An RNA polymerase II holoenzyme responsive to activators

scientific article (publication date: 31 March 1994)

An RNA polymerase II holoenzyme responsive to activators is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1045788393
P356DOI10.1038/368466A0
P3181OpenCitations bibliographic resource ID2110705
P698PubMed publication ID8133894

P2093author name stringYoung RA
Koleske AJ
P2860cites workA multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.Q27931243
A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID.Q27936818
DNA topology and a minimal set of basal factors for transcription by RNA polymerase IIQ28646851
Five intermediate complexes in transcription initiation by RNA polymerase IIQ29616444
A mediator required for activation of RNA polymerase II transcription in vitroQ34095554
RNA polymerase B (II) and general transcription factorsQ34222071
Advances in RNA polymerase II transcriptionQ35673499
A heteromeric transcription factor required for mammalian RNA polymerase II.Q35870944
Dynamic interaction between a Drosophila transcription factor and RNA polymerase II.Q36763575
Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activationQ37158674
Yeast RNA polymerase II initiation factor e: isolation and identification as the functional counterpart of human transcription factor IIBQ37317083
Initiation by yeast RNA polymerase II at the adenoviral major late promoter in vitroQ38343145
General initiation factors for RNA polymerase II.Q40835254
Isolation of two genes that encode subunits of the yeast transcription factor IIAQ42459697
Physical Analysis of Transcription Preinitiation Complex Assembly on a Class II Gene PromoterQ45226839
The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo.Q45910393
Cloning of a subunit of yeast RNA polymerase II transcription factor b and CTD kinaseQ48158311
Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequencesQ59074628
RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitroQ67782272
Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding proteinQ68133927
P433issue6470
P407language of work or nameEnglishQ1860
P304page(s)466-9
P577publication date1994-03-31
P1433published inNatureQ180445
P1476titleAn RNA polymerase II holoenzyme responsive to activators
P478volume368

Reverse relations

cites work (P2860)
Q33368388A CTD function linking transcription to splicing
Q54976735A Cotton Cyclin-Dependent Kinase E Confers Resistance to Verticillium dahliae Mediated by Jasmonate-Responsive Pathway.
Q33651485A TATA-binding protein mutant defective for TFIID complex formation in vivo
Q36556030A class of activation domains interacts directly with TFIIA and stimulates TFIIA-TFIID-promoter complex assembly
Q27940291A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling
Q34081613A conserved GA element in TATA-less RNA polymerase II promoters
Q27935262A functional module of yeast mediator that governs the dynamic range of heat-shock gene expression
Q30815733A genetic strategy to eliminate self-activator baits prior to high-throughput yeast two-hybrid screens
Q27933520A highly conserved ATPase protein as a mediator between acidic activation domains and the TATA-binding protein.
Q27939183A highly conserved domain of RNA polymerase II shares a functional element with acidic activation domains of upstream transcription factors
Q28276653A human RNA polymerase II complex associated with SRB and DNA-repair proteins
Q24522669A human RNA polymerase II complex containing factors that modify chromatin structure
Q27930481A kinase-cyclin pair in the RNA polymerase II holoenzyme.
Q34295542A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription
Q24322024A mammalian SRB protein associated with an RNA polymerase II holoenzyme
Q24324110A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains
Q27936438A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae
Q39722071A multiplicity of mediators: alternative forms of transcription complexes communicate with transcriptional regulators
Q36561614A new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo
Q22011164A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth
Q22008779A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
Q22008652A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2
Q27936954A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.
Q35171792A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme
Q42479261A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulation
Q35154714A role of transcriptional activators as antirepressors for the autoinhibitory activity of TATA box binding of transcription factor IID.
Q36565816A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo
Q38315368A single point mutation in TFIIA suppresses NC2 requirement in vivo
Q40018556A three-step pathway of transcription initiation leading to promoter clearance at an activation RNA polymerase II promoter
Q59071495A transcription reinitiation intermediate that is stabilized by activator
Q24645448A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans
Q42519847A yeast transcriptional stimulatory protein similar to human PC4.
Q27939725ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.
Q27930121ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex
Q27932447ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription
Q53947997ATP-mediated activation of RNA polymerase II transcription complexes.
