UCS proteins: chaperones for myosin and co-chaperones for Hsp90.

scientific article published on January 2015

UCS proteins: chaperones for myosin and co-chaperones for Hsp90. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/978-3-319-11731-7_7
P698PubMed publication ID25487020

P2093author name stringWeiming Ni
Odutayo O Odunuga
P2860cites workThe structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactionsQ24533152
GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathwayQ24548013
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motilityQ24672758
Myosin chaperonesQ26863588
UCS protein Rng3p is essential for myosin-II motor activity during cytokinesis in fission yeastQ27302780
Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heartQ27318284
The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart modelQ27330328
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machineQ27622332
UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding regionQ27666105
X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogasterQ27667259
The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegansQ27675937
Three-dimensional structure of myosin subfragment-1: a molecular motorQ27731679
A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).Q27932386
Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic proteinsQ27933630
The UCS Domain Protein She4p Binds to Myosin Motor Domains and Is Essential for Class I and Class V Myosin FunctionQ27939426
More than folding: localized functions of cytosolic chaperonesQ28209802
A repeating amino acid motif shared by proteins with diverse cellular rolesQ28237358
Structure of the actin-myosin complex and its implications for muscle contractionQ28259888
Effect of ADP and ionic strength on the kinetic and motile properties of recombinant mouse myosin VQ28369753
Unc45 activates Hsp90-dependent folding of the myosin motor domainQ28586476
Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domainQ28588643
The tetratricopeptide repeat: a structural motif mediating protein-protein interactionsQ29541281
Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos.Q30481082
Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky tickerQ30495962
unc-45 gene of Caenorhabditis elegans encodes a muscle-specific tetratricopeptide repeat-containing proteinQ30658184
A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesisQ30667531
Lack of developmental redundancy between Unc45 proteins in zebrafish muscle developmentQ31106786
Coexpression and assembly of myosin heavy chain and myosin light chain in Escherichia coli.Q33651955
Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos.Q33694916
Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and functionQ33770538
A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserinaQ33888398
Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegansQ34043288
Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functionsQ34152511
The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataractQ34356748
Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stabilityQ34574189
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structuresQ34764587
The UCS family of myosin chaperonesQ34925335
UCS proteins: managing the myosin motorQ35169547
Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter.Q35926209
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegansQ36118132
Immunochemical localization of myosin heavy chain isoforms and paramyosin in developmentally and structurally diverse muscle cell types of the nematode Caenorhabditis elegansQ36217044
Genetic analysis of myosin II assembly and organization in model organismsQ36248984
Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assemblyQ36256331
Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac developmentQ36290852
UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.Q36322706
Caenorhabditis elegans UNC-45 is a component of muscle thick filaments and colocalizes with myosin heavy chain B, but not myosin heavy chain AQ36326269
Regulation of myosin self-assembly: phosphorylation of Dictyostelium heavy chain inhibits formation of thick filamentsQ36419052
Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibrilQ36534622
Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cellsQ36725660
Loss of unc45a precipitates arteriovenous shunting in the aortic arches.Q36791623
The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegansQ36995989
Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancerQ39498220
GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificityQ39646236
A non-muscle myosin required for embryonic polarity in Caenorhabditis elegansQ39757928
UNC45A confers resistance to histone deacetylase inhibitors and retinoic acidQ39785378
She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiaeQ39890714
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathyQ40157250
Lack of Apobec2-related proteins causes a dystrophic muscle phenotype in zebrafish embryosQ40464531
Chaperone-mediated folding and assembly of myosin in striated muscleQ40601638
Folding of the striated muscle myosin motor domainQ40719397
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosinQ40754906
Myosin II folding is mediated by a molecular chaperoninQ40929937
Glycine 699 is pivotal for the motor activity of skeletal muscle myosinQ41180316
Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase.Q41200755
Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationallyQ41839057
Two homogeneous myosins in body-wall muscle of Caenorhabditis elegansQ44866474
Structural insight into the UNC-45-myosin complexQ45223476
Maternal UNC-45 is involved in cytokinesis and colocalizes with non-muscle myosin in the early Caenorhabditis elegans embryoQ47068663
Mutants with altered muscle structure of Caenorhabditis elegansQ47068879
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegansQ47068938
Differential localization of two myosins within nematode thick filamentsQ47069424
The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafishQ47073763
Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafishQ47074153
Temperature-sensitive mutation affecting myofilament assembly in Caenorhabditis elegansQ47849134
Importance of a myosin II-containing progenitor for actomyosin ring assembly in fission yeast.Q52120122
UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans.Q53505697
Regulatory and essential light-chain-binding sites in myosin heavy chain subfragment-1 mapped by site-directed mutagenesis.Q54727361
Kinetic tuning of myosin via a flexible loop adjacent to the nucleotide binding pocketQ74299321
P921main subjectmolecular chaperonesQ422496
P304page(s)133-152
P577publication date2015-01-01
P1433published inSub-cellular biochemistryQ26853962
P1476titleUCS proteins: chaperones for myosin and co-chaperones for Hsp90.
P478volume78

Reverse relations

cites work (P2860)
Q48056048Fission yeast myosin Myo2 is down-regulated in actin affinity by light chain phosphorylation.
Q47105030Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
Q41176499Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival
Q33815675Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii
Q47243892UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM.
Q57464561UNC-45A is a Novel Microtubule-associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells
Q92064892UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs
Q42175690UNC-45A is required for neurite extension via controlling NMII activation.

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