Mechanism of action and clinical activity of tasquinimod in castrate-resistant prostate cancer

scientific article

Mechanism of action and clinical activity of tasquinimod in castrate-resistant prostate cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.2147/OTT.S53524
P932PMC publication ID3928061
P698PubMed publication ID24600234
P5875ResearchGate publication ID260560224

P2093author name stringRoberto Pili
Li Shen
Neha Gupta
Omar Al-Ustwani
P2860cites workIdentification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamidesQ21145828
Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression, angiogenesis, invasion and metastasisQ84595151
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumorsQ21245714
Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cellsQ24308708
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic nicheQ24606366
Abiraterone in metastatic prostate cancer without previous chemotherapyQ24612084
Myeloid-derived suppressor cells: linking inflammation and cancerQ24641811
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 proteinQ24641894
Open-label, clinical phase I studies of tasquinimod in patients with castration-resistant prostate cancerQ24647897
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cellsQ24658240
Cancer statistics, 2013Q27860762
CYP1A1: friend or foe?Q28259718
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancerQ29616123
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancerQ29616218
Increased survival with enzalutamide in prostate cancer after chemotherapyQ29617511
Cabazitaxel plus prednisone for metastatic castration-resistant prostate cancer progressing after docetaxel: results from the German compassionate-use programmeQ33404163
Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working GroupQ33566395
Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trialsQ33898885
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factorQ33947807
The long and winding road for the development of tasquinimod as an oral second-generation quinoline-3-carboxamide antiangiogenic drug for the treatment of prostate cancerQ34013840
Current Management of Castrate-Resistant Prostate CancerQ34111641
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapyQ34157098
Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancerQ34217642
Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050).Q34250496
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone miceQ34405669
Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancerQ34563829
The quinoline-3-carboxamide anti-angiogenic agent, tasquinimod, enhances the anti-prostate cancer efficacy of androgen ablation and taxotere without effecting serum PSA directly in human xenograftsQ34610434
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2Q35130971
Tumor angiogenesis correlates with metastasis in invasive prostate carcinomaQ35833169
Regulation of tumor angiogenesis by thrombospondin-1.Q36365861
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasionQ37098976
Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation.Q37758250
Growth/differentiation factor-15: prostate cancer suppressor or promoter?Q37988746
Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings.Q38020235
Advanced clinical states in prostate cancerQ38053681
Radium-223 for the treatment of prostate cancerQ38073823
Cabazitaxel: a guide to its use in hormone-refractory metastatic prostate cancerQ38093471
Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2).Q39218029
Role of microvessel density in predicting recurrence in pathologic Stage T3 prostatic adenocarcinomaQ39517040
Tasquinimod prevents the angiogenic rebound induced by fractionated radiation resulting in an enhanced therapeutic response of prostate cancer xenograftsQ41836745
Myeloid-derived suppressor cells interact with tumors in terms of myelopoiesis, tumorigenesis and immunosuppression: thick as thievesQ41952605
The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitisQ44133715
Linomide suppresses acute experimental autoimmune encephalomyelitis in Lewis rats by counter-acting the imbalance of pro-inflammatory versus anti-inflammatory cytokinesQ46238133
Antiangiogenic treatment with linomide as chemoprevention for prostate, seminal vesicle, and breast carcinogenesis in rodents.Q53452479
Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to boneQ60504419
A treatment for metastasis of murine ocular melanomaQ67930666
Effects of the immunomodulator LS 2616 on growth and metastasis of the murine B16-F10 melanomaQ68796580
Inhibition of tumor angiogenesis and the therapeutic ability of linomide against rat prostatic cancersQ71693655
Anti-angiogenic treatment with linomide as adjuvant to surgical castration in experimental prostate cancerQ73589315
Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostateQ77359737
The treatment of hormone-refractory prostate cancer: docetaxel and beyondQ79190111
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)223-34
P577publication date2014-01-01
P1433published inOncoTargets and TherapyQ7092081
P1476titleMechanism of action and clinical activity of tasquinimod in castrate-resistant prostate cancer
P478volume7

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cites work (P2860)
Q39333529Myeloid-derived cells in prostate cancer progression: phenotype and prospective therapies.
Q38267175Pharmacotherapeutic management of metastatic, castration-resistant prostate cancer in the elderly: focus on non-chemotherapy agents
Q88777747Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9
Q37113485Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer

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