Q36568453Accurate positioning of RNA polymerase II on a natural TATA-less promoter is independent of TATA-binding-protein-associated factors and initiator-binding proteins
Q40445630Activated transcription independent of the RNA polymerase II holoenzyme in budding yeast
Q37297562Activation domain-mediated enhancement of activator binding to chromatin in mammalian cells
Q36239308Activation of RNA polymerase II by topologically linked DNA-tracking proteins
Q54567789Activation of prokaryotic transcription through arbitrary protein-protein contacts.
Q47858055Activation of transcription in vitro by recruitment of the yeast RNA polymerase II holoenzyme
Q24540745Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation
Q38297759Additive activation of yeast LEU4 transcription by multiple cis elements
Q73248351Affinity purification of a human RNA polymerase II complex using monoclonal antibodies against transcription factor IIF
Q28572297Affinity purification of mammalian RNA polymerase I. Identification of an associated kinase
Q24530608An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor
Q40018593An activation domain of the helix-loop-helix transcription factor E2A shows cell type preference in vivo in microinjected zebra fish embryos
Q27938223An activator target in the RNA polymerase II holoenzyme
Q24649275An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae
Q78101732An interaction between the N-terminal region and the core domain of yeast TFIIB promotes the formation of TATA-binding protein-TFIIB-DNA complexes
Q27939835An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.
Q73094158Analysis by atomic force microscopy of Med8 binding to cis-acting regulatory elements of the SUC2 and HXK2 genes of saccharomyces cerevisiae
Q27929743Artificial recruitment of certain Mediator components affects requirement of basal transcription factor IIE.
Q28236002Association of Cdk-activating kinase subunits with transcription factor TFIIH
Q28304889Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes
Q24675704BRCA1 is a component of the RNA polymerase II holoenzyme
Q42484764Basal promoter elements as a selective determinant of transcriptional activator function
Q29614681Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme
Q24609153Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53
Q33635743Biochemistry meets genetics in the holoenzyme
Q74380467Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo
Q24315725CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription
Q27935522Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme
Q74342700Characterization of NOT5 that encodes a new component of the Not protein complex
Q58130306Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding Protein
Q24550927Characterization of mediator complexes from HeLa cell nuclear extract
Q27930708Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae
Q34601114Characterization of the interaction between the acidic activation domain of VP16 and the RNA polymerase II initiation factor TFIIB
Q42444028Chicken vigilin gene: a distinctive pattern of hypersensitive sites is characteristic for its transcriptional activity.
Q34064159Chromatin-remodeling complexes involved in gene activation by the glucocorticoid receptor
Q41477035Common themes in the function of transcription and splicing enhancers
Q36035094Considerations of transcriptional control mechanisms: do TFIID-core promoter complexes recapitulate nucleosome-like functions?
Q40970406Contacts in context: promoter specificity and macromolecular interactions in transcription
Q40999474Control of transcription by steroid hormones
Q33671418Cooperative assembly of RNA polymerase II transcription complexes
Q71841189Core promoter elements are essential as selective determinants for function of the yeast transcription factor GAL11
Q42435364Critical role of the second stirrup region of the TATA-binding protein for transcriptional activation both in yeast and human
Q74263600Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH
Q27939285Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast
Q60073666Cyclins in initiation
Q39575245DA-complex assembly activity required for VP16C transcriptional activation
Q43749179DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates
Q33886575Developmentally regulated initiation of DNA synthesis by telomerase: evidence for factor-assisted de novo telomere formation
Q39539576Differences in determinants required for complex formation and transactivation in related VP16 proteins
Q28207943Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II
Q27930411Direct interaction of RNA polymerase II and mediator required for transcription in vivo.
Q28115255Direct interaction of TFIIB and the IE protein of equine herpesvirus 1 is required for maximal trans-activation function
Q28131632Dissecting the regulatory circuitry of a eukaryotic genome
Q34179615Dissection of transcription factor TFIIF functional domains required for initiation and elongation
Q27939905Dissociable Rpb4-Rpb7 subassembly of rna polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation.
Q41076983Distinct activated and non-activated RNA polymerase II complexes in yeast
Q28209264Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme
Q37380380Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.
Q33969120Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes
Q33967777Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters
Q35910114Emerging Views on the CTD Code
Q33361712Epigenomics and bolting tolerance in sugar beet genotypes
Q33970848Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes
Q36178456Evidence for a mediator cycle at the initiation of transcription.
