The role of pattern-recognition receptors in graft-versus-host disease and graft-versus-leukemia after allogeneic stem cell transplantation

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The role of pattern-recognition receptors in graft-versus-host disease and graft-versus-leukemia after allogeneic stem cell transplantation is …
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scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2014.00337
P3181OpenCitations bibliographic resource ID1950663
P932PMC publication ID4102927
P698PubMed publication ID25101080
P5875ResearchGate publication ID264640088

P50authorMarcel R.M. van den BrinkQ17198821
P2093author name stringSimon Heidegger
Hendrik Poeck
Tobias Haas
P2860cites workHematopoietic stem cell transplantation: a global perspectiveQ24624697
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantationQ24626051
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host diseaseQ24626202
NOD-Like Receptors: Master Regulators of Inflammation and CancerQ26865199
Recognition of cytosolic DNA by cGAS and other STING-dependent sensorsQ27000358
Ex vivo T cell-depleted versus unmodified allografts in patients with acute myeloid leukemia in first complete remissionQ33760933
Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantationQ33839876
Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemiaQ33857573
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantationQ33898254
Advances in graft-versus-host disease biology and therapyQ34031916
Signalling C-type lectins in antimicrobial immunityQ34916633
Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunityQ35691842
Phase 1/2 randomized, placebo-control trial of palifermin to prevent graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).Q35849064
LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantationQ36028584
Acute graft versus host diseaseQ36059671
Antimicrobial prophylaxis in allogeneic bone marrow transplantation. Guidelines of the infectious diseases working party (AGIHO) of the german society of haematology and oncology.Q36132972
Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγtQ36139724
Comparative outcomes of donor graft CD34+ selection and immune suppressive therapy as graft-versus-host disease prophylaxis for patients with acute myeloid leukemia in complete remission undergoing HLA-matched sibling allogeneic hematopoietic cell tQ36212392
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissuesQ36228795
Sensing and reacting to microbes through the inflammasomesQ36253171
Graft-versus-host diseaseQ36793622
Dissecting graft-versus-leukemia from graft-versus-host-disease using novel strategiesQ36819337
TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejectionQ36941127
The Nlrp3 inflammasome regulates acute graft-versus-host diseaseQ37194967
NOD2 regulates hematopoietic cell function during graft-versus-host diseaseQ37377427
Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethalityQ37460355
TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantationQ37729354
IL-22, not simply a Th17 cytokineQ38081171
Interactions between Nod-Like Receptors and Intestinal BacteriaQ38175027
Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5Q38237638
Role of Bacterial Microflora in Development of Intestinal Lesions From Graft-Versus-Host ReactionQ39137615
Improved outcome of hematopoietic SCT in patients with homozygous gene variant of Toll-like receptor 9.Q39878275
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantationQ40516766
Graft-versus-leukemia reactions after bone marrow transplantationQ41198977
The role of bacteria and pattern recognition receptors in GVHDQ41218452
Prevention of graft-versus-host disease by adoptive T regulatory therapy is associated with active repression of peripheral blood Toll-like receptor 5 mRNA expressionQ41826765
Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R.Q42794018
MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host diseaseQ42966829
Role of the mycobiome in human acute graft-versus-host diseaseQ44211125
Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.Q44848328
The history of Toll-like receptors - redefining innate immunity.Q46240771
NOD2/CARD15 variants are not a risk factor for clinical outcome after nonmyeloablative allogeneic stem cell transplantationQ46588677
Effect of recombinant human keratinocyte growth factor (rHuKGF) on the immunopathogenesis of intestinal graft-vs.-host disease induced without a preconditioning regimen.Q47943611
Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cellsQ50332623
Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins.Q51169431
NOD2 polymorphisms predict severe acute graft-versus-host and treatment-related mortality in T-cell-depleted haematopoietic stem cell transplantation.Q51819756
P2X7 receptor polymorphism and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation.Q53571198
Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation.Q54620738
Anti-endotoxin antibody for prevention of acute GVHDQ54689661
Type I-IFNs control GVHD and GVL responses after transplantationQ57252624
Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantationQ62658643
Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantationQ62658651
Evidence that sustained growth suppression of intestinal anaerobic bacteria reduces the risk of acute graft-versus-host disease after sibling marrow transplantationQ67919340
Observations on the role of endotoxin in graft-versus-host diseaseQ68150323
Antibody titres to a rough-mutant strain of Escherichia coli in patients undergoing allogeneic bone-marrow transplantation. Evidence of a protective effect against graft-versus-host diseaseQ69891899
Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microfloraQ70043938
Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environmentQ70239474
A clinical phase I/II study of recombinant human interleukin-1 receptor in glucocorticoid-resistant graft-versus-host diseaseQ71588928
Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantationQ74444949
Probiotic effects on experimental graft-versus-host disease: let them eat yogurtQ76319360
Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantationQ78410438
Critical role of TLR9 in acute graft-versus-host diseaseQ79675206
No impact of NOD2/CARD15 on outcome after SCTQ80813551
Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontaminationQ82312167
Donor TLR9 gene tagSNPs influence susceptibility to aGVHD and CMV reactivation in the allo-HSCT setting without polymorphisms in the TLR4 and NOD2 genesQ86518787
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)337
P577publication date2014-01-01
P1433published inFrontiers in ImmunologyQ27723748
P1476titleThe role of pattern-recognition receptors in graft-versus-host disease and graft-versus-leukemia after allogeneic stem cell transplantation
P478volume5

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