A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction

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A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1033472Y
P356DOI10.1371/JOURNAL.PONE.0133472
P932PMC publication ID4512710
P698PubMed publication ID26204265
P5875ResearchGate publication ID280777405

P50authorJianyun YanQ59683819
Shegufta RazzaqueQ59688077
P2093author name stringDavid S Park
Lu Zhang
Jun Hu
Lei Bu
Chen-Leng Cai
Akshay Shekhar
Nishat Sultana
P2860cites workCardiac alpha-myosin (MYH6) is the predominant sarcomeric disease gene for familial atrial septal defectsQ21134934
Mutation in myosin heavy chain 6 causes atrial septal defectQ24296801
Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathyQ24306812
Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart blockQ24338156
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Development of heart valves requires Gata4 expression in endothelial-derived cellsQ27863348
Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septationQ28509085
Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heartQ28594286
Congenital heart disease: entering a new era of human genetics.Q52647783
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.Q54609364
Notch Signaling Contributes to the Expression of Cardiac Markers in Human Circulating Progenitor CellsQ58816239
Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heartQ70162261
Widespread recombinase expression using FLPeR (flipper) miceQ73266365
MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failureQ79922459
The incidence of congenital heart diseaseQ29614195
A robust and high-throughput Cre reporting and characterization system for the whole mouse brainQ29616609
Regulation of smooth muscle alpha-actin expression in vivo is dependent on CArG elements within the 5' and first intron promoter regionsQ30303899
New approaches in small animal echocardiography: imaging the sounds of silenceQ30461404
Development of the aortic vessel wall as defined by vascular smooth muscle and extracellular matrix markersQ30469176
Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouseQ33590571
Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in miceQ33790139
Complex genetics and the etiology of human congenital heart diseaseQ33790650
The Notch pathway controls fibrotic and regenerative repair in the adult heartQ34071933
Inducible gene expression and gene modification in transgenic miceQ34077415
The molecular genetics of congenital heart disease: a review of recent developmentsQ34100720
Hand2 function in second heart field progenitors is essential for cardiogenesis.Q34574679
Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic miceQ35087050
Smad4 regulates ureteral smooth muscle cell differentiation during mouse embryogenesisQ35225701
Genetic modification of the heart: exploring necessity and sufficiency in the past 10 yearsQ35769478
Generation of a tamoxifen inducible Tnnt2MerCreMer knock-in mouse model for cardiac studiesQ35779565
Developmental regulation of myosin gene expression in mouse cardiac muscleQ36224282
With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failureQ37101602
Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death.Q37287468
Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver.Q37287472
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesisQ37597645
System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in miceQ38502825
Inducible site-directed recombination in mouse embryonic stem cellsQ39715564
Loss of MCL-1 leads to impaired autophagy and rapid development of heart failureQ41887614
Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion modelsQ42560803
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) miceQ42923082
Cardiomyocyte cell cycle control and growth estimation in vivo--an analysis based on cardiomyocyte nucleiQ43195307
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre proteinQ43664631
Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.Q48505009
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecttamoxifenQ412178
P304page(s)e0133472
P577publication date2015-07-23
P1433published inPLOS OneQ564954
P1476titleA Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction
P478volume10