Viral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins

scientific article

Viral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/V8070208
P3181OpenCitations bibliographic resource ID4429632
P932PMC publication ID4974542
P698PubMed publication ID27455310

P50authorRichard KormelinkQ38323683
Marcio HedilQ57385087
P2093author name stringRichard Kormelink
Marcio Hedil
P2860cites workViral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platformQ24294301
Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responsesQ24324685
Antiviral silencing in animalsQ24539005
Double-stranded RNA binding may be a general plant RNA viral strategy to suppress RNA silencingQ24546070
Mechanisms of arthropod transmission of plant and animal virusesQ24548551
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysQ24564402
Massive production of small RNAs from a non-coding region of Cauliflower mosaic virus in plant defense and viral counter-defenseQ24597396
Tissue Barriers to Arbovirus Infection in MosquitoesQ24701759
Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiotaQ24701764
RNA interference-mediated antiviral defense in insectsQ24701809
Small Interfering RNA Pathway Modulates Initial Viral Infection in Midgut Epithelium of Insect after Ingestion of VirusQ26314662
Phleboviruses and the Type I Interferon ResponseQ26747457
The evolving world of small RNAs from RNA virusesQ26752449
Insect-Specific Virus Discovery: Significance for the Arbovirus CommunityQ26785945
viral silencing suppressors: Tools forged to fine-tune host-pathogen coexistenceQ27006899
Silencing and innate immunity in plant defense against viral and non-viral pathogensQ27010305
RNAi and antiviral defense in Drosophila: setting up a systemic immune responseQ27026403
Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plantsQ27320962
Nairovirus RNA Sequences Expressed by a Semliki Forest Virus Replicon Induce RNA Interference in Tick CellsQ27470017
La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian HostsQ27480353
Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoesQ27488248
RNAi Targeting of West Nile Virus in Mosquito Midguts Promotes Virus DiversificationQ27488775
Role of Bunyamwera Orthobunyavirus NSs Protein in Infection of Mosquito CellsQ27500261
Size selective recognition of siRNA by an RNA silencing suppressorQ27642862
Structural basis for RNA-silencing suppression by Tomato aspermy virus protein 2bQ27651032
Role for a bidentate ribonuclease in the initiation step of RNA interferenceQ27860832
Interferons and viruses: an evolutionary arms race of molecular interactionsQ28083788
A species of small antisense RNA in posttranscriptional gene silencing in plantsQ28146107
Identification of a novel RNA silencing suppressor, NSs protein of Tomato spotted wilt virusQ28216424
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogasterQ28271770
Evolutionary and phenotypic analysis of live virus isolates suggests arthropod origin of a pathogenic RNA virus familyQ28648106
Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA virusesQ28650411
Degradation of the antiviral component ARGONAUTE1 by the autophagy pathwayQ28727286
Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAsQ28757141
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defenseQ28766178
Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversityQ29041244
Analysis of Tospovirus NSs Proteins in Suppression of Systemic SilencingQ29396772
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathwaysQ29618467
Induction and suppression of RNA silencing by an animal virusQ29618494
Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in DrosophilaQ30556603
The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arbovirusesQ31034150
RNAi in Arthropods: Insight into the Machinery and Applications for Understanding the Pathogen-Vector InterfaceQ37508188
Characterization of a novel Negevirus and a novel Bunyavirus isolated from Culex (Culex) declarator mosquitoes in TrinidadQ37565486
Three distinct suppressors of RNA silencing encoded by a 20-kb viral RNA genomeQ37591797
Mechanisms of recognition in dominant R gene mediated resistance.Q37683089
RNA-based antiviral immunityQ37779725
Viral RNA silencing suppressors (RSS): Novel strategy of viruses to ablate the host RNA interference (RNAi) defense systemQ37800635
Non-structural proteins of arthropod-borne bunyaviruses: roles and functionsQ38150190
Is RNA interference a physiologically relevant innate antiviral immune response in mammals?Q38153908
The diversity, biogenesis, and activities of endogenous silencing small RNAs in ArabidopsisQ38192033
Dominant resistance against plant virusesQ38229020
Orthobunyaviruses: recent genetic and structural insightsQ38246823
Functional non-coding RNAs derived from the flavivirus 3' untranslated region.Q38347334
The silencing suppressor (NSs) protein of the plant virus Tomato spotted wilt virus enhances heterologous protein expression and baculovirus pathogenicity in cells and lepidopteran insects.Q38839369
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinaseQ39195523
RNA interference targets arbovirus replication in Culicoides cellsQ39220412
NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.Q39547955
Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAsQ39614599
Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmissionQ35078008
Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression.Q35091233
Gouleako virus isolated from West African mosquitoes constitutes a proposed novel genus in the family BunyaviridaeQ35192825
Analysis of the A-U rich hairpin from the intergenic region of tospovirus S RNA as target and inducer of RNA silencingQ35287008
Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencingQ36018096
Modification of small RNAs associated with suppression of RNA silencing by tobamovirus replicase protein.Q36099087
The conserved FRNK box in HC-Pro, a plant viral suppressor of gene silencing, is required for small RNA binding and mediates symptom development.Q36315847
Nomenclature and functions of RNA-directed RNA polymerasesQ36394550
Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein.Q36423374
The Non-structural Protein of Crimean-Congo Hemorrhagic Fever Virus Disrupts the Mitochondrial Membrane Potential and Induces ApoptosisQ36442330
Dicer-2- and Piwi-mediated RNA interference in Rift Valley fever virus-infected mosquito cellsQ36559849
Inhibition of 3' modification of small RNAs in virus-infected plants require spatial and temporal co-expression of small RNAs and viral silencing-suppressor proteinsQ36777783
Small RNA sorting: matchmaking for Argonautes.Q36990580
dsRNA with 5' overhangs contributes to endogenous and antiviral RNA silencing pathways in plantsQ37133172
Elimination of antiviral defense by viral RNase III.Q37223241
Insect vector interactions with persistently transmitted virusesQ37235297
Discovery of a unique novel clade of mosquito-associated bunyavirusesQ37336396
Unrelated viral suppressors of RNA silencing mediate the control of ARGONAUTE1 level.Q50749103
Symbiont-mediated RNA interference in insects.Q51158261
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.Q51562160
Synthetic shRNAs as potent RNAi triggers.Q51562164
The Polerovirus silencing suppressor P0 targets ARGONAUTE proteins for degradation.Q53562373
Cucumber Mosaic Virus 2b Protein Subcellular Targets and Interactions: Their Significance to RNA Silencing Suppressor ActivityQ58765436
The Polerovirus F box protein P0 targets ARGONAUTE1 to suppress RNA silencingQ81297125
Comparative Analysis of the Capacity of Tombusvirus P22 and P19 Proteins to Function as Avirulence Determinants in Nicotiana speciesQ82063462
Polerovirus protein P0 prevents the assembly of small RNA-containing RISC complexes and leads to degradation of ARGONAUTE1Q82767738
The Enamovirus P0 protein is a silencing suppressor which inhibits local and systemic RNA silencing through AGO1 degradationQ83504677
The plant virus Tomato Spotted Wilt Tospovirus activates the immune system of its main insect vector, Frankliniella occidentalisQ31053487
Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodiesQ33420049
Generation of mutant Uukuniemi viruses lacking the nonstructural protein NSs by reverse genetics indicates that NSs is a weak interferon antagonistQ33420335
Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activationQ33425728
Two plant viral suppressors of silencing require the ethylene-inducible host transcription factor RAV2 to block RNA silencingQ33525043
The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegyptiQ33567335
The NSs protein of tomato spotted wilt virus is required for persistent infection and transmission by Frankliniella occidentalisQ33602836
Viral protein inhibits RISC activity by argonaute binding through conserved WG/GW motifs.Q33640289
Emerging phlebovirusesQ33652514
C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference ResponseQ33737835
Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein.Q33816777
The helper component-proteinase of the Zucchini yellow mosaic virus inhibits the Hua Enhancer 1 methyltransferase activity in vitroQ33905087
Recent advances in the molecular and cellular biology of bunyavirusesQ34002210
Extensive 3' modification of plant small RNAs is modulated by helper component-proteinase expressionQ34016082
Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation.Q34136640
Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate stepQ34142615
The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development.Q34142660
Negative-strand RNA viruses: the plant-infecting counterpartsQ34220715
Traffic into silence: endomembranes and post-transcriptional RNA silencingQ34323847
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activityQ34353759
Independent parallel functions of p19 plant viral suppressor of RNA silencing required for effective suppressor activity.Q34372940
RNA interference functions as an antiviral immunity mechanism in mammalsQ34376950
Antiviral RNA interference in mammalian cellsQ34376958
RNA silencing suppression by plant pathogens: defence, counter-defence and counter-counter-defenceQ34377957
Interferon-stimulated genes: a complex web of host defensesQ34405609
The long and short of antiviral defense: small RNA-based immunity in insectsQ34415168
Bunyavirus-vector interactionsQ34448192
Negative-strand tospoviruses and tenuiviruses carry a gene for a suppressor of gene silencing at analogous genomic positionsQ34465842
F-box-like domain in the polerovirus protein P0 is required for silencing suppressor functionQ34478774
Small RNA binding is a common strategy to suppress RNA silencing by several viral suppressorsQ34530577
Dicer-2 processes diverse viral RNA speciesQ34592647
Viral RNAi suppressor reversibly binds siRNA to outcompete Dicer and RISC via multiple turnoverQ34774601
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon.Q35000433
Differential expression of tomato spotted wilt virus-derived viral small RNAs in infected commercial and experimental host plantsQ35021617
A silencing suppressor protein (NSs) of a tospovirus enhances baculovirus replication in permissive and semipermissive insect cell lines.Q39640664
A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAsQ39644930
P0 of beet Western yellows virus is a suppressor of posttranscriptional gene silencingQ39683914
Suppression of RNA silencing by Flock house virus B2 protein is mediated through its interaction with the PAZ domain of DicerQ39887463
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcriptionQ39960501
Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoterQ40092449
Characterization of silencing suppressor 2b of cucumber mosaic virus based on examination of its small RNA-binding abilitiesQ40120187
Viral suppressors of RNA interference impair RNA silencing induced by a Semliki Forest virus replicon in tick cellsQ40270265
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activationQ40354595
La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA.Q40481133
Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonistQ40554311
Small RNA profiles of wild-type and silencing suppressor-deficient tomato spotted wilt virus infected Nicotiana benthamiana.Q40865340
Cytorhabdovirus P protein suppresses RISC-mediated cleavage and RNA silencing amplification in planta.Q40952336
Comparison of small RNA profiles in Nicotiana benthamiana and Solanum lycopersicum infected by polygonum ringspot tospovirus reveals host-specific responses to viral infection.Q40968107
Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex moleculesQ41775094
Identification of the domains of cauliflower mosaic virus protein P6 responsible for suppression of RNA silencing and salicylic acid signallingQ41781097
Aureusvirus P14 is an efficient RNA silencing suppressor that binds double-stranded RNAs without size specificityQ41894386
Transgenically expressed viral RNA silencing suppressors interfere with microRNA methylation in ArabidopsisQ41977529
The nonstructural protein (NSS) encoded by the ambisense S RNA segment of tomao spotted wilt virus is associated with fibrous structures in infected plant cellsQ42072267
RNA interference tools for the western flower thrips, Frankliniella occidentalis.Q42153379
Cytorhabdovirus phosphoprotein shows RNA silencing suppressor activity in plants, but not in insect cellsQ42174939
The P0 protein encoded by cotton leafroll dwarf virus (CLRDV) inhibits local but not systemic RNA silencingQ42235477
Analysis of Tomato spotted wilt virus NSs protein indicates the importance of the N-terminal domain for avirulence and RNA silencing suppression.Q42264099
Genetic determinants of Potato virus Y required to overcome or trigger hypersensitive resistance to PVY strain group O controlled by the gene Ny in potatoQ42288217
Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4.Q42396551
The NS3 protein of Rice hoja blanca tenuivirus suppresses RNA silencing in plant and insect hosts by efficiently binding both siRNAs and miRNAsQ42742914
Plant virus-derived small interfering RNAs originate predominantly from highly structured single-stranded viral RNAs.Q42847004
The p122 subunit of Tobacco Mosaic Virus replicase is a potent silencing suppressor and compromises both small interfering RNA- and microRNA-mediated pathwaysQ42910304
Characterization and subcellular localization of an RNA silencing suppressor encoded by Rice stripe tenuivirusQ43515683
The P0 gene of Sugarcane yellow leaf virus encodes an RNA silencing suppressor with unique activitiesQ43878572
Rice yellow stunt rhabdovirus protein 6 suppresses systemic RNA silencing by blocking RDR6-mediated secondary siRNA synthesisQ44067727
Multiplication of tomato spotted wilt virus in its insect vector, Frankliniella occidentalisQ44235403
P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unctionQ44314640
The HC-Pro and P3 cistrons of an avirulent Soybean mosaic virus are recognized by different resistance genes at the complex Rsv1 locusQ44565335
Suppression of Arabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, and DNA methylation by distinct domains of the Cucumber mosaic virus 2b proteinQ45238025
Tsw gene-based resistance is triggered by a functional RNA silencing suppressor protein of the Tomato spotted wilt virus.Q45352887
Multiple domains of the tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencingQ45359749
Interference in plant defense and development by non-structural protein NSs of Groundnut bud necrosis virus.Q45363245
Cucumber mosaic virus suppressor 2b binds to AGO4-related small RNAs and impairs AGO4 activitiesQ45363762
Ectopic expression of the p23 silencing suppressor of Citrus tristeza virus differentially modifies viral accumulation and tropism in two transgenic woody hostsQ45365251
Size-Independent and Noncooperative Recognition of dsRNA by the Rice Stripe Virus RNA Silencing Suppressor NS3Q45372339
Expression, purification and functional characterization of recombinant Zucchini yellow mosaic virus HC-Pro.Q45374091
The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cellsQ45398583
Suppressor of RNA silencing encoded by Tomato yellow leaf curl virus-IsraelQ45412099
Dual modes of RNA-silencing suppression by Flock House virus protein B2.Q45423252
RNA silencing-suppressor function of Turnip crinkle virus coat protein cannot be attributed to its interaction with the Arabidopsis protein TIP.Q45564502
A positive-strand RNA virus replication complex parallels form and function of retrovirus capsidsQ45733045
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
virologyQ7215
regulation of gene expressionQ411391
viral proteinQ952587
gene silencingQ1431332
evasion of host immune responseQ1660157
host microbial interactionQ68260314
P304page(s)208
P577publication date2016-07-23
P1433published inVirusesQ7935305
P1476titleViral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins
P478volume8

Reverse relations

cites work (P2860)
Q41927644Biochemical analysis of NSs from different tospoviruses.
Q40233874Identification and characterization of two RNA silencing suppressors encoded by ophioviruses.
Q52563024Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20.
Q37747063Intracellular Localization, Interactions and Functions of Capsicum Chlorosis Virus Proteins
Q92239805Priming of Plant Resistance to Heat Stress and Tomato Yellow Leaf Curl Thailand Virus With Plant-Derived Materials
Q54941184Revalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americas.
Q38655941The first phlebo-like virus infecting plants: a case study on the adaptation of negative-stranded RNA viruses to new hosts
Q102049785The genomes of Mourilyan virus and Wēnzhōu shrimp virus 1 of prawns comprise 4 RNA segments
Q52656055Tomato Spotted Wilt Virus NSs Protein Supports Infection and Systemic Movement of a Potyvirus and Is a Symptom Determinant.
Q39110012Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins
Q33794601Viral Delivery of dsRNA for Control of Insect Agricultural Pests and Vectors of Human Disease: Prospects and Challenges

Search more.