| P50 | author | Emily R Theisen | Q85735132 |
| P2093 | author name string | Stephen L Lessnick | |
| | Kathleen I Pishas | |
| | Ranajeet S Saund | |
| P2860 | cites work | EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma | Q21144325 |
| | The epidemiology of sarcoma | Q21195878 |
| | p53 is regulated by the lysine demethylase LSD1 | Q24292925 |
| | Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours | Q24298221 |
| | Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors | Q24299384 |
| | The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1 | Q24306590 |
| | LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer | Q24308737 |
| | KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints | Q24312768 |
| | LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription | Q24312958 |
| | Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 | Q24336747 |
| | EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. | Q24522406 |
| | Mutational heterogeneity in cancer and the search for new cancer-associated genes | Q24606956 |
| | The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1 | Q24629399 |
| | Decitabine in the treatment of myelodysplastic syndromes | Q24641906 |
| | Microsatellites as EWS/FLI response elements in Ewing's sarcoma | Q36786777 |
| | Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer | Q37272420 |
| | Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines | Q37397291 |
| | ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma | Q37424383 |
| | EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma | Q37461081 |
| | Histone H3 lysine 4 (H3K4) methylation in development and differentiation | Q37585674 |
| | EWS-FLI-1 regulates the neuronal repressor gene REST, which controls Ewing sarcoma growth and vascular morphology | Q37672300 |
| | The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells | Q37732529 |
| | Emerging epigenetic targets and therapies in cancer medicine | Q38010385 |
| | The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis | Q38015891 |
| | Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date | Q38270780 |
| | The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners | Q38303012 |
| | Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1. | Q38338516 |
| | A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors | Q38491930 |
| | A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. | Q38852985 |
| | Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity. | Q38931537 |
| | Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. | Q38981458 |
| | LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer | Q39117867 |
| | MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A. | Q39196320 |
| | Epigenetic control of type 2 and 3 deiodinases in myogenesis: role of Lysine-specific Demethylase enzyme and FoxO3. | Q39196974 |
| | Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention | Q26994739 |
| | Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine | Q27645835 |
| | Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system | Q27659896 |
| | Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1 | Q27662593 |
| | The genomic landscape of pediatric Ewing sarcoma | Q27853063 |
| | Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma | Q27853188 |
| | Lysine acetylation targets protein complexes and co-regulates major cellular functions | Q27860589 |
| | High-resolution profiling of histone methylations in the human genome | Q27860906 |
| | Chromatin modifications and their function | Q27861067 |
| | Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes | Q27932919 |
| | Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy | Q28235397 |
| | Histone methylation: a dynamic mark in health, disease and inheritance | Q28263573 |
| | An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation | Q28265681 |
| | Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology | Q28269080 |
| | Regulation of LSD1 histone demethylase activity by its associated factors | Q28270391 |
| | Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence | Q28277232 |
| | Opposing LSD1 complexes function in developmental gene activation and repression programmes | Q28295495 |
| | The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation | Q28304726 |
| | Comprehensive molecular characterization of urothelial bladder carcinoma | Q28306864 |
| | Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1 | Q28510591 |
| | A novel mammalian flavin-dependent histone demethylase | Q28587686 |
| | Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development | Q28589088 |
| | The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer | Q28687241 |
| | Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. | Q30496670 |
| | Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance Epidemiology and End Results data. | Q31157886 |
| | A mechanism-based inactivator for histone demethylase LSD1. | Q33238864 |
| | trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. | Q33279148 |
| | Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation | Q33401808 |
| | The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function | Q33420364 |
| | The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation | Q33881163 |
| | Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications | Q33997049 |
| | Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo | Q34000149 |
| | Mesenchymal stem cell features of Ewing tumors | Q34003979 |
| | Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. | Q35887221 |
| | Prognostic role of LSD1 in various cancers: evidence from a meta-analysis | Q36116596 |
| | Novel mutations target distinct subgroups of medulloblastoma. | Q36143877 |
| | Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis | Q36434436 |
| | Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia | Q36515569 |
| | Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells | Q36539785 |
| | Tranylcypromine: new perspectives on an "old" drug | Q36574603 |
| | Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer | Q36579430 |
| | EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. | Q36701142 |
| | Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex. | Q34073864 |
| | Enhancer decommissioning by LSD1 during embryonic stem cell differentiation | Q34088491 |
| | High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. | Q34107754 |
| | Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma | Q34109415 |
| | Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma | Q34166817 |
| | Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability | Q34178072 |
| | EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model | Q34206278 |
| | Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma. | Q34340537 |
| | Locus-specific editing of histone modifications at endogenous enhancers | Q34369340 |
| | Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast | Q34392800 |
| | Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes | Q34411003 |
| | The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes. | Q34414087 |
| | Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1. | Q34464009 |
| | Structure and chromosomal DNA binding of the SWIRM domain | Q34469098 |
| | BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma | Q34635079 |
| | Late effects of chemotherapy and radiotherapy in osteosarcoma and Ewing sarcoma patients: the Italian Sarcoma Group Experience (1983-2006). | Q34636631 |
| | Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations | Q34691553 |
| | Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer. | Q34897761 |
| | Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]. | Q34905762 |
| | High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors | Q35044161 |
| | Selective targeting of histone methylation | Q35045315 |
| | Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer | Q35050623 |
| | Crystal structure of human histone lysine-specific demethylase 1 (LSD1). | Q35080371 |
| | RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1. | Q35097968 |
| | Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors | Q35133399 |
| | Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis | Q35145374 |
| | EWS-FLI1 employs an E2F switch to drive target gene expression. | Q35171620 |
| | Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing | Q35212670 |
| | Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors | Q35224188 |
| | Functional annotation of native enhancers with a Cas9-histone demethylase fusion. | Q35554363 |
| | A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis | Q35665048 |
| | miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells | Q35818683 |
| | EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma | Q35820934 |
| | Experimental evidence for a neural origin of Ewing's sarcoma of bone | Q35856430 |
| | Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer. | Q35860815 |
| | Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma | Q39239580 |
| | Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription. | Q39442604 |
| | miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy | Q39465507 |
| | Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition | Q39513776 |
| | Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors | Q39550777 |
| | Lysine methylation regulates E2F1-induced cell death | Q39684254 |
| | EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells | Q39716224 |
| | Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers | Q39723644 |
| | Identification of cell-active lysine specific demethylase 1-selective inhibitors | Q39768788 |
| | Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1. | Q39786614 |
| | EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice | Q40079342 |
| | Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. | Q40219007 |
| | EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors | Q40414553 |
| | EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma | Q40521738 |
| | EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts. | Q40909245 |
| | EWS and RE1-Silencing Transcription Factor Inhibit Neuronal Phenotype Development and Oncogenic Transformation in Ewing Sarcoma | Q41782910 |
| | A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation | Q41850380 |
| | Histone demethylase LSD1 regulates adipogenesis | Q41852966 |
| | Azacytidine (Vidaza(R)) in the treatment of myelodysplastic syndromes | Q41980293 |
| | The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma | Q42530521 |
| | Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins | Q42804345 |
| | Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II. | Q42827236 |
| | Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene | Q42830152 |
| | Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines | Q42838218 |
| | LSD1 is required for chromosome segregation during mitosis | Q43147492 |
| | GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance | Q43283509 |
| | Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group | Q44557261 |
| | The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells | Q45375299 |
| | Human histone demethylase LSD1 reads the histone code | Q46751765 |
| | Prognostic factors for local and distant control in Ewing sarcoma family of tumors | Q46903228 |
| | Crystal structure and mechanism of human lysine-specific demethylase-1. | Q49485495 |
| | Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein. | Q50767221 |
| | Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. | Q50791495 |
| | Histone H3 peptide based LSD1-selective inhibitors. | Q53276317 |
| | Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. | Q53286652 |
| | Classics in oncology. Diffuse endothelioma of bone. James Ewing. Proceedings of the New York Pathological Society, 1921 | Q69371853 |
| | Characterization of neural cell adhesion molecules (NCAM) expressed by Ewing and neuroblastoma cell lines | Q70182804 |
| | Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein | Q73226056 |
| | An hsRPB4/7-dependent yeast assay for trans-activation by the EWS oncogene | Q73787210 |
| | EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing | Q74303777 |
| P275 | copyright license | Creative Commons Attribution 2.5 Generic | Q18810333 |
| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Ewing sarcoma | Q1138580 |
| | bone neoplasm | Q1328805 |
| | soft tissue neoplasm | Q17640201 |
| | Fli-1 proto-oncogene, ETS transcription factor | Q21114539 |
| | RNA-binding protein EWS | Q24784077 |
| | histone demethylases | Q76721828 |
| | fusion oncogene proteins | Q78441425 |
| P1104 | number of pages | 15 | |
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 17616-17630 | |
| P577 | publication date | 2016-04-05 | |
| P1433 | published in | Oncotarget | Q1573155 |
| P1476 | title | Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting | |
| P478 | volume | 7 | |