Remodelling the extracellular matrix in development and disease

scientific article

Remodelling the extracellular matrix in development and disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1045412252
P356DOI10.1038/NRM3904
P3181OpenCitations bibliographic resource ID513077
P932PMC publication ID4316204
P698PubMed publication ID25415508

P50authorZena WerbQ20642782
P2093author name stringJonathan Chou
Caroline Bonnans
P2860cites workType IV collagen-initiated signals provide survival and growth cues required for liver metastasisQ83818872
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesisQ24298598
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3Q24302283
Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated geneQ24312758
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.Q24541580
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic nicheQ24600542
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic nicheQ24606366
Matrix crosslinking forces tumor progression by enhancing integrin signalingQ24646370
Collagenolytic activity in amphibian tissues: a tissue culture assayQ24648397
A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanismsQ24655131
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumorsQ24678647
Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney diseaseQ25256594
Diverse functions of matrix metalloproteinases during fibrosisQ26825368
ECM-modulated cellular dynamics as a driving force for tissue morphogenesisQ26830415
Host responses in tissue repair and fibrosisQ26852800
Exploring mechanisms of FGF signalling through the lens of structural biologyQ27015054
Tensional homeostasis and the malignant phenotypeQ27860932
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteinsQ27863380
Identification of stem cells in small intestine and colon by marker gene Lgr5Q28131701
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisQ28140740
Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.Q37068448
Protective effects of matrix metalloproteinase-12 following corneal injuryQ37132508
Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strengthQ37143394
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathwayQ37161227
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasisQ37224984
Regulation of angiogenesis: apoptotic cues from the ECM.Q37302754
The perivascular niche regulates breast tumour dormancy.Q37305997
The ADAMs: signalling scissors in the tumour microenvironmentQ37324256
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organsQ37374921
Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutationsQ37389055
Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanismQ37434526
Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophagesQ37452352
Disruption of the myocardial extracellular matrix leads to cardiac dysfunctionQ37526800
Hyaluronan digestion controls DC migration from the skin.Q37602171
Regulation of cell signalling by uPAR.Q37660895
Fibrotic extracellular matrix activates a profibrotic positive feedback loopQ37678004
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.Q37694973
Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor actionQ37698859
A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammationQ37721498
The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90βQ36804122
A focal adhesion protein-based mechanochemical checkpoint regulates cleft progression during branching morphogenesisQ36825307
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic responseQ36905046
The metastatic niche: adapting the foreign soilQ36928869
Laminin alpha 5 influences the architecture of the mouse small intestine mucosaQ36983184
Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules.Q36995587
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndromeQ28204201
Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimersQ28210655
RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasisQ28236828
Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrinQ28271413
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasisQ28276647
The impact of the extracellular matrix on inflammationQ28294058
The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectivelyQ28302805
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasisQ28305755
Btbd7 regulates epithelial cell dynamics and branching morphogenesisQ28509214
The spatial and temporal expression of the α2β1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesisQ28594318
miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumorsQ28742532
Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.Q29347269
Functional regeneration of respiratory pathways after spinal cord injuryQ29396222
Matrix Metalloproteinase Inhibitors and Cancer--Trials and TribulationsQ29544430
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progressionQ29614274
Hepatocellular carcinomaQ29615765
The extracellular matrix: not just pretty fibrilsQ29617251
Influence of tumour micro-environment heterogeneity on therapeutic responseQ29617534
The extracellular matrix: a dynamic niche in cancer progressionQ29617793
Matrix metalloproteinases: regulators of the tumor microenvironmentQ29619858
Mechanisms of fibrosis: therapeutic translation for fibrotic diseaseQ29620307
Sequence of a cDNA clone encoding the zinc metalloproteinase hemorrhagic toxin e from Crotalus atrox: evidence for signal, zymogen, and disintegrin-like structuresQ30311415
ADAMs: modulators of cell–cell and cell–matrix interactionsQ30311872
The extracellular matrix in development and morphogenesis: a dynamic viewQ30432483
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.Q30497855
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumorsQ30505678
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.Q30540007
MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assemblyQ30590712
Matrikines from basement membrane collagens: a new anti-cancer strategy.Q30729819
Integrins and human intestinal cell functionsQ33541259
Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-βQ33601451
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungsQ33609142
ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.Q33676656
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cellsQ33689582
Extracellular matrix molecules: potential targets in pharmacotherapy.Q33694487
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta.Q33721793
Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasisQ33760068
Guidance molecules in axon regenerationQ37762337
New Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane-Anchored MMPs with Therapeutic AntibodiesQ37820192
Extracellular matrix determinants of proteolytic and non-proteolytic cell migration.Q37950665
Matrikines and the lungsQ37988251
Extracellular matrix and cytoskeletal dynamics during branching morphogenesis.Q38011553
Establishment of intestinal stem cell niche during amphibian metamorphosisQ38076518
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applicationsQ38112669
Role of the extracellular matrix in regulating stem cell fateQ38120486
Metalloproteinases and their natural inhibitors in inflammation and immunity.Q38130854
Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymesQ38166449
The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut.Q38170837
Proteases and small intestinal barrier function in health and diseaseQ38180285
Cysteine cathepsins and extracellular matrix degradation.Q38200374
Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.Q38302488
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.Q38955683
Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor modelQ39076874
Cetuximab attenuates its cytotoxic and radiosensitizing potential by inducing fibronectin biosynthesisQ39109654
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironmentQ39659310
Expression of matrix metalloproteinase genes in regressing or remodeling organs during amphibian metamorphosisQ40163791
Extracellular matrix components in intestinal developmentQ40412676
Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins.Q40601873
Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4Q40794919
Invasive three-dimensional organotypic neoplasia from multiple normal human epitheliaQ41681817
Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitorsQ41827780
