Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?

scientific article

Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.FREERADBIOMED.2009.12.015
P932PMC publication ID2819595
P698PubMed publication ID20036736
P5875ResearchGate publication ID40785490

P50authorArlan G. RichardsonQ21062344
P2093author name stringAdam B Salmon
Viviana I Pérez
P2860cites workDeletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegansQ21145012
Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic MiceQ22242267
No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8Q78772821
Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster?Q78968772
High oxidative damage levels in the longest-living rodent, the naked mole-ratQ79282502
Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized miceQ79319551
Protein oxidation and agingQ79336883
Disparate patterns of age-related changes in lipid peroxidation in long-lived naked mole-rats and shorter-lived miceQ79385277
Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in miceQ80302426
Essential role of extracellular SOD in reparative neovascularization induced by hindlimb ischemiaQ80547915
Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in miceQ80649565
Acceleration of diabetic renal injury in the superoxide dismutase knockout mouse: effects of tempolQ80794376
Cultured renal epithelial cells from birds and mice: enhanced resistance of avian cells to oxidative stress and DNA damageQ80806946
Skeletal muscle reperfusion injury is enhanced in extracellular superoxide dismutase knockout mouseQ81546367
Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondriaQ81932010
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalaseQ83292772
Selecting the "right" mouse model for metabolic syndrome and type 2 diabetes researchQ84018470
Effects of dietary restriction and exercise on the age-related pathology of the ratQ86630295
Articular aging and osteoarthrosis in dwarf miceQ93733512
Cellular glutathione peroxidase protects mice against lethal oxidative stress induced by various doses of diquatQ73189569
Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosisQ73669583
Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway controlQ74113046
Properties and biological activities of thioredoxinsQ74150080
Transgenic models for the study of lung antioxidant defense: enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxiaQ74419927
Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout miceQ77419196
High-quality life extension by the enzyme peptide methionine sulfoxide reductaseQ24530884
Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogasterQ24542578
Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model miceQ24544265
Extracellular superoxide dismutase in human tissues and human cell linesQ24563402
Is the oxidative stress theory of aging dead?Q24645213
Insulin resistance is a cellular antioxidant defense mechanismQ24650976
The in vivo gene expression signature of oxidative stressQ24653033
Methionine residues as endogenous antioxidants in proteinsQ24658367
Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase.Q24671735
Aging: a theory based on free radical and radiation chemistryQ27860549
Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivoQ27932583
Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of agingQ27935539
Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiaeQ27936862
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate agingQ28191739
Trends in oxidative aging theoriesQ28237122
The biologic clock: the mitochondria?Q28249363
'Accelerated aging': a primrose path to insight?Q28252271
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutaseQ28284593
MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse modelsQ28291510
Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutaseQ28504993
MnSOD deficiency increases endothelial dysfunction in ApoE-deficient miceQ28506178
Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell deathQ28506873
Increased sensitivity of homozygous Sod2 mutant mice to oxygen toxicityQ28508044
Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epitheliumQ28508690
Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophyQ28508937
Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutaseQ28509343
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stressQ28509555
Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineQ28510205
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injuryQ28511628
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone productionQ28511652
Cellular glutathione peroxidase deficiency and endothelial dysfunctionQ28513107
Mitochondrial disease in superoxide dismutase 2 mutant miceQ28513450
Reduced fertility in female mice lacking copper-zinc superoxide dismutaseQ28584957
Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damageQ36459878
Age-related cardiac muscle sarcopenia: Combining experimental and mathematical modeling to identify mechanismsQ36571044
Phenotypic rescue by a bovine transgene in a Cu/Zn superoxide dismutase-null mutant of Drosophila melanogasterQ36646590
Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase.Q36940416
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegansQ37010759
Genetics of atherosclerosis in murine modelsQ37017734
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat.Q37117504
The overexpression of major antioxidant enzymes does not extend the lifespan of miceQ37155784
Molecular inflammation: underpinnings of aging and age-related diseasesQ37197324
Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superoxide dismutase overexpression.Q37206608
Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's diseaseQ37275995
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life spanQ37355376
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.Q37380117
Overexpression of Mn superoxide dismutase does not increase life span in miceQ37381527
Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenoneQ37398644
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevityQ37432488
Lifespan extension in genetically modified miceQ37503535
The role of selenium peroxidases in the protection against oxidative damage of membranesQ39673091
Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null miceQ39879189
Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf miceQ40231160
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.Q40460380
Extracellular superoxide dismutase attenuates lipopolysaccharide-induced neutrophilic inflammationQ40534991
Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in miceQ41725180
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient miceQ41913870
Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance of oxidative stressQ41951033
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humansQ42247172
Fowl play and the price of petrel: long-living Procellariiformes have peroxidation-resistant membrane composition compared with short-living GalliformesQ42276949
Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds.Q42488705
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.Q42521789
The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasisQ43102762
Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cellsQ43672896
Overexpression of copper/zinc-superoxide dismutase protects from kanamycin-induced hearing lossQ43688650
Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondriaQ43708597
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosisQ43713944
Extracellular superoxide dismutase deficiency and atherosclerosis in miceQ43738083
Strain-dependent high-level expression of a transgene for manganese superoxide dismutase is associated with growth retardation and decreased fertilityQ43762650
Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant miceQ43777195
Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout miceQ43811182
Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicalsQ43901756
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.Q44357321
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfismQ44505357
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life spanQ44559269
Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processesQ44627926
Catalase transgenic mice: characterization and sensitivity to oxidative stressQ44753791
Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouseQ28585450
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insultsQ28587364
Glutathione-peroxidase-1 null muscle progenitor cells are globally defectiveQ28587484
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammalsQ28587714
Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 miceQ28588882
Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degenerationQ28590177
Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 geneQ28593572
Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stressQ28752254
Increased oxidative stress in obesity and its impact on metabolic syndromeQ29012150
Extension of murine life span by overexpression of catalase targeted to mitochondriaQ29614546
The p66shc adaptor protein controls oxidative stress response and life span in mammalsQ29614553
IGF-1 receptor regulates lifespan and resistance to oxidative stress in miceQ29616382
The free radical theory of aging maturesQ29618019
Oxidative stress, caloric restriction, and agingQ29618229
Reactive oxygen species have a causal role in multiple forms of insulin resistanceQ29619831
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidationQ29620430
Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's diseaseQ30483386
Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's diseaseQ30489145
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.Q30491795
Long-lived ames dwarf mice are resistant to chemical stressorsQ30497373
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic miceQ30768763
Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) versus two non-flying mammalsQ30827243
MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein formQ30850851
Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosisQ33208094
Mitochondrial oxidative stress causes hyperphosphorylation of tau.Q33288260
Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-spanQ33614307
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.Q33806916
Fundamental aspects of reactive oxygen species, or what's the matter with oxygen?Q33836182
Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevityQ33850583
Principles of animal use for gerontological researchQ33906163
Reactive oxygen species enhance insulin sensitivityQ33941647
FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster fliesQ33957068
Methionine oxidation and agingQ33984659
Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 miceQ33999522
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intakeQ34051250
Stress resistance and aging: influence of genes and nutrition.Q34072427
Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistantQ34076174
Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxiaQ34111409
Prolonged longevity of hypopituitary dwarf miceQ34132612
A Sod2 null mutation confers severely reduced adult life span in DrosophilaQ34287545
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in lifeQ34366017
RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stressQ34415722
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxiaQ34430043
The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous miceQ34463545
The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approachQ34468457
Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function.Q34655209
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosisQ34693231
Life and death: metabolic rate, membrane composition, and life span of animals.Q34700154
Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide.Q34751217
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.Q34763602
Rate of generation of oxidative stress-related damage and animal longevityQ34979739
Diabetes, oxidative stress, and antioxidants: a reviewQ35077717
Behavioral and physiologic responses to caloric restriction in miceQ35826663
The role of insulin and insulin-like growth factor-I in mammalian ageingQ35840262
The role of oxidative damage and stress in aging.Q35947926
Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damageQ36178648
Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain.Q36269656
