The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model

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The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...622579M
P356DOI10.1371/JOURNAL.PONE.0022579
P932PMC publication ID3143160
P698PubMed publication ID21799905
P5875ResearchGate publication ID51531309

P50authorSanford BernsteinQ42880156
P2093author name stringKaren Ocorr
Rolf Bodmer
Girish C Melkani
P2860cites workDrawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 speciesQ21092862
KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of agingQ24681227
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding regionQ27666105
X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogasterQ27667259
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigmsQ28203734
A genome-wide transgenic RNAi library for conditional gene inactivation in DrosophilaQ28236209
Hold me tight: Role of the heat shock protein family of chaperones in cardiac diseaseQ28296634
Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domainQ28588643
A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathyQ28593682
The Genetic Basis for CardiomyopathyQ29300961
Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle functionQ30449673
Drosophila as a model for the identification of genes causing adult human heart diseaseQ30476715
Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac musclesQ30481206
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.Q30494112
Morphology of the pupal heart, adult heart, and associated tissues in the fruit fly, Drosophila melanogaster.Q52570904
UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans.Q53505697
Alpha B-crystallin mutation in dilated cardiomyopathyQ55671182
Differential Expression of Heat Shock Proteins in Normal and Failing Human HeartsQ59192159
Fission yeast Rng3p: an UCS-domain protein that mediates myosin II assembly during cytokinesisQ73893519
A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse heartsQ30494115
Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky tickerQ30495962
Signalling pathways involved in adult heart formation revealed by gene expression profiling in DrosophilaQ33302677
Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos.Q33694916
Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functionsQ34152511
Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stabilityQ34574189
Sarcomere gene mutations in hypertrophy and heart failureQ34626686
Control of cardiac development by an evolutionarily conserved transcriptional networkQ34654786
UCS proteins: managing the myosin motorQ35169547
Genetic approaches to understanding muscle development.Q35491615
Genetic control of heart function and aging in DrosophilaQ35945999
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegansQ36118132
Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assemblyQ36256331
UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.Q36322706
Loss of unc45a precipitates arteriovenous shunting in the aortic arches.Q36791623
Hereditary myosin myopathiesQ36791853
Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure.Q37257754
Build it up-Tear it down: protein quality control in the cardiac sarcomereQ37313697
Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium.Q37374337
Fluorescent labeling of Drosophila heart structuresQ38272328
Semi-automated Optical Heartbeat Analysis of small hearts.Q39900702
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathyQ40157250
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosinQ40754906
Myosin II folding is mediated by a molecular chaperoninQ40929937
Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase.Q41200755
Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationallyQ41839057
Structure and function of contractile proteins in human dilated cardiomyopathyQ42495495
Myosin assembly, maintenance and degradation in muscle: Role of the chaperone UNC-45 in myosin thick filament dynamicsQ43187716
Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cellsQ43552390
Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in DrosophilaQ44768547
Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heartQ46801086
A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of DrosophilaQ47071291
Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesisQ47072392
The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesisQ47073713
The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafishQ47073763
Temperature-sensitive mutation affecting myofilament assembly in Caenorhabditis elegansQ47849134
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
molecular chaperonesQ422496
P304page(s)e22579
P577publication date2011-01-01
P1433published inPLOS OneQ564954
P1476titleThe UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model
P478volume6

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cites work (P2860)
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Q34039121Functional and genomic analyses of alpha-solenoid proteins
Q34055646Getting folded: chaperone proteins in muscle development, maintenance and disease
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Q45223476Structural insight into the UNC-45-myosin complex
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Q48113345UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
Q47621531UNC-45a promotes myosin folding and stress fiber assembly.
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Q33950581Using Caenorhabditis elegans as a model system to study protein homeostasis in a multicellular organism

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