Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family

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Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0925-4439(03)00058-9
P698PubMed publication ID12757929

P2093author name stringJames W Goding
Bert Grobben
Herman Slegers
P2860cites workDifferential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytesQ22010626
Potential signalling roles for UTP and UDP: sources, regulation and release of uracil nucleotidesQ41633188
Ecto-nucleotide pyrophosphatase modulates the purinoceptor-mediated signal transduction and is inhibited by purinoceptor antagonistsQ41790500
Purification and properties of nucleotide pyrophosphatase from human placentaQ42067772
Reversal of increased lymphocyte PC-1 activity in patients with type 2 diabetes treated with metformin.Q42482330
Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnQ42489803
Agonists of the P2Y(AC)-receptor activate MAP kinase by a ras-independent pathway in rat C6 gliomaQ42510805
Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeysQ42519172
Assignment of Pdnp2, the gene encoding phosphodiesterase I/nucleotide pyrophosphatase 2, to mouse chromosome 15D2.Q42620525
Phosphorylation and nucleotide-dependent dephosphorylation of hepatic polypeptides related to the plasma cell differentiation antigen PC-1.Q42810437
No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytesQ42813816
A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.Q42817181
Regulation of purified hepatic PC-1 (phosphodiesterase-I/nucleotide pyrophosphatase) by threonine auto(de)phosphorylation and by binding of acidic fibroblast growth factorQ42824256
Evidence that P2Y4 nucleotide receptors are involved in the regulation of rat aortic smooth muscle cells by UTP and ATP.Q43183864
Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcificationQ43607181
Enzymatic activation of autotaxin by divalent cations without EF-hand loop region involvementQ43628431
A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalitiesQ43687884
Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patientsQ43690511
Multiple ecto-nucleotidases in PC12 cells: identification and cellular distribution after heterologous expressionQ43735199
Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cellsQ43748942
Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant ratsQ43771427
Polymorphism in ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene (ENPP1/PC-1) and early development of advanced diabetic nephropathy in type 1 diabetesQ43935493
Mechanisms of apoptosis induced by purine nucleosides in astrocytes.Q43968136
Skeletal muscle content of membrane glycoprotein PC-1 in obesity. Relationship to muscle glucose transport.Q46042563
Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor siteQ46114318
Inhibition of insulin receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine triphosphate or the generation of adenosineQ46157707
The development of insulin resistance with high fat feeding in rats does not involve either decreased insulin receptor tyrosine kinase activity or membrane glycoprotein PC-1.Q46413723
Expression of the nucleoside triphosphate pyrophosphohydrolase PC-1 is induced by basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in osteoblast-like osteosarcoma cellsQ46831739
Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signalingQ47904035
Treatment of fibroblast-like synoviocytes with IFN-gamma results in the down-regulation of autotaxin mRNA.Q48056751
Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatumQ48160127
Role of the mouse ank gene in control of tissue calcification and arthritisQ22254612
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcificationQ24290745
The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)Q24291091
Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitusQ24310636
Disruption of IRS-2 causes type 2 diabetes in miceQ24316112
Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cellsQ24319171
Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2)Q24319985
Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genesQ24321341
Mutations in ANKH cause chondrocalcinosisQ24616817
Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. Regulation of PC-1 expression in osteosarcoma cells by transforming growth factor-betaQ24628679
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid productionQ24673806
Molecular cloning of cDNAs for human fibroblast nucleotide pyrophosphataseQ28115252
Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunitQ28141526
Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)Q28142507
A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistanceQ28144111
Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cellsQ28145952
The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3Q28187816
Inorganic pyrophosphate generation and disposition in pathophysiologyQ28201357
New perspectives into the molecular pathogenesis and treatment of type 2 diabetesQ28203726
PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patientsQ28216380
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesteraseQ28217851
Identification of the disulfide bonds in the recombinant somatomedin B domain of human vitronectinQ28218295
Autotaxin is an N-linked glycoprotein but the sugar moieties are not needed for its stimulation of cellular motilityQ28284827
Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxinQ28289403
Autophosphorylation of PC-1 (alkaline phosphodiesterase I/nucleotide pyrophosphatase) and analysis of the active siteQ28300765
Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activitiesQ28301252
IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA)Q28347268
P2Y(AC)(-)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinaseQ28359340
A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican AmericansQ28361785
Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spineQ28505453
Effect of in situ retroviral interleukin-4 transfer on established intracranial tumorsQ48267756
Phosphodiesterase I, a novel adhesion molecule and/or cytokine involved in oligodendrocyte function.Q48579837
The paracrine role of tumour-derived mIL-4 on tumour-associated endothelium.Q48638541
The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.Q50567631
Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis.Q51553988
Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity.Q51576506
Identification of B10, an alkaline phosphodiesterase of the apical plasma membrane of hepatocytes and biliary cells, in rat serum: increased levels following bile duct ligation and during the development of cholangiocarcinoma.Q53437411
An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma.Q55477149
Mutant insulin receptors in syndromes of insulin resistanceQ61908582
Plasma cell membrane glycoprotein gene Pca-1 (alkaline phosphodiesterase I) is linked to the proto-oncogene Myb on mouse chromosome 10Q67517963
Effect of colchicine and phalloidin on the distribution of three plasma membrane antigens in rat hepatocytes: comparison with bile duct ligationQ68203992
Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilageQ68242453
Immunoaffinity purification and characterization of nucleotide pyrophosphatase from human placentaQ69808751
Synovial fluid inorganic pyrophosphate concentration and nucleotide pyrophosphohydrolase activity in basic calcium phosphate deposition arthropathy and Milwaukee shoulder syndromeQ69824060
Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritisQ69923865
The inhibition of the insulin receptor by the receptor protein PC-1 is not specific and results from the hydrolysis of ATPQ71150200
Assignment of the gene for gp 130RB13-6 (Pdnpno) to rat chromosome band 1p12 by in situ hybridizationQ71234007
Elevated plasma levels of transforming growth factor-beta 1 in NIDDMQ71715886
PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivityQ71736384
Threonine autophosphorylation and nucleotidylation of the hepatic membrane protein PC-1Q71776721
Adenosine effects upon insulin action on lipolysis and glucose transport in human adipocytesQ71926800
Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signalingQ71984903
Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein-1. RelevanceQ71993438
Elevation of alkaline phosphatase activity induced by parathyroid hormone in osteoblast-like cells from the spinal hyperostotic mouse TWY (twy/twy)Q72207190
Biosynthesis and intracellular transport of a bile canalicular plasma membrane protein: studies in vivo and in the perfused rat liverQ72271852
Modulation of ecto-nucleoside triphosphate pyrophosphatase activity of human osteoblast-like bone cells by 1 alpha,25-dihydroxyvitamin D3, 24R,25-dihydroxyvitamin D3, parathyroid hormone, and dexamethasoneQ72846799
Inhibition of phosphodiesterase/pyrophosphatase activity of PC-1 by its association with glycosaminoglycansQ73036334
Expression of the putative inhibitor of the insulin receptor tyrosine kinase PC-1 in dermal fibroblasts from patients with syndromes of severe insulin resistanceQ73709697
A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuriaQ73929166
Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinaseQ77180614
Growth inhibition of HL-60 cells by extracellular ATP: concentration-dependent involvement of a P2 receptor and adenosine generationQ77350654
A third fibronectin type III domain in the extracellular region of the insulin receptor familyQ77779611
Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individualsQ77982972
Adenosine and cerebral ischemia: therapeutic future or death of a brave concept?Q78166840
Pyrophosphohydrolase activity and inorganic pyrophosphate content of cultured human skin fibroblasts. Elevated levels in some patients with calcium pyrophosphate dihydrate deposition diseaseQ34578925
Animal models of pathologic calcificationQ34618202
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic RasQ35193411
Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor geneQ35233886
Signaling by extracellular ATP: physiological and pathological considerations in neuronal-astrocytic interactionsQ35238710
Surface alloantigens of plasma cellsQ36270407
Inhibition of angiogenesis by interleukin 4.Q36401812
Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1.Q36701829
In vitro differentiation of neural progenitor cells from prenatal rat brain: common cell surface glycoprotein on three glial cell subsetsQ36857604
Insulin resistance--mechanisms, syndromes, and implicationsQ37278330
ATP--a fast neurotransmitter.Q40487593
Purinergic receptors on insulin-secreting cellsQ40666423
A central role for the JNK pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-beta-driven SMAD3/4-specific gene expression.Q40690939
