EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers.

scientific article published on 6 April 2018

EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers. is …
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scholarly articleQ13442814

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P356DOI10.3390/CANCERS10040109
P932PMC publication ID5923364
P698PubMed publication ID29642420

P50authorMarc BlondelQ56423155
Henri GruffatQ61106762
Evelyne ManetQ43113835
P2093author name stringPierre Busson
Robin Fahraeus
Joanna B Wilson
P2860cites workHMG1 and 2: architectural DNA-binding proteinsQ22121969
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilizationQ24292930
ORC binding to TRF2 stimulates OriP replicationQ24294674
Molecular recognition of p53 and MDM2 by USP7/HAUSPQ24304312
RNA-dependent recruitment of the origin recognition complexQ24336965
EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance.Q24517055
EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinasesQ24529069
Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic miceQ24562912
An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactionsQ24614360
Global mapping of c-Myc binding sites and target gene networks in human B cellsQ24675083
EBNA1 partitions Epstein-Barr virus plasmids in yeast cells by attaching to human EBNA1-binding protein 2 on mitotic chromosomesQ24675498
The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.Q52122308
Lymphomas driven by Epstein-Barr virus nuclear antigen-1 (EBNA1) are dependant upon Mdm2.Q54228841
Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the NasopharynxQ56689988
Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2FQ73925270
Human CD8+ T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processingQ74045603
The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma lineQ74083363
Establishment of VCA and EBNA1 IgA-based combination by enzyme-linked immunosorbent assay as preferred screening method for nasopharyngeal carcinoma: a two-stage design with a preliminary performance study and a mass screening in southern ChinaQ84821085
Epstein-Barr virus and gastric carcinomaQ93889525
Epstein-Barr virus nuclear antigen-1 renders lymphocytes responsive to IL-2 but not IL-15 for survival.Q45389759
Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III.Q45412522
DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1Q45715501
Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virusQ45721968
Reactivity with A monoclonal antibody to Epstein-Barr virus (EBV) nuclear antigen 1 defines a subset of aggressive breast cancers in the absence of the EBV genomeQ45723747
Demonstration of Epstein-Barr virus in carcinomas of various sitesQ45731119
Telomeric proteins regulate episomal maintenance of Epstein-Barr virus origin of plasmid replicationQ45733048
Variation in the sequence of Epstein Barr virus nuclear antigen 1 in normal peripheral blood lymphocytes and in Burkitt's lymphomasQ45769710
Identification of Epstein-Barr virus nuclear antigen 1 protein domains that direct interactions at a distance between DNA-bound proteinsQ45772573
Stabilization of the EBNA1 protein on the Epstein-Barr virus latent origin of DNA replication by a DNA looping mechanism.Q45776796
Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's diseaseQ45782539
Separation of Epstein-Barr virus DNA from large chromosomal DNA in non-virus-producing cells.Q45820444
Epstein-Barr virus-associated complement-fixing and nuclear antigens in Burkitt lymphoma biopsiesQ45826475
Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell linesQ45826585
Expression of Epstein-Barr virus-encoded proteins in nasopharyngeal carcinoma.Q45841044
The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replicationQ45845623
Overproduction, purification, and characterization of EBNA1, the origin binding protein of Epstein-Barr virusQ45854874
PI3Kδ activates E2F1 synthesis in response to mRNA translation stressQ47117105
Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus.Q36828339
Telomere Repeat Binding Factors TRF1, TRF2, and hRAP1 Modulate Replication of Epstein-Barr Virus OriPQ36890221
A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting componentsQ36891387
trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.Q36899288
The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4Q36994613
The c-myc promoter: still MysterY and challengeQ37013896
mRNA translation regulation by the Gly-Ala repeat of Epstein-Barr virus nuclear antigen 1Q37051602
Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomesQ37127891
Gly-Ala repeats induce position- and substrate-specific regulation of 26 S proteasome-dependent partial processingQ37142562
One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine copolymer domainQ37349287
Phosphorylation sites of Epstein-Barr virus EBNA1 regulate its functionQ37450613
Nucleolin is important for Epstein-Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcriptionQ37475294
EBNA1 binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cellsQ37524565
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemiaQ37535238
Antibodies against a synthetic peptide identify the Epstein-Barr virus-determined nuclear antigenQ37560230
The amino terminus of Epstein-Barr Virus (EBV) nuclear antigen 1 contains AT hooks that facilitate the replication and partitioning of latent EBV genomes by tethering them to cellular chromosomesQ37583383
PI3Kδ and primary immunodeficiencies.Q37623828
Small molecule inhibition of Epstein-Barr virus nuclear antigen-1 DNA binding activity interferes with replication and persistence of the viral genomeQ37660246
A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virusQ37682377
Epstein-Barr virus-encoded EBNA1 and ZEBRA: targets for therapeutic strategies against EBV-carrying cancersQ38245881
The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elementsQ38302512
Epstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cellsQ38306265
Binding of myc proteins to canonical and noncanonical DNA sequencesQ38316286
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathwayQ38320884
High affinity interactions of nucleolin with G-G-paired rDNA.Q38324508
G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D, A role for G-G pairing in immunoglobulin switch recombinationQ38329955
Sequence-specific DNA binding by the c-Myc proteinQ38338266
Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factorsQ38340868
Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA.Q38360539
Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptorQ38524452
The long-lasting love affair between the budding yeast Saccharomyces cerevisiae and the Epstein-Barr virusQ38574687
Humanized mouse models for Epstein Barr virus infectionQ38637726
Recent advances in viral evasion of the MHC Class I processing pathwayQ38804445
The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfoldQ24685733
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathwayQ25255608
Structure of RCC1 chromatin factor bound to the nucleosome core particleQ27664183
Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1Q27729477
The 2.2 A structure of a permanganate-sensitive DNA site bound by the Epstein-Barr virus origin binding protein, EBNA1Q27766425
Modulation of the p53/MDM2 interplay by HAUSP inhibitorsQ28075457
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSPQ28204725
Epstein-Barr virus U leader exon contains an internal ribosome entry siteQ28205747
Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by gemininQ28213116
Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalizationQ28243346
A dynamic role of HAUSP in the p53-Mdm2 pathwayQ28253645
Tumour suppression: disruption of HAUSP gene stabilizes p53Q28254102
Signaling by the phosphoinositide 3-kinase family in immune cellsQ28283677
HAUSP/USP7 as an Epstein-Barr virus targetQ28288651
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayQ28608965
RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complexQ28910442
A systems analysis of importin-{alpha}-{beta} mediated nuclear protein importQ30436382
The genetic landscape of mutations in Burkitt lymphomaQ30453771
Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryosQ30476914
Interaction between basic residues of Epstein-Barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenanceQ30543103
Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7.Q30941966
Producing nature's gene-chips: the generation of peptides for display by MHC class I moleculesQ32063827
Human RPA (hSSB) interacts with EBNA1, the latent origin binding protein of Epstein-Barr virusQ32156436
Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1Q33466782
EBNA1 regulates cellular gene expression by binding cellular promotersQ33563969
Promoter-specific targeting of human SWI-SNF complex by Epstein-Barr virus nuclear protein 2.Q33604108
Pathways of antigen processingQ33631854
Epstein-barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt's lymphoma reflect virus strains prevalent in different geographic areas.Q33640115
Transcription profiling of Epstein-Barr virus nuclear antigen (EBNA)-1 expressing cells suggests targeting of chromatin remodeling complexesQ33656437
Epstein-Barr virus provides a survival factor to Burkitt's lymphomasQ33716529
Epstein Barr Virus-Encoded EBNA1 Interference with MHC Class I Antigen Presentation Reveals a Close Correlation between mRNA Translation Initiation and Antigen PresentationQ33728510
Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K.Q40399583
Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1.Q40445894
Protein and sequence requirements for the recruitment of the human origin recognition complex to the latent cycle origin of DNA replication of Epstein-Barr virus oriP.Q40527147
Epstein-Barr virus nuclear antigen 1 (EBNA1) induced cytotoxicity in epithelial cells is associated with EBNA1 degradation and processingQ40637962
Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodelingQ40687983
HCF1 and OCT2 Cooperate with EBNA1 To Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr VirusQ40742979
Regulation of c-myc transcription by interleukin-2 (IL-2). Identification of a novel IL-2 response element interacting with STAT-4.Q40897143
The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cellsQ41112391
Mitotic chromosome interactions of Epstein-Barr nuclear antigen 1 (EBNA1) and human EBNA1-binding protein 2 (EBP2)Q41370670
Identification of integrated Epstein-Barr virus in nasopharyngeal carcinoma using pulse field gel electrophoresisQ41494156
Epstein-Barr nuclear antigen 1 (EBNA1)-dependent recruitment of origin recognition complex (Orc) on oriP of Epstein-Barr virus with purified proteins: stimulation by Cdc6 through its direct interaction with EBNA1.Q41818409
Nucleophosmin contributes to the transcriptional activation function of the Epstein-Barr virus EBNA1 proteinQ41908850
Functions of the Epstein-Barr virus EBNA1 protein in viral reactivation and lytic infectionQ42019706
The latent origin of replication of Epstein-Barr virus directs viral genomes to active regions of the nucleusQ42118228
Modelling the structure of full-length Epstein-Barr virus nuclear antigen 1.Q42206678
Autorepression of Epstein-Barr virus nuclear antigen 1 expression by inhibition of pre-mRNA processingQ42244791
A minimal glycine-alanine repeat prevents the interaction of ubiquitinated I kappaB alpha with the proteasome: a new mechanism for selective inhibition of proteolysisQ42459737
bcl-xL and RAG genes are induced and the response to IL-2 enhanced in EmuEBNA-1 transgenic mouse lymphocytes.Q42681249
Sensitive, high-resolution chromatin and chromosome mapping in situ: presence and orientation of two closely integrated copies of EBV in a lymphoma lineQ42817375
EBNA1 efficiently assembles on chromatin containing the Epstein-Barr virus latent origin of replicationQ43505203
Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance regionQ44286183
Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1.Q44575280
Epstein-Barr-encoded RNA in situ hybridization: diagnostic applicationsQ44895986
Small molecule and peptide-mediated inhibition of Epstein-Barr virus nuclear antigen 1 dimerizationQ45356566
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesisQ36204234
Transcriptional regulation and transformation by Myc proteinsQ36215755
A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cellsQ36263086
Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 ActivityQ36387594
Splicing up mdm2 for cancer proteome diversityQ36387622
Endogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus-encoded nuclear antigen 1.Q36399179
Identification of MEF2B, EBF1, and IL6R as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte SurvivalQ36433955
Interaction between HMGA1a and the origin recognition complex creates site-specific replication originsQ36446490
Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1.Q36541024
Initiation of latent DNA replication in the Epstein-Barr virus genome can occur at sites other than the genetically defined originQ36551194
EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replicationQ36656334
c-Myc enhances protein synthesis and cell size during B lymphocyte developmentQ36668198
Functional domains of Epstein-Barr virus nuclear antigen EBNA-1.Q36682530
The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteinsQ36684853
Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cellsQ36688190
Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcriptsQ36696963
Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition.Q36756835
Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen EBNA-1 with its DNA-binding sitesQ36779998
Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNAQ36806138
A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection.Q36828303
Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism.Q33733617
Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell linesQ33784685
Functional analyses of the EBNA1 origin DNA binding protein of Epstein-Barr virusQ33787020
Epstein-Barr virus serology as a potential screening marker for nasopharyngeal carcinoma among high-risk individuals from multiplex families in TaiwanQ33847952
The replicator of the Epstein-Barr virus latent cycle origin of DNA replication, oriP, is composed of multiple functional elementsQ33848552
Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNAQ33891292
Natural Variation of Epstein-Barr Virus Genes, Proteins, and Primary MicroRNA.Q33907682
Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virusQ33942957
EBV latency types adopt alternative chromatin conformationsQ33987454
Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signalingQ34039568
The Rb/E2F pathway: expanding roles and emerging paradigmsQ34052659
Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1.Q34107917
Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicerQ34261764
Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1.Q34294106
G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translationQ34303299
Separation of the DNA replication, segregation, and transcriptional activation functions of Epstein-Barr nuclear antigen 1.Q34332147
Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathwayQ34347586
Translocations involving c-myc and c-myc functionQ34405431
Premature chromosome condensation is induced by a point mutation in the hamster RCC1 geneQ34419033
Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.Q34467720
The myc oncogene: MarvelouslY ComplexQ34555987
Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cellsQ34564031
Regulation of the EBNA1 Epstein-Barr virus protein by serine phosphorylation and arginine methylationQ34648403
Emerging roles of E2Fs in cancer: an exit from cell cycle controlQ35009182
Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cellsQ35076361
Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genesQ35080523
Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynxQ35119129
Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphomaQ35603098
An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP geneQ35838226
oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.Q35867579
Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosisQ35943704
The AT-hook DNA binding ability of the Epstein Barr virus EBNA1 protein is necessary for the maintenance of viral genomes in latently infected cellsQ36052985
Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine designQ36072450
Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survivalQ36141691
The V-val subtype Epstein-Barr virus nuclear antigen 1 promotes cell survival after serum withdrawal.Q38936952
Mechanisms and regulation of DNA replication initiation in eukaryotesQ39017132
Efficient replication of Epstein-Barr virus-derived plasmids requires tethering by EBNA1 to host chromosomesQ39091793
The linking regions of EBNA1 are essential for its support of replication and transcriptionQ39445473
Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinomaQ39455578
RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor SurveillanceQ39456968
Coupling of mitotic chromosome tethering and replication competence in epstein-barr virus-based plasmidsQ39530529
Expression of epstein-barr virus nuclear antigen 1 is associated with enhanced expression of CD25 in the Hodgkin cell line L428.Q39549562
Mapping EBNA-1 domains involved in binding to metaphase chromosomes.Q39550682
Expression of epstein-barr virus encoded nuclear antigen 1 in benign and malignant tissues harbouring EBV.Q39599529
Promoter-proximal regulatory elements involved in oriP-EBNA1-independent and -dependent activation of the Epstein-Barr virus C promoter in B-lymphoid cell linesQ39603122
Replication from oriP of Epstein-Barr virus requires exact spacing of two bound dimers of EBNA1 which bend DNA.Q39604900
Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell linesQ39612332
Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivinQ39629572
Genome-wide analysis of host-chromosome binding sites for Epstein-Barr Virus Nuclear Antigen 1 (EBNA1).Q39647281
E2F1 inhibits MDM2 expression in a p53-dependent manner.Q39656469
Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodiesQ39666008
Reconstitution of Epstein-Barr virus-based plasmid partitioning in budding yeastQ39696990
Mechanistic studies on the DNA linking activity of Epstein-Barr nuclear antigen 1.Q39725201
Computational analysis of EBNA1 "druggability" suggests novel insights for Epstein-Barr virus inhibitor designQ39743323
Nucleosome assembly proteins bind to Epstein-Barr virus nuclear antigen 1 and affect its functions in DNA replication and transcriptional activationQ39804470
Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachmentQ39816429
Plasmid maintenance of derivatives of oriP of Epstein-Barr virusQ39868910
Multiple regions within EBNA1 can link DNAs.Q39872012
Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatinQ39883316
Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitroQ39927855
Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the proteinQ40016147
A yeast model for the mechanism of the Epstein-Barr virus immune evasion identifies a new therapeutic target to interfere with the virus stealthinessQ40039701
Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell linesQ40044261
Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytesQ40048949
Binding of EBNA-1 to DNA creates a protease-resistant domain that encompasses the DNA recognition and dimerization functionsQ40065691
Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome MaintenanceQ40125313
Epstein-Barr virus (EBV) provides survival factors to EBV+ diffuse large B-cell lymphoma (DLBCL) lines and modulates cytokine induced specific chemotaxis in EBV+ DLBCL.Q40126382
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processingQ40128647
Replication of latent Epstein-Barr virus genomes in Raji cellsQ40132478
Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFbeta signaling pathwaysQ40135893
Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis modelQ40146526
Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men.Q40206465
Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cellsQ40233677
Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycleQ40296910
siRNAs against the Epstein Barr virus latency replication factor, EBNA1, inhibit its function and growth of EBV-dependent tumor cellsQ40341019
Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.Q40375637
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectevasion of host immune responseQ1660157
Epstein–Barr virusQ6900
P577publication date2018-04-06
P1433published inCancersQ27722963
P1476titleEBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers.
P478volume10

Reverse relations

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