Collagenase inhibitor stimulates cleft formation during early morphogenesis of mouse salivary glandQ41929525
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosisQ41945735
Collagen VI is a basement membrane component that regulates epithelial cell-fibronectin interactionsQ42485290
Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary glandQ42506155
Immunocytochemical localization of extracellular-matrix proteins in relation to rat intestinal morphogenesisQ42511530
Stromal matrix metalloproteinase-11 is involved in the mammary gland postnatal development.Q42811458
Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodentsQ42851985
Integrin α8β1 confers anoikis susceptibility to human intestinal epithelial crypt cellsQ42949357
Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventionsQ44050330
Extracellular matrix structure and tissue stiffness control postnatal lung development through the lipoprotein receptor-related protein 5/Tie2 signaling systemQ45263048
A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammationQ46941338
Transcriptional activation of the matrix metalloproteinase gene stromelysin-3 coincides with thyroid hormone-induced cell death during frog metamorphosisQ48076070
The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection.Q51027821
Fibronectin requirement in branching morphogenesis.Q52103932
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome.Q53514045
Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue HealingQ53527947
Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis.Q54665746
Collagenase: Effect on the Morphogenesis of Embryonic Salivary Epithelium in vitroQ72573839
Meprin mRNA in rat intestine during normal and glucocorticoid-induced maturation: divergent patterns of expression of alpha and beta subunitsQ73327914
Proteolysis of subendothelial adhesive glycoproteins (fibronectin, thrombospondin, and von Willebrand factor) by plasmin, leukocyte cathepsin G, and elastaseQ73815975
The laminins: role in intestinal morphogenesis and differentiationQ77935851
The matrix metalloproteinase stromelysin-3 cleaves laminin receptor at two distinct sites between the transmembrane domain and laminin binding sequence within the extracellular domainQ81550469
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.Q33844240
Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesisQ33910462
Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarctionQ34035670
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.Q34081690
The extracellular matrix at a glanceQ34152843
Extracellular matrix degradation and remodeling in development and diseaseQ34216389
Mammographic density and breast cancer risk: current understanding and future prospectsQ34235753
Interactions between cancer stem cells and their niche govern metastatic colonizationQ34239769
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.Q34352074
Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation.Q34441121
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivoQ34503877
IL-13 promotes collagen accumulation in Crohn's disease fibrosis by down-regulation of fibroblast MMP synthesis: a role for innate lymphoid cells?Q34540573
Basement membranes: cell scaffoldings and signaling platforms.Q34576367
The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a reviewQ34760044
The gut microbiome in intestinal fibrosis: environmental protector or provocateur?Q34778411
Metalloproteinase inhibitors: biological actions and therapeutic opportunities.Q34863959
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritisQ34997730
Identification of a mechanochemical checkpoint and negative feedback loop regulating branching morphogenesisQ35244374
FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling.Q35551588
Overview of the matrisome--an inventory of extracellular matrix constituents and functionsQ35645897
Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis developmentQ35676538
Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant gliomaQ35780214
Regulation of matrix biology by matrix metalloproteinasesQ35885655
Discoidin domain receptor tyrosine kinases: new players in cancer progressionQ35957518
Type IV collagen mRNA accumulates in the mesenchymal compartment at early stages of murine developing intestine.Q36222661
Modelling glandular epithelial cancers in three-dimensional culturesQ36251934
Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrixQ36254949
Requirement for matrix metalloproteinase stromelysin-3 in cell migration and apoptosis during tissue remodeling in Xenopus laevisQ36328675
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.Q36503385
Cysteine cathepsins: multifunctional enzymes in cancerQ36600996
Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1.Q36683688
The role of extracellular matrix in CNS regenerationQ36707967
Thyroid hormone-induced cell-cell interactions are required for the development of adult intestinal stem cellsQ36753359
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectextracellular matrixQ193825
P304page(s)786-801
P577publication date2014-12-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleRemodelling the extracellular matrix in development and disease
P478volume15

Reverse relations

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Q101476452Deciphering cell-cell interactions and communication from gene expression
Q90526340Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility
Q47292144Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.
Q38871847Decorin in Human Colon Cancer: Localization In Vivo and Effect on Cancer Cell Behavior In Vitro
Q64947408Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis.
Q100515377Delivery of therapeutics from layer-by-layer electrospun nanofiber matrix for wound healing: An update
Q47318977Designer biomaterials for mechanobiology.
Q89964334Destroy to Rebuild: The Connection Between Bone Tissue Remodeling and Matrix Metalloproteinases
Q92782466Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides
Q49966463Diagnostic and prognostic tests in systemic lupus erythematosus.
Q52641256Dickkopf‑3 upregulation mediates the cardioprotective effects of curcumin on chronic heart failure.
Q58614808Dietary ω-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD
Q36595699Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
Q88692884Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery
Q55008802Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue.
Q57160671Dissecting MMP P' and P' subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library
Q52315593Dissecting the sources of gene expression variation in a pan-cancer analysis identifies novel regulatory mutations.
Q42278359Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization
Q30818159Distinct biological events generated by ECM proteolysis by two homologous collagenases
Q48120889Diverse patterns of molecular changes in the mechano-responsiveness of focal adhesions.
Q58795714Dose-Dependent Antifibrotic Effect of Chrysin on Regression of Liver Fibrosis: The Role in Extracellular Matrix Remodeling
Q64234750Dose-Dependent Influences of Ethanol on Ischemic Stroke: Role of Inflammation
Q38859710Drug Development for Metastasis Prevention
Q48169387Dual Regulation of Decorin by Androgen and Hedgehog Signaling During Prostate Morphogenesis
Q90216259Dynamic Substrates for Cell Biology
Q64376260Dysregulation of Krüppel-like factor 12 in the development of endometrial cancer
Q36970861ECM hydrogel for the treatment of stroke: Characterization of the host cell infiltrate
Q94595975ECMPride: prediction of human extracellular matrix proteins based on the ideal dataset using hybrid features with domain evidence
Q91658489EDB-FN Targeted Peptide-Drug Conjugates for Use against Prostate Cancer
Q100737208ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells
Q98243698Early intervention with Di-Dang Decoction prevents macrovascular fibrosis in diabetic rats by regulating the TGF-β1/Smad signalling pathway
Q90189976Effect of Laminin Derived Peptides IKVAV and LRE Tethered to Hyaluronic Acid on hiPSC Derived Neural Stem Cell Morphology, Attachment and Neurite Extension
Q92324307Effect of MMP-2 gene silencing on radiation-induced DNA damage in human normal dermal fibroblasts and breast cancer cells
Q53691439Effect of Resistance Training on Extracellular Matrix Adaptations in Skeletal Muscle of Older Rats.
