Ectonucleotidases in tumor cells and tumor-associated immune cells: an overview

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Ectonucleotidases in tumor cells and tumor-associated immune cells: an overview is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2012/959848
P8608Fatcat IDrelease_qoqpbvrsbnh3zbslpyp3zwwmri
P932PMC publication ID3477596
P698PubMed publication ID23118517
P5875ResearchGate publication ID232766313

P50authorAna Maria Oliveira BattastiniQ88779587
P2093author name stringMaria Isabel Albano Edelweiss
Rafael Fernandes Zanin
Elizandra Braganhol
Letícia Scussel Bergamin
P2860cites workAdenosine extracellular levels in human brain gliomas: an intraoperative microdialysis study.Q44506310
Altered extracellular ATP, ADP and AMP catabolism in glioma cell linesQ44574592
Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell linesQ44617224
Altered purinergic signaling in CD73-deficient mice inhibits tumor progressionQ45848130
The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterizationQ24323556
Identification and characterization of CD39/vascular ATP diphosphohydrolaseQ24336540
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyQ24629255
Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiationQ24645394
Inflammation and cancerQ24649640
Inflammation and cancer: back to Virchow?Q28036756
Neural stem cells and the origin of gliomasQ28268847
The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogasterQ28277416
Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferaseQ28473067
Functional characterization of rat ecto-ATPase and ecto-ATP diphosphohydrolase after heterologous expression in CHO cells.Q50519006
An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma.Q55477149
Inflaming metastasisQ56942551
Overexpression of Ecto-5'-Nucleotidase (CD73) promotes T-47D human breast cancer cells invasion and adhesion to extracellular matrixQ57376131
Ecto-5′-nucleotidase promotes invasion, migration and adhesion of human breast cancer cellsQ63561226
Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytesQ73267219
Lymphocytic ecto 5'-nucleotidase (ecto-5'NT) levels in acute lymphoblastic leukemia and non-Hodgkin's lymphomaQ81245125
Expression of CD73 and its ecto-5'-nucleotidase activity are elevated in papillary thyroid carcinomasQ83175044
NTPDase1 controls IL-8 production by human neutrophilsQ84353068
P2 receptor modulation and cytotoxic function in cultured CNS neuronsQ43960634
Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors.Q44376599
Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinaseQ44401723
Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8Q28506029
5′-Nucleotidase: molecular structure and functional aspectsQ28620587
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionQ29615344
Modulation of P2Z/P2X(7) receptor activity in macrophages infected with Chlamydia psittaci.Q31715200
Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responsesQ31838449
Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1.Q32051034
ATP stimulates chemokine production via a store-operated calcium entry pathway in C6 glioma cellsQ33518046
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppressionQ33533705
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasisQ33667612
Nucleotide pyrophosphatases/phosphodiesterases on the moveQ33934668
Cellular function and molecular structure of ecto-nucleotidases.Q34031794
Tumor-promoting functions of adenosineQ34047331
Physiological regulation of ATP release at the apical surface of human airway epitheliaQ34074722
CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in miceQ34091467
Extracellular metabolism of ATP and other nucleotidesQ34101805
Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidaseQ34163423
Expression of CD39 on FoxP3+ T regulatory cells correlates with progression of HBV infection.Q34226860
Malignant glioma: genetics and biology of a grave matter.Q34272357
Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation.Q34539873
Genetics of brain neoplasmsQ34566430
NTPDase1 governs P2X7-dependent functions in murine macrophagesQ34610192
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.Q34621389
Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphateQ34633667
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significanceQ34769236
CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in miceQ35015717
A2A adenosine receptor protects tumors from antitumor T cells.Q35016529
Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase familyQ35131762
Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancerQ35136797
T-cell specific defect in expression of the NTPDase CD39 as a biomarker for lupusQ35199844
Cancer stem cells in nervous system tumorsQ35892122
Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injuryQ35953950
Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host diseaseQ35995245
Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null miceQ36007505
CD73 promotes tumor growth and metastasisQ36038399
Microglia function in brain tumorsQ36164949
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCIDQ36185196
Natural regulatory T cells: mechanisms of suppressionQ36719995
Altered macrophage differentiation and immune dysfunction in tumor developmentQ36809767
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphatesQ37235068
Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancerQ37390515
Adenosine: an endogenous modulator of innate immune system with therapeutic potentialQ37493077
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammationQ37594369
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunityQ37876541
The role of the adenosinergic pathway in immunosuppression mediated by human regulatory T cells (Treg).Q37956691
Purinergic signalling: Its unpopular beginning, its acceptance and its exciting futureQ37975129
In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.Q38391466
CD73-deficient mice are resistant to carcinogenesisQ39384112
Involvement of ecto-5'-nucleotidase/CD73 in U138MG glioma cell adhesion.Q39486535
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.Q39531156
CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasisQ39598074
The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade.Q39613403
Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptorsQ39748947
Selective NTPDase2 expression modulates in vivo rat glioma growthQ39832590
Differential ectonucleotidase expression in human bladder cancer cell linesQ39860148
TNF-alpha- and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microgliaQ39926475
The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferationQ39959907
Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas.Q39972447
Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells.Q40038767
Adenosine uptake-dependent C6 cell growth inhibitionQ40079091
RNA interference of ecto-5'-nucleotidase (CD73) inhibits human breast cancer cell growth and invasionQ40116286
NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor.Q40118717
Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma.Q40276687
In vitro evaluation of adenosine 5'-monophosphate as an imaging agent of tumor metabolismQ40286491
Combined affinity labelling and mass spectrometry analysis of differential cell surface protein expression in normal and prostate cancer cellsQ40399386
Increased resistance of glioma cell lines to extracellular ATP cytotoxicity.Q40462194
Ecto-ATPases: identities and functions.Q40509071
Role of estrogen receptor in the regulation of ecto-5'-nucleotidase and adenosine in breast cancerQ40593419
Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP.Q40665495
The p53 gene and protein in human brain tumorsQ40811243
Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrationsQ40866051
Molecular pathways in the formation of gliomas.Q40961534
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomasQ41020104
Antigen recognition by CTL is dependent upon ectoATPase activity.Q41335232
Irreversible inhibition of human natural killer cell natural cytotoxicity by modification of the extracellular membrane by the adenine nucleotide analog 5'-p-(fluorosulfonyl)benzoyl adenosineQ41376977
Identification and partial characterization of an ectoATPase expressed by human natural killer cellsQ41542375
Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosineQ41834732
Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsivenessQ41849280
Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activityQ42606557
An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brainQ42667087
P(2Y) purinoceptor subtypes recruit different mek activators in astrocytesQ42744879
Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39.Q43140401
Glutamate release promotes growth of malignant gliomasQ43726770
CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsivenessQ43943686
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectneoplasmQ1216998
cellQ7868
enzymeQ8047
cancerQ12078
hemic and immune systemsQ70202933
P304page(s)959848
P577publication date2012-01-01
2012-10-14
P1433published inJournal of Biomedicine and BiotechnologyQ15752146
P1476titleEctonucleotidases in tumor cells and tumor-associated immune cells: an overview
P478volume2012

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cites work (P2860)
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Q42321503Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

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