Q28216498Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man
Q30700508Evidence that TAF-TATA box-binding protein interactions are required for activated transcription in mammalian cells
Q27934996Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo
Q34594401Experimentally determined weight matrix definitions of the initiator and TBP binding site elements of promoters
Q36623298Extensive purification of a putative RNA polymerase I holoenzyme from plants that accurately initiates rRNA gene transcription in vitro
Q22003918FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO
Q24546284Factors associated with the mammalian RNA polymerase II holoenzyme
Q24554477Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex
Q27937030Fluorescence-based analyses of the effects of full-length recombinant TAF130p on the interaction of TATA box-binding protein with TATA box DNA.
Q58696257Functional analysis of the Ume3p/ Srb11p-RNA polymerase II holoenzyme interaction
Q52668783Functional and physical interactions within the middle domain of the yeast mediator.
Q27939623Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo
Q27935993Functional connections between mediator components and general transcription factors of Saccharomyces cerevisiae
Q36421299Functional conservation of the glutamine-rich domains of yeast Gal11 and human SRC-1 in the transactivation of glucocorticoid receptor Tau 1 in Saccharomyces cerevisiae
Q42453747Functional correlation among Gal11, transcription factor (TF) IIE, and TFIIH in Saccharomyces cerevisiae. Gal11 and TFIIE cooperatively enhance TFIIH-mediated phosphorylation of RNA polymerase II carboxyl-terminal domain sequences
Q34602774Functional interaction between TFIIB and the Rpb9 (Ssu73) subunit of RNA polymerase II in Saccharomyces cerevisiae
Q28143389Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68
Q27935484Functional interactions within yeast mediator and evidence of differential subunit modifications
Q91828974Functional interplay between Mediator and RNA polymerase II in Rad2/XPG loading to the chromatin
Q36412489Functional metabolomics as a tool to analyze Mediator function and structure in plants
Q39574441Functional relationships of Srb10-Srb11 kinase, carboxy-terminal domain kinase CTDK-I, and transcriptional corepressor Ssn6-Tup1.
Q40793485Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.
Q24533173Functional studies of the carboxy-terminal repeat domain of Drosophila RNA polymerase II in vivo
Q34309986GAL4 interacts with TATA-binding protein and coactivators
Q41675693Gene regulation by the yeast Ssn6-Tup1 corepressor
Q24561963General requirement for RNA polymerase II holoenzymes in vivo
Q34610050Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast
Q40056449Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae.
Q35036891Genome-wide computational prediction and analysis of core promoter elements across plant monocots and dicots
Q41100105Global steps during initiation by RNA polymerase II.
Q34524536Gradual phosphorylation regulates PC4 coactivator function
Q40015882HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae
Q51687001HSI2 Repressor Recruits MED13 and HDA6 to Down-Regulate Seed Maturation Gene Expression Directly During Arabidopsis Early Seedling Growth.
Q43872500Head module control of mediator interactions
Q39631335Heat shock factor increases the reinitiation rate from potentiated chromatin templates.
Q45764450Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5.
Q33812313Herpes simplex virus type 1 ICP4 promotes transcription preinitiation complex formation by enhancing the binding of TFIID to DNA
Q24647364Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation
Q33957262Histone acetyltransferase and protein kinase activities copurify with a putative Xenopus RNA polymerase I holoenzyme self-sufficient for promoter-dependent transcription
Q77652527Histone-like TAFs are essential for transcription in vivo
Q27934566Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA polymerase II holoenzyme.
Q24310197Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation
Q24324051Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors
Q35661538Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors
Q24310867Human mediator subunit MED26 functions as a docking site for transcription elongation factors
Q48038615Identification and analysis of homologues of Saccharomyces cerevisiae Spt3 suggest conserved functional domains
Q33958879Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae
Q28587897Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation
Q46042839Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme
Q41296506Identification of a Transactivation Function in the Progesterone Receptor That Interacts with the TAFII110 Subunit of the TFIID Complex
Q24651940Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex
Q22253992Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb
Q35190927Identification of an autonomously initiating RNA polymerase III holoenzyme containing a novel factor that is selectively inactivated during protein synthesis inhibition
Q33965153Identification of genes required for alpha 2 repression in Saccharomyces cerevisiae
Q52566722Identification of highly conserved amino-terminal segments of dTAFII230 and yTAFII145 that are functionally interchangeable for inhibiting TBP-DNA interactions in vitro and in promoting yeast cell growth in vivo.
