| scholarly article | Q13442814 |
| P50 | author | Fabio Martelli | Q38304871 |
| Carlo Gaetano | Q56615953 | ||
| Simona Greco | Q57093036 | ||
| Alessandra Magenta | Q88685388 | ||
| Maurizio C. Capogrossi | Q114438884 | ||
| P2860 | cites work | Negative Control of p53 by Sir2α Promotes Cell Survival under Stress | Q24291828 |
| Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction | Q24292963 | ||
| Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase | Q24310456 | ||
| A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction | Q24338592 | ||
| Sir2 mediates longevity in the fly through a pathway related to calorie restriction | Q24560016 | ||
| MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3 | Q24607952 | ||
| MicroRNAs: target recognition and regulatory functions | Q24609584 | ||
| The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer? | Q24617121 | ||
| MicroRNA dysregulation in diabetic ischemic heart failure patients | Q24618462 | ||
| Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial | Q24654699 | ||
| Sirt1 regulates aging and resistance to oxidative stress in the heart | Q44830459 | ||
| p66ShcA modulates tissue response to hindlimb ischemia. | Q44917966 | ||
| Deletion of p66shc gene protects against age-related endothelial dysfunction | Q45124664 | ||
| Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide | Q45160492 | ||
| Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress. | Q45161413 | ||
| p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose | Q46100245 | ||
| Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice | Q46133555 | ||
| Maternal hypercholesterolemia enhances atherogenesis in normocholesterolemic rabbits, which is inhibited by antioxidant or lipid-lowering intervention during pregnancy: an experimental model of atherogenic mechanisms in human fetuses | Q46158387 | ||
| Early decrease of oxidative stress by atorvastatin in hypercholesterolaemic patients: effect on circulating vitamin E. | Q46861532 | ||
| G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells | Q47283265 | ||
| Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes | Q50951019 | ||
| Relation between the plasma levels of LDL-cholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene p66ShcA in pacemaker-implanted patients | Q51040369 | ||
| Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). | Q51555318 | ||
| Smad-interacting protein-1 and microRNA 200 family define a nitric oxide-dependent molecular circuitry involved in embryonic stem cell mesendoderm differentiation | Q51891376 | ||
| MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. | Q38311517 | ||
| Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | Q39481540 | ||
| Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo | Q39602218 | ||
| Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation | Q39957980 | ||
| Role of the life span determinant P66(shcA) in ethanol-induced liver damage. | Q39980519 | ||
| AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation | Q40046348 | ||
| Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study | Q40498881 | ||
| Taxol mediates serine phosphorylation of the 66-kDa Shc isoform. | Q40851562 | ||
| Seminars in medicine of the Beth Israel Hospital, Boston. Platelet-endothelium interactions. | Q40874088 | ||
| Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice | Q41811906 | ||
| Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. | Q41862776 | ||
| Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme | Q42119587 | ||
| Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts | Q42443933 | ||
| A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. | Q42521789 | ||
| Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. | Q42610778 | ||
| Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence | Q42717216 | ||
| Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction | Q42730254 | ||
| Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways | Q42800339 | ||
| 12-O-Tetradecanoylphorbol-13-acetate activates the Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of SOS involving serine phosphorylation of Shc in NIH3T3 cells | Q42833321 | ||
| Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats | Q43120253 | ||
| Effect of endothelium-specific insulin resistance on endothelial function in vivo | Q43242187 | ||
| Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks. | Q43573537 | ||
| Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells | Q43798535 | ||
| Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. | Q43823904 | ||
| Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway | Q43909621 | ||
| Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray | Q43921907 | ||
| Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation | Q43963523 | ||
| Prevention of accelerated atherosclerosis by angiotensin-converting enzyme inhibition in diabetic apolipoprotein E-deficient mice | Q44053753 | ||
| Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study | Q44324611 | ||
| Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study | Q44493428 | ||
| Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen | Q44690025 | ||
| Irbesartan but not amlodipine suppresses diabetes-associated atherosclerosis | Q44801373 | ||
| MicroRNAs in diabetes: tiny players in big disease | Q37496457 | ||
| Targeting the Nrf2 pathway against cardiovascular disease | Q37521075 | ||
| Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases | Q37591250 | ||
| Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade | Q37671114 | ||
| Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway | Q37762813 | ||
| Novel therapeutic strategies targeting vascular endothelium in essential hypertension | Q37798006 | ||
| Is oxidative stress a therapeutic target in cardiovascular disease? | Q37803047 | ||
| Epigenetics: mechanisms and implications for diabetic complications | Q37819518 | ||
| Anti‐diabetic effects of resveratrol | Q37831928 | ||
| Diabetes mellitus, a microRNA-related disease? | Q37855088 | ||
| Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species | Q37979774 | ||
| Teaching an old dogma new tricks: twenty years of Shc adaptor signalling. | Q38042699 | ||
| Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? | Q38121600 | ||
| Oxidative stress and microRNAs in vascular diseases. | Q38131402 | ||
| Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage | Q52565046 | ||
| Shear stress inhibition of H(2)O(2) induced p66(Shc) phosphorylation by ASK1-JNK inactivation in endothelium | Q53514079 | ||
| Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation. | Q53542852 | ||
| Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease | Q54338245 | ||
| Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis | Q58454329 | ||
| Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes | Q59279106 | ||
| Allopurinol Normalizes Endothelial Dysfunction in Type 2 Diabetics With Mild Hypertension | Q61831037 | ||
| p66ShcAand Oxidative Stress Modulate Myogenic Differentiation and Skeletal Muscle Regeneration after Hind Limb Ischemia | Q62236571 | ||
| Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS) | Q71060539 | ||
| Reversing endothelial dysfunction with ACE inhibitors. A new trend | Q71401306 | ||
| Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cells | Q72724940 | ||
| Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin | Q73010911 | ||
| Proinflammatory cytokines downregulate gene expression and activity of constitutive nitric oxide synthase in porcine pulmonary artery endothelial cells | Q73403342 | ||
| The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons | Q73406764 | ||
| Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype | Q79319710 | ||
| Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc | Q79711268 | ||
| Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes | Q79843154 | ||
| Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances | Q80499734 | ||
| Caloric restriction delays disease onset and mortality in rhesus monkeys | Q24655994 | ||
| Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression | Q24679740 | ||
| Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part II | Q27026993 | ||
| C-reactive protein and incident cardiovascular events among men with diabetes | Q28168019 | ||
| The function of GRB2 in linking the insulin receptor to Ras signaling pathways | Q28259867 | ||
| Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Q28274682 | ||
| A family of Shc related proteins with conserved PTB, CH1 and SH2 regions | Q28287159 | ||
| Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis | Q28290519 | ||
| Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide | Q28370621 | ||
| Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling | Q28388989 | ||
| P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction | Q28570648 | ||
| Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner | Q28578147 | ||
| Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts | Q28578240 | ||
| Not all Shc's roads lead to Ras | Q28609214 | ||
| The p66shc adaptor protein controls oxidative stress response and life span in mammals | Q29614553 | ||
| Inflammation and atherosclerosis | Q29615203 | ||
| Oxidative Stress and Diabetic Complications | Q29615423 | ||
| Gene silencing by microRNAs: contributions of translational repression and mRNA decay | Q29615825 | ||
| Role of oxidative modifications in atherosclerosis | Q29617974 | ||
| C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus | Q29619398 | ||
| Reactive oxygen species have a causal role in multiple forms of insulin resistance | Q29619831 | ||
| Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats | Q33857313 | ||
| Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications | Q33901576 | ||
| Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia | Q34082176 | ||
| Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. | Q34237731 | ||
| Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress | Q34298316 | ||
| P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity | Q34314579 | ||
| Multiple role of reactive oxygen species in the arterial wall. | Q34334387 | ||
| Scavenger receptors, oxidized LDL, and atherosclerosis | Q34496960 | ||
| The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis | Q34571691 | ||
| Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? | Q34663670 | ||
| Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. | Q34763602 | ||
| A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal | Q34894173 | ||
| Pathophysiological implications of insulin resistance on vascular endothelial function. | Q35098805 | ||
| Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium | Q35179335 | ||
| miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition | Q35210642 | ||
| Linking oxidative stress and genetics of aging with p66Shc signaling and forkhead transcription factors | Q35539040 | ||
| Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. | Q35691127 | ||
| Ischemia-reperfusion in humans. Appearance of xanthine oxidase activity | Q35811440 | ||
| Antioxidant vitamin supplements and cardiovascular disease | Q35853759 | ||
| Vascular protection by dietary polyphenols | Q35908569 | ||
| The emerging role of autophagy in the pathophysiology of diabetes mellitus | Q35985421 | ||
| SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase | Q35990346 | ||
| Advanced glycation endproducts--role in pathology of diabetic complications | Q35994161 | ||
| Redox modulation of vascular tone: focus of potassium channel mechanisms of dilation | Q36037985 | ||
| Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction | Q36115533 | ||
| Differential recruitment of PKC isoforms in HeLa cells during redox stress | Q36259332 | ||
| NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation | Q36362688 | ||
| FOXO transcription factors: key regulators of cell fate | Q36628599 | ||
| Endothelial function and dysfunction: testing and clinical relevance | Q36758044 | ||
| The role of redox signaling in epigenetics and cardiovascular disease | Q36761147 | ||
| Insulin action and insulin resistance in vascular endothelium. | Q36847470 | ||
| Improvement of insulin sensitivity by antagonism of the renin-angiotensin system | Q36854401 | ||
| Oxidative stress, AGE, and atherosclerosis | Q36891939 | ||
| NADPH oxidase inhibitors: new antihypertensive agents? | Q36897941 | ||
| Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia | Q36916418 | ||
| p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria | Q37072296 | ||
| Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis | Q37100138 | ||
| Why have antioxidants failed in clinical trials? | Q37161580 | ||
| Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials | Q37211556 | ||
| Nitrate-induced toxicity and preconditioning: a rationale for reconsidering the use of these drugs. | Q37219154 | ||
| Emerging roles of SIRT1 in vascular endothelial homeostasis | Q37222082 | ||
| The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species. | Q37321137 | ||
| Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling | Q37380419 | ||
| Endothelial function and oxidative stress in cardiovascular diseases | Q37385702 | ||
| Molecular and clinical aspects of endothelial dysfunction in diabetes. | Q37413067 | ||
| eNOS uncoupling and endothelial dysfunction in aged vessels | Q37431006 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | nitric oxide | Q207843 |
| oxidative stress | Q898814 | ||
| vascular disease | Q1266890 | ||
| diabetes | Q12206 | ||
| shc signaling adaptor proteins | Q77034750 | ||
| vascular endothelium | Q30103326 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 193095 | |
| P577 | publication date | 2014-01-01 | |
| 2014-03-05 | |||
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | BioMed Research International | Q17509958 |
| P1476 | title | Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction | |
| P478 | volume | 2014 |
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| Q50907604 | Endocan Levels and Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus |
| Q35547367 | Endocan, a putative endothelial cell marker, is elevated in preeclampsia, decreased in acute pyelonephritis, and unchanged in other obstetrical syndromes |
| Q36742028 | Fenofibrate plus Metformin Produces Cardioprotection in a Type 2 Diabetes and Acute Myocardial Infarction Model. |
| Q46294733 | IR- Role of adaptor protein p66Shc in renal pathologies |
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