Outer membrane protein A (OmpA): a new player in shigella flexneri protrusion formation and inter-cellular spreading

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Outer membrane protein A (OmpA): a new player in shigella flexneri protrusion formation and inter-cellular spreading is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...749625A
P356DOI10.1371/JOURNAL.PONE.0049625
P932PMC publication ID3498225
P698PubMed publication ID23166731
P5875ResearchGate publication ID233725643

P2093author name stringCecilia Ambrosi
Mauro Nicoletti
Monica Pompili
Carlo Zagaglia
Sandro Ripa
Daniela Scribano
P2860cites workNeural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneriQ24533240
Actin-based motility of intracellular microbial pathogensQ24548463
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR productsQ27860842
The function of OmpA in Escherichia coliQ28208392
Insights into the structure and assembly of Escherichia coli outer membrane protein AQ30155388
Contribution of the periplasmic chaperone Skp to efficient presentation of the autotransporter IcsA on the surface of Shigella flexneriQ30157451
Secondary structure of the outer membrane proteins OmpA of Escherichia coli and OprF of Pseudomonas aeruginosaQ30176815
Major heat-modifiable outer membrane protein in gram-negative bacteria: comparison with the ompA protein of Escherichia coliQ30451417
Requirement for formin-induced actin polymerization during spread of Shigella flexneriQ33557956
Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actinQ33859430
Polar targeting of Shigella virulence factor IcsA in Enterobacteriacae and VibrioQ33934139
Actin-based motility of pathogens: the Arp2/3 complex is a central playerQ34156259
A molecular Swiss army knife: OmpA structure, function and expressionQ34636047
Outer membrane protein A (OmpA) of Shigella flexneri 2a links innate and adaptive immunity in a TLR2-dependent manner and involvement of IL-12 and nitric oxideQ35874571
Outer membrane protein A and OprF: versatile roles in Gram-negative bacterial infectionsQ35918591
IcsA surface presentation in Shigella flexneri requires the periplasmic chaperones DegP, Skp, and SurA.Q35949250
Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gelsQ36327033
Protein synthesis in HeLa or Henle 407 cells infected with Shigella dysenteriae 1, Shigella flexneri 2a, or Salmonella typhimurium W118.Q36422250
Involvement of a plasmid in the invasive ability of Shigella flexneri.Q36437346
Mutagenesis of the Shigella flexneri autotransporter IcsA reveals novel functional regions involved in IcsA biogenesis and recruitment of host neural Wiscott-Aldrich syndrome proteinQ36747291
Intercellular spread of Shigella flexneri through a monolayer mediated by membranous protrusions and associated with reorganization of the cytoskeletal protein vinculinQ36987733
Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulationQ37007773
Plaque formation by virulent Shigella flexneriQ37048229
Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysisQ37056339
Pathogens and polymers: microbe-host interactions illuminate the cytoskeletonQ37942128
A multifactor regulatory circuit involving H-NS, VirF and an antisense RNA modulates transcription of the virulence gene icsA of Shigella flexneri.Q38333799
A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gelsQ39512862
Outer membrane protein A of Escherichia coli contributes to invasion of brain microvascular endothelial cells.Q39823939
Secretion of Ipa proteins by Shigella flexneri: inducer molecules and kinetics of activation.Q39831093
Cleavage of Shigella surface protein VirG occurs at a specific site, but the secretion is not essential for intracellular spreadingQ39836159
Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movementQ39927930
EPITHELIAL CELL PENETRATION AS AN ESSENTIAL STEP IN THE PATHOGENESIS OF BACILLARY DYSENTERY.Q40250130
Cross-reactivity of major outer membrane proteins of Enterobacteriaceae, studied by crossed immunoelectrophoresis.Q40335921
Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent.Q40376661
Genetic modulation of Shigella flexneri 2a lipopolysaccharide O antigen modal chain length reveals that it has been optimized for virulence.Q40657135
Purification of protein A, an outer membrane component missing in Escherichia coli K-12 ompA mutantsQ40787094
Regulation of the actin cytoskeleton by inositol phospholipid pathwaysQ41067338
Actin-based motility is sufficient for bacterial membrane protrusion formation and host cell uptakeQ41474918
The making of a gradient: IcsA (VirG) polarity in Shigella flexneriQ41475084
Identification and characterization of a chromosomal virulence gene, vacJ, required for intercellular spreading of Shigella flexneriQ41499413
Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread.Q42069451
Extracellular loops of the Eschericia coli outer membrane protein A contribute to the pathogenesis of meningitisQ42725869
A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a.Q44058237
Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneriQ44369955
IcsA, a polarly localized autotransporter with an atypical signal peptide, uses the Sec apparatus for secretion, although the Sec apparatus is circumferentially distributedQ47608547
Bacterial invasion: a new strategy to dominate cytoskeleton plasticityQ47926680
SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneriQ48053197
Decrease by psychotropic drugs and local anaesthetics of membrane fluidity measured by fluorescence anisotropy in Escherichia coliQ51678868
Effect of mutations in Shigella flexneri chromosomal and plasmid-encoded lipopolysaccharide genes on invasion and serum resistance.Q54566517
In vitro insertion and assembly of outer membrane protein PhoE of Escherichia coli K-12 into the outer membrane. Role of Triton X-100.Q54588208
Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coliQ57809995
Major Outer Membrane Proteins: Common Antigens in Enterobacteriaceae SpeciesQ72616319
Lipopolysaccharide O antigen chains mask IcsA (VirG) in Shigella flexneriQ73341660
The development of a FACS-based strategy for the isolation of Shigella flexneri mutants that are deficient in intercellular spreadQ73537502
The actin-based motility defect of a Shigella flexneri rmlD rough LPS mutant is not due to loss of IcsA polarityQ73669123
The unipolar Shigella surface protein IcsA is targeted directly to the bacterial old pole: IcsP cleavage of IcsA occurs over the entire bacterial surfaceQ77410714
Purification and characterization of an immunogenic outer membrane protein of Shigella flexneri 2aQ84363216
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmembrane proteinQ423042
Shigella flexneriQ1644417
P304page(s)e49625
P577publication date2012-11-14
P1433published inPLOS OneQ564954
P1476titleOuter membrane protein A (OmpA): a new player in shigella flexneri protrusion formation and inter-cellular spreading
P478volume7

