The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans

scientific article

The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.271.18.10433
P8608Fatcat IDrelease_qfeds4jabbabpb4wh3vytqya3a
P698PubMed publication ID8631835
P5875ResearchGate publication ID14568396

P2093author name stringLazdunski M
Voilley N
Waldmann R
Champigny G
Lauritzen I
P2860cites workImproved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channelQ24304253
The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloningQ24562135
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunitsQ28249570
Epithelial sodium channel related to proteins involved in neurodegenerationQ28262910
Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerinsQ28262953
A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATPQ28573068
Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphineQ37555862
A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegansQ38311352
When more is less: pathogenesis of glutamine repeat neurodegenerative diseasesQ40405315
Oxidative stress, glutamate, and neurodegenerative disordersQ40618533
Molecular mechanisms of mechanosensation?Q40704715
Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2.Q44597687
Presenilins and Alzheimer diseaseQ44642995
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel.Q48068516
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegansQ48085066
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degenerationQ48235681
Pharmacia Biotech & Science prize. Grand prize winner. Life and death decisions: ced-9 and programmed cell death in Caenorhabditis elegansQ48389276
Missing Alzheimer's gene found.Q53201156
A simple and rapid method for the selection of oligodeoxynucleotide-directed mutants.Q54748538
Trinity of cation channelsQ56975040
The identification and suppression of inherited neurodegeneration in Caenorhabditis elegansQ59088240
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectneurodegenerationQ1755122
Caenorhabditis elegansQ91703
P304page(s)10433-10436
P577publication date1996-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans
P478volume271