Q42177388Effect of bosentan is correlated with MMP-9/TIMP-1 ratio in bleomycin-induced pulmonary fibrosis
Q38942800Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder
Q58725170Effects of a 15-month anti-TNF-α treatment on plasma levels of glycosaminoglycans in women with rheumatoid arthritis
Q90324687Elastin is a key factor of tumor development in colorectal cancer
Q52365807Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication.
Q37593533Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells
Q41003981Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel
Q36220259Endostatin's emerging roles in angiogenesis, lymphangiogenesis, disease, and clinical applications.
Q50066012Engineering Approaches to Study Cellular Decision-Making.
Q92764779Engineering Biocompatible Scaffolds through the Design of Elastin-Based Short Peptides
Q90719267Engineering clinically-relevant human fibroblastic cell-derived extracellular matrices
Q92059936Engineering of Aerogel-Based Biomaterials for Biomedical Applications
Q90295146Enhancement of collagen deposition and cross-linking by coupling lysyl oxidase with bone morphogenetic protein-1 and its application in tissue engineering
Q35983435Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis
Q27317379Enzymatically Regulated Peptide Pairing and Catalysis for the Bioanalysis of Extracellular Prometastatic Activities of Functionally Linked Enzymes
Q26801442Epithelia migration: a spatiotemporal interplay between contraction and adhesion
Q89805613Esophageal Cancer Development: Crucial Clues Arising from the Extracellular Matrix
Q97530232Esophageal extracellular matrix hydrogel mitigates metaplastic change in a dog model of Barrett's esophagus
Q55276271Evaluation of Fluorine-18-Labeled α1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase.
Q91621157Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
Q39553253Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients
Q92060214Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis
Q41592769Excessive matrix metalloprotease-mediated degradation of interstitial tissue (type I collagen) independently predicts short-term survival in an observational study of postmenopausal women diagnosed with cancer
Q36762296Expression and localization of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct during maturation
Q92758046Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
Q36061121Extensive Transcriptomic and Genomic Analysis Provides New Insights about Luminal Breast Cancers
Q90574724Extracellular Matrix Alterations in Metastatic Processes
Q97526447Extracellular Matrix Mimicking Nanofibrous Scaffolds Modified With Mesenchymal Stem Cell-Derived Extracellular Vesicles for Improved Vascularization
Q38716501Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases
Q90461405Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases
Q35742523Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation
Q97519611Extracellular Matrix and Oxidative Phosphorylation: Important Role in the Regulation of Hypothalamic Function by Gut Microbiota
Q41684260Extracellular Matrix in Plants and Animals: Hooks and Locks for Viruses
Q38932298Extracellular matrix and the myeloid-in-myeloma compartment: balancing tolerogenic and immunogenic inflammation in the myeloma niche
Q89769212Extracellular matrix as a driver of progressive fibrosis
Q36381030Extracellular matrix assembly: a multiscale deconstruction
Q34506409Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis
Q50530044Extracellular matrix couples the convergence movements of mesoderm and neural plate during the early stages of neurulation.
Q64058762Extracellular matrix from decellularized mesenchymal stem cells improves cardiac gene expressions and oxidative resistance in cardiac C-kit cells
Q37395986Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification
Q41592312Extracellular matrix microarrays to study inductive signaling for endoderm specification
Q50147080Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets.
Q37730682Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
Q45073825Extracellular matrix remodeling in 3D: implications in tissue homeostasis and disease progression
Q42514682Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells.
Q101051400Exuberant fibroblast activity compromises lung function via ADAMTS4
Q58122457Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel
Q30835803Fibronectin-guided migration of carcinoma collectives
Q90138987Fibrosis and cancer: A strained relationship
Q64891983Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential.
Q38801418Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease
Q92336443Fra-2-expressing macrophages promote lung fibrosis in mice
Q55096200From Structure to Phenotype: Impact of Collagen Alterations on Human Health.
Q92704094From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues
Q37735126From embryonic development to human diseases: The functional role of caveolae/caveolin
Q39284465From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells
Q27332091Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis
Q45872947Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Q39384191Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.
Q26786515Functional significance of macrophages in pancreatic cancer biology
Q93166987Functionalized Enzyme-Responsive Biomaterials to Model Tissue Stiffening in vitro
Q57178278Future Research Directions in the Design of Versatile Extracellular Matrix in Tissue Engineering
Q104742151Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma
Q38660472Gaining myocytes or losing fibroblasts: Challenges in cardiac fibroblast reprogramming for infarct repair
Q90673117Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics
Q51321427Gelatin-Hyaluronic Acid Hydrogels with Tuned Stiffness to Counterbalance Cellular Forces and Promote Cell Differentiation.
Q90724463Gene Expression Profiling of the Extracellular Matrix Signature in Macrophages of Different Activation Status: Relevance for Skin Wound Healing
Q38599922Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy
Q38762471Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
Q88963822Genetic Modifiers of the Breast Tumor Microenvironment
Q38630630Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival
Q64057072Genome-wide Analysis Reveals DNA Methylation Alterations in Obesity Associated with High Risk of Colorectal Cancer
Q47111892Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer
Q52668564Genome-wide transcriptome analysis identifies alternative splicing regulatory network and key splicing factors in mouse and human psoriasis.