Reverse relations

cites work (P2860)
Q31126928Combining Shigella Tn-seq data with gold-standard E. coli gene deletion data suggests rare transitions between essential and non-essential gene functionality
Q92824404Establishment of a Protein Concentration Gradient in the Outer Membrane Requires Two Diffusion-Limiting Mechanisms
Q93090016Extensive inter-strain diversity among clinical isolates of Shigella flexneri with reference to its serotype, virulence traits and plasmid incompatibility types, a study from south India over a 6-year period
Q88954037Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion
Q51320080Immunization with r-Lactococcus lactis expressing outer membrane protein A of Shigella dysenteriae type-1: evaluation of oral and intranasal route of administration.
Q28537818Impact of dynasore an inhibitor of dynamin II on Shigella flexneri infection
Q41148852Key residues of S. flexneri OmpA mediate infection by bacteriophage Sf6.
Q26750855Molecular and Cellular Mechanisms of Shigella flexneri Dissemination
Q30578890OmpA and OmpC are critical host factors for bacteriophage Sf6 entry in Shigella
Q35108869Polar localization of PhoN2, a periplasmic virulence-associated factor of Shigella flexneri, is required for proper IcsA exposition at the old bacterial pole
Q35183286RNA-seq analysis of the influence of anaerobiosis and FNR on Shigella flexneri
Q40572595Selenium nanoparticles incorporated into titania nanotubes inhibit bacterial growth and macrophage proliferation
Q38869534Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP.
Q41682716The Shigella flexneri OmpA amino acid residues 188EVQ190 are essential for the interaction with the virulence factor PhoN2.
Q37299240The outer membrane phospholipase A is essential for membrane integrity and type III secretion in Shigella flexneri.

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