Reverse relations

cites work (P2860)
Q33336547A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes
Q24656746A genomewide association study of citalopram response in major depressive disorder
Q33790439A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Q28572405A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells
Q37544583A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons
Q50516655A pore segment in DEG/ENaC Na(+) channels.
Q24329227A proton-gated cation channel involved in acid-sensing
Q73537177A weakly voltage-dependent, nonselective cation channel mediates toxic sodium influx in wheat
Q28278216ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters
Q36541413ASIC proteins regulate smooth muscle cell migration
Q48667570ASIC-like, proton-activated currents in rat hippocampal neurons
Q34143944ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury
Q31156844ASIC2 subunits facilitate expression at the cell surface and confer regulation by PSD-95.
Q28592489ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95
Q52725279ASIC3 fine-tunes bladder sensory signaling.
Q26830391ASICs and cardiovascular homeostasis
Q38319784ASICs and neuropeptides
Q90484697Acid sensing ion channel 2: A new potential player in the pathophysiology of multiple sclerosis
Q28588134Acid sensing ion channels in dorsal spinal cord neurons
Q93498239Acid-sensing (proton-gated) ion channels (ASICs)
Q34092517Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia
Q36370955Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression
Q24544425Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons
Q34703337Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases.
Q37575276Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice.
Q38170044Acid-sensing ion channels contribute to neurotoxicity.
Q42437027Acid-sensing ion channels in malignant gliomas
Q26829975Acid-sensing ion channels in pain and disease.
Q43074259Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus
Q55268854Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing.
Q34320487Acid-sensing ion channels: trafficking and synaptic function
Q39140559Acidity and Acid-Sensing Ion Channels in the Normal and Alzheimer's Disease Brain
Q41949728Alterations in subcellular expression of acid-sensing ion channels in the rat forebrain following chronic amphetamine administration
Q28609375Amiloride-sensitive Na channels
Q41953156Asp433 in the closing gate of ASIC1 determines stability of the open state without changing properties of the selectivity filter or Ca2+ block
Q35794487Association between the ACCN1 gene and multiple sclerosis in Central East Sardinia
Q24320245BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
Q34436770Biochemical basis of touch perception: mechanosensory function of degenerin/epithelial Na+ channels
Q36473848Ca2+ -permeable acid-sensing ion channels and ischemic brain injury
Q39269905Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels
Q37903657Calcium in tumour metastasis: new roles for known actors.
Q36090699Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury
Q41876264Cell surface expression and biosynthesis of epithelial Na+ channels
Q56980248Chapter 13 Finding Sensory Neuron Mechanotransduction Components
Q58162894Chapter 8 Acid Sensing Ionic Channels
Q42082307Characterization of acid signaling in rat vagal pulmonary sensory neurons.
Q34093989Chemical mediators of pain due to tissue damage and ischemia
Q28595007Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals
Q55034437Closing in on a mammalian touch receptor.
Q37479384Conformational changes associated with proton-dependent gating of ASIC1a
Q44505350Contribution of Drosophila DEG/ENaC genes to salt taste
Q51056084Current perspectives on acid-sensing ion channels: new advances and therapeutic implications.
Q33725682DEG/ENaC channels: a touchy superfamily that watches its salt
Q35949020DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
Q35900722ENaCs and ASICs as therapeutic targets
Q48610726Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels
Q41385983Enhanced maximal exercise capacity, vasodilation to electrical muscle contraction, and hind limb vascular density in ASIC1a null mice
Q37700685Eukaryotic mechanosensitive channels
Q44091935Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium transport
Q35520072Expression and activity of acid-sensing ion channels in the mouse anterior pituitary
Q41099787Families of ion channels with two hydrophobic segments
Q35094105From genes to integrative physiology: ion channel and transporter biology in Caenorhabditis elegans
Q33764301Functional domains within the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels
Q88471126Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8
Q36440897Gating induces a conformational change in the outer vestibule of ENaC
Q33637976Gene delivery systems using the Sendai virus
Q93389616Genetic analysis of KillerRed in C. elegans identifies a shared role of calcium genes in ROS-mediated neurodegeneration
Q34350636Genetic models of mechanotransduction: the nematode Caenorhabditis elegans
Q36719346Genetically targeted cell disruption in Caenorhabditis elegans
Q34158811Genetics of sensory mechanotransduction
Q37209075Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility
Q30579548H(+)-gated cation channels
Q47754214H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels
Q28585795Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
Q90152219High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures
Q42450977How Nerve Growth Factor Drives Physiological and Inflammatory Expressions of Acid-sensing Ion Channel 3 in Sensory Neurons
Q36579435Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis
Q34438987Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant
Q36445421Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating
Q48298996Immunolocalization of the acid-sensing ion channel 2a in the rat cerebellum
Q50497285In vivo structure-function analyses of Caenorhabditis elegans MEC-4, a candidate mechanosensory ion channel subunit.
Q37394153Insights into the molecular determinants of proton inhibition in an acid-inactivated degenerins and mammalian epithelial Na(+) channel
Q24292192Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)
Q48951272Interactions between subunits of the human epithelial sodium channel.
Q91866868Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain
Q93551704Ion Channels
Q37734810Ion channels and migraine
Q33903469Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
Q36843147Isolation of chicken alpha ENaC splice variants from a cochlear cDNA library
Q28587926Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing
Q64233006Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites
Q30576923Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.
Q33266973Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia.
Q31106248Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type
Q91762213Loci associated with conception rate in crossbred beef heifers
Q43903505MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
Q28145822Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+
Q34705398Mechanotransduction: touch and feel at the molecular level as modeled in Caenorhabditis elegans
Q55109882Molecular basis of inhibition of acid sensing ion channel 1A by diminazene.
Q42447138Molecular cloning and characterization of human acid sensing ion channel (ASIC)2 gene promoter
Q34487130Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties
Q24312949Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis
Q28582678Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons
Q28609330Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine
Q30481753Mutant sodium channel for tumor therapy.
Q47982379Mutations causing neurodegeneration in Caenorhabditis elegans drastically alter the pH sensitivity and inactivation of the mammalian H+-gated Na+ channel MDEG1.
Q34093243Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum
Q53042410Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors.
Q71971010Neuropathology of degenerative cell death in Caenorhabditis elegans
Q28143657Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels
Q28189783Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors
Q24633434Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior
Q48917631Paradoxical stimulation of a DEG/ENaC channel by amiloride
Q24655070Permeability properties of ENaC selectivity filter mutants
Q50640640Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a.
Q28295869Phylogenetic characterization of the epithelial Na+ channel (ENaC) family
Q26741089Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development
Q28512128Presynaptic release probability is increased in hippocampal neurons from ASIC1 knockout mice
Q34165309Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels.
Q57635778Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel
Q40735743Proton-gated channels in PC12 cells
Q73296470Proton-gated ion channels in cultured mouse cortical neurons
Q48356920Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration.
Q49355607Recent Advances in Pharmacotherapy for Migraine Prevention: From Pathophysiology to New Drugs
Q42320196Restoration of Epithelial Sodium Channel Function by Synthetic Peptides in Pseudohypoaldosteronism Type 1B Mutants
Q36254915Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons.
Q34093813Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF.
Q35819038Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC).
Q83839898Silencing acid-sensing ion channel 1a alters cone-mediated retinal function
Q48321717Spinal cord plasticity and acid-sensing ion channels involvement in a rodent model of irritable bowel syndrome.
Q28286776Stomatin modulates gating of acid-sensing ion channels
Q26852449Structure and activity of the acid-sensing ion channels
Q34083380Studying human neurodegenerative diseases in flies and worms
Q28585240Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels
Q55417449Targeted Acid-Sensing Ion Channel Therapies for Migraine.
Q34169947Tetraethylammonium block of the BNC1 channel.
Q35209215The ASICs: signaling molecules? Modulators?
Q30486735The Concise Guide to PHARMACOLOGY 2013/14: ion channels
Q28593088The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice
Q58034881The ENaC/Deg family of cation channels
Q28209966The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons
Q41045756The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer
Q36987732The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization.
Q24296641The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory
Q28253784The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties
Q38173627The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC
Q34219234The biochemistry of neuronal necrosis: rogue biology?
Q48230717The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1.
Q28585052The mammalian sodium channel BNC1 is required for normal touch sensation
Q89490812The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans
Q47069224The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations
Q46229892The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation
Q24544187The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a
Q89994745The synaptic action of Degenerin/Epithelial sodium channels
Q24657402The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration
Q37379467Thermosensory and mechanosensory perception in human genetic disease
Q48278180Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome.
Q38175917Translational strategies for neuroprotection in ischemic stroke--focusing on acid-sensing ion channel 1a.
Q28594059Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons
Q28082631Two aspects of ASIC function: Synaptic plasticity and neuronal injury
Q28211828Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes
Q36562530What is the hair cell transduction channel?
Q43678707Zn2+ and H+ are coactivators of acid-sensing ion channels
Q43714160pH alterations "reset" Ca2+ sensitivity of brain Na+ channel 2, a degenerin/epithelial Na+ ion channel, in planar lipid bilayers
Q34414566unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion

Search more.