| scholarly article | Q13442814 |
| P50 | author | Yigong Shi | Q8053577 |
| P2093 | author name string | Muyang Li | |
| Wei Gu | |||
| Min Hu | |||
| Lichuan Gu | |||
| Philip D Jeffrey | |||
| P2860 | cites work | Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 | Q22253350 |
| A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains | Q24291050 | ||
| Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization | Q24292930 | ||
| Downstream regulator TANK binds to the CD40 recognition site on TRAF3 | Q24297105 | ||
| Distinct molecular mechanism for initiating TRAF6 signalling | Q24302174 | ||
| Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 | Q24303581 | ||
| Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain | Q24314763 | ||
| Mdm2 promotes the rapid degradation of p53 | Q24322597 | ||
| Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 | Q24328775 | ||
| Molecular basis for CD40 signaling mediated by TRAF3 | Q24656208 | ||
| Improved methods for building protein models in electron density maps and the location of errors in these models | Q26776980 | ||
| Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination | Q26778405 | ||
| Processing of X-ray diffraction data collected in oscillation mode | Q26778468 | ||
| Structural basis for self-association and receptor recognition of human TRAF2 | Q27617947 | ||
| The structural basis for the recognition of diverse receptor sequences by TRAF2 | Q27619945 | ||
| Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde | Q27640257 | ||
| Regulation of p53 stability by Mdm2 | Q27860744 | ||
| p53, the cellular gatekeeper for growth and division | Q27860990 | ||
| N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation | Q72194418 | ||
| Signaling to p53: breaking the MDM2-p53 circuit | Q77430977 | ||
| Deconstruction of p53 functions and regulation | Q78560235 | ||
| The CCP4 suite: programs for protein crystallography | Q27861090 | ||
| Surfing the p53 network | Q28032484 | ||
| Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase | Q28139082 | ||
| Deubiquitinating enzymes--the importance of driving in reverse along the ubiquitin-proteasome pathway | Q28188326 | ||
| Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP | Q28204725 | ||
| Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization | Q28243346 | ||
| A dynamic role of HAUSP in the p53-Mdm2 pathway | Q28253645 | ||
| Tumour suppression: disruption of HAUSP gene stabilizes p53 | Q28254102 | ||
| Amplification of a gene encoding a p53-associated protein in human sarcomas | Q28270924 | ||
| The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation | Q28280958 | ||
| Mechanism and function of deubiquitinating enzymes | Q28295758 | ||
| HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized | Q28579703 | ||
| The p53-mdm-2 autoregulatory feedback loop | Q28609811 | ||
| Mapping of the p53 and mdm-2 Interaction Domains | Q28609886 | ||
| Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 | Q29615851 | ||
| AMoRe: an automated package for molecular replacement | Q29642803 | ||
| Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7. | Q30941966 | ||
| Correlated phasing of multiple isomorphous replacement data | Q33205560 | ||
| Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome | Q33975534 | ||
| The p53-Mdm2 module and the ubiquitin system. | Q35036580 | ||
| Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation | Q35089377 | ||
| Deubiquitinating enzymes as cellular regulators | Q35207963 | ||
| Regulating the p53 system through ubiquitination | Q35691573 | ||
| HAUSP is required for p53 destabilization | Q40561105 | ||
| Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential | Q41451986 | ||
| Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination. | Q42617203 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | e27 | |
| P577 | publication date | 2006-01-17 | |
| P1433 | published in | PLOS Biology | Q1771695 |
| P1476 | title | Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway | |
| P478 | volume | 4 |
| Q51658298 | (1)H, (13)C and (15)N backbone resonance assignment for the 40.5 kDa catalytic domain of Ubiquitin Specific Protease 7 (USP7). |
| Q27680523 | A Role for USP7 in DNA Replication |
| Q39991228 | A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model |
| Q35489050 | A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses |
| Q34649757 | A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation |
| Q34385189 | ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53. |
| Q33791305 | Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. |
| Q34056449 | Autoactivation of the MDM2 E3 ligase by intramolecular interaction |
| Q27675410 | Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein |
| Q42917799 | C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site |
| Q92618327 | Clinical significance of USP7 and EZH2 in predicting prognosis of laryngeal squamous cell carcinoma and their possible functional mechanism |
| Q33951142 | Computational methods for de novo protein design and its applications to the human immunodeficiency virus 1, purine nucleoside phosphorylase, ubiquitin specific protease 7, and histone demethylases |
| Q27003831 | Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival |
| Q58708548 | Control of DNA Replication Initiation by Ubiquitin |
| Q28547943 | Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7 |
| Q38911123 | DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer |
| Q37538046 | DUBs at a glance |
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| Q36536984 | Deubiquitinating enzymes as novel anticancer targets |
| Q36732782 | Deubiquitination in virus infection |
| Q36232579 | Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling |
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| Q21131571 | EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication |
| Q38597231 | EBNA1. |
| Q52593708 | EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers. |
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| Q37311332 | Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stability through its deubiquitinating activity. |
| Q40155261 | Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma |
| Q58116151 | Identification and Characterization of USP7 Targets in Cancer Cells |
| Q38801652 | Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7. |
| Q33802926 | Inactivation of HAUSP in vivo modulates p53 function |
| Q34097947 | Inhibition of interferon induction and action by the nairovirus Nairobi sheep disease virus/Ganjam virus |
| Q37500984 | K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression |
| Q60907800 | Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity |
| Q34296531 | Mechanism of p53 stabilization by ATM after DNA damage |
| Q28075457 | Modulation of the p53/MDM2 interplay by HAUSP inhibitors |
| Q27646751 | Molecular Basis for Bre5 Cofactor Recognition by the Ubp3 Deubiquitylating Enzyme |
| Q35609022 | Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. |
| Q34758670 | New insights into p53 activation |
| Q33307875 | Patented small molecule inhibitors in the ubiquitin proteasome system |
| Q96348276 | Regulating tumor suppressor genes: post-translational modifications |
| Q35098801 | Roles of HAUSP-mediated p53 regulation in central nervous system development |
| Q34579190 | SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization |
| Q36544196 | STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation |
| Q64234008 | Small molecule activators of the p53 response |
| Q41992139 | Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair |
| Q36951802 | Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis |
| Q37269483 | Strategies for the identification of novel inhibitors of deubiquitinating enzymes |
| Q27661081 | Structural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase Module |
| Q38847962 | Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1. |
| Q80100153 | Structural basis of ubiquitin recognition by the deubiquitinating protease USP2 |
| Q38936001 | Structural insights into the coordination of plastid division by the ARC6-PDV2 complex. |
| Q35022820 | Structural insights into the tumor-promoting function of the MTDH-SND1 complex. |
| Q54352725 | Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway. |
| Q33721242 | TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability |
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| Q37323654 | The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth |
| Q38166365 | The Epstein-Barr Virus EBNA1 Protein |
| Q36387600 | The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53. |
| Q27932371 | The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiae |
| Q46666141 | The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila. |
| Q24296502 | The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 |
| Q37862125 | The multifaceted roles of USP7: new therapeutic opportunities |
| Q43118033 | The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP. |
| Q28118567 | The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7 |
| Q58690927 | The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel |
| Q37143739 | The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X |
| Q24304871 | The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-catenin |
| Q36086767 | The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNA |
| Q24296967 | USP10 regulates p53 localization and stability by deubiquitinating p53 |
| Q24300434 | USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 |
| Q98771728 | USP7 Is a Master Regulator of Genome Stability |
| Q63246433 | USP7 Regulates Cytokinesis through FBXO38 and KIF20B |
| Q38931404 | USP7 controls Chk1 protein stability by direct deubiquitination |
| Q38918184 | USP7 cooperates with SCML2 to regulate the activity of PRC1. |
| Q50290334 | USP7 deubiquitinates MDM2 |
| Q50290335 | USP7 deubiquitinates TP53 and counteracts MDM2 |
| Q90100499 | USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin |
| Q96828977 | USP7 manipulation by viral proteins |
| Q33707419 | USP7/HAUSP Promotes the Sequence-Specific DNA Binding Activity of p53 |
| Q51665623 | USP7/HAUSP: A SUMO deubiquitinase at the heart of DNA replication. |
| Q64079043 | USP7: Novel Drug Target in Cancer Therapy |
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| Q37875076 | Ubiquitin-specific proteases as cancer drug targets |
| Q33815907 | WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway |
| Q39061575 | p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3. |
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