Q41176136Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro
Q26745510Glycosylation of matrix metalloproteases and tissue inhibitors: present state, challenges and opportunities
Q47144328Goats without Prion Protein Display Enhanced Proinflammatory Pulmonary Signaling and Extracellular Matrix Remodeling upon Systemic Lipopolysaccharide Challenge
Q36811729Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon
Q91081558HIF-1α metabolically controls collagen synthesis and modification in chondrocytes
Q92890533Harnessing the secreted extracellular matrix to engineer tissues
Q38654054Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics
Q104111173Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
Q40200602Hepatic stellate cells as key target in liver fibrosis
Q38957511Heralding a new paradigm in 3D tumor modeling
Q37713095Heterogeneity in Cancer Metabolism: New Concepts in an Old Field
Q48018273High Grade T1 Papillary Urothelial Bladder Cancer Shows Prominent Peritumoral Retraction Clefting.
Q90662117High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1β-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes
Q64980612How electrostatic networks modulate specificity and stability of collagen.
Q91794722Human Platelet Lysates-Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion Assessment
Q90071439Human placental villi contain stromal macrovesicles associated with networks of stellate cells
Q41701136Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1
Q33638958Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time.
Q38638213Hyaluronan's Role in Fibrosis: A Pathogenic Factor or a Passive Player?
Q46264415Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells
Q89725633Hypoxic-ischemic-related cerebrovascular changes and potential therapeutic strategies in the neonatal brain
Q33799143Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands
Q92217667Identification of Pparγ-modulated miRNA hubs that target the fibrotic tumor microenvironment
Q50953445Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing.
Q36544030Identification of ageing-associated naturally occurring peptides in human urine
Q36548357Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway
Q41957615Identification of genes expressed in the migrating primitive myeloid lineage of Xenopus laevis
Q64276181Identification of hub genes and therapeutic drugs in esophageal squamous cell carcinoma based on integrated bioinformatics strategy
Q91689551Identification of key candidate genes for pancreatic cancer by bioinformatics analysis
Q29299789Impact of the physical microenvironment on tumor progression and metastasis
Q42184310Implantation of Brain-Derived Extracellular Matrix Enhances Neurological Recovery after Traumatic Brain Injury.
Q42628541In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides.
Q38707919In Vitro Models to Study Human Lung Development, Disease and Homeostasis.
Q48093287In focus in HCB.
Q26775715In vivo experience with natural scaffolds for myocardial infarction: the times they are a-changin'
Q42355442In vivo magnetic resonance imaging of a mouse model of myelofibrosis.
Q47205457In-vitro analysis of Quantum Molecular Resonance effects on human mesenchymal stromal cells
Q96954755Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway
Q36536885Independent Control of Topography for 3D Patterning of the ECM Microenvironment
Q48042673Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance.
Q89605884Inflammation and matrix metalloproteinase 9 (Mmp-9) regulate photoreceptor regeneration in adult zebrafish
Q94450959Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease
Q57838594Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts
Q53670734Influence of the alginate production on cell-to-cell communication in Pseudomonas aeruginosa PAO1.
Q42653992Inhibition of extracellular matrix mediated TGF-β signalling suppresses endometrial cancer metastasis
Q91940266Inhibition of miR-9 attenuates fibroblast proliferation in human hyperplastic scar by regulating TGF-β1
Q38688202Insider trading: Extracellular matrix proteins and their non-canonical intracellular roles
Q40415132Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4
Q98735779Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Pathways Associated With Clinical Outcome in Hepatocellular Carcinoma
Q77790315Integration of inflammation, fibrosis, and cancer induced by carbon nanotubes
Q88727919Integration of miRNA weighted gene co-expression network and miRNA-mRNA co-expression analyses reveals potential regulatory functions of miRNAs in calf rumen development
Q42110868Integrative Systems Biology Investigation of Fabry Disease.
Q92480194Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance
Q101038696Integrin alpha V (ITGAV) expression in esophageal adenocarcinoma is associated with shortened overall-survival
Q92643473Integrins as biomechanical sensors of the microenvironment
Q38538187Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact
Q52895606Interleukin-6 increases expression of serine protease inhibitor Kazal type 1 through STAT3 in colorectal adenocarcinoma.
Q27316850Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling
Q42730658Intestinal Stem Cell Niche Insights Gathered from Both In Vivo and Novel In Vitro Models
Q41395432Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components.
Q38662882Intravital Insights into Heterogeneity, Metastasis, and Therapy Responses
Q55508822Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p.
Q55278651Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish.
Q90643352Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Q90507465Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain
Q52649424Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices.
Q89546073Isolation of Highly Migratory and Invasive Cells in Three-Dimensional Gels
Q92996195Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways
Q100432621Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformations
Q102210982LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage
Q56975738LRP1 is required for novobiocin-mediated fibronectin turnover
Q55016886Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation.
Q90591063Laminin-driven Epac/Rap1 regulation of epithelial barriers on decellularized matrix
Q64898913Large-Area Biomolecule Nanopatterns on Diblock Copolymer Surfaces for Cell Adhesion Studies.
Q50218712Late Somatic Gene 2 disrupts parental spheroids cooperatively with Volvox hatching enzyme A in Volvox.
Q90233649Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
Q46253395Learning from regeneration research organisms: The circuitous road to scar free wound healing.
Q57428850Leveraging Physiology for Precision Drug Delivery
Q37581972Lipid raft localization of epidermal growth factor receptor alters matrix metalloproteinase-1 expression in SiHa cells via the MAPK/ERK signaling pathway
Q41611913Loss of fibulin-2 expression is involved in the inhibition of breast cancer invasion and forms a new barrier in addition to the basement membrane
Q37406845Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer
Q55477841Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.
Q41331553Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide
Q39237924Lung carcinogenesis and fibrosis taken together: just coincidence?
Q49739030Lysyl oxidases expression and histopathological changes of the diabetic rat nephron.
Q92758109M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling
Q26746892MLK3 Signaling in Cancer Invasion
Q47104693MMP-2 and MMP-13 affect vasculogenic mimicry formation in large cell lung cancer
Q92740963MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury
Q92534720MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2
Q64998993MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells.
Q42353260MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment.