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cellsQ40739267
Apoptosis induced by extracellular ATP in the mouse neuroblastoma cell line N1E-115: studies on involvement of P2 receptors and adenosineQ40740508
Adenosine-induced apoptosis in glomerular mesangial cellsQ40741926
Inducible expression of a constitutively active mutant of mitogen-activated protein kinase kinase 7 specifically activates c-JUN NH2-terminal protein kinase, alters expression of at least nine genes, and inhibits cell proliferationQ40767784
Retinoic acid-induced expression of autotaxin in N-myc-amplified neuroblastoma cellsQ40807002
Cellular insulin action and insulin resistanceQ40812896
Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrationsQ40866051
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cellsQ40904277
Autotaxin expression in non-small-cell lung cancerQ40939277
Matrix vesicle plasma cell membrane glycoprotein-1 regulates mineralization by murine osteoblastic MC3T3 cells.Q40951338
Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.Q40968846
Purines and their roles in apoptosisQ41080130
Modulation of nucleotide pyrophosphatase in plasmacytoma cellsQ41155376
Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous systemQ41205766
Ectonucleotidases, purine nucleoside transporter, and function of the bile canalicular plasma membrane of the hepatocyte.Q41353443
Ecto-nucleoside triphosphate pyrophosphohydrolase activity and calcium pyrophosphate dihydrate crystal deposition diseaseQ41366822
Understanding inorganic pyrophosphate metabolism: toward prevention of calcium pyrophosphate dihydrate crystal depositionQ41471077
Comparison of phosphohydrolase activities from articular cartilage in Calcium Pyrophosphate deposition disease and primary osteoarthritisQ41531668
Developmental expression analysis of murine autotaxin (ATX)Q28511840
Biochemical and molecular identification of distinct forms of alkaline phosphodiesterase I expressed on the apical and basolateral plasma membrane surfaces of rat hepatocytesQ28570773
EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptorsQ28573695
Identification of a phosphodiesterase I/nucleotide pyrophosphatase-related gene mRNA in rat vascular smooth muscle cells by the differential display approachQ28576171
Identification and characterization of a soluble form of the plasma cell membrane glycoprotein PC-1 (5'-nucleotide phosphodiesterase)Q28589328
Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatasesQ28590714
Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodiesQ28592839
Banting lecture 1988. Role of insulin resistance in human diseaseQ29547283
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
An integrated physical map of 8q22-q24: use in positional cloning and deletion analysis of Langer-Giedion syndrome.Q30650410
Beta,gamma-methylene ATP-induced cAMP formation in C6Bu-1 cells: involvement of local metabolism and subsequent stimulation of adenosine A2B receptorQ31832292
Neuroprotective role of adenosine in cerebral ischaemiaQ33188275
Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed jointsQ33563495
Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation?Q33763432
Modulation of purinergic neurotransmission.Q33768366
Release of ATP and UTP from astrocytoma cellsQ33768392
Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytesQ33838365
Differential regulation of the expression of nucleotide pyrophosphatases/phosphodiesterases in rat liverQ33860934
Pharmacology of cloned P2X receptorsQ33932194
Nucleotide pyrophosphatases/phosphodiesterases on the moveQ33934668
Characterization of a di-leucine-based signal in the cytoplasmic tail of the nucleotide-pyrophosphatase NPP1 that mediates basolateral targeting but not endocytosisQ33948220
Adenosine in the central nervous system: release mechanisms and extracellular concentrationsQ33955930
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralizationQ34035649
Extracellular metabolism of ATP and other nucleotidesQ34101805
Molecular pharmacology of P2Y-receptorsQ34101812
Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profilingQ34113095
Differential effect of adenosine on tumor and normal cell growth: focus on the A3 adenosine receptorQ34124450
Comparison of alterations in insulin signalling pathway in adipocytes from Type II diabetic pregnant women and women with gestational diabetes mellitusQ34130391
Phosphatidylinositol 3-kinases in tumor progressionQ34135631
Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition diseaseQ34165065
Recent advances in our understanding of insulin action and insulin resistanceQ34209698
ATP-induced chondrocalcinosisQ34289601
Purinergic signalling: ATP releaseQ34431931
Purinergic signaling and vascular cell proliferation and deathQ34555187
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpathophysiologyQ1135939
P304page(s)1-19
P577publication date2003-05-01
P1433published inBiochimica et Biophysica ActaQ864239
P1476titlePhysiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family
P478volume1638

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Q96109756Skeletal abnormalities secondary to antenatal etidronate treatment for suspected generalised arterial calcification of infancy
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