Studies of aging in ames dwarf mice: Effects of caloric restrictionQ36270099
Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic miceQ36270598
A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegansQ36416267
Altered oxidative stress response of the long-lived Snell dwarf mouseQ44899540
Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegansQ44941245
Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E.Q45140733
Superoxide dismutase 1 protects retinal cells from oxidative damageQ45858830
Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicityQ46070812
SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by coldQ46212369
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeothermsQ46426971
Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotypeQ46432912
Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life spanQ46499340
Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-ratQ46640434
Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influenceQ46675293
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.Q46706796
Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stressQ46829413
MsrA protects cardiac myocytes against hypoxia/reoxygenation induced cell deathQ46847971
Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomics.Q46889077
Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cellsQ46918399
Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathyQ46966545
Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 miceQ46967933
Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet.Q46968906
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.Q47593587
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneuronsQ47991847
Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouseQ48255624
Kleemeier award lecture: are there genes for aging?Q48376887
Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.Q48486981
Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase.Q48504517
Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity.Q48555925
Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.Q48685833
Response of lens epithelial cells to hydrogen peroxide stress and the protective effect of caloric restriction.Q48726624
Effect of food restriction on life span and immune functions in long-lived Fischer-344 x Brown Norway F1 rats.Q48772745
Differential MRI patterns of brain atrophy in double or single transgenic mice for APP and/or SOD.Q49051051
Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutQ49157605
Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.Q50707608
Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.Q51670074
Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters.Q51966561
Glutathione peroxidase protects mice from viral-induced myocarditis.Q52531835
Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster.Q52539677
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.Q52539802
Endogenous and exogenous thioredoxin 1 prevents goblet cell hyperplasia in a chronic antigen exposure asthma model.Q53388199
Multiplex stress resistance in cells from long-lived dwarf mice.Q53925947
Positive correlation between mammalian life span and cellular resistance to stress.Q54098417
Thioredoxin protects against joint destruction in a murine arthritis model.Q54603342
Dwarf mice and the ageing process.Q55066759
Statistical methods for testing effects on “maximum lifespan”Q57314349
Antioxidant defenses, longevity and ecophysiology of South American batsQ58837421
Inactivation of Extracellular Superoxide Dismutase Contributes to the Development of High-Volume HypertensionQ60722964
Extension of Life-Span with Superoxide Dismutase/Catalase MimeticsQ62472542
Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell linesQ70141675
Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injuryQ73082035
Deficiency in superoxide dismutases shortens life span of yeast cellsQ73145979
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevityQ73188869
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectoxidative stressQ898814
P304page(s)642-655
P577publication date2009-12-28
P1433published inFree Radical Biology and MedicineQ5500023
P1476titleUpdate on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
P478volume48

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Q48002812Mice with heterozygous deficiency of manganese superoxide dismutase (SOD2) have a skin immune system with features of "inflamm-aging".
Q90408273Microvascular function and oxidative stress in adult individuals with early onset of cardiovascular disease
Q34665297Mitochondrial DNA damage and animal longevity: insights from comparative studies
Q26799985Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction
Q33911069Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?
Q35538600Mitochondrial maintenance failure in aging and role of sexual dimorphism
Q28383638Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration
Q37903182Molecular and structural antioxidant defenses against oxidative stress in animals
Q26749241NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis
Q37154162Naturally high plasma glucose levels in mourning doves (Zenaida macroura) do not lead to high levels of reactive oxygen species in the vasculature
Q34624910Neuronal calcium homeostasis and dysregulation
Q36243410Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice.
Q36238968Nutraceutical interventions for promoting healthy aging in invertebrate models
Q35807099Nutraceuticals for geriatrics
Q36240788Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster
Q38936629Nutrigenomics at the Interface of Aging, Lifespan, and Cancer Prevention
Q47635239Obsolete ideas and logical confusions can be obstacles for biogerontology research
Q37622395Ovarian aging-like phenotype in the hyperandrogenism-induced murine model of polycystic ovary
Q60949465Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment
Q37195821Oxidative damage and cellular defense mechanisms in sea urchin models of aging
Q45419859Oxidative damage and plasma antioxidant capacity in relation to body size, age, male sexual traits and female reproductive performance in the collared flycatcher (Ficedula albicollis).