Q57801720Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland
Q54951433Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions.
Q89047134Maintenance of Proper Germline Stem Cell Number Requires Adipocyte Collagen in Adult Drosophila Females
Q47311789Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer
Q47378990Mapping Extracellular Matrix Proteins in Formalin-Fixed, Paraffin-Embedded Tissues by MALDI Imaging Mass Spectrometry.
Q40068821Mapping the Nonreciprocal Micromechanics of Individual Cells and the Surrounding Matrix Within Living Tissues.
Q35556624Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis
Q39240676Maternal lactocrine programming of porcine reproductive tract development.
Q90501810MatrisomeDB: the ECM-protein knowledge database
Q64112470Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study
Q53747809Matrix Metalloproteases as Biomarkers of Disease.
Q64069891Matrix Metalloproteinase 11 Is a Potential Therapeutic Target in Lung Adenocarcinoma
Q37268569Matrix Metalloproteinase Expression in the Rat Myometrium During Pregnancy, Term Labor, and Postpartum
Q35947519Matrix Metalloproteinase Mediated Type I Collagen Degradation - An Independent Risk Factor for Mortality in Women.
Q47255847Matrix Metalloproteinases (MMPs) in Liver Diseases
Q36278535Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development.
Q93049332Matrix Nanopatterning Regulates Mesenchymal Differentiation through Focal Adhesion Size and Distribution According to Cell Fate
Q37088316Matrix Remodeling in Pulmonary Fibrosis and Emphysema.
Q47221688Matrix biomechanics and dynamics in pulmonary fibrosis
Q83227916Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into flight muscles
Q59281349Matrix metalloproteinase-13 unlucky for the forming thrombus
Q89916901Matrix metalloproteinases regulate ECM accumulation but not larval heart growth in Drosophila melanogaster
Q64057399Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis
Q58132098Mechanical Forces in Tumor Angiogenesis
Q90748226Mechanical Regulation of Nuclear Translocation in Migratory Neurons
Q59698916Mechanical and Systems Biology of Cancer
Q89686914Mechanical regulation of glycolysis via cytoskeleton architecture
Q54982400Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis.
Q38872160Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling
Q36180735Mechanisms and Targets Involved in Dissemination of Ovarian Cancer
Q93027832Mechanisms of physiological tissue remodeling in animals: Manipulating tissue, organ, and organism morphology
Q64993228Mechanobiology of Cancer Stem Cells and Their Niche.
Q92409416Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition
Q26998075Mechanotransduction and extracellular matrix homeostasis
Q33624824Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis
Q49206497Mesenchymal stromal cell-derived exosome-rich fractionated secretome confers a hepatoprotective effect in liver injury.
Q92156218Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis
Q36955864Metalloproteinases: a Functional Pathway for Myeloid Cells
Q41829912Methanethiol Binding Strengths and Deprotonation Energies in Zn(II)-Imidazole Complexes from M05-2X and MP2 Theories: Coordination Number and Geometry Influences Relevant to Zinc Enzymes
Q37699027Method to study cell migration under uniaxial compression
Q93354312MiR-192, miR-200c and miR-17 are fibroblast-mediated inhibitors of colorectal cancer invasion
Q47267587MiR-411 suppressed vein wall fibrosis by downregulating MMP-2 via targeting HIF-1α.
Q64941127MicroRNA hsa-miR-623 directly suppresses MMP1 and attenuates IL-8-induced metastasis in pancreatic cancer.
Q38712880MicroRNA-29a mediates the impairment of intestinal epithelial integrity induced by intrauterine growth restriction in pig.
Q94560347Microanalysis of Fish Ovarian Follicular Atresia: A Possible Synergic Action of Somatic and Immune Cells
Q38588066Microenvironment in metastasis: roadblocks and supportive niches
Q96693540Microenvironment remodeled by tumor and stromal cells elevates fibroblast-derived COL1A1 and facilitates ovarian cancer metastasis
Q38857139Microenvironmental Control of Adipocyte Fate and Function.
Q39433862Microenvironmental regulation of tumour angiogenesis
Q58722306Mineralocorticoid Receptor and Aldosterone-Related Biomarkers of End-Organ Damage in Cardiometabolic Disease
Q54195728Mining TCGA database for genes of prognostic value in glioblastoma microenvironment.
Q54957861Mithramycin A Alleviates Osteoarthritic Cartilage Destruction by Inhibiting HIF-2α Expression.
Q59133328Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age
Q90585651Modeling Tissue Polarity in Context
Q103002609Modeling the effects of hyaluronic acid degradation on the regulation of human astrocyte phenotype using multicomponent interpenetrating polymer networks (mIPNs)
Q92702708Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs)
Q61798674Molecular Players in Hematologic Tumor Cell Trafficking
Q57146133Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin
Q37643379Molecular signature of anastasis for reversal of apoptosis
Q39018865Morphoregulatory pathways in prostate ductal development
Q91788756Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
Q64059526Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury
Q38680872Multicellular tumor invasion and plasticity in biomimetic materials
Q52723794Multifaced Roles of the αvβ3 Integrin in Ehlers-Danlos and Arterial Tortuosity Syndromes' Dermal Fibroblasts.
Q89496785Multiphoton microscopy of the dermoepidermal junction and automated identification of dysplastic tissues with deep learning
Q64923455Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells.
Q42315586Multiscale microenvironmental perturbation of pluripotent stem cell fate and self-organization
Q58617563Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
Q64118724Myosin II Activity Is Selectively Needed for Migration in Highly Confined Microenvironments in Mature Dendritic Cells
Q91994891NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction
Q92832813Nano-mechanical mapping of interdependent cell and ECM mechanics by AFM force spectroscopy
Q41633874NanoVelcro-captured CTC number concomitant with enhanced serum levels of MMP7 and MMP9 enables accurate prediction of metastasis and poor prognosis in patients with lung adenocarcinoma
Q89630010Neovascularization is a key feature of liver fibrosis progression: anti-angiogenesis as an innovative way of liver fibrosis treatment
Q47165813Network Modularity in Breast Cancer Molecular Subtypes
Q39929900Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.
