative players in chick and murine programmed retinal cell death
Q50924153Trichoderma reesei histone acetyltransferase Gcn5 regulates fungal growth, conidiation, and cellulase gene expression.
Q39594198Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes
Q92719155Two factor authentication: Asf1 mediates crosstalk between H3 K14 and K56 acetylation
Q40902813c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300.
Q35698749dbHiMo: a web-based epigenomics platform for histone-modifying enzymes.
Q33738453p300 and CBP: partners for life and death