Molecular and Cellular Mechanisms of Shigella flexneri Dissemination

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Molecular and Cellular Mechanisms of Shigella flexneri Dissemination is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FCIMB.2016.00029
P932PMC publication ID4786538
P698PubMed publication ID27014639

P2093author name stringHervé Agaisse
P2860cites workA secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneriQ81785474
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome proteinQ22253357
Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defensesQ24297790
Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneriQ24533240
Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motilityQ24683572
The Shigella flexneri type 3 secretion system is required for tyrosine kinase-dependent protrusion resolution, and vacuole escape during bacterial disseminationQ27327186
Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneriQ28139161
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assemblyQ28609843
Reconstitution of actin-based motility of Listeria and Shigella using pure proteinsQ29617447
Bacterial actin assembly requires toca-1 to relieve N-wasp autoinhibitionQ30481248
Bruton's tyrosine kinase regulates Shigella flexneri dissemination in HT-29 intestinal cellsQ30532825
Arp2/3-mediated actin-based motility: a tail of pathogen abuseQ30572619
Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spreadQ30581595
The serine/threonine kinase STK11 promotes Shigella flexneri dissemination through establishment of cell-cell contacts competent for tyrosine kinase signalingQ30603690
Identification of chromosomal Shigella flexneri genes induced by the eukaryotic intracellular environmentQ30836926
Contagious acute gastrointestinal infectionsQ33209507
Requirement for formin-induced actin polymerization during spread of Shigella flexneriQ33557956
Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading.Q33764731
Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actinQ33859430
A comparative study of the actin-based motilities of the pathogenic bacteria Listeria monocytogenes, Shigella flexneri and Rickettsia conoriiQ33861430
Polar targeting of Shigella virulence factor IcsA in Enterobacteriacae and VibrioQ33934139
dksA is required for intercellular spread of Shigella flexneri via an RpoS-independent mechanism.Q34009042
Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium's epithelial nicheQ34261901
Disulfide oxidoreductase activity of Shigella flexneri is required for release of Ipa proteins and invasion of epithelial cellsQ34275598
The absence of a surface protease, OmpT, determines the intercellular spreading ability of Shigella: the relationship between the ompT and kcpA lociQ70511697
Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motilityQ71246595
Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movementQ72399089
Regulation of O-antigen chain length is required for Shigella flexneri virulenceQ73351036
IcsB, secreted via the type III secretion system, is chaperoned by IpgA and required at the post-invasion stage of Shigella pathogenicityQ73406278
The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneriQ73510444
The development of a FACS-based strategy for the isolation of Shigella flexneri mutants that are deficient in intercellular spreadQ73537502
Myosin light chain kinase plays an essential role in S. flexneri disseminationQ74308390
Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreadingQ77936917
Myosin IIA is essential for Shigella flexneri cell-to-cell spread.Q42207770
Molecular and cellular mechanisms of invasion of the intestinal barrier by enteric pathogens. The paradigm of ShigellaQ42460332
Identification and characterization of virK, a virulence-associated large plasmid gene essential for intercellular spreading of Shigella flexneriQ42604068
icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spreadQ42607219
A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a.Q44058237
Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneriQ44369955
Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cellsQ44502159
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
IcsA, a polarly localized autotransporter with an atypical signal peptide, uses the Sec apparatus for secretion, although the Sec apparatus is circumferentially distributedQ47608547
Identification and characterization of ispA, a Shigella flexneri chromosomal gene essential for normal in vivo cell division and intracellular spreadingQ48066493
Rho family GTPases control entry of Shigella flexneri into epithelial cells but not intracellular motility.Q48916065
A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread.Q50461263
Regulation of transcription by the activity of the Shigella flexneri type III secretion apparatus.Q54546861
Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.Q54560755
Shigella subverts the host recycling compartment to rupture its vacuole.Q55058595
MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion systemQ34316975
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complexQ34334221
Outer membrane protein A (OmpA): a new player in shigella flexneri protrusion formation and inter-cellular spreadingQ34482609