Q26746714Neural regulation of cancer: from mechanobiology to inflammation
Q37070125Neutrophils: Critical components in experimental animal models of cancer
Q90162256New Insights into ADAMTS Metalloproteases in the Central Nervous System
Q39447253New Insights into the Role of Matrix Metalloproteinases in Preeclampsia
Q39374847New endoscopic approach of anti-fibrotic therapy for inflammatory bowel disease
Q36338452Nicotinic alpha 7 receptor expression and modulation of the lung epithelial response to lipopolysaccharide.
Q60043969Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients
Q91863543Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix
Q90053582Novel Associations Within the Tumor Microenvironment: Fibulins Meet ADAMTSs
Q50100394Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Q89972840Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD
Q64236788OCT4B Isoform Promotes Anchorage-Independent Growth of Glioblastoma Cells
Q28072140Obesity: An Immunometabolic Perspective
Q100385817Omidenepag, a non-prostanoid EP2 receptor agonist, induces enlargement of the 3D organoid of 3T3-L1 cells
Q38355587On the move: endocytic trafficking in cell migration.
Q38699073On-command on/off switching of progenitor cell and cancer cell polarized motility and aligned morphology via a cytocompatible shape memory polymer scaffold.
Q58743871Oocyte growth, follicular complex formation and extracellular-matrix remodeling in ovarian maturation of the imperial zebra pleco fish Hypancistrus zebra
Q89555393Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases
Q38737016Osteopontin expression in co-cultures of human squamous cell carcinoma-derived cells and osteoblastic cells and its effects on the neoplastic cell phenotype and osteoclastic activation.
Q99551083Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells
Q52717140Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer.
Q26799981Overview of Methods for Overcoming Hindrance to Drug Delivery to Tumors, with Special Attention to Tumor Interstitial Fluid
Q94562389Pancreatic cancer stroma: an update on therapeutic targeting strategies
Q48181118Pancreatic gene expression during recovery after pancreatitis reveals unique transcriptome profiles
Q93186425Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis
Q93075393Pathogenesis of fibrostenosing Crohn's disease
Q29994686Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ
Q41462744Pathophysiological Mechanisms in Sclerosing Skin Diseases
Q52677688Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma.
Q92356186Perspectives on Directions and Priorities for Future Preclinical Studies in Regenerative Medicine
Q36593214Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?
Q39290025Pharmacological modulation of cell death in organ transplantation.
Q98282968Phenotypic and gene expression features associated with variation in chronic ethanol consumption in heterogeneous stock collaborative cross mice
Q92133058Photoacoustic imaging as a tool to probe the tumour microenvironment
Q56886411Phrase mining of textual data to analyze extracellular matrix protein patterns across cardiovascular disease
Q58583166Physical control of tissue morphogenesis across scales
Q89348534Physical properties of the photodamaged human skin dermis: Rougher collagen surface and stiffer/harder mechanical properties
Q38963431Plasticity of tumor cell invasion: governance by growth factors and cytokines.
Q64263715Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms
Q37398895Pleiotropic roles of metallothioneins as regulators of chondrocyte apoptosis and catabolic and anabolic pathways during osteoarthritis pathogenesis.
Q93272415Polarimetric second-harmonic generation microscopy of the hierarchical structure of collagen in stage I-III non-small cell lung carcinoma
Q93017651Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases
Q58737385Priming the seed: alters epithelial cell invasiveness in early gastric carcinogenesis
Q92236455Prognostic significance of periostin in colorectal cancer
Q45904707Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway.
Q91785569Prospective molecular mechanism of COL5A1 in breast cancer based on a microarray, RNA sequencing and immunohistochemistry
Q26747722Protease inhibition as new therapeutic strategy for GI diseases
Q48691301Protease-activated nanomaterials for targeted cancer theranostics.
Q33795055Proteases Revisited: Roles and Therapeutic Implications in Fibrosis
Q48192654Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion.
Q54119266Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis.
Q61795741Proteogenomics Uncovers Critical Elements of Host Response in Bovine Soft Palate Epithelial Cells Following In Vitro Infection with Foot-And-Mouth Disease Virus
Q91813656Proteomic Identification and Time-Course Monitoring of Secreted Proteins During Expansion of Human Mesenchymal Stem/Stromal in Stirred-Tank Bioreactor
Q92916319Proteomics Analysis of Extracellular Matrix Remodeling During Zebrafish Heart Regeneration
Q36601156Pushing, pulling, and squeezing our way to understanding mechanotransduction
Q92096774Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue
Q37575966Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Q33844218RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients
Q52716082RNA-sequencing reveals long-term effects of silver nanoparticles on human lung cells.
Q38761174Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?
Q47321968Recellularization of decellularized adipose tissue-derived stem cells: role of the cell-secreted extracellular matrix in cellular differentiation.
Q91869776Recent advances in tissue imaging for cancer research
Q47394596Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer
Q91334860Reduction of cardiac TGFβ-mediated profibrotic events by inhibition of Hsp90 with engineered protein
Q36475231Reduction of fibroblast size/mechanical force down-regulates TGF-β type II receptor: implications for human skin aging
Q37313634Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells
Q92923216Regulation of the Extracellular Matrix by Ciliary Machinery
Q47242744Releasing Addiction Memories Trapped in Perineuronal Nets
Q26777144Remodeling Components of the Tumor Microenvironment to Enhance Cancer Therapy
Q33820881Reorganized Collagen in the Tumor Microenvironment of Gastric Cancer and Its Association with Prognosis
Q64256184Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix
Q46528200Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands
Q57032072Reversible self-assembly of superstructured networks
Q61807550Reversion of in vivo fibrogenesis by novel chromone scaffolds
Q90668321Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function
Q58702065Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma
Q57027553Role of Extracellular Matrix in Development and Cancer Progression
Q38665718Role of Hypohalous Acids in Basement Membrane Homeostasis
Q89905744Role of Region-Specific Brain Decellularized Extracellular Matrix on In Vitro Neuronal Maturation
Q28069417Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis
Q64946390Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression.