Q37005075Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.
Q26853196Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?
Q63681998Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people
Q35904697Oxidative stress and life histories: unresolved issues and current needs.
Q34745222Oxidative stress and longevity in okinawa: an investigation of blood lipid peroxidation and tocopherol in okinawan centenarians
Q38084435Oxidative stress and the ageing endocrine system
Q38230280Oxidative stress in pregnancy and fertility pathologies
Q38207007Oxidative stress in the etiology of age-associated decline in glucose metabolism
Q39152460Oxidative stress markers and all-cause mortality at older age: a population-based cohort study
Q26782125Oxidative stress, thyroid dysfunction & Down syndrome
Q64935973Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview.
Q35234072Pathways to aging: the mitochondrion at the intersection of biological and psychosocial sciences.
Q41612631Peroxiredoxin 6 overexpression attenuates lipopolysaccharide-induced acute kidney injury
Q36927688Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives
Q41438914Phenotypes, antioxidant responses, and gene expression changes accompanying a sugar-only diet in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae).
Q50510778Polyphenols decreased liver NADPH oxidase activity, increased muscle mitochondrial biogenesis and decreased gastrocnemius age-dependent autophagy in aged rats.
Q37944053Potential role of antioxidant food supplements, preservatives and colorants in the pathogenesis of allergy and asthma
Q35086834Premature aging with impaired oxidative stress defense in mice lacking TR4.
Q34343191Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1.
Q34118916Proteomic identification of carbonylated proteins and their oxidation sites
Q28085421Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform
Q36077635Reactive oxygen species and hematopoietic stem cell senescence
Q46522556Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence
Q46255766Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.
Q37939948Redox balance in the aging microcirculation: new friends, new foes, and new clinical directions.
Q27323151Reduced expression of MYC increases longevity and enhances healthspan
Q41873332Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice
Q36758014Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype?
Q35673711Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice.
Q38202479Revisiting an age-old question regarding oxidative stress
Q96641760Rodent Model of Muscular Atrophy for Sarcopenia Study
Q46252997Role of Trace Elements, Oxidative Stress and Immune System: a Triad in Premature Ovarian Failure
Q37652832Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats
Q38730906Role of reactive oxygen species in age-related neuromuscular deficits
Q47663373Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state
Q34464696Stress activated protein kinase pathway modulates homologous recombination in fission yeast
Q37267831Stress and stem cells
Q38082744Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation
Q53365942Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk.
Q57276930The Impact of Aging on Cancer Progression and Treatment
Q64265328The Naked Mole Rat: A Unique Example of Positive Oxidative Stress
Q33760075The Protective Effect of N-Acetylcysteine on Ionizing Radiation Induced Ovarian Failure and Loss of Ovarian Reserve in Female Mouse
Q26750137The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases
Q36528271The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster
Q28392215The effects of oxidative stress on female reproduction: a review
Q36298718The evolution of sex: A new hypothesis based on mitochondrial mutational erosion: Mitochondrial mutational erosion in ancestral eukaryotes would favor the evolution of sex, harnessing nuclear recombination to optimize compensatory nuclear coadaptati
Q34025605The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan.
Q57921401The peroxisome: an update on mysteries 2.0
Q41298557The role of oxidative stress in nervous system aging.
Q64902390The subchronic exposure to malathion, an organophosphate pesticide, causes lipid peroxidation, oxidative stress, and tissue damage in rats: the protective role of resveratrol.
Q48887911Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice.
Q36587651Time line of redox events in aging postmitotic cells
Q61066509Transcripts encoding free radical scavengers in human granulosa cells from primordial and primary ovarian follicles
Q92156078Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
Q36161869Vitellogenin-RNAi and ovariectomy each increase lifespan, increase protein storage, and decrease feeding, but are not additive in grasshoppers.
Q41979844What is the Proximal Cause of Aging?
Q55176338Young and Especially Senescent Endothelial Microvesicles Produce NADPH: The Fuel for Their Antioxidant Machinery.

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