Q27940073Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae
Q58322274Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome
Q27931755Identification of the gene (SSU71/TFG1) encoding the largest subunit of transcription factor TFIIF as a suppressor of a TFIIB mutation in Saccharomyces cerevisiae
Q40019304Identifying a species-specific region of yeast TF11B in vivo
Q22009365Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
Q22008534Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes
Q71747838Immunoaffinity purification of RNA polymerase II and transcription factors using polyol-responsive monoclonal antibodies
Q74326166Immunoaffinity purification of the human multisubunit transcription factor IIH
Q27938987Impaired core promoter recognition caused by novel yeast TAF145 mutations can be restored by creating a canonical TATA element within the promoter region of the TUB2 gene
Q42264268Improving Saccharomyces cerevisiae ethanol production and tolerance via RNA polymerase II subunit Rpb7.
Q24551113In vivo requirement of activator-specific binding targets of mediator
Q28207045Independent recruitment in vivo by Gal4 of two complexes required for transcription
Q44991848Interaction between acidic transcriptional activation domains of herpes simplex virus activator protein VP16 and transcriptional initiation factor IID.
Q41791540Interaction of PC4 with melted DNA inhibits transcription
Q22254261Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes
Q27938465Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression
Q28249621Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators
Q24654156Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF
Q24313335Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor
Q24301521Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP)
Q42137229Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes
Q33775117Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme
Q27935508Isolation and characterization of TAF25, an essential yeast gene that encodes an RNA polymerase II-specific TATA-binding protein-associated factor
Q22008025Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation
Q28586142Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription
Q38929299Kin28 regulates the transient association of Mediator with core promoters
Q42058280Kinase activity and phosphorylation of the largest subunit of TFIIF transcription factor
Q84534876Knockdown of NtMed8, a Med8-like gene, causes abnormal development of vegetative and floral organs in tobacco (Nicotiana tabacum L.).
Q34318190MC EMiNEM maps the interaction landscape of the Mediator
Q24554446MCM proteins are associated with RNA polymerase II holoenzyme
Q37484442MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators
Q40020073Mad proteins contain a dominant transcription repression domain.
Q38077643Mechanisms of Mediator complex action in transcriptional activation.
Q34806650Mechanisms of basal and kinase-inducible transcription activation by CREB.
Q33892757Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions.
Q41066911Mechanisms of transcription complex assembly
Q41441677Mechanisms of transcriptional activation: differences and similarities between yeast, Drosophila, and man.
Q41439676Mechanisms of transcriptional regulation and neural gene expression
Q27933388Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes
Q41627698Mediator binds to boundaries of chromosomal interaction domains and to proteins involved in DNA looping, RNA metabolism, chromatin remodeling, and actin assembly.
Q47383454Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.
Q26800203Mediator kinase module and human tumorigenesis
Q34790743Mediator protein mutations that selectively abolish activated transcription
Q42508865Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock
Q33947315Mitotic recombination in yeast: elements controlling its incidence
Q27934831Molecular characterization of Saccharomyces cerevisiae TFIID.
Q39528206Molecular genetic dissection of TAF25, an essential yeast gene encoding a subunit shared by TFIID and SAGA multiprotein transcription factors
Q29620260Molecular genetics of the RNA polymerase II general transcriptional machinery
Q34597589Molecular weight determination of plasmid DNA using electrospray ionization mass spectrometry
Q22122454Multi-protein complexes in eukaryotic gene transcription
Q33957679Multiple layers of cooperativity regulate enhanceosome-responsive RNA polymerase II transcription complex assembly
Q28576482Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120
Q36044214Mutational studies of yeast transcription factor IIB in vivo reveal a functional surface important for gene activation
Q42494682Mutations in the TATA-binding protein, affecting transcriptional activation, show synthetic lethality with the TAF145 gene lacking the TAF N-terminal domain in Saccharomyces cerevisiae
Q42524559Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair
Q28282085NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
Q71533736New chemistry for the study of multiprotein complexes: the six-histidine tag as a receptor for a protein crosslinking reagent
Q40731209Novel Mediator proteins of the small Mediator complex in Drosophila SL2 cells
Q33757699Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
Q28074780Nucleosome distortion as a possible mechanism of transcription activation domain function
Q46552388Nucleotide requirements for activated RNA polymerase II open complex formation in vitro
Q50457007PHYTOCHROME AND FLOWERING TIME1/MEDIATOR25 Regulates Lateral Root Formation via Auxin Signaling in Arabidopsis
Q36557179Paf1p, an RNA polymerase II-associated factor in Saccharomyces cerevisiae, may have both positive and negative roles in transcription
Q36788358Partial truncation of the yeast RNA polymerase II carboxyl-terminal domain preferentially reduces expression of glycolytic genes
Q71000825Phosphorylation dependence of the initiation of productive transcription of Balbiani ring 2 genes in living cells
Q34093159Phosphorylation in transcription: the CTD and more
Q44117541Physical association of the APIS complex and general transcription factors
Q33367783Pieces of the puzzle: assembling the preinitiation complex of Pol II.
Q48362347Plant-plant interactions influence developmental phase transitions, grain productivity and root system architecture in Arabidopsis via auxin and PFT1/MED25 signalling.
Q36332739Polycomb repressive complex 1 (PRC1) disassembles RNA polymerase II preinitiation complexes.
Q24548316Positive and negative TAF(II) functions that suggest a dynamic TFIID structure and elicit synergy with traps in activator-induced transcription
Q47829612Preinitation complex assembly: potentially a bumpy path.
Q44560693Preponderance of free mediator in the yeast Saccharomyces cerevisiae
Q36573810Promoter activity of Tat at steps subsequent to TATA-binding protein recruitment
Q41100064Promoters and basal transcription machinery in eubacteria and eukaryotes: concepts, definitions, and analogies
Q41032848Properties of PC4 and an RNA polymerase II complex in directing activated and basal transcription in vitro
Q45970861Protease footprinting analysis of ternary complex formation by human TFIIA.
Q36288964Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking
Q46216244Purification and characterization of an RNA polymerase II phosphatase from yeast
Q75231661Purification and transcriptional analysis of RNA polymerase I holoenzymes from broccoli (Brassica oleracea) and frog (Xenopus laevis)
Q41100162Purification of yeast RNA polymerase II holoenzymes
Q24317228Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes
Q39446590Quantitation of RNA polymerase II and its transcription factors in an HeLa cell: little soluble holoenzyme but significant amounts of polymerases attached to the nuclear substructure
Q41076429Quantitation of putative activator-target affinities predicts transcriptional activating potentials
Q35182494Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors
Q36649506RAP74 induces promoter contacts by RNA polymerase II upstream and downstream of a DNA bend centered on the TATA box.
Q22008019RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein
Q41350631RNA polymerase II C-terminal domain required for enhancer-driven transcription
Q33632354RNA polymerase II as a control panel for multiple coactivator complexes
Q33905060RNA polymerase II carboxy-terminal domain kinases: emerging clues to their function
Q39035964RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe
Q41477041RNA polymerase II holoenzyme and transcriptional regulation
Q70908581RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling
Q73205344RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter
Q34067671RNA polymerase II holoenzymes and subcomplexes.
Q58701536RNA polymerase II transcription complex assembly in nuclear extracts
Q27933821RSC, an essential, abundant chromatin-remodeling complex
Q36555479Recruiting TATA-binding protein to a promoter: transcriptional activation without an upstream activator
Q34011557Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation
Q27631291Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain
Q28646829Recycling of the general transcription factors during RNA polymerase II transcription
Q34011585Region of yeast TAF 130 required for TFIID to associate with promoters
Q54228372Regulation of Mammalian Ribosomal Gene Transcription by RNA Polymerase I
Q77485523Regulatory targets in the RNA polymerase II holoenzyme
Q28289887Requirement for TFIIH kinase activity in transcription by RNA polymerase II
Q32036964Requirement for a functional interaction between mediator components Med6 and Srb4 in RNA polymerase II transcription
Q36567515Retinoid X receptor:vitamin D3 receptor heterodimers promote stable preinitiation complex formation and direct 1,25-dihydroxyvitamin D3-dependent cell-free transcription
Q36556040Reversal of in vitro p53 squelching by both TFIIB and TFIID
Q33964585Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence
Q33671382Role of general and gene-specific cofactors in the regulation of eukaryotic transcription
Q73947536Rpb4, a non-essential subunit of core RNA polymerase II of Saccharomyces cerevisiae is important for activated transcription of a subset of genes
Q27929864SPN1, a conserved gene identified by suppression of a postrecruitment-defective yeast TATA-binding protein mutant
Q27933314SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II
Q27933054SUG1, a component of the 26 S proteasome, is an ATPase stimulated by specific RNAs
Q42439710Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription
Q34472506Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module
Q58422699Simplifying the complex
Q37228807Single molecule microscopy reveals mechanistic insight into RNA polymerase II preinitiation complex assembly and transcriptional activity
Q36710832Sir2 silences gene transcription by targeting the transition between RNA polymerase II initiation and elongation
Q37073125Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid
Q74754870Small-molecule-based strategies for controlling gene expression
Q41980416Spe3, which encodes spermidine synthase, is required for full repression through NRE(DIT) in Saccharomyces cerevisiae
Q90471342Specific functions for Mediator complex subunits from different modules in the transcriptional response of Arabidopsis thaliana to abiotic stress
Q33903270Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription
Q24540125Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD
Q36254517Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-mRNA
Q27933861Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1.
Q36724531Strong transcriptional activators isolated from viral DNA by the 'activator trap', a novel selection system in mammalian cells
Q42041363Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator
Q35669885Structure and function of the TFIID complex
Q27666838Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation
Q24304075Subcellular localization of RPB5-mediating protein and its putative functional partner
Q24633293Subunit architecture of general transcription factor TFIIH
Q41932256Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II
Q36300660Synergistic and promoter-selective activation of transcription by recruitment of transcription factors TFIID and TFIIB.
Q41064463Synergistic enhancement of both initiation and elongation by acidic transcription activation domains.
Q27938743Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo
Q42459088TAFII-independent activation mediated by human TBP in the presence of the positive cofactor PC4
Q28581872TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism
Q33962132TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo
Q40791931TATA-binding protein-associated factors enhance the recruitment of RNA polymerase II by transcriptional activators
Q37695809TBP mutants defective in activated transcription in vivo.
Q33832058TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes
Q42522148TBP-associated factors are not generally required for transcriptional activation in yeast
Q34718574TFIIA plays a role in the response to oxidative stress
Q34654319TFIIB and the regulation of transcription by RNA polymerase II.
Q40018632TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4.
Q35207267TFIID-specific yeast TAF40 is essential for the majority of RNA polymerase II-mediated transcription in vivo
Q28116305Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription
Q27934702Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases
Q33753938Tfg3, a subunit of the general transcription factor TFIIF in Schizosaccharomyces pombe, functions under stress conditions
Q28570708The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins
Q52119435The C-terminal domain of the largest subunit of RNA polymerase II is required for stationary phase entry and functionally interacts with the Ras/PKA signaling pathway.
Q33887586The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex
Q33772811The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex
Q48874029The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans
Q24609120The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain
Q27937894The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression.
Q28299679The Mediator complex and transcription regulation
Q35131077The Mediator complex of Caenorhabditis elegans: insights into the developmental and physiological roles of a conserved transcriptional coregulator
Q36119053The Mediator complex subunit 8 regulates organ size in Arabidopsis thaliana
Q28623816The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1
Q28623435The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc
Q37671309The Paf1 complex: platform or player in RNA polymerase II transcription?
Q29622942The RNA polymerase II holoenzyme and its implications for gene regulation
Q39721405The RNA polymerase II preinitiation complex formed in the presence of ATP
Q27939572The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo.
Q24298533The TBN Protein, which Is Essential for Early Embryonic Mouse Development, Is an Inducible TAFII Implicated In Adipogenesis
Q24336424The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor
Q33794695The activation domain of GAL4 protein mediates cooperative promoter binding with general transcription factors in vivo
Q28248516The ancient regulatory-protein family of WD-repeat proteins
Q78680279The co-activator p300 associates physically with and can mediate the action of the distal enhancer of the FGF-4 gene
Q24598984The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation
Q41756430The estrogen receptor gene: promoter organization and expression
Q35805081The eukaryotic Ccr4-not complex: a regulatory platform integrating mRNA metabolism with cellular signaling pathways?
Q28619324The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter
Q24600925The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
Q27930236The histone H3-like TAF is broadly required for transcription in yeast
Q22001483The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex
Q28304955The mammalian Mediator complex
Q35669882The mediator complex
Q43293809The mediator complex subunit PFT1 is a key regulator of jasmonate-dependent defense in Arabidopsis
Q46371249The photoactivated cross-linking of recombinant C-terminal domain to proteins in a HeLa cell transcription extract that comigrate with transcription factors IIE and IIF.
Q35887891The product of the adenovirus intermediate gene IX is a transcriptional activator.
Q25255839The proteasomal ATPase complex is required for stress-induced transcription in yeast
Q39681879The role of TFIIB-RNA polymerase II interaction in start site selection in yeast cells
Q40672423The role of activators in assembly of RNA polymerase II transcription complexes
Q41557723The role of chromatin in transcriptional regulation.
Q27932113The rye mutants identify a role for Ssn/Srb proteins of the RNA polymerase II holoenzyme during stationary phase entry in Saccharomyces cerevisiae
Q24652864The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acids
Q27934704The yeast GAL11 protein binds to the transcription factor IIE through GAL11 regions essential for its in vivo function
Q42966231The yeast HRS1 gene encodes a polyglutamine-rich nuclear protein required for spontaneous and hpr1-induced deletions between direct repeats.
Q27932742The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex
Q42629947Three classes of mammalian transcription activation domain stimulate transcription in Schizosaccharomyces pombe
Q24532893Three transitions in the RNA polymerase II transcription complex during initiation
Q41361209Topological localization of the carboxyl-terminal domain of RNA polymerase II in the initiation complex
Q48174606Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly
Q74033390Towards a minimal motif for artificial transcriptional activators
Q38348614Transcription Activation by a PNA-Peptide Chimera in a Mammalian Cell Extract
Q39716921Transcription activation by GC-boxes: evaluation of kinetic and equilibrium contributions
Q47858026Transcription activation via enhanced preinitiation complex assembly in a human cell-free system lacking TAFIIs
Q41046368Transcription factor AP-1, and the role of Fra-2.
Q45730477Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr.
Q41442509Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes
Q29618752Transcription regulation and animal diversity
Q50057687Transcription regulation by the Mediator complex
Q37353465Transcription syndromes and the role of RNA polymerase II general transcription factors in human disease
Q41044026Transcription: basal factors and activation.
Q73159428Transcription: why are TAFs essential?
Q40494477Transcriptional Activation: Tuning-up transcription
Q36573748Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains
Q35058398Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences
Q29615048Transcriptional activation by recruitment
Q40935476Transcriptional activation. A holistic view of the complex.
Q28486904Transcriptional activators control splicing and 3'-end cleavage levels
Q40951549Transcriptional coactivators in yeast and beyond
Q24554483Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner
Q24530710Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes
Q36558597Transcriptional corepression in vitro: a Mot1p-associated form of TATA-binding protein is required for repression by Leu3p
Q73019085Transcriptional enhancement by acidic activators
Q33904338Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
Q35964659Transcriptional regulation: contending with complexity
Q39870080Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.
Q27930891Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF.
Q44341024Two forms of RNA polymerase II holoenzyme display different abundance during the cell cycle.
Q28507179Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice
Q41056225Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair
Q42966234Underproduction of the largest subunit of RNA polymerase II causes temperature sensitivity, slow growth, and inositol auxotrophy in Saccharomyces cerevisiae
Q40423733Unraveling the mechanism of a potent transcriptional activator
Q92684595Unveiling the gene regulatory landscape in diseases through the identification of DNase I-hypersensitive sites
Q27929931Vanishingly low levels of Ess1 prolyl-isomerase activity are sufficient for growth in Saccharomyces cerevisiae
Q40395601Variable pause positions of RNA polymerase II lie proximal to the c-myc promoter irrespective of transcriptional activity.
Q34613177Viral transactivators E1A and VP16 interact with a large complex that is associated with CTD kinase activity and contains CDK8
Q38307266Virtually unidirectional binding of TBP to the AdMLP TATA box within the quaternary complex with TFIIA and TFIIB.
Q42497133Yeast GAL11 protein stimulates basal transcription in a gene-specific manner by a mechanism distinct from that by DNA-bound activators
Q27934583Yeast Gal11 and transcription factor IIE function through a common pathway in transcriptional regulation
Q24563103Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4
Q29622932Yeast carbon catabolite repression
Q33739221Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.
Q33971943Yeast two-hybrid systems and protein interaction mapping projects for yeast and worm
Q73728723[Activation of transcription in eukaryotic cells: interactions between transcription factors and components of the basal transcriptional mechanism]
Q24602633mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain
Q77652532yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complex

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