Q57040347Roles of glycosaminoglycans as regulators of ligand/receptor complexes
Q52368449SWATH mass spectrometry as a tool for quantitative profiling of the matrisome.
Q58569274Sequential modes of crosslinking tune viscoelasticity of cell-instructive hydrogels
Q36566822Severe Infection With Avian Influenza A Virus is Associated With Delayed Immune Recovery in Survivors
Q49853441Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse.
Q38763946Silencing of OTUB1 inhibits migration of human glioma cells in vitro
Q89762331Simulated Microgravity Influences VEGF, MAPK, and PAM Signaling in Prostate Cancer Cells
Q98245613Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
Q91995495Single-cell connectomic analysis of adult mammalian lungs
Q55214898Sleeping Beauty and the Microenvironment Enchantment: Microenvironmental Regulation of the Proliferation-Quiescence Decision in Normal Tissues and in Cancer Development.
Q97570299Small nucleolar RNAs signature (SNORS) identified clinical outcome and prognosis of bladder cancer (BLCA)
Q40112869Soft matrices inhibit cell proliferation and inactivate the fibrotic phenotype of deep endometriotic stromal cells in vitro
Q89582523Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis
Q55004841Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development.
Q97522427Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks
Q99710926Spatial mapping of the collagen distribution in human and mouse tissues by force volume atomic force microscopy
Q37161721Spatially patterned matrix elasticity directs stem cell fate
Q60046807Spatio-Temporal Control of Cell Adhesion: Toward Programmable Platforms to Manipulate Cell Functions and Fate
Q37451283Spatiotemporal dynamics of androgen signaling underlie sexual differentiation and congenital malformations of the urethra and vagina
Q33624763Spondyloarthritis: Matrix Metalloproteinasesas Biomarkers of Pathogenesis and Response to Tumor Necrosis Factor (TNF) Inhibitors
Q33572252Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment.
Q58592367Steps in Mechanotransduction Pathways that Control Cell Morphology
Q50109651Strategies to Target Matrix Metalloproteinases as Therapeutic Approach in Cancer.
Q89764049Stretching Single Collagen Fibrils Reveals Nonlinear Mechanical Behavior
Q53342529Stretching the boundaries of extracellular matrix research.
Q90237236Stromal Cells in the Pathogenesis of Inflammatory Bowel Disease
Q48160145Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2.
Q52715213Substrate stiffness-dependent exacerbation of endothelial permeability and inflammation: mechanisms and potential implications in ALI and PH (2017 Grover Conference Series).
Q41148781Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling.
Q46252111Supplemental psyllium fibre regulates the intestinal barrier and inflammation in normal and colitic mice.
Q55447608Syndecans and Enzymes Involved in Heparan Sulfate Biosynthesis and Degradation Are Differentially Expressed During Human Odontogenesis.
Q90704870Syndecans and Enzymes for Heparan Sulfate Biosynthesis and Modification Differentially Correlate With Presence of Inflammatory Infiltrate in Periodontitis
Q90055149Syndecans in Inflammation at a Glance
Q90169780T Cell Cytokines Impact Epithelial Cell Responses during Helicobacter pylori Infection
Q92932341T lymphocytes against solid malignancies: winning ways to defeat tumours
Q89768092TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway
Q39155183TGF-β Family Signaling in Connective Tissue and Skeletal Diseases
Q100762253TGF-β suppresses type 2 immunity to cancer
Q92347732TLR3 Deficiency Leads to a Dysregulation in the Global Gene-Expression Profile in Murine Oviduct Epithelial Cells Infected with Chlamydia muridarum
Q36103058TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation
Q90411009Tamoxifen calms down the distressed PDAC stroma
Q94948652Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
Q98466261Targeting the Extra-Cellular Matrix-Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors
Q47748198Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions.
Q52322982Targeting the tumour stroma to improve cancer therapy.
Q38666356Taspase1: a 'misunderstood' protease with translational cancer relevance.
Q41628709Temporal Modulation of Stem Cell Activity Using Magnetoactive Hydrogels
Q91606840Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling
Q92503762Tendinopathy: Pathophysiology, Therapeutic Options, and Role of Nutraceutics. A Narrative Literature Review
Q90293432The Air Sac Primordium of Drosophila: A Model for Invasive Development
Q96303235The Bone Extracellular Matrix in Bone Formation and Regeneration
Q92256310The Diverse Roles of TIMP-3: Insights into Degenerative Diseases of the Senescent Retina and Brain
Q58093770The Emerging Role of the Microenvironment in Endometrial Cancer
Q64901089The Evaluation of Glutathione Reductase and Malondialdehyde Levels in Patients With Lumbar Disc Degeneration Disease.
Q92242795The Expression, Regulation, and Biomarker Potential of Glypican-1 in Cancer
Q57159994The Extracellular Matrix and Pancreatic Cancer: A Complex Relationship
Q33361929The Extracellular Matrix in Epithelial Ovarian Cancer - A Piece of a Puzzle
Q89660060The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
Q90114450The G Protein-Coupled Estrogen Receptor (GPER) Expression Correlates with Pro-Metastatic Pathways in ER-Negative Breast Cancer: A Bioinformatics Analysis
Q92702620The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy
Q57295316The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells
Q97557237The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
Q90241038The Interplay of Autophagy and Tumor Microenvironment in Colorectal Cancer-Ways of Enhancing Immunotherapy Action
Q93103387The Janus Face of Tumor Microenvironment Targeted by Immunotherapy
Q90169803The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them
Q88936916The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate
Q28082121The Road not Taken: Less Traveled Roads from the TGN to the Plasma Membrane
Q33361879The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle
Q93155787The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration
Q58774855The VP1 unique region of human parvovirus B19 and human bocavirus induce lung injury in naïve Balb/c mice
Q88945645The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function
Q33619657The arterial microenvironment: the where and why of atherosclerosis
Q91663923The congenital clubfoot - immunohistological analysis of the extracellular matrix
Q97643506The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis
Q64080318The effect of the chitosan-collagen membrane on wound healing process in rat mandibular defect
Q47378378The effects of conditioned media generated by polarized macrophages on the cellular behaviours of bone marrow mesenchymal stem cells.