OspE2 of Shigella sonnei is required for the maintenance of cell architecture of bacterium-infected cells.Q34602029
A Shigella flexneri virulence plasmid encoded factor controls production of outer membrane vesiclesQ34714016
Polar localization of PhoN2, a periplasmic virulence-associated factor of Shigella flexneri, is required for proper IcsA exposition at the old bacterial poleQ35108869
The class II phosphatidylinositol 3-phosphate kinase PIK3C2A promotes Shigella flexneri dissemination through formation of vacuole-like protrusionsQ35187522
Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membraneQ35380050
Molecular, genetic, and topological characterization of O-antigen chain length regulation in Shigella flexneriQ35579726
Genetic reporter system for positioning of proteins at the bacterial poleQ35826987
IcsA surface presentation in Shigella flexneri requires the periplasmic chaperones DegP, Skp, and SurA.Q35949250
Bacterial spread from cell to cell: beyond actin-based motilityQ36030736
Exerimental acute colitis in the Rhesus monkey following peroral infection with Shigella flexneri. An electron microscope studyQ36051645
Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulenceQ36106821
Antivirulence genes: insights into pathogen evolution through gene lossQ36396759
The role of clathrin-dependent endocytosis in bacterial internalizationQ36589955
Mutagenesis of the Shigella flexneri autotransporter IcsA reveals novel functional regions involved in IcsA biogenesis and recruitment of host neural Wiscott-Aldrich syndrome proteinQ36747291
Movement along actin filaments of the perijunctional area and de novo polymerization of cellular actin are required for Shigella flexneri colonization of epithelial Caco-2 cell monolayersQ36956026
Intercellular spread of Shigella flexneri through a monolayer mediated by membranous protrusions and associated with reorganization of the cytoskeletal protein vinculinQ36987733
Plaque formation by virulent Shigella flexneriQ37048229
An ABC transport system that maintains lipid asymmetry in the gram-negative outer membraneQ37194777
Actin network disassembly powers dissemination of Listeria monocytogenes.Q37418474
The Vps/VacJ ABC transporter is required for intercellular spread of Shigella flexneriQ37546476
Autotransporter ProteinsQ38601000
Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1.Q38819620
Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA.Q38870471
Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cellsQ39361599
Key role for DsbA in cell-to-cell spread of Shigella flexneri, permitting secretion of Ipa proteins into interepithelial protrusionsQ39516954
Shigella flexneri DegP facilitates IcsA surface expression and is required for efficient intercellular spreadQ39663436
Induction of expression of hfq by DksA is essential for Shigella flexneri virulenceQ40223748
Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathwayQ40366591
Escape of intracellular Shigella from autophagyQ40485419
Cdc42 facilitates invasion but not the actin-based motility of ShigellaQ40748370
Rough mutant of Shigella flexneri 2a that penetrates tissue culture cells but does not evoke keratoconjunctivitis in guinea pigsQ40788689
A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular disseminationQ40917707
Identification of a novel virulence gene, virA, on the large plasmid of Shigella, involved in invasion and intercellular spreadingQ41333107
Cadherin expression is required for the spread of Shigella flexneri between epithelial cellsQ41481257
MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular disseminationQ41493869
Identification and characterization of a chromosomal virulence gene, vacJ, required for intercellular spreading of Shigella flexneriQ41499413
Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread.Q42069451
Role of the Pst system in plaque formation by the intracellular pathogen Shigella flexneriQ42146925
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectvacuoleQ127702
actinQ185269
intestinal epitheliumQ509615
Shigella flexneriQ1644417
bacillary dysenteryQ3778137
type III protein secretion system complexQ21199165
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)29
P577publication date2016-03-11
P1433published inFrontiers in Cellular and Infection MicrobiologyQ27724376
P1476titleMolecular and Cellular Mechanisms of Shigella flexneri Dissemination
P478volume6

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cites work (P2860)
Q92058258A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis
Q38635942Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence
Q63976613Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery
Q91621514Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection
Q90385992Mechanisms of bacillary dysentery: lessons learnt from infant rabbits
Q54245973MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47.
Q56340683Spatial, Temporal, and Functional Assessment of LC3-Dependent Autophagy in Shigella flexneri Dissemination
Q93109786The Autotransporter IcsA Promotes Shigella flexneri Biofilm Formation in the Presence of Bile Salts
Q41950223VirF Relieves the Transcriptional Attenuation of the Virulence Gene icsA of Shigella flexneri Affecting the icsA mRNA-RnaG Complex Formation

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