The tetratricopeptide repeat: a structural motif mediating protein-protein interactions

scientific article (publication date: 11 October 1999)

The tetratricopeptide repeat: a structural motif mediating protein-protein interactions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/(SICI)1521-1878(199911)21:11<932::AID-BIES5>3.0.CO;2-N

P2093author name stringGregory L. Blatch
Michael Lässle
P2860cites workThe 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteinsQ24305192
Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutantsQ24533793
p62cdc23 of Saccharomyces cerevisiae: a nuclear tetratricopeptide repeat protein with two mutable domainsQ30450281
Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulationQ36561302
Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70Q36660658
Transcriptional repression in Saccharomyces cerevisiae by a SIN3-LexA fusion proteinQ36676648
The N-terminal TPR region is the functional domain of SSN6, a nuclear phosphoprotein of Saccharomyces cerevisiaeQ36724306
Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiaeQ36759808
TPR proteins as essential components of the yeast cell cycleQ37057013
The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequencesQ40023857
A tetratricopeptide repeat mutation in yeast transcription factor IIIC131 (TFIIIC131) facilitates recruitment of TFIIB-related factor TFIIIB70.Q40024092
Rapsyn's knobs and holes: eight tetratrico peptide repeatsQ42981343
ppt-1, a Neurospora crassa PPT/PP5 subfamily serine/threonine protein phosphataseQ48047206
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectprotein-protein interactionQ896177
P304page(s)932-939
P577publication date1999-10-11
P1433published inBioEssaysQ4914614
P1476titleThe tetratricopeptide repeat: a structural motif mediating protein-protein interactions
P478volume21

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cites work (P2860)
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Q33340985CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis
Q24293195CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation
Q39177058Ca(2+) /S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication
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Q24685229Calsyntenin-1 docks vesicular cargo to kinesin-1
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Q24290899Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
Q36992187Catalytic-independent roles of UTX-1 in C. elegans development
Q35562543CcmI subunit of CcmFHI heme ligation complex functions as an apocytochrome c chaperone during c-type cytochrome maturation
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Q34307110Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus
Q37861008Chaperone receptors: guiding proteins to intracellular compartments
Q36325691Characterization of Tbc2, a nucleus-encoded factor specifically required for translation of the chloroplast psbC mRNA in Chlamydomonas reinhardtii
Q37719511Characterization of the Soluble NSF Attachment Protein gene family identifies two members involved in additive resistance to a plant pathogen
Q36821039Characterization of the Thermotoga maritima chemotaxis methylation system that lacks pentapeptide-dependent methyltransferase CheR:MCP tethering
Q30152946Characterization of the β-barrel assembly machine accessory lipoproteins from Borrelia burgdorferi
Q26824841Charcot-Marie-Tooth disease and intracellular traffic
Q38231368Chemical tools to explore nutrient-driven O-GlcNAc cycling
Q27664968Combination of Two Separate Binding Domains Defines Stoichiometry between Type III Secretion System Chaperone IpgC and Translocator Protein IpaB
Q24598765Common variants at 30 loci contribute to polygenic dyslipidemia
Q34469036Comparative genomics suggests an independent origin of cytoplasmic incompatibility in Cardinium hertigii
Q28190754Composition and function of the eukaryotic N-terminal acetyltransferase subunits
Q50879692Confirmation of TTC8 as a disease gene for nonsyndromic autosomal recessive retinitis pigmentosa (RP51).
Q33197434Consensus design of repeat proteins.
Q42605524Conserved Ser/Arg-rich motif in PPZ orthologs from fungi is important for its role in cation tolerance
Q44674004Conserved sequence motifs and the structure of the mTOR kinase domain
Q34236677Control of triglyceride storage by a WD40/TPR‐domain protein
Q36861754Coordination of gene expression between organellar and nuclear genomes
Q24300333Crooked neck is a component of the human spliceosome and implicated in the splicing process
Q37114599Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity
Q42380526CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
Q53600709Cryopreservation effects on Wharton's Jelly Stem Cells proteome.
Q27672780Crystal Structure of the N-Terminal Domain of Nup358/RanBP2
Q27670887Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms
Q27659055Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand
Q28265251Crystal structure of human eIF3k, the first structure of eIF3 subunits
Q27670797Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
Q27681220Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD
Q27667434Crystal structure of theLeishmania majorMIX protein: A scaffold protein that mediates protein-protein interactions
Q27662140Crystal structure of  -COP in complex with  -COP provides insight into the architecture of the COPI vesicular coat
Q38866802Ctr9, a Protein in the Transcription Complex Paf1, Regulates Dopamine Transporter Activity at the Plasma Membrane.
Q44628543Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells
Q35903463Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone.
Q24610829Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold
Q27641184Design of Stable α-Helical Arrays from an Idealized TPR Motif
Q34613362Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm
Q24563549Distinct mutations in PlcR explain why some strains of the Bacillus cereus group are nonhemolytic
Q35956910Diverse high-torque bacterial flagellar motors assemble wider stator rings using a conserved protein scaffold
Q97597495Diversity of activator of G-Protein signaling (AGS)-family proteins and their impact on asymmetric cell division across taxa
Q36126486Does O-GlcNAc play a role in neurodegenerative diseases?
Q24600056Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation
Q47072203Drosophila rolling pebbles: a multidomain protein required for myoblast fusion that recruits D-Titin in response to the myoblast attractant Dumbfounded
Q48057821Dual functions of the nucleus-encoded factor TDA1 in trapping and translation activation of atpA transcripts in Chlamydomonas reinhardtii chloroplasts
Q27336113Emergence and modular evolution of a novel motility machinery in bacteria
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Q44038183Equilibrium folding and stability of myotrophin: a model ankyrin repeat protein
Q48377032Expression and characterization of a magnetosome-associated protein, TPR-containing MAM22, in Escherichia coli.
Q40416314Expression profile of interferon stimulated genes in central nervous system of mice infected with dengue virus Type-1.
Q44687922Fkbp8: novel isoforms, genomic organization, and characterization of a forebrain promoter in transgenic mice
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Q33916158Functional characterization of a lipoprotein-encoding operon in Campylobacter jejuni
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Q39283190Functional genomic signatures of sponge bacteria reveal unique and shared features of symbiosis
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Q24322880Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia
Q28509285Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip)
Q38285293Functions of the Hsp90-binding FKBP immunophilins.
Q51072284Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation.
Q28510044G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor
Q24548013GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway
Q28580508Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity
Q33993060Genetic causes of high and low serum HDL-cholesterol
Q37185446Genetics and cell biology of magnetosome formation in magnetotactic bacteria
Q34451819Genome-wide analysis of Cyclophilin gene family in soybean (Glycine max).
Q30621206Genome-wide association study reveals a set of genes associated with resistance to the Mediterranean corn borer (Sesamia nonagrioides L.) in a maize diversity panel.
Q40858523Genome-wide survey and expression analysis of the PUB family in Chinese cabbage (Brassica rapa ssp. pekinesis).
Q28215081HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110
Q38982591HOP3, a member of the HOP family in Arabidopsis, interacts with BiP and plays a major role in the ER stress response
Q48065152Hdsp, a horizontally transferred gene required for social behavior and halotolerance in salt-tolerant Myxococcus fulvus HW-1.
Q35927008Highly dynamic exon shuffling in candidate pathogen receptors ... what if brown algae were capable of adaptive immunity?
Q27863921Hijacking of the host-cell response and translational control during influenza virus infection
Q35671687Histone modifications in corepressor functions
Q44309455Homozygous truncating mutation of the KBP gene, encoding a KIF1B-binding protein, in a familial case of fetal polymicrogyria
Q36092601How Quorum Sensing Connects Sporulation to Necrotrophism in Bacillus thuringiensis
Q27643082Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain
Q24301474Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling
Q90970901IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling
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Q35861128Identification and Phylogeny of the First T Cell Epitope Identified from a Human Gut Bacteroides Species
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Q89556317Identification and characterization of novel filament-forming proteins in cyanobacteria
Q24307878Identification and characterization of the human ARD1-NATH protein acetyltransferase complex
Q24673386Identification of Tetratricopeptide Repeat 1 as an Adaptor Protein That Interacts with Heterotrimeric G Proteins and the Small GTPase Ras
Q36009566Identification of a Non-Pentapeptide Region Associated with Rapid Mycobacterial Evolution
Q24299263Identification of a Novel HSP70-binding Cochaperone Critical to HSP90-mediated Activation of Small Serine/Threonine Kinase
Q34305500Identification of a novel splice variant: human SGT1B (SUGT1B).
Q33745790Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA
Q34022202Identification of immunity-related genes in the burying beetle Nicrophorus vespilloides by suppression subtractive hybridization
Q34592872Identification of odor-processing genes in the emerald ash borer, Agrilus planipennis
Q33224654Identification of proteins from a cell wall fraction of the diatom Thalassiosira pseudonana: insights into silica structure formation.
Q73763944Identification of residues in the TPR domain of Ssn6 responsible for interaction with the Tup1 protein
Q33948913Identification of the gene that, when mutated, causes the human obesity syndrome BBS4.
Q46237734Identification, characterization, expression profiling, and virus-induced gene silencing of armadillo repeat-containing proteins in tomato suggest their involvement in tomato leaf curl New Delhi virus resistance
Q30370261Identifying tandem Ankyrin repeats in protein structures
Q27026407In sickness and in health: the role of TRAPP and associated proteins in disease
Q33697717In silico identification of carboxylate clamp type tetratricopeptide repeat proteins in Arabidopsis and rice as putative co-chaperones of Hsp90/Hsp70
Q38161378Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity
Q36406261Inferring repeat-protein energetics from evolutionary information.
Q28201501Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis
Q38797599Inhibition of eukaryotic translation by tetratricopeptide-repeat proteins of Orientia tsutsugamushi
Q44234570Interaction of FLU, a negative regulator of tetrapyrrole biosynthesis, with the glutamyl-tRNA reductase requires the tetratricopeptide repeat domain of FLU.
Q34239126Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes
Q57431175Is adaptation or transformation needed? Active nanomaterials and risk analysis
Q33289350JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain
Q34365379Kinesin carries the signal
Q36379939Kinesin delivers: identifying receptors for motor proteins
Q28594088Kinesin-1/Hsc70-dependent mechanism of slow axonal transport and its relation to fast axonal transport
Q24324022LEPREL1, a novel ER and Golgi resident member of the Leprecan family
Q28506266LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1
Q30823415Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes
Q34398063Linkers, packages and pathways: new concepts in axonal transport
Q43634193Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia
Q33936836Local and long-range stability in tandemly arrayed tetratricopeptide repeats
Q36791623Loss of unc45a precipitates arteriovenous shunting in the aortic arches.
Q30157374Membrane protein architects: the role of the BAM complex in outer membrane protein assembly.
Q36293715Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans
Q30157131Missense mutations in the SH3TC2 protein causing Charcot-Marie-Tooth disease type 4C affect its localization in the plasma membrane and endocytic pathway.
Q38693299Mitochondrial Dynamics and Heart Failure
Q42134557Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors.
Q27679359Molecular basis for N-terminal acetylation by the heterodimeric NatA complex
Q24649519Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides
Q104745195Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron
Q37243604Molecular biology of gibberellins signaling in higher plants
Q73435261Molecular chaperones and the art of recognizing a lost cause
Q31109177Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1.
Q36042285Molecular motors and mechanisms of directional transport in neurons
Q24338706Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies
Q24532191Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy
Q44776050Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans
Q24302202NATH, a novel gene overexpressed in papillary thyroid carcinomas
Q58227231Neurobiology and neurogenetics of dyslexia
Q34309932Neuroimmunophilins: novel neuroprotective and neuroregenerative targets
Q56687739Novel TTC19 mutation in a family with severe psychiatric manifestations and complex III deficiency
Q34539384Novel protein phosphatases in yeast.
Q27931656Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.
Q37208542Nuclear alpha spectrin: Critical roles in DNA interstrand cross-link repair and genomic stability
Q35163991O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar
Q33810805O-GlcNAc-ylation in the Nuclear Pore Complex
Q35077018O-GlcNAc: a regulatory post-translational modification.
Q37445785O-GlcNAcomics--Revealing roles of O-GlcNAcylation in disease mechanisms and development of potential diagnostics
Q38468665Organization of chlorophyll biosynthesis and insertion of chlorophyll into the chlorophyll-binding proteins in chloroplasts
Q48226891Outer membrane vesicles from Fibrobacter succinogenes S85 contain an array of carbohydrate-active enzymes with versatile polysaccharide-degrading capacity
Q40458454Overexpression of small glutamine-rich TPR-containing protein promotes apoptosis in 7721 cells.
Q27678746Peptide-binding dependent conformational changes regulate the transcriptional activity of the quorum-sensor NprR
Q39742401Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant
Q24300529Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
Q44094456Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones
Q35817912Phylogenomics and sequence-structure-function relationships in the GmrSD family of Type IV restriction enzymes
Q36124314Phylum-wide analysis of genes/proteins related to the last steps of assembly and export of extracellular polymeric substances (EPS) in cyanobacteria
Q21092256Plasmids and rickettsial evolution: insight from Rickettsia felis
Q24633410Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia
Q35108297Polyene antibiotic biosynthesis gene clusters.
Q81414345Positional cloning of the Ttc7 gene required for normal iron homeostasis and mutated in hea and fsn anemia mice
Q36195820Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins
Q37112713Posttranslational modifications in type I collagen from different tissues extracted from wild type and prolyl 3-hydroxylase 1 null mice.
Q38176700Prenylation defects in inherited retinal diseases.
Q24646993Profile-profile comparisons by COMPASS predict intricate homologies between protein families
Q24647730Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains
Q30327647Protein phosphatase 5 in signal transduction.
Q37383489Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import.
Q30400364Protein tyrosine phosphatase interacting protein 51--a jack-of-all-trades protein
Q24301852PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
Q38259588Quorum sensing in group A Streptococcus
Q44602438RNA‐binding properties of HCF152, an Arabidopsis PPR protein involved in the processing of chloroplast RNA
Q28578339Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex
Q28576466Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells
Q39515906Rearranging and concatenating a native RTX domain to understand sequence modularity
Q42627394Recognition of fold and sugar linkage for glycosyltransferases by multivariate sequence analysis
Q44217992Redox control of Hsp70-Co-chaperone interaction revealed by expression of a thioredoxin-like Arabidopsis protein
Q36055423Regulated proteolysis of a cross-link-specific peptidoglycan hydrolase contributes to bacterial morphogenesis
Q24304150Regulation of nuclear localization signal-importin α interaction by Ca2+/S100A6
Q37780582Rickettsial evolution in the light of comparative genomics
Q24321640RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3
Q28138315Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clustering
Q34193954Roles of the Tetratricopeptide Repeat Domain in O-GlcNAc Transferase Targeting and Protein Substrate Specificity
Q24562044Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
Q35922351S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation
Q24301261S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats
Q57243831SARS-CoV accessory protein 7a directly interacts with human LFA-1
Q34473389SEL1L a multifaceted protein playing a role in tumor progression.
Q38118665SGTA: a new player in the molecular co-chaperone game
Q30576722ST proteins, a new family of plant tandem repeat proteins with a DUF2775 domain mainly found in Fabaceae and Asteraceae
Q48875568STI1 antagonizes cytoskeleton collapse mediated by small GTPase Rnd1 and regulates neurite growth.
Q58814321Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1
Q39336891Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function
Q38480451Sequencing, De Novo assembly and annotation of the Colorado Potato Beetle, Leptinotarsa decemlineata, Transcriptome
Q27931036Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p
Q37090385SlTPR1, a tomato tetratricopeptide repeat protein, interacts with the ethylene receptors NR and LeETR1, modulating ethylene and auxin responses and development.
Q37054276Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice
Q37090590Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids
Q28076790Specificity and complexity in bacterial quorum-sensing systems
Q38522735Splitting up the powerhouse: structural insights into the mechanism of mitochondrial fission
Q47138054Ssn6-Tup1 global transcriptional co-repressor: Role of the N-terminal glutamine-rich region of Ssn6.
Q36210392Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.
Q27930101Structural Studies and the Assembly of the Heptameric Post-translational Translocon Complex
Q27675676Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR
Q46323748Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc.
Q43984053Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop.
Q34572286Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex
Q35291591Structural insights into RNA polymerase recognition and essential function of Myxococcus xanthus CdnL
Q36582143Structural insights into protein-only RNase P complexed with tRNA.
Q30152701Structural snapshots of the β-barrel assembly machinery
Q41850474Structural studies on AIPL1 and its functional interactions with NUB1 to identify key interacting residues in LCA4.
Q27676285Structure of Minimal Tetratricopeptide Repeat Domain Protein Tah1 Reveals Mechanism of Its Interaction with Pih1 and Hsp90
Q27628646Structure of the TPR domain of p67phox in complex with Rac.GTP
Q24682614Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression
Q28271763Support for EKN1 as the susceptibility locus for dyslexia on 15q21
Q46227198Suramin is a novel activator of PP5 and biphasically modulates S100-activated PP5 activity
Q40583898Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network
Q55113468TOM and SAM Machineries in Mitochondrial Protein Import and Outer Membrane Biogenesis
Q28205092TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1
Q40835998TTC4, a novel candidate tumor suppressor gene at 1p31 is often mutated in malignant melanoma of the skin
Q38234720Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease
Q30847190Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1.
Q38359786Tetratricopeptide repeat motif-mediated Hsc70-mSTI1 interaction. Molecular characterization of the critical contacts for successful binding and specificity
Q50932214Tetratricopeptide repeat protein Pyg7 is essential for photosystem I assembly by interacting with PsaC in Arabidopsis.
Q47845290Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators
Q27675697The 1.75 Å resolution structure of fission protein Fis1 fromSaccharomyces cerevisiaereveals elusive interactions of the autoinhibitory domain
Q24337908The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression
Q27320804The C. elegans TPR Containing Protein, TRD-1, Regulates Cell Fate Choice in the Developing Germ Line and Epidermis
Q27308887The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones
Q59260613The ECF Classification: A Phylogenetic Reflection of the Regulatory Diversity in the Extracytoplasmic Function σ Factor Protein Family
Q27684029The FKBP-type domain of the human aryl hydrocarbon receptor-interacting protein reveals an unusual Hsp90 interaction
Q34184261The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells.
Q33692255The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
Q27687861The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins
Q47727168The TPR domain of BepA is required for productive interaction with substrate proteins and the β-barrel assembly machinery complex
Q28975759The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis
Q53150338The archetype Pseudomonas aeruginosa proteins TssB and TagJ form a novel subcomplex in the bacterial type VI secretion system.
Q27676637The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
Q52541570The auxilin-like phosphoprotein Swa2p is required for clathrin function in yeast.
Q51582129The chloroplast protease subunit ClpP4 is a substrate of the E3 ligase AtCHIP and plays an important role in chloroplast function.
Q27637139The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein
Q41961747The cytochrome c maturation components CcmF, CcmH, and CcmI form a membrane-integral multisubunit heme ligation complex
Q37386477The diversity of plant U-box E3 ubiquitin ligases: from upstream activators to downstream target substrates
Q24309349The early onset dystonia protein torsinA interacts with kinesin light chain 1
Q39324009The emerging link between O-GlcNAcylation and neurological disorders.
Q35209271The folding and design of repeat proteins: reaching a consensus
Q21563620The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite
Q28239233The human small glutamine-rich TPR-containing protein is required for progress through cell division
Q46222902The in vitro phosphorylation of the co-chaperone mSTI1 by cell cycle kinases substantiates a predicted casein kinase II-p34cdc2-NLS (CcN) motif
Q24321910The interferon stimulated gene 54 promotes apoptosis
Q28478144The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response
Q34683020The making of a sweet modification: structure and function of O-GlcNAc transferase.
Q37834642The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins
Q34815714The role of chaperone proteins in the aryl hydrocarbon receptor core complex
Q34143486The s-layer glycome-adding to the sugar coat of bacteria
Q37736297The soybean GmSNAP18 gene underlies two types of resistance to soybean cyst nematode
Q54721978The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) sigma factor protein family.
Q24653224The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides
Q34268050Thermodynamic Characterization of the Binding of Activator of G Protein Signaling 3 (AGS3) and Peptides Derived from AGS3 with Gαi1
Q37428613Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription
Q48931581Tracking the unfolding pathway of a multirepeat protein via tryptophan scanning: evidence of localized instability in the mitochondrial import receptor Tom70.
Q33932264Transcript analysis of the extended hyp-operon in the cyanobacteria Nostoc sp. strain PCC 7120 and Nostoc punctiforme ATCC 29133.
Q47109373Transcriptome analysis of the salivary glands of the grain aphid, Sitobion avenae
Q44957240Triallelic inheritance: a bridge between Mendelian and multifactorial traits
Q36322706UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.
Q38285301UCS proteins: chaperones for myosin and co-chaperones for Hsp90.
Q38494780Unbiased label-free quantitative proteomic profiling and enriched proteomic pathways in seminal plasma of adult men before and after varicocelectomy.
Q34351471Unfolding retinal dystrophies: a role for molecular chaperones?
Q29871503Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2
Q37873359Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration
Q37649607Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs
Q35056237Versatile TPR domains accommodate different modes of target protein recognition and function
Q77070509What curves alpha-solenoids? Evidence for an alpha-helical toroid structure of Rpn1 and Rpn2 proteins of the 26 S proteasome
Q28506423ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over
Q28185056hSGT interacts with the N-terminal region of myostatin
Q46813527mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression
Q28586841mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development
Q44800136yciM is an essential gene required for regulation of lipopolysaccharide synthesis in Escherichia coli

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