Q94555032The effects of growth hormone on therapy resistance in cancer
Q90208339The emerging roles of eosinophils in mucosal homeostasis
Q39021700The epigenetic landscape of renal cancer
Q48209805The epitope-mediated MMP activation assay: detection and quantification of the activation of Mmp2 in vivo in the zebrafish embryo
Q52365502The extracellular matrix as a key regulator of intracellular signalling networks.
Q39341011The extracellular matrix in IBD: a dynamic mediator of inflammation
Q39429635The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform
Q28831183The extracellular matrix: Tools and insights for the "omics" era
Q28076570The fibrosis-cell death axis in heart failure
Q38949781The function of heparan sulfate during branching morphogenesis
Q47291833The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Q48247148The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.
Q50433076The laminin-derived peptide C16 regulates GPNMB expression and function in breast cancer.
Q57752423The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation
Q97426299The liver matrisome - looking beyond collagens
Q98196884The mesenchymal context in inflammation, immunity and cancer
Q47836659The multifaceted role of periostin in priming the tumor microenvironments for tumor progression
Q92977314The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation
Q36782384The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma
Q97570267The prognostic value and potential mechanism of Matrix Metalloproteinases among Prostate Cancer
Q48106053The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.
Q90013636The role of extracellular matrix stiffness in regulating cytoskeletal remodeling via vinculin in synthetic smooth muscle cells
Q39117766The role of the extracellular matrix in primary myelofibrosis
Q47343542The spatial patterning of RGD and BMP-2 mimetic peptides at the subcellular scale modulates human mesenchymal stem cells osteogenesis.
Q52720562The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution.
Q28077074The tumor microenvironment in esophageal cancer
Q36281053The use of urinary proteomics in the assessment of suitability of mouse models for ageing
Q50049076Therapeutic targets for altering mitochondrial dysfunction associated with diabetic retinopathy.
Q49283462Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning.
Q47134459Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology.
Q49902354Three-dimensional visualization of extracellular matrix networks during murine development.
Q61811369Time-course analysis of cardiac and serum galectin-3 in viral myocarditis after an encephalomyocarditis virus inoculation
Q61037999Tissue Destruction Caused by Entamoeba histolytica Parasite: Cell Death, Inflammation, Invasion, and the Gut Microbiome
Q50077270Tissue Force Programs Cell Fate and Tumor Aggression.
Q36338681Tissue matrix arrays for high-throughput screening and systems analysis of cell function
Q90073173Tissue rheology in embryonic organization
Q47365590Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells
Q89638598Towards extracellular matrix normalization for improved treatment of solid tumors
Q39191612Towards integrating extracellular matrix and immunological pathways.
Q92267159Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states
Q92631183Tracking Extracellular Matrix Remodeling in Lungs Induced by Breast Cancer Metastasis. Fourier Transform Infrared Spectroscopic Studies
Q27468674Transcriptome meta-analysis reveals a dysregulation in extra cellular matrix and cell junction associated gene signatures during Dengue virus infection
Q91638878Transcriptome sequencing reveals dynamic changes in matrix metalloproteinases in facet joint osteoarthritis
Q92602894Transcriptomic Profiling of Adipose Derived Stem Cells Undergoing Osteogenesis by RNA-Seq
Q89785669Transcriptomic analysis of the testicular fusion in Spodoptera litura
Q47393365Trial watch: Immune checkpoint blockers for cancer therapy
Q36819764Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model
Q64246051Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors
Q35646453Tumor Interstitial Fluid Formation, Characterization, and Clinical Implications
Q39143305Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy
Q55518010Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers.
Q47115406Tumor microenvironment as a potential source of clinical biomarkers in non-small cell lung cancer: can we use enemy territory at our advantage?
Q35674775Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases
Q64880703Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition.
Q93336606Turning foes to friends: targeting cancer-associated fibroblasts
Q88731404Two-Step Senescence-Focused Cancer Therapies
Q42701706Ulcerative colitis, Crohn's disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn's disease
Q91853110Umbrella Visualization: A method of analysis dedicated to glycan flexibility with UnityMol
Q47677252Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes.
Q42143202Unique insight into microenvironmental changes in colorectal cancer: Ex vivo assessment of matrix metalloprotease-mediated molecular changes in human colorectal tumor tissue and corresponding non-neoplastic adjacent tissue
Q64248984Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases
Q91725258Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma
Q36413776Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients
Q52723689Urinary CE-MS peptide marker pattern for detection of solid tumors.
Q50900169Urinary bladder extracellular matrix hydrogels and matrix-bound vesicles differentially regulate central nervous system neuron viability and axon growth and branching.
Q53311622Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus.
Q47448333VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix
Q28070315Vascular proteomics in metabolic and cardiovascular diseases
Q37733382Vesicoureteral reflux and the extracellular matrix connection
Q91644139Whole-Section Tumor Micro-Architecture Analysis by a Two-Dimensional Phasor-Based Approach Applied to Polarization-Dependent Second Harmonic Imaging
Q91867284Wnt/β-Catenin Pathway-Regulated Fibromodulin Expression Is Crucial for Breast Cancer Metastasis and Inhibited by Aspirin
Q47116645miRNA-1273g-3p Involvement in Development of Diabetic Retinopathy by Modulating the Autophagy-Lysosome Pathway.
Q64100135miRNA-155 expression and role in pathogenesis in spinal tuberculosis-induced intervertebral disc destruction
Q89997522nanite: using machine learning to assess the quality of atomic force microscopy-enabled nano-indentation data
Q48331796α5β1 integrin mediates pulmonary epithelial cyst formation.
Q47135493μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure

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