| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1019893987 |
| P356 | DOI | 10.1038/SJ.ONC.1205513 |
| P698 | PubMed publication ID | 12032825 |
| P5875 | ResearchGate publication ID | 11339366 |
| P50 | author | Paolo Bernardi | Q16199016 |
| Valeria Petronilli | Q46477142 | ||
| Marco Giorgio | Q67521799 | ||
| Luisa Lanfrancone | Q73107940 | ||
| Saverio Minucci | Q87085503 | ||
| Mirella Trinei | Q117233430 | ||
| Enrica Migliaccio | Q117241458 | ||
| Angelo Cicalese | Q117241461 | ||
| P2093 | author name string | Pier Giuseppe Pelicci | |
| Veronica A Raker | |||
| Marco Maccarana | |||
| Sara Barozzi | |||
| Andrea Ventura | |||
| Ines Martin Padura | |||
| Elisabetta Milia | |||
| P2860 | cites work | A model for p53-induced apoptosis | Q24313374 |
| A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction | Q24338592 | ||
| Oxidants, antioxidants, and the degenerative diseases of aging | Q24561734 | ||
| The aging process | Q24616537 | ||
| Surfing the p53 network | Q28032484 | ||
| Oxidants, oxidative stress and the biology of ageing | Q28131725 | ||
| Genetic pathways that regulate ageing in model organisms | Q28138437 | ||
| The p66shc adaptor protein controls oxidative stress response and life span in mammals | Q29614553 | ||
| Why do we age? | Q29615672 | ||
| Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress | Q29619552 | ||
| p53 mutant mice that display early ageing-associated phenotypes | Q29622826 | ||
| Novel homologs of gp91phox. | Q34069745 | ||
| Oxidative damage to mitochondria and aging | Q34280171 | ||
| Reactive oxygen species are downstream mediators of p53-dependent apoptosis | Q34403292 | ||
| Role of mitochondria in ultraviolet-induced oxidative stress | Q40842936 | ||
| Involvement of p85 in p53-dependent apoptotic response to oxidative stress | Q41061530 | ||
| p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. | Q41723055 | ||
| p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. | Q42125448 | ||
| Genetic determinants of p53-induced apoptosis and growth arrest | Q42812233 | ||
| 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage | Q46754338 | ||
| Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain | Q48342412 | ||
| Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel. | Q52518634 | ||
| Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics | Q62472542 | ||
| Multiple deletions are detectable in mitochondrial DNA of aging mice | Q71743349 | ||
| Urinary mediators and asthma | Q77586407 | ||
| P433 | issue | 24 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | apoptotic process | Q14599311 |
| P304 | page(s) | 3872-3878 | |
| P577 | publication date | 2002-05-01 | |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis | |
| P478 | volume | 21 |
| Q42834816 | A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria |
| Q29547303 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine |
| Q37323041 | A novel role of Shc adaptor proteins in steroid hormone-regulated cancers. |
| Q53542852 | Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation. |
| Q28576904 | Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease |
| Q36558108 | Activation of the lifespan regulator p66Shc through reversible disulfide bond formation |
| Q57033552 | Adaptor Protein p66Shc: A Link Between Cytosolic and Mitochondrial Dysfunction in the Development of Diabetic Retinopathy |
| Q47609609 | Ageing and the mystery at Arles |
| Q37635409 | Aluminum-phthalocyanine chloride associated to poly(methyl vinyl ether-co-maleic anhydride) nanoparticles as a new third-generation photosensitizer for anticancer photodynamic therapy |
| Q36569112 | An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations |
| Q36246029 | An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation |
| Q30157997 | Antagonism of p66shc by melanoma inhibitory activity |
| Q92309398 | Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway |
| Q36670205 | Characterization of skeletal alterations in a model of prematurely aging mice |
| Q36936592 | Chronic nicotine exposure augments renal oxidative stress and injury through transcriptional activation of p66shc |
| Q91554961 | Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity |
| Q33896926 | Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration |
| Q37691228 | Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. |
| Q33352540 | Cytochrome c signalosome in mitochondria |
| Q35659007 | D,L‐sulforaphane‐induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc |
| Q35561699 | Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling |
| Q37037701 | Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury. |
| Q34078928 | Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene |
| Q34763602 | Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. |
| Q91387219 | Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53 |
| Q37282833 | Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans |
| Q36275402 | Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc. |
| Q28572126 | Distinct signaling functions for Shc isoforms in the heart |
| Q35618954 | Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? |
| Q33911129 | ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress |
| Q46426999 | Effect of potential role of p53 on embryo development arrest induced by H2O2 in mouse |
| Q36954194 | Electrophilic cyclopentenone isoprostanes in neurodegeneration |
| Q46370097 | Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos |
| Q35747409 | Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts |
| Q92990060 | Evolution Shapes the Gene Expression Response to Oxidative Stress |
| Q40371697 | Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells. |
| Q45012424 | Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts |
| Q24632551 | FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin |
| Q36249665 | Folic acid protects against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1. |
| Q36423249 | Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. |
| Q33559637 | FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice |
| Q37853051 | FoxOs: Unifying Links Between Oxidative Stress and Skeletal Homeostasis |
| Q46514631 | Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease. |
| Q35691127 | Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. |
| Q54314174 | Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways |
| Q35639657 | Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts |
| Q40598968 | Glutathione S-transferase overexpression protects against anthracycline-induced H9C2 cell death |
| Q38358175 | Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death. |
| Q36676675 | How does suppression of IGF-1 signaling by DNA damage affect aging and longevity? |
| Q44491455 | Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress |
| Q34663670 | Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? |
| Q34132479 | Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells |
| Q33588657 | Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc |
| Q46976925 | Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease. |
| Q34500344 | Increased p66Shc in the inner ear of D-galactose-induced aging mice with accumulation of mitochondrial DNA 3873-bp deletion: p66Shc and mtDNA damage in the inner ear during aging |
| Q46887314 | Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage |
| Q35960753 | Infection and inflammation in somatic maintenance, growth and longevity |
| Q38715885 | Influence of oxygen partial pressure on the characteristics of human hepatocarcinoma cells. |
| Q44773187 | Inhibition of ShcA isoforms p46/p52Shc enhances HIV-1 replication in CD4+ T-lymphocytes |
| Q35511952 | Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection |
| Q47164766 | Insights into the Shc Family of Adaptor Proteins. |
| Q33865202 | Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination |
| Q42443933 | Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts |
| Q42958081 | Is eternal youth scientifically plausible? Research on the role of free radicals in ageing gives cause for optimism |
| Q42373482 | Lack of Contribution of p66shc and Its Mitochondrial Translocation to Ischemia-Reperfusion Injury and Cardioprotection by Ischemic Preconditioning |
| Q41786653 | Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B. |
| Q36766862 | Longevity in mice: is stress resistance a common factor? |
| Q34068122 | Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance |
| Q34191852 | Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. |
| Q58882374 | Melanoma: targeting signaling pathways and RaLP |
| Q36239686 | Metabolic regulation of oxygen and redox homeostasis by p53: Lessons from evolutionary biology? |
| Q38700928 | Metabolomics revealed the toxicity of cationic liposomes in HepG2 cells using UHPLC-Q-TOF/MS and multivariate data analysis. |
| Q46337431 | MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes |
| Q38311517 | MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. |
| Q37991631 | Mitochondria and Reactive Oxygen Species. Which Role in Physiology and Pathology? |
| Q36827897 | Mitochondria and cardioprotection |
| Q37421172 | Mitochondria and vascular pathology. |
| Q26799985 | Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction |
| Q90057043 | Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy |
| Q92132339 | Mitochondrial dysfunction and oxidative stress in heart disease |
| Q34767374 | Mitochondrial longevity pathways |
| Q33913079 | Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release |
| Q37419562 | Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells. |
| Q38395524 | Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri |
| Q64107680 | Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66 |
| Q34567458 | Molecular bases of progeroid syndromes. |
| Q24632770 | Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury |
| Q33723676 | Monoamine oxidases as sources of oxidants in the heart |
| Q28072348 | NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? |
| Q85014016 | NOX2 activated by α1-adrenoceptors modulates hepatic metabolic routes stimulated by β-adrenoceptors |
| Q36414017 | Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma |
| Q26830607 | Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction |
| Q36494428 | Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney |
| Q38957007 | Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway |
| Q43294877 | Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis |
| Q35920697 | Ovarian Toxicity in Female Rats after Oral Administration of Melamine or Melamine and Cyanuric Acid |
| Q35089394 | Oxidant signals and oxidative stress |
| Q37661369 | Oxidative imbalance and anxiety disorders |
| Q37005075 | Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging. |
| Q36019900 | Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes. |
| Q26998478 | Oxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical students |
| Q38171333 | Oxygen regulates molecular mechanisms of cancer progression and metastasis |
| Q34314579 | P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity |
| Q34194303 | P66SHC and Ageing: ROS and TOR? |
| Q36863716 | P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan |
| Q64077558 | P66Shc and vascular endothelial function |
| Q33588755 | P66Shc signals to age. |
| Q39241816 | P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1. |
| Q38941744 | P66Shc-SIRT1 Regulation of Oxidative Stress Protects Against Cardio-cerebral Vascular Disease |
| Q39185268 | P66Shc-rac1 pathway-mediated ROS production and cell migration is downregulated by ascorbic acid. |
| Q33981210 | P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers. |
| Q34624515 | PAC1 is a direct transcription target of E2F-1 in apoptotic signaling |
| Q36321606 | Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity |
| Q39636299 | Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity |
| Q40839899 | Propofol ameliorates endothelial inflammation induced by hypoxia/reoxygenation in human umbilical vein endothelial cells: Role of phosphatase A2. |
| Q47825164 | Propofol protects against angiotensin II-induced mouse hippocampal HT22 cells apoptosis via inhibition of p66Shc mitochondrial translocation. |
| Q33899052 | Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells |
| Q44827073 | Proteome analysis of DNA damage-induced neuronal death using high throughput mass spectrometry |
| Q37190004 | RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence |
| Q37085000 | ROS and p53: a versatile partnership |
| Q34298316 | Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress |
| Q36287875 | Radical medicine: treating ageing to cure disease |
| Q42412082 | Reactive oxygen species and age-related genes p66shc, Sirtuin, FOX03 and Klotho in senescence |
| Q35607438 | Reactive oxygen species in skeletal muscle signaling. |
| Q37181390 | Recombinant adenovirus of human p66Shc inhibits MCF-7 cell proliferation |
| Q36266420 | Redox regulation of PI 3-kinase signalling via inactivation of PTEN |
| Q37824851 | Regulation of Endothelial Function by Mitochondrial Reactive Oxygen Species |
| Q37461363 | Regulation of Reactive Oxygen Species Generation in Cell Signaling |
| Q91795595 | Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC |
| Q36642761 | Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc. |
| Q37084922 | Renal ageing: changes in the cellular mechanism of energy metabolism and oxidant handling |
| Q39103238 | Role of p66shc in renal toxicity of oleic acid |
| Q39980519 | Role of the life span determinant P66(shcA) in ethanol-induced liver damage. |
| Q37167578 | Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress |
| Q39858269 | SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence |
| Q33235602 | Search for genetic variants in the p66Shc longevity gene by PCR-single strand conformational polymorphism in patients with early-onset cardiovascular disease |
| Q34977371 | Semaphorins: green light for redox signaling? |
| Q47389465 | Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice |
| Q24629563 | Single-gene mutations and healthy ageing in mammals |
| Q35058081 | Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids |
| Q35581517 | Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema |
| Q33802622 | Steroids Up-Regulate p66Shc Longevity Protein in Growth Regulation by Inhibiting Its Ubiquitination |
| Q37932440 | Strategies to target mitochondria and oxidative stress by antioxidants: key points and perspectives |
| Q28303730 | Stressing the role of FoxO proteins in lifespan and disease |
| Q46280809 | Subcellular Redox Signaling |
| Q35568805 | The Free Radical Theory of Aging |
| Q93190124 | The Mitochondria-Endoplasmic Reticulum Contacts and Their Critical Role in Aging and Age-Associated Diseases |
| Q36146320 | The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. |
| Q36898560 | The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration. |
| Q37593273 | The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia |
| Q37903700 | The Role of p53 in Metabolic Regulation |
| Q38014850 | The Role of p66shc in Oxidative Stress and Apoptosis |
| Q38861229 | The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo. |
| Q44886980 | The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. |
| Q41609724 | The effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality |
| Q87406781 | The expression of p66Shc protein in benign, premalignant, and malignant gastrointestinal lesions |
| Q34229666 | The influence of Shc proteins on life span in mice. |
| Q42490911 | The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism |
| Q33307804 | The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro |
| Q37514387 | The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos |
| Q42152595 | The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells. |
| Q39239232 | The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen species. |
| Q33613299 | Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc. |
| Q37948470 | Tumor suppressor genes and ROS: complex networks of interactions |
| Q78599742 | Tumour suppression: something for nothing? |
| Q33643276 | Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? |
| Q87526348 | [New from old : relevant factors for fracture healing in aging bone] |
| Q37625622 | let-7-repressesed Shc translation delays replicative senescence |
| Q37093673 | mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN. |
| Q29617084 | p53 and metabolism |
| Q33819250 | p53 and mitochondrial function in neurons |
| Q35151322 | p53, Oxidative Stress, and Aging |
| Q34768712 | p53: good cop/bad cop. |
| Q58454317 | p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis |
| Q40583604 | p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. |
| Q35229542 | p66Shc aging protein in control of fibroblasts cell fate |
| Q28084081 | p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis |
| Q33793988 | p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells |
| Q92525309 | p66Shc promotes HCC progression in the tumor microenvironment via STAT3 signaling |
| Q38839763 | p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts. |
| Q37867129 | p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress |
| Q37072296 | p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria |
| Q34015848 | p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis. |
| Q36990193 | p66Shc-generated oxidative signal promotes fat accumulation |
| Q33747925 | p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation |
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