Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis

scientific article

Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.1158/0008-5472.CAN-07-6655
P3181OpenCitations bibliographic resource ID1423534
P932PMC publication ID2562630
P698PubMed publication ID18593903
P5875ResearchGate publication ID5259356

P50authorCarlo Maria CroceQ640381
Thomas D. SchmittgenQ56867888
Stefano VoliniaQ28324641
P2093author name stringBo Wang
Huban Kutay
Kalpana Ghoshal
Samson T Jacob
Gerard J Nuovo
Sarmila Majumder
Chang-Gong Liu
Jharna Datta
Mohd W Nasser
P2860cites workEUKARYOTIC CYTOSINE METHYLTRANSFERASESQ22255656
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancerQ24564615
DNA methylation and gene silencing in cancerQ36338042
Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expressionQ36459023
Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcriptionQ36459959
Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascadeQ36512697
The Met pathway: master switch and drug target in cancer progressionQ36549360
c-Met and hepatocyte growth factor: potential as novel targets in cancer therapyQ36731520
Mechanisms of microRNA-mediated gene regulation in animal cellsQ36763232
DNA methyltransferases as targets for cancer therapyQ36870920
FOXP1: a potential therapeutic target in cancer.Q36871999
Unraveling the epigenetic code of cancer for therapyQ36903205
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structureQ39675513
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function.Q40169748
Suppression of metallothionein gene expression in a rat hepatoma because of promoter-specific DNA methylationQ42481666
Analysis of promoter methylation and its role in silencing metallothionein I gene expression in tumor cellsQ44037788
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1.Q44343231
Met-thodologyQ79715135
Downregulation of miR-122 in the rodent and human hepatocellular carcinomasQ24631076
The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 bindingQ24644692
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiationQ24650204
Chromosomal rearrangements and microRNAs: a new cancer link with clinical implicationsQ24683729
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
Identification of tissue-specific microRNAs from mouseQ27860892
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Q27860893
MicroRNA signatures in human cancersQ27860962
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAsQ27861053
Switching from repression to activation: microRNAs can up-regulate translationQ28131790
DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsQ28212826
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and preventionQ28240437
Histone deacetylases and cancerQ28240447
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cellsQ28245307
Human FOX gene family (Review)Q28288603
Genetic unmasking of an epigenetically silenced microRNA in human cancer cellsQ28288806
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2Q28295844
Hepatocellular carcinoma: epidemiology and molecular carcinogenesisQ28306363
5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signalQ28384242
A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 ratsQ28566367
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatomaQ28572444
Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cellsQ28580458
DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2Q28584099
MicroRNA biogenesis: coordinated cropping and dicingQ29547496
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesisQ29547607
Phenotypic plasticity and the epigenetics of human diseaseQ29614515
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancerQ29615066
Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomasQ33193334
Regulation of metallothionein gene expressionQ34070583
Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatinQ34188997
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotypeQ34619635
Reversal of gene silencing as a therapeutic target for cancer--roles for DNA methylation and its interdigitation with chromatinQ35788665
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
gene silencingQ1431332
carcinogenesisQ1637543
P304page(s)5049-58
P577publication date2008-07-01
P1433published inCancer ResearchQ326097
P1476titleMethylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis
P478volume68

Reverse relations

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Q33675855PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.
Q92220024Photoradiosynthesis of 68Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors
Q40305547Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370.
Q38070490Potential applications of miRNAs as diagnostic and prognostic markers in liver cancer
Q38067621Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies
Q34102579Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis
Q51541233Prognostic significance of FOXP1 as an oncogene in hepatocellular carcinoma.
Q33275146Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma
Q30989557Proteomic identification of microRNA-122a target proteins in hepatocellular carcinoma.
Q98287691Regulation of DNA methylation machinery by epi-miRNAs in human cancer: emerging new targets in cancer therapy
Q28077331Regulation of class IIa HDAC activities: it is not only matter of subcellular localization
Q34803043Regulation of glucose metabolism in hepatocarcinogenesis by microRNAs
Q38153384Regulation of hepatitis B virus replication by epigenetic mechanisms and microRNAs
Q39030944Regulation of microRNA-1 (miR-1) expression in human cancer
Q37418150Regulation of microRNAs by epigenetics and their interplay involved in cancer
Q38746401Regulation of the MET oncogene: molecular mechanisms
Q38885469Relationship Between Noncoding RNA Dysregulation and Epigenetic Mechanisms in Cancer
Q84106401Repression of transposable-elements - a microRNA anti-cancer defense mechanism?
Q39561328Restoration of miR-517a expression induces cell apoptosis in bladder cancer cell lines
Q34389406Retracted: The Effect of miR-338-3p on HBx Deletion-Mutant (HBx-d382) Mediated Liver-Cell Proliferation through CyclinD1 Regulation
Q92705196Reversible photo-cross-linking of the GCN4 peptide containing 3-cyanovinylcarbazole amino acid to double-stranded DNA
Q27023524Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma
Q52743958Role of miR-1 expression in clear cell renal cell carcinoma (ccRCC): A bioinformatics study based on GEO, ArrayExpress microarrays and TCGA database.
Q38264776Role of miRNA in head and neck squamous cell carcinoma
Q33737275Role of microRNA-1 in human cancer and its therapeutic potentials
Q24657152Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice
Q38190418Role of microRNAs in malignant mesothelioma.
Q42555454Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors
Q37376378Roles of microRNAs in the hepatitis B virus infection and related diseases
Q26795757Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease
Q33924619SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation
Q38441349Screening for genes, transcription factors and miRNAs associated with the myogenic and osteogenic differentiation of human adipose tissue-derived stem cells
Q34151439Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma
Q54439228Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer.
Q44500035Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma
Q35070602Shielding the messenger (RNA): microRNA-based anticancer therapies
Q39319151Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer
Q37753238Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis
Q38777547Suberoylanilide hydroxamic acid inhibits growth of head and neck cancer cell lines by reactivation of tumor suppressor microRNAs
Q36629543Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies
Q33793560Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution
Q33754007TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.
Q42182089Targeted delivery of tumor suppressor microRNA-1 by transferrin-conjugated lipopolyplex nanoparticles to patient-derived glioblastoma stem cells
Q51650211Targeting Apoptosis Through Foxp1, and N-cadherin with Glatiramer Acetate in Chick Embryos During Neural Tube Development.
Q34205088Targeting Notch signaling pathway to overcome drug resistance for cancer therapy
Q38744551Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol
Q37296159Targeting histone deacetylases for the treatment of disease
Q36021066Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression
Q57001209The Emerging Role of MicroRNAs in Hepatocellular Carcinoma
Q49562931The Importance of miRNAs and Epigenetics in Acute Lymphoblastic Leukemia Prognosis.
Q97561930The Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways
Q38723285The PI3K/mTOR dual inhibitor BEZ235 suppresses proliferation and migration and reverses multidrug resistance in acute myeloid leukemia
Q91469110The Regulatory Role of MicroRNA in Hepatitis-B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) Pathogenesis
Q24629522The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders
Q38109410The epigenetic feedback loop between DNA methylation and microRNAs in fibrotic disease with an emphasis on DNA methyltransferases
Q38054883The expression patterns and clinical significance of microRNAs in liver diseases and hepatocellular carcinoma
Q39508843The functional significance of miR-1 and miR-133a in renal cell carcinoma
Q27003050The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update
Q37286651The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation
Q27014062The parallel universe: microRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis
Q40928109The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer
Q39877545The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.
Q38056415The role and clinical implications of microRNAs in hepatocellular carcinoma
Q55387493The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer.
Q38213933The role of micro-RNAs in hepatocellular carcinoma: from molecular biology to treatment.
Q37601781The role of microRNAs in endometriosis and associated reproductive conditions
Q26861699The role of microRNAs in human liver cancers
Q37974141The role of microRNAs in liver cancer
Q34543731The role of microRNAs in liver cancer progression.
Q38210729The role of vitamins and minerals in modulating the expression of microRNA.
Q34163386The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer
Q38054873Therapeutically targeting microRNAs in liver cancer
Q37799251Towards novel paradigms for cancer therapy.
Q36966903Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.
Q36766784Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer
Q43147470Transcriptional activation of the IGF-II/IGF-1R axis and inhibition of IGFBP-3 by miR-155 in hepatocellular carcinoma.
Q34318106Transcriptional and epigenetic regulation of human microRNAs
Q38139824Transcriptional and epigenetic regulation of neural crest induction during neurulation
Q39426763Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer
Q34251059Tumor suppressive microRNA-1285 regulates novel molecular targets: aberrant expression and functional significance in renal cell carcinoma
Q41091875Tumor suppressor miR-1 inhibits tumor growth and metastasis by simultaneously targeting multiple genes
Q37982793Tumor-suppressive microRNA silenced by tumor-specific DNA hypermethylation in cancer cells
Q36889632Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.
Q91810080Unmasking the pathological and therapeutic potential of histone deacetylases for liver cancer
Q28389159Unraveling 50-Year-Old Clues Linking Neurodegeneration and Cancer to Cycad Toxins: Are microRNAs Common Mediators?
Q64271788Upregulation of FoxP4 in HCC promotes migration and invasion through regulation of EMT
Q38913245Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma
Q94597594Upregulation of microRNA‑1 inhibits proliferation and metastasis of breast cancer
Q45426468Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer
Q52369050circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways.
Q33802900miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer
Q35640157miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma
Q28397782miR-1 induces growth arrest and apoptosis in malignant mesothelioma
Q38795917miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma
Q53694593miR-1-3p and miR-206 sensitizes HGF-induced gefitinib-resistant human lung cancer cells through inhibition of c-Met signalling and EMT.
Q64063248miR-1-3p suppresses proliferation of hepatocellular carcinoma through targeting SOX9
Q100395970miR-100 inhibits cell proliferation in mantle cell lymphoma by targeting mTOR
Q35008738miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma
Q28579456miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival
Q34125608miR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27(Kip1)- and MEK/ERK-mediated cell cycle regulation
Q39143346miR-224 functions as an onco-miRNA in hepatocellular carcinoma cells by activating AKT signaling
Q39125538miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2.
Q92020429miR-639 Expression Is Silenced by DNMT3A-Mediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells
Q39472687miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line
Q37394073miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1.
Q33954625microRNA and cancer
Q37873513microRNA involvement in hepatocellular carcinoma
Q34252329microRNA-1/133a and microRNA-206/133b clusters: dysregulation and functional roles in human cancers
Q35840197microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cɛ.
Q53181847microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect.
Q38224238microRNA-133: expression, function and therapeutic potential in muscle diseases and cancer
Q49254805microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma.
Q38175875microRNA: a promising diagnostic biomarker and therapeutic target for hepatocellular carcinoma
Q35011762microRNA: emerging therapeutic targets in acute ischemic diseases
Q90400723microRNAs: Key players in virus-associated hepatocellular carcinoma

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