UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans.

scientific article published on 4 December 2007

UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YDBIO.2007.11.028
P698PubMed publication ID18190904
P5875ResearchGate publication ID5660422

P50authorDavid PilgrimQ43138583
P2093author name stringAnjon Audhya
Torah M Kachur
P2860cites workDissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.Q24294556
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motilityQ24672758
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functionsQ24803805
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansQ27860867
Dissecting temporal and spatial control of cytokinesis with a myosin II InhibitorQ28183531
Cell Polarity and the Cytoskeleton in theCaenorhabditis ElegansZygoteQ28184418
Genome-wide RNAi screening in Caenorhabditis elegansQ29617900
Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryosQ30506257
unc-45 gene of Caenorhabditis elegans encodes a muscle-specific tetratricopeptide repeat-containing proteinQ30658184
A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserinaQ33888398
The Caenorhabditis elegans gonad: a test tube for cell and developmental biologyQ33924971
Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functionsQ34152511
The molecular requirements for cytokinesisQ34404139
The UCS family of myosin chaperonesQ34925335
How one becomes many: blastoderm cellularization in Drosophila melanogasterQ34974409
The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesisQ35506248
PAR proteins and the establishment of cell polarity during C. elegans developmentQ36018009
Regulation of myosin II during cytokinesis in higher eukaryotesQ36151437
Fluorescence visualization of the distribution of microfilaments in gonads and early embryos of the nematode Caenorhabditis elegansQ36216689
Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assemblyQ36256331
Myosin-II reorganization during mitosis is controlled temporally by its dephosphorylation and spatially by Mid1 in fission yeastQ36322424
UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.Q36322706
Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegansQ36323415
Caenorhabditis elegans UNC-45 is a component of muscle thick filaments and colocalizes with myosin heavy chain B, but not myosin heavy chain AQ36326269
Acto-myosin reorganization and PAR polarity in C. elegansQ36730900
A mitotic kinesin-like protein required for normal karyokinesis, myosin localization to the furrow, and cytokinesis in DictyosteliumQ37621049
Myosin structure and function in cell motilityQ39683835
A non-muscle myosin required for embryonic polarity in Caenorhabditis elegansQ39757928
Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryoQ40483476
Chaperone-mediated folding and assembly of myosin in striated muscleQ40601638
Folding of the striated muscle myosin motor domainQ40719397
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosinQ40754906
Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phasesQ42149368
A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans.Q44259964
Distinct roles for two C. elegans anillins in the gonad and early embryoQ44769074
Maternal UNC-45 is involved in cytokinesis and colocalizes with non-muscle myosin in the early Caenorhabditis elegans embryoQ47068663
Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegansQ47068918
TheCaenorhabditis elegansnonmuscle myosin genesnmy-1andnmy-2function as redundant components of thelet-502/Rho-binding kinase andmel-11/myosin phosphatase pathway during embryonic morphogenesisQ47069469
Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryosQ47069501
The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafishQ47073763
Temperature-sensitive mutation affecting myofilament assembly in Caenorhabditis elegansQ47849134
A zebrafish unc-45-related gene expressed during muscle developmentQ48285164
CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization.Q53608548
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectCaenorhabditis elegansQ91703
P1104number of pages13
P304page(s)287-299
P577publication date2007-12-04
P1433published inDevelopmental BiologyQ3025402
P1476titleUNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans.
P478volume314

Reverse relations

cites work (P2860)
Q64106996A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites
Q30500031A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue
Q34614173A secreted protein promotes cleavage furrow maturation during cytokinesis
Q51635704ASSET: a robust algorithm for the automated segmentation and standardization of early Caenorhabditis elegans embryos.
Q34727856Active torque generation by the actomyosin cell cortex drives left-right symmetry breaking
Q50091958Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells during Caenorhabditis elegans embryogenesis
Q35158993An extracellular matrix protein prevents cytokinesis failure and aneuploidy in the C. elegans germline
Q50547684Antagonistic Behaviors of NMY-1 and NMY-2 Maintain Ring Channels in the C. elegans Gonad.
Q41570390At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis
Q30583153C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization
Q90379784C. elegans germ cells divide and differentiate in a folded tissue
Q41764579C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress
Q36197468CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis
Q37612443Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos
Q27320530Cell interactions and patterned intercalations shape and link epithelial tubes in C. elegans
Q34574189Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability
Q36290852Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development
Q34063804EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans
Q30510175GPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans
Q30491435In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation
Q30497921Internalization of multiple cells during C. elegans gastrulation depends on common cytoskeletal mechanisms but different cell polarity and cell fate regulators
Q31106786Lack of developmental redundancy between Unc45 proteins in zebrafish muscle development
Q30513991Laminin is required to orient epithelial polarity in the C. elegans pharynx
Q36344078Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells
Q27321081Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos
Q28116344Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes
Q27309001Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes
Q43187716Myosin assembly, maintenance and degradation in muscle: Role of the chaperone UNC-45 in myosin thick filament dynamics
Q26863588Myosin chaperones
Q42167958PAR proteins regulate maintenance-phase myosin dynamics during Caenorhabditis elegans zygote polarization
Q36245121Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans
Q48217215Protease dead separase inhibits chromosome segregation and RAB-11 vesicle trafficking
Q35107326Quantitative analysis and modeling probe polarity establishment in C. elegans embryos
Q34579574RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database
Q24653982Regulated trafficking of the MSP/Eph receptor during oocyte meiotic maturation in C. elegans
Q47125851SID-1 Domains Important for dsRNA Import in Caenorhabditis elegans
Q46009957Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans.
Q52580548The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell.
Q27330328The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model
Q34477894The UNC-45 myosin chaperone: from worms to flies to vertebrates.
Q34356748The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataract
Q30509509Triggering a cell shape change by exploiting preexisting actomyosin contractions
Q27305022Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad
Q38285301UCS proteins: chaperones for myosin and co-chaperones for Hsp90.
Q28586476Unc45 activates Hsp90-dependent folding of the myosin motor domain
Q47074153Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish
Q41461248aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity