Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development

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Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2016/2190216
P8608Fatcat IDrelease_6pdtwt4uhvgj3cpr5eiktwkr7u
P3181OpenCitations bibliographic resource ID780646
P932PMC publication ID4926023
P698PubMed publication ID27403419

P2093author name stringCui Liu
Hong-Long Ji
Siguang Xu
Xiumin Li
Yana Ma
P2860cites workpH sensing and regulation in cancerQ21129239
Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous systemQ24530236
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunitsQ28249570
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activationQ28263551
How many drug targets are there?Q28276660
Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestineQ28609330
Dissemination and growth of cancer cells in metastatic sitesQ29555846
alpha-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferationQ30488635
Volume regulation during recovery from chronic hypertonicity in brain glial cellsQ31061674
BK channels in human glioma cellsQ31841557
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude miceQ79834386
Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinasesQ79896094
Involvement of p38 MAPK in hypotonic stress-induced stimulation of beta- and gamma-ENaC expression in renal epitheliumQ80345394
Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidneyQ43607662
Volume-activated chloride currents contribute to the resting conductance and invasive migration of human glioma cells.Q43744858
Blockade of acid-sensing ion channels protects articular chondrocytes from acid-induced apoptotic injuryQ44172963
A Ca2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cellsQ44241609
Role of Ca2+ signaling in initiation of stretch-induced apoptosis in neonatal heart cells.Q44604442
Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal deathQ46814703
Modulation of glioma cell migration and invasion using Cl(-) and K(+) ion channel blockersQ48160605
Osmotic pressure regulates alpha beta gamma-rENaC expressed in Xenopus oocytes.Q50741916
Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration.Q52890847
Ca2+ concentrations are key determinants of ischemia-reperfusion-induced apoptosis: significance for the molecular mechanism of Bcl-2 action.Q53370364
Knockdown of ASIC2a subunit aggravates injury of rat C6 glioma cells in acidosisQ55463691
Membrane potential and sodium flux in neuroblastoma X glioma hybrid cells: effects of amiloride and serum.Q55489633
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigarginQ72401042
Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentasQ33568810
The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegansQ34379814
Glucocorticoid-induced Leucine Zipper 1 Stimulates the Epithelial Sodium Channel by Regulating Serum- and Glucocorticoid-induced Kinase 1 Stability and Subcellular LocalizationQ34400942
The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmissionQ34416680
Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cellsQ34527019
Proton-gated cation channels--neuronal acid sensors in the central and peripheral nervous system.Q34597642
Amiloride-sensitive Na+ channels contribute to regulatory volume increases in human glioma cellsQ34646759
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.Q34711250
Reduced expression of Enac in Placenta tissues of patients with severe preeclampsia is related to compromised trophoblastic cell migration and invasion during pregnancyQ34973456
Determining the pathogenicity of genetic variants associated with cardiac channelopathiesQ34997072
Epoxyeicosatrienoic acids attenuating hypotonic-induced apoptosis of IMCD cells via γ-ENaC inhibitionQ35142683
Cancer as a channelopathy: ion channels and pumps in tumor development and progressionQ35184108
Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1Q35213503
Ion channels and amino acid transporters support the growth and invasion of primary brain tumors.Q35700625
Glioma-specific cation conductance regulates migration and cell cycle progressionQ35763208
Cell shrinkage and monovalent cation fluxes: role in apoptosisQ35928320
Physical and functional interactions between a glioma cation channel and integrin-β1 require α-actininQ36017626
Hypotonic stress upregulates β- and γ-ENaC expression through suppression of ERK by inducing MKP-1Q36114979
Ion channels and cancerQ36345954
Sodium channel γENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cellsQ36689366
Relative contribution of chloride channels and transporters to regulatory volume decrease in human glioma cellsQ36901718
Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration.Q37433408
Ion channels in toxicologyQ37768125
Regulation of breast tumorigenesis through acid sensors.Q38810445
ENaC mediates human extravillous trophblast cell line (HTR8/SVneo) invasion by regulating levels of matrix metalloproteinase 2 (MMP2).Q38906840
Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasionQ38917411
Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiformeQ39084895
The migratory capacity of human trophoblastic BeWo cells: effects of aldosterone and the epithelial sodium channelQ39203698
Cell migration in BeWo cells and the role of epithelial sodium channelsQ39775299
Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migrationQ40007443
Expression analysis of the epithelial Na+ channel delta subunit in human melanoma G-361 cellsQ40036759
Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cellsQ40079074
The relevance of tumour pH to the treatment of malignant diseaseQ40079987
Identification of acid-sensing ion channels in adenoid cystic carcinomasQ40166394
Extracellular acidification enhances DNA binding activity of MafG-FosB heterodimerQ40435819
Migration of transformed renal epithelial cells is regulated by K+ channel modulation of actin cytoskeleton and cell volumeQ40943199
Inhibition of Na+ influx and DNA synthesis in human fibroblasts and neuroblastoma-glioma hybrid cells by amiloride analogsQ41608075
Acid-sensing ion channels in malignant gliomasQ42437027
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectamilorideQ419995
epithelial sodium channelQ424948
neoplasmQ1216998
acid-sensing ion channelQ4222244
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)2190216
P577publication date2016-06-15
P1433published inBioMed Research InternationalQ17509958
P1476titlePotential